Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,304

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

Varon, R., Vissinga, C., Platzer, M., Cerosaletti, K. M., Chrzanowska, K. H., Saar, K., Beckmann, G., Seemanová, E., Cooper, P. R., Nowak, N. J., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81174-5 · Cited by 1,079

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

Botuyan, M. V., Lee, J., Ward, I. M., Kim, J., Thompson, J. R., Chen, J., & Mer, G. (2006) · Cell · doi:10.1016/j.cell.2006.10.043 · Cited by 1,011

The ATM–Chk2 and ATR–Chk1 Pathways in DNA Damage Signaling and Cancer

Smith, J., Tho, L. M., Xu, N., & Gillespie, D. A. (2010) · Advances in cancer research · doi:10.1016/b978-0-12-380888-2.00003-0 · Cited by 1,331

Double-strand break repair: 53BP1 comes into focus

Panier, S., & Boulton, S. J. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3719 · Cited by 1,168

Alternative lengthening of telomeres: models, mechanisms and implications

Cesare, A. J., & Reddel, R. R. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2763 · Cited by 1,107

DNA repair mechanisms in dividing and non-dividing cells

Iyama, T., & Wilson, D. M. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.04.015 · Cited by 697

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

Chen, H., Li, Y., Li, H., Chen, X., Fu, H., Mao, D., Chen, W., Lan, L., Wang, C., Hu, K., et al. (2024) · Nature · doi:10.1038/s41586-024-07620-9 · Cited by 639

Ionizing Radiation-Induced DNA Damage, Response, and Repair

Santivasi, W. L., & Xia, F. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5668 · Cited by 637

Molecular mechanisms of tumor resistance to radiotherapy

Wu, Y., Song, Y., Wang, R., & Wang, T. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01801-2 · Cited by 527

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

Sun, Y., Jiang, X., Xu, Y., Ayrapetov, M. K., Moreau, L. A., Whetstine, J. R., & Price, B. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1982 · Cited by 454

Human Papillomaviruses Activate the ATM DNA Damage Pathway for Viral Genome Amplification upon Differentiation

Moody, C. A., & Laimins, L. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000605 · Cited by 391

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

Zhao, L.-Y., Mei, J.-X., Yu, G., Lei, L., Zhang, W.-H., Liu, K., Chen, X.-L., Kołat, D., Yang, K., & Hu, J.-K. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01406-7 · Cited by 359

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357

Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

Buis, J. M., Wu, Y., Deng, Y., Leddon, J. L., Westfield, G., Eckersdorff, M., Sekiguchi, J., Chang, S. S., & Ferguson, D. O. (2008) · Cell · doi:10.1016/j.cell.2008.08.015 · Cited by 357

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2)

Pommier, Y. G., Huang, S.-Y. N., Gao, R., Das, B. B., Murai, J., & Marchand, C. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.03.020 · Cited by 347

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

Rass, E., Grabarz, A., Plo, I., Gautier, J., Bertrand, P., & López, B. S. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1641 · Cited by 370

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

Ditch, S., & Paull, T. T. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.10.002 · Cited by 333

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

Hinz, M., Stilmann, M., Arslan, S. Ç., Khanna, K. K., Dittmar, G., & Scheidereit, C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.008 · Cited by 280

BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery

Facchino, S., Abdouh, M., Chatoo, W., & Bernier, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1634-10.2010 · Cited by 253

The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage

Mastrocola, A. S., Kim, S. H., Trinh, A. T., Rodenkirch, L. A., & Tibbetts, R. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.497974 · Cited by 280

Multiple roles of ATM in monitoring and maintaining DNA integrity

Derheimer, F. A., & Kastan, M. B. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.05.031 · Cited by 265

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

Wang, H., Shi, L. Z., Wong, C. C. L., Han, X., Hwang, P. Y.-H., Truong, L. N., Zhu, Q., Shao, Z., Chen, D. J., Berns, M. W., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003277 · Cited by 276

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

Dobbin, M. M., Madabhushi, R., Pan, L., Chen, Y., Kim, D., Gao, J., Ahanonu, B., Pao, P.-C., Qiu, Y., Zhao, Y., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3460 · Cited by 250

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247

Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response

Stracker, T. H., Usui, T., & Petrini, J. H. J. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.012 · Cited by 262

Genetic causes of microcephaly and lessons for neuronal development

Gilmore, E. C., & Walsh, C. A. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.89 · Cited by 254

ATM and the Molecular Pathogenesis of Ataxia Telangiectasia

McKinnon, P. J. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132509 · Cited by 245

A nuclear poly(ADP-Ribose)-dependent signalosome confers DNA damage-induced IκB kinase activation.

Stilmann, M., Hinz, M., Arslan, S. Ç., Zimmer, A., Schreiber, V., & Scheidereit, C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.032 · Cited by 232

CtIP Links DNA Double-Strand Break Sensing to Resection

You, Z., Shi, L. Z., Zhu, Q., Wu, P., Zhang, Y.-W., Basilio, A., Tonnu, N., Verma, I. M., Berns, M. W., & Hunter, T. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.12.002 · Cited by 231

Tip60: Connecting chromatin to DNA damage signaling

Sun, Y., Jiang, X., & Price, B. D. (2010) · Cell Cycle · doi:10.4161/cc.9.5.10931 · Cited by 230

Radiation Induced Non-targeted Response: Mechanism and Potential Clinical Implications

Hei, T. K., Zhou, H., Chai, Y., Ponnaiya, B., & Ivanov, V. N. (2011) · Current Molecular Pharmacology · doi:10.2174/1874467211104020096 · Cited by 224

Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response

Salton, M., Lerenthal, Y., Wang, S., Chen, D. J., & Shiloh, Y. (2010) · Cell Cycle · doi:10.4161/cc.9.8.11298 · Cited by 218

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

Lammens, K., Bemeleit, D., Möckel, C., Clausing, E., Schele, A., Hartung, S., Schiller, C., Lucas, M., Angermueller, C., Söding, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.038 · Cited by 216

ATM signalling and cancer

Cremona, C. A., & Behrens, A. (2013) · Oncogene · doi:10.1038/onc.2013.275 · Cited by 219

Cell-Cell Communication in the Tumor Microenvironment, Carcinogenesis, and Anticancer Treatment

Brücher, B. L. D. M., & Jamall, I. S. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000362978 · Cited by 210

Multiple functions of MRN in end-joining pathways during isotype class switching

Dinkelmann, M., Spehalski, E. I., Stoneham, T., Buis, J. M., Wu, Y., Sekiguchi, J., & Ferguson, D. O. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1639 · Cited by 218

Rare, Evolutionarily Unlikely Missense Substitutions in ATM Confer Increased Risk of Breast Cancer

Tavtigian, S. V., Oefner, P. J., Babikyan, D., Hartmann, A., Healey, S. C., Calvez‐Kelm, F. L., Lesueur, F., Byrnes, G. B., Chuang, S., Forey, N., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.08.018 · Cited by 195

Shelterin complex and associated factors at human telomeres

Diotti, R., & Loayza, D. (2011) · Nucleus · doi:10.4161/nucl.2.2.15135 · Cited by 195

Epigenetic Modifications in Double-Strand Break DNA Damage Signaling and Repair

Rossetto, D., Truman, A. W., Kron, S. J., & Côté, J. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0513 · Cited by 183

MRE11 UFMylation promotes ATM activation

Wang, Z., Gong, Y., Peng, B., Shi, R., Fan, D., Zhao, H., Zhu, M., Zhang, H., Lou, Z., Zhou, J., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz110 · Cited by 169

Targeting the DNA Damage Response in Cancer

Ljungman, M. E. (2009) · Chemical Reviews · doi:10.1021/cr900047g · Cited by 164

The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis

Farg, M. A., Konopka, A., Soo, K. Y., Ito, D., & Atkin, J. D. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx170 · Cited by 173

Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis

Pouget, J., Georgakilas, A. G., & Ravanat, J. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7267 · Cited by 172

ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor

Lavin, M. F., Kozlov, S., Gatei, M. H., & Kijas, A. W. (2015) · Biomolecules · doi:10.3390/biom5042877 · Cited by 164

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA‐PK

Das, B. B., Antony, S., Gupta, S., Dexheimer, T. S., Redon, C. E., Garfield, S., Shiloh, Y., & Pommier, Y. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.302 · Cited by 151

Overexpression of the Circadian Clock Gene Bmal1 Increases Sensitivity to Oxaliplatin in Colorectal Cancer

Zeng, Z.-L., Luo, H., Yang, J., Wu, W.-J., Chen, D.-L., Huang, P., & Xu, R. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0171 · Cited by 154

ATP‐driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

Deshpande, R. A., Williams, G. J., Limbo, O., Williams, R. S., Kuhnlein, J., Lee, J., Classen, S., Guenther, G., Russell, P. R., Tainer, J. A., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201386100 · Cited by 160

Wip1 phosphatase is associated with chromatin and dephosphorylates γH2AX to promote checkpoint inhibition

Macůrek, L., Lindqvist, A., Voets, O., Kool, J., Vos, H. R., & Medema, R. H. (2010) · Oncogene · doi:10.1038/onc.2009.501 · Cited by 153

Telomere structure and telomerase in health and disease

Gomez, D. E., Armando, R. G., Fariña, H. G., Menna, P. L., Cerrudo, C. S., Ghiringhelli, P. D., & Alonso, D. F. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1611 · Cited by 155

Evolution of human vocal production

Ghazanfar, A. A., & Drew Rendall, A. (2008) · Current Biology · doi:10.1016/j.cub.2008.03.030 · Cited by 144

Regulation of Protein Synthesis by Ionizing Radiation

Braunstein, S. E., Badura, M. L., Xi, Q., Formenti, S. C., & Schneider, R. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00711-09 · Cited by 141

The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation

Nicholson, T. B., Chen, T., & Richard, S. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.07.006 · Cited by 142

New Approaches to Radiation Protection

Rosen, E. M., Day, R. M., & Singh, V. K. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2014.00381 · Cited by 140

The role of the DNA damage response in neuronal development, organization and maintenance

Barzilai, A., Biton, S., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.005 · Cited by 139

DNA single-strand break-induced DNA damage response causes heart failure

Higo, T., Naito, A. T., Sumida, T. S., Shibamoto, M., Okada, K., Nomura, S., Nakagawa, A., Yamaguchi, T., Sakai, T., Hashimoto, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms15104 · Cited by 135

Accumulation of Cytoplasmic DNA Due to ATM Deficiency Activates the Microglial Viral Response System with Neurotoxic Consequences

Song, X., Ma, F., & Herrup, K. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0774-19.2019 · Cited by 133

The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle

Biton, S., Barzilai, A., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.006 · Cited by 136

DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe

Ashley, A. K., Shrivastav, M., Nie, J., Amerin, C. L., Troksa, K. A., Glanzer, J. G., Liu, S., Opiyo, S. O., Dimitrova, D. D., Le, P. N., et al. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.04.008 · Cited by 141

Activation of DSB Processing Requires Phosphorylation of CtIP by ATR

Peterson, S., Li, Y., Wu-Baer, F., Chait, B. T., Baer, R. J., Yan, H., Gottesman, M. E., & Gautier, J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.020 · Cited by 137

Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1

Wu, J., Zhang, X., Zhang, L., Wu, C., Rezaeian, A. H., Chan, C., Li, J.-M., Wang, J., Gao, Y., Han, F., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.02.018 · Cited by 135

Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process

Alessio, N., Gaudio, S. D., Capasso, S., Bernardo, G. D., Cappabianca, S., Cipollaro, M., Peluso, G., & Galderisi, U. (2014) · Oncotarget · doi:10.18632/oncotarget.2692 · Cited by 124

Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress

Kemp, M. G., Akan, Z., Yilmaz, S., Grillo, M., Smith‐Roe, S. L., Kang, T., Cordeiro‐Stone, M., Kaufmann, W. K., Abraham, R. T., Sancar, A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.110304 · Cited by 129

Productive Replication of Human Papillomavirus 31 Requires DNA Repair Factor Nbs1

Anacker, D. C., Gautam, D., Gillespie, K. A., Chappell, W. H., & Moody, C. A. (2014) · Journal of Virology · doi:10.1128/jvi.00517-14 · Cited by 122

PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis?

Swindall, A. F., Stanley, J. A., & Yang, E. S.-H. (2013) · Cancers · doi:10.3390/cancers5030943 · Cited by 123

ATM protein kinase: the linchpin of cellular defenses to stress

Bhatti, S., Kozlov, S., Farooqi, A. A., Naqi, A., Lavin, M., & Khanna, K. K. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0683-9 · Cited by 116

Adeno-Associated Virus Replication Induces a DNA Damage Response Coordinated by DNA-Dependent Protein Kinase

Schwartz, R. A., Carson, C. T., Schuberth, C., & Weitzman, M. D. (2009) · Journal of Virology · doi:10.1128/jvi.00318-09 · Cited by 115

Dealing with DNA damage: Relationships between checkpoint and repair pathways

Warmerdam, D. O., & Kanaar, R. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2009.12.001 · Cited by 122

Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required for Mitotic ATM Activation and the Spindle Checkpoint

Yang, C., Tang, X., Guo, X., Niikura, Y., Kitagawa, K., Cui, K., Wong, S. T. C., Fu, L., & Xu, B. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.09.016 · Cited by 115

The cellular response to DNA damage: A focus on MDC1 and its interacting proteins

Coster, G., & Goldberg, M. (2010) · Nucleus · doi:10.4161/nucl.1.2.11176 · Cited by 115

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

Daniel, J. A., Pellegrini, M., Lee, J., Paull, T. T., Feigenbaum, L., & Nussenzweig, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200805154 · Cited by 113

Targeting the Checkpoint to Kill Cancer Cells

Benada, J., & Macůrek, L. (2015) · Biomolecules · doi:10.3390/biom5031912 · Cited by 115

DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression

Wang, W., Mani, A. M., & Wu, Z. (2017) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2017.03 · Cited by 112

DNA lesions sequestered in micronuclei induce a local defective-damage response

Terradas, M., Martín, M., Tusell, L., & Genescà, A. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.07.004 · Cited by 110

Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase

Kass, E. M., Helgadottir, H. R., Chen, C.-C., Barbera, M. A., Wang, R., Westermark, U., Ludwig, T., Moynahan, M. E., & Jasin, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216824110 · Cited by 110

Inhibition of AMP-activated Protein Kinase α (AMPKα) by Doxorubicin Accentuates Genotoxic Stress and Cell Death in Mouse Embryonic Fibroblasts and Cardiomyocytes

Wang, S., Song, P., & Zou, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.315812 · Cited by 111

Ataxia Telangiectasia-Mutated Damage-Signaling Kinase- and Proteasome-Dependent Destruction of Mre11-Rad50-Nbs1 Subunits in Simian Virus 40-Infected Primate Cells

Zhao, X., Madden-Fuentes, R. J., Lou, B. X., Pipas, J. M., Gerhardt, J., Rigell, C. J., & Fanning, E. (2008) · Journal of Virology · doi:10.1128/jvi.02677-07 · Cited by 104

Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair

Korsholm, L. M., Gál, Z., Lin, L., Quevedo, O., Ahmad, D. A., Dulina, E., Luo, Y., Bártek, J., & Larsen, D. H. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz518 · Cited by 102

DNA damage checkpoint response to aflatoxin B1

Engin, A. B., & Engin, A. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.12.006 · Cited by 104

FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage

Chung, Y. M., Park, S., Tsai, W.-B., Wang, S., Ikeda, M.-A., Berek, J. S., Chen, D. J., & Hu, M. C. ‐. (2012) · Nature Communications · doi:10.1038/ncomms2008 · Cited by 104

DIM (3,3′-diindolylmethane) confers protection against ionizing radiation by a unique mechanism

Fan, S., Meng, Q., Xu, J., Jiao, Y., Zhao, L., Zhang, X., Sarkar, F. H., Brown, M. L., Dritschilo, A., & Rosen, E. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308206110 · Cited by 99

ATM prevents DSB formation by coordinating SSB repair and cell cycle progression

Khoronenkova, S. V., & Dianov, G. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416031112 · Cited by 111

Ack1-mediated Androgen Receptor Phosphorylation Modulates Radiation Resistance in Castration-resistant Prostate Cancer

Mahajan, K. N., Coppola, D., Rawal, B., Chen, Y. A., Lawrence, H. R., Engelman, R. W., Lawrence, N. J., & Mahajan, N. P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.357384 · Cited by 98

Role of p53 in human chondrocyte apoptosis in response to shear strain

Hashimoto, S., Nishiyama, T., Hayashi, S., Fujishiro, T., Takebe, K., Kanzaki, N., Kuroda, R., & Kurosaka, M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24706 · Cited by 94

Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

Carson, C. T., Orazio, N. I., Lee, D. V., Suh, J., Bekker‐Jensen, S., Araujo, F. D., Lakdawala, S. S., Lilley, C. E., Bártek, J., Lukas, J., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.15 · Cited by 95

Regulation of DNA replication by the S-phase DNA damage checkpoint

Willis, N. A., & Rhind, N. (2009) · Cell Division · doi:10.1186/1747-1028-4-13 · Cited by 105

Phosphatases in the cellular response to DNA damage

Freeman, A. K., & Monteiro, Á. N. A. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-27 · Cited by 104

Sirtuins and DNA damage repair: SIRT7 comes to play

Vázquez, B. N., Thackray, J. K., & Serrano, L. (2017) · Nucleus · doi:10.1080/19491034.2016.1264552 · Cited by 96

Rad17 recruits the MRE11‐RAD50‐NBS1 complex to regulate the cellular response to DNA double‐strand breaks

Wang, Q., Goldstein, M., Alexander, P. B., Wakeman, T. P., Sun, T., Feng, J., Lou, Z., Kastan, M. B., & Wang, X.-F. (2014) · The EMBO Journal · doi:10.1002/embj.201386064 · Cited by 102

Adenovirus E1B 55-Kilodalton Protein Is a p53-SUMO1 E3 Ligase That Represses p53 and Stimulates Its Nuclear Export through Interactions with Promyelocytic Leukemia Nuclear Bodies

Pennella, M. A., Liu, Y., Woo, J. L., Kim, C. A., & Berk, A. J. (2010) · Journal of Virology · doi:10.1128/jvi.01442-10 · Cited by 89

Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection

Paull, T. T. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.015 · Cited by 90

FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA

Geng, Y., Long, X., Zhang, Y., Wang, Y., You, G., Guo, W., Zhang, Y., Zhang, Y., Cheng, X., Yuan, Z., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04461-4 · Cited by 83

HSV-1 DNA Replication—Coordinated Regulation by Viral and Cellular Factors

Packard, J. E., & Dembowski, J. A. (2021) · Viruses · doi:10.3390/v13102015 · Cited by 82

Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair

Kumar, V., Fleming, T. H., Terjung, S., Gorzelanny, C., Gebhardt, C., Agrawal, R., Mall, M. A., Ranzinger, J., Zeier, M. G., Madhusudhan, T., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx705 · Cited by 82

Molecular aberrations, targeted therapy, and renal cell carcinoma: current state-of-the-art

Randall, J. M., Millard, F. E., & Kurzrock, R. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-014-9533-1 · Cited by 82

Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1

Lin, H.-P., Lin, C., Huo, C., Hsiao, P.-H., Su, L., Jiang, S. S., Chan, T.-M., Chang, C.-H., Chen, L., Kung, H.-J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3246 · Cited by 82

ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells

Marabitti, V., Lillo, G., Malacaria, E., Palermo, V., Sanchez, M., Pichierri, P., & Franchitto, A. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz025 · Cited by 82

Mitochondria at the crossroads of ATM-mediated stress signaling and regulation of reactive oxygen species

Lee, J., & Paull, T. T. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101511 · Cited by 83

CD155/TIGIT, a novel immune checkpoint in human cancers (Review)

Liu, L., You, X., Han, S., Sun, Y., Zhang, J., & Zhang, Y. (2021) · Oncology Reports · doi:10.3892/or.2021.7943 · Cited by 80

Targeting BRCA1‐BER deficient breast cancer by ATM or DNA‐PKcs blockade either alone or in combination with cisplatin for personalized therapy

Albarakati, N., Abdel-Fatah, T. M. A., Doherty, R. E., Russell, R., Agarwal, D., Moseley, P. M., Perry, C., Arora, A., Alsubhi, N. H., Seedhouse, C., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.08.001 · Cited by 79

Regulators of homologous recombination repair as novel targets for cancer treatment

Krajewska, M., Fehrmann, R. S. N., de Vries, E. G. E., & van Vugt, M. A. T. M. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00096 · Cited by 81

Dancing on Damaged Chromatin: Functions of ATM and the RAD50/MRE11/NBS1 Complex in Cellular Responses to DNA Damage

Iijima, K., Ohara, M., Seki, R., & Tauchi, H. (2008) · Journal of Radiation Research · doi:10.1269/jrr.08065 · Cited by 77

Epigenetic regulation of genomic integrity

Deem, A. K., Li, X., & Tyler, J. K. (2012) · Chromosoma · doi:10.1007/s00412-011-0358-1 · Cited by 78

ATM activation by DNA double-strand breaks through

Lee, J., & Paull, T. T. (2016)

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Characterization of the mechanisms of ATM activation by the MRN complex and DNA

Lee, J. H. (2005) · Texas ScholarWorks (Texas Digital Library)

Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

Dupré, A., Boyer-Châtenet, L., & Gautier, J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1090 · Cited by 248

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2004) · Science · doi:10.1126/science.1091496 · Cited by 762