Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

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ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,304

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

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Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

Botuyan, M. V., Lee, J., Ward, I. M., Kim, J., Thompson, J. R., Chen, J., & Mer, G. (2006) · Cell · doi:10.1016/j.cell.2006.10.043 · Cited by 1,011

The Protumorigenic Role of Caspase-8 in Neuroblastoma

Twitchell, D. D. (2013) · doi:10.21007/etd.cghs.2013.0327

The Role of Telomere Maintenance in Adult Mammalian Acute Central Nervous System Injury and Retinal Ganglion Cell Apoptosis

Lysko, M. D. (2016) · TSpace (University of Toronto)

Genomics and proteomics approaches to identify resveratrol targets in cancer

López‐Camarillo, C., Medina‐Aguilar, R., Flores, C. P., & Marchat, L. A. (2017) · Wiley eBooks · doi:10.1002/9781119101277.ch7

Estudo de letalidade sintética em células transformadas por papilomavírus humano (HPV).

Abjaude, W. D. S. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2017.tde-15052017-144525

The Ubiquitin Proteasome System and Cerebellar Developmental Disease

Vriend, J. P., & Jiao, X. (2017) · Contemporary clinical neuroscience · doi:10.1007/978-3-319-59749-2_9

Inhibition of the kinase Wee1 - Cytotoxic mechanisms and autoprotection by the tumor suppressor p53

Li, Y. (2017) · doi:10.53846/goediss-6554

Hypoxia and the DNA Damage Response

Pires, I. M., Poole, R. L., & Hammond, E. M. (2010) · Wiley eBooks · doi:10.1002/9780470669891.ch10

Cancer drugs targeting DNA replication: Molecular strategies to enhance specificity and efficacy

Li, Y. (2020) · doi:10.53846/goediss-8088

Classification of genetic variants in hereditary cancer genes

Feliubadaló, L., Parsons, M. T., Pineda, M., & Tudini, E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820519-8.00003-x

ANALYSIS OF THE ASSOCIATION OF ATM AND TP53 GENES POLYMORPHISM WITH IRRADIATION FACTOR IN KAZAKHSTAN POPULATIONS

Khussainova, E., Bekmanov, B., Zhunisbekova, B. B., Amirgalieva, A. S., & Muratova, F. T. (2021) · SERIES OF BIOLOGICAL AND MEDICAL · doi:10.32014/2020.2519-1629.51

Faculty Opinions recommendation of Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.

Dutta, A. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1168065.1636054

Faculty Opinions recommendation of Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.

Nussenzweig, A. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1138929.604402

DNA Repair, Overview

Barbe, J. H., O’Hayer, K., & Brody, J. R. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6613-0_107-1

Implicación de las quinasas humanas VRK1 y VRK2 en las rutas de respuesta a daño genético y apoptosis

Monsalve, D. M. (2014) · Gredos (University of Salamanca) · doi:10.14201/gredos.124182

Multicolor Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers

Laubenthal, J., Gdula, M. R., Dhawan, A., & Anderson, D. C. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9646-9_15

A Narrative Review of ATM Diagnosis Methods: Comparative Analyzing

(2020) · International Journal of Clinical Chemistry and Laboratory Medicine · doi:10.20431/2455-7153.0602002

DNA Tamir Mekanizması İlişkili Genlerin Biyoinformatik Yöntemlerle Glioblastomda Tanımlanması

Çağlar, H. O. (2022) · Kocaeli Üniversitesi Sağlık Bilimleri Dergisi · doi:10.30934/kusbed.1003777

Application of nuclear magnetic resonance spectroscopy for the detection of metabolic changes in blood cells with defective DNA repair

Vanderstichelen, G. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.68013

The Ubiquitin–Proteasome System and Cerebellar Developmental Disease

Vriend, J. P., & Jiao, X. (2023) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-23104-9_12

DNA Damage Response in Early Breast Cancer: A Phase III Cohort in the Phobos Study

Krasniqi, E., Ercolani, C., Benedetto, A. D., Lisa, F. S. D., Filomeno, L., Arcuri, T., Botti, C., Pelle, F., Cavicchi, F., Cappelli, S., et al. (2024) · Cancers · doi:10.3390/cancers16152628

Temporal patterns of melanopsin-evoked calcium signaling engage NF-κB-associated transcriptional and phosphoproteomic responses

Nikpour, P., Varas‐Godoy, M., Tenghamn, J., Uhlén, P., & Smedler, E. (2026) · iScience · doi:10.1101/2025.10.10.676024

Multicolor Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers

Laubenthal, J., Krist, B., Dhawan, A., Anderson, D. C., & Gdula, M. R. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4976-3_14

Réparation des cassures double brin de l'adn chez les mammifères : rôle des protéines MRE11 et BLM dans l’initiation de la ligature d’extrémités non homologues (NHEJ )

Grabarz, A. (2011) · theses.fr (ABES) · doi:10.70675/02d2d5f8z36aaz4d04z9d37z5384351bf9cf

Chromatin structure and DNA repair

Hoffbeck, A.-S. (2013) · theses.fr (ABES) · doi:10.70675/ab1412f8zbddbz4ed2z8999zbb37db7c920a

Comprendre et perturber le choix de la voie de réparation des cassures double brin de l'ADN pour augmenter l'efficacité et la sélectivité des agents anticancéreux génotoxiques

Chanut, P. (2017) · theses.fr (ABES) · doi:10.70675/8712c9e0za693z4ff3zac1cz5973c1d276f9

Radiosensitizing effect of AGuIX® in Head and Neck Squamous Cell Carcinoma (HNSCC) : from cellular uptake to subcellular damage

Simonet, S. (2018) · theses.fr (ABES) · doi:10.70675/791e42afzc736z4d97zb3ccz2fb0fb5f761d

3-D Genome organization of DNA damage repair

Banerjee, U. K. (2017) · theses.fr (ABES) · doi:10.70675/25480b49zc194z4a4bzb6b0z2f84dab6ccef

DNA double-strand break formation and signalling in response to transcription-blocking topoisomerase I complexes

Cristini, A. (2015) · theses.fr (ABES) · doi:10.70675/89719cadza51cz4509zbd9fz3da99c280491

Implication of DNA damage and repair in viability and differentiation of muscle stem cells

Sutcu, H. H. (2018) · theses.fr (ABES) · doi:10.70675/16d90ec5z5de0z495fzb8c9zc61a837a276b

Caractérisation fonctionnelle de la tolérance aux endommagements de l’ADN des embryons précoces

Furno, E. L. (2019) · theses.fr (ABES) · doi:10.70675/cf32bcd5z3031z4693z8b1bz62fe76673ccc

Rôles d’Arpin dans la migration cellulaire et la réparation de l’ADN

Simanov, G. (2021) · theses.fr (ABES) · doi:10.70675/f7d81667z3bc8z4803zb7c9z03c815cb6e5c

Development of an enzymatic assay on biochip measuring DNA double strand breaks repair capacity : biological validation and applications

Tatin, X. (2021) · theses.fr (ABES) · doi:10.70675/2e1efdc7ze73bz4150za65dzec3d74346874

Stiffness-dependent alveolar type II cell senescence in idiopathic pulmonary fibrosis

Lin, C.-R., Woranam, K., Hayek, H., Jeger, J., Karim, L., Kośmider, B., Kaminski, R., Schultz, C. W., Bolla, S., Marchetti, N., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02881-5

ATM Inhibitor KU-60019 Induces Extracellular Vesicle Secretion in HeLa Cells

Aleksandrov, A., Iliev, D., Bankov, B., Antov, G., & Stoichev, S. (2026) · European Journal of Biology · doi:10.26650/eurjbiol.2026.1869737

WWOX contributes to DNA damage, but not somatic instability in Huntington’s diseasePreprint

Petrozziello, T., McLean, Z. L., Boudi, A., Huntress, S. S., Granucci, E. J., Field, G. A., Monsanto, R. Z. B., Torres, A. L. C., Roy, J. C. L., Kesavan, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.24.734331

MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in micePreprint

Lukaszewicz, A., Wilson, T. E., Kim, S., Keeney, S., & Jasin, M. (2026) · Genes & Development · doi:10.1101/gad.353693.126

BindingDB Entry 50022515: Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.

BindingDB (2025) · UC San Diego · doi:10.7270/q2vx0n7p

ATM activation by DNA double-strand breaks through

Lee, J., & Paull, T. T. (2016)

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Characterization of the mechanisms of ATM activation by the MRN complex and DNA

Lee, J. H. (2005) · Texas ScholarWorks (Texas Digital Library)

Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

Dupré, A., Boyer-Châtenet, L., & Gautier, J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1090 · Cited by 248

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2004) · Science · doi:10.1126/science.1091496 · Cited by 762