Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,304

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

Varon, R., Vissinga, C., Platzer, M., Cerosaletti, K. M., Chrzanowska, K. H., Saar, K., Beckmann, G., Seemanová, E., Cooper, P. R., Nowak, N. J., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81174-5 · Cited by 1,079

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

Botuyan, M. V., Lee, J., Ward, I. M., Kim, J., Thompson, J. R., Chen, J., & Mer, G. (2006) · Cell · doi:10.1016/j.cell.2006.10.043 · Cited by 1,011

Artemis and Nonhomologous End Joining-Independent Influence of DNA-Dependent Protein Kinase Catalytic Subunit on Chromosome Stability

Stracker, T. H., Williams, B. R., Deriano, L., Theunissen, J.-W. F., Adelman, C. A., Roth, D. B., & Petrini, J. H. J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01354-08 · Cited by 20

Tanshinol suppresses osteosarcoma by specifically inducing apoptosis of U2-OS cells through p53-mediated mechanism

Yu, S., Guo, L., Yan, B., Yuan, Q., Shan, L., Zhou, L., & Efferth, T. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115214 · Cited by 18

Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline ATM sequence variants

Richardson, M. E., Holdren, M. A., Brannan, T., de la Hoya, M., Spurdle, A. B., Tavtigian, S. V., Young, C. C., Zec, L., Hiraki, S. C., Anderson, M. J., et al. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.08.022 · Cited by 20

Giant cell formation: the way to cell death or cell survival?

Horbay, R., & Stoika, R. S. (2011) · Open Life Sciences · doi:10.2478/s11535-011-0058-0 · Cited by 19

Enhanced cellular radiosensitivity induced by cofilin-1 over-expression is associated with reduced DNA repair capacity

Leu, J., Chiu, Y.-W., Lo, C.-C., Chiang, P.-H., Chiu, S.-J., Tsai, C.-H., Hwang, J., Chen, R.-C., Gorbunova, V. A., & Lee, Y. (2013) · International Journal of Radiation Biology · doi:10.3109/09553002.2013.767992 · Cited by 18

Topical Curcumin: A Review of Mechanisms and uses in Dermatology

Heng, M. (2017) · International Journal of Dermatology and Clinical Research · doi:10.17352/2455-8605.000020 · Cited by 18

ATM and p53 combined analysis predicts survival in glioblastoma multiforme patients: A clinicopathologic study

Romano, F. J., Guadagno, E., Solari, D., Borrelli, G., Pignatiello, S., Cappabianca, P., & De, M. D. B. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26699 · Cited by 18

Endosulfan causes the alterations of DNA damage response through ATM-p53 signaling pathway in human leukemia cells

Xu, D., Dong, L., Guo, Y., & Sun, Y. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.03.044 · Cited by 18

Transcriptomic Analysis of HCN-2 Cells Suggests Connection among Oxidative Stress, Senescence, and Neuron Death after SARS-CoV-2 Infection

Valeri, A., Chiricosta, L., Calcaterra, V., Biasin, M., Cappelletti, G., Carelli, S., Zuccotti, G., Bramanti, P., Pelizzo, G., Mazzon, E., et al. (2021) · Cells · doi:10.3390/cells10092189 · Cited by 18

DNA damage response as a biomarker in treatment of leukemias

Halicka, H. D., Ozkaynak, F. M., Levendoglu‐Tugal, O., Sandoval, C., Seiter, K. P., Kajstura, M. A., Traganos, F., Jayabose, S., & Darżynkiewicz, Z. (2009) · Cell Cycle · doi:10.4161/cc.8.11.8598 · Cited by 18

A-T neurodegeneration and DNA damage-induced transcriptional stress

Paull, T. T., & Woolley, P. R. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103647 · Cited by 17

Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts

Kumar, S., Yoo, H. Y., Kumagai, A., Shevchenko, A., Shevchenko, A., & Dunphy, W. G. (2012) · Cell Cycle · doi:10.4161/cc.11.6.19636 · Cited by 17

Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in�vitro

Li, J., & Zheng, J. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9745 · Cited by 17

Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF‐κB via targeting of Mre11

Zhang, J., Xin, X., Chen, Q., Xie, Z., Gui, M., Chen, Y., Lin, L., Feng, J., Li, Q., Ding, J., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.26021 · Cited by 17

Breaks invisible to the DNA damage response machinery accumulate in ATM‐deficient cells

Martı́n, M., Terradas, M., Iliakis, G. E., Tusell, L., & Genescà, A. (2009) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20679 · Cited by 17

Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition

Ogi, H., Goto, G. H., Ghosh, A. K., Zencir, S., Henry, E., & Sugimoto, K. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-05-0259 · Cited by 21

Predisposition to hematopoietic malignancies by deleterious germline CHEK2 variants

Stubbins, R. J., Arnovitz, S., Vagher, J., Asom, A. S., Perpich, M., Pies, M., Akpan, I. J., Chew, E., Bridgers, J., Karsan, A., et al. (2025) · Leukemia · doi:10.1038/s41375-025-02635-1 · Cited by 16

A Kinase-Independent Role for the Rad3ATR-Rad26ATRIP Complex in Recruitment of Tel1ATM to Telomeres in Fission Yeast

Subramanian, L., & Nakamura, T. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000839 · Cited by 16

Ionizing radiation and toll like receptors: A systematic review article

Mehdipour, A., Yousefi‐Ahmadipour, A., Kennedy, D. D., & Arababadi, M. K. (2021) · Human Immunology · doi:10.1016/j.humimm.2021.03.008 · Cited by 16

Activation of ATM/Chk2 by Zanthoxylum armatum DC extract induces DNA damage and G1/S phase arrest in BRL 3A cells.

Jiang, J., Huang, Y., Wang, W., Sun, C., Liu, Q., Chen, Y., Hu, T., Ma, X., Peng, C. Y., Ma, Y., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114832 · Cited by 16

The Hus1 homologue of Leishmania major encodes a nuclear protein that participates in DNA damage response

Nunes, V. S., Damasceno, J. D., Freire, R., & Tosi, L. R. O. (2011) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2011.01.011 · Cited by 16

Activation of Interferon-Stimulated Genes by γ-Ray Irradiation Independently of the Ataxia Telangiectasia Mutated–p53 Pathway

Sugihara, T., Murano, H., Nakamura, M. M., Ichinohe, K., & Tanaka, K. J. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0358 · Cited by 17

Sensors and Inhibitors for the Detection of Ataxia Telangiectasia Mutated (ATM) Protein Kinase

Huang, C., Filippone, N. R., Reiner, T., & Roberts, S. S. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00166 · Cited by 17

Mael is essential for cancer cell survival and tumorigenesis through protection of genetic integrity

Kim, S.-H., Park, E., Cho, E., Jung, W.-H., Jeon, J., Joo, H.-Y., Lee, K.-H., & Shin, H.-J. (2016) · Oncotarget · doi:10.18632/oncotarget.13756 · Cited by 16

Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway

Purandare, N., Kunji, Y., Xi, Y., Romero, R. J., Gomez‐Lopez, N., Fribley, A. M., Grossman, L. I., & Aras, S. (2022) · iScience · doi:10.1016/j.isci.2022.105342 · Cited by 15

A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein

Bhat, D. S., Spies, M., & Spies, M. (2022) · DNA repair · doi:10.1016/j.dnarep.2022.103421 · Cited by 15

Livin expression is an independent factor in rectal cancer patients with or without preoperative radiotherapy

Ding, Z., Zhang, H., Adell, G., Olsson, B., & Sun, X. (2013) · Radiation Oncology · doi:10.1186/1748-717x-8-281 · Cited by 15

EZH2 Loss Drives Resistance to Carboplatin and Paclitaxel in Serous Ovarian Cancers Expressing ATM

Naskou, J., Beiter, Y., van Rensburg, R., Honisch, E., Rudelius, M., Schlensog, M., Gottstein, J., Walter, L., Braicu, E. I., Sehouli, J., et al. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0141 · Cited by 15

Distinct Epidermal Keratinocytes Respond to Extremely Low-Frequency Electromagnetic Fields Differently

Huang, C.-Y., Chuang, C., Shu, W., Chang, C.-W., Chen, C.-R., Fan, T. C., & Hsu, I. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113424 · Cited by 16

Bone Marrow Failure and Immunodeficiency Associated with Human RAD50 Variants

Takagi, M., Hoshino, A., Bousset, K., Röddecke, J., Martin, H. L., Folcut, I., Tomomasa, D., Yang, X., Kobayashi, J., Sakata, N., et al. (2023) · Journal of Clinical Immunology · doi:10.1007/s10875-023-01591-8 · Cited by 14

Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators

Guan, R., Wen, X., Wu, J., Duan, R. C., Cao, H., Lam, S., Hou, D., Wang, Y., Hu, J., & Chen, Z. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1262-6 · Cited by 14

Arabidopsis thaliana MRE 11 is essential for activation of cell cycle arrest, transcriptional regulation and DNA repair upon the induction of double‐stranded DNA breaks

Šamanić, I., Cvitanić, R., Simunić, J., & Puizina, J. (2016) · Plant Biology · doi:10.1111/plb.12453 · Cited by 14

ATM inhibition enhances Auranofin-induced oxidative stress and cell death in lung cell lines

Ehrenfeld, V., Heusel, J. R., Fulda, S., & van Wijk, S. J. L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244060 · Cited by 14

Disorder, oscillatory dynamics and state switching: the role of c-Myc

Rangarajan, N., Fox, Z., Singh, A., Kulkarni, P., & Govindan Rangarajan, C. (2015) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2015.09.013 · Cited by 14

Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors

Wang, W. T., Catto, J. W. F., & Meuth, M. (2014) · Oncogene · doi:10.1038/onc.2014.221 · Cited by 14

The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence

Li, X., Xu, H., Chong-an, X., Lin, M., Song, X., Yi, F., Feng, Y., Coughlan, K. A., Cho, W., Kim, S. W., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14022431 · Cited by 18

Mechanism of Radiation Carcinogenesis: Role of the TGFBI Gene and the Inflammatory Signaling Cascade

Hei, T. K., Zhao, Y., Zhou, H., & Ivanov, V. N. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0254-1_13 · Cited by 13

Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes

Wang, X., Lupton, C., Lauth, A., Wan, T. C., Foster, P., Patterson, M., Auchampach, J. A., & Lough, J. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.02.005 · Cited by 13

Mycotoxin source and its exposure causing mycotoxicoses

Alshammari, N. (2023) · Bioinformation · doi:10.6026/97320630019348 · Cited by 13

Prognostic Significance of Nuclear Phospho-ATM Expression in Melanoma

Bhandaru, M., Martinka, M., McElwee, K. J., & Rotte, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134678 · Cited by 13

Differential responses to genotoxic agents between induced pluripotent stem cells and tumor cell lines

Lu, Y., Xu, D., Zhou, J., Ma, Y., Jiang, Y., Zeng, W., & Dai, W. H. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-71 · Cited by 13

Accumulation of DNA damage and alteration of the DNA damage response in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia

Popp, H. D., Flach, J., Brendel, S., Ruppenthal, S., Kleiner, H., Seifarth, W., Schneider, S. O., Schulze, T. J., Weiß, C., Wenz, F. K., et al. (2018) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2018.1498494 · Cited by 13

ATM localization and gene expression in the adult mouse eye.

Leemput, J., Masson, C., Bigot, K., Errachid, A., Dansault, A., Provost, A. C., Gadin, S., Aoufouchi, S., Ménasche, M., & Abitbol, M. M. (2009) · PubMed Central · Cited by 12

Diversity of ATM gene variants: a population-based genome data analysis for precision medicine

Fukunaga, H., Taki, Y., & Prise, K. M. (2019) · Human Genomics · doi:10.1186/s40246-019-0234-2 · Cited by 12

Turning the Mre11/Rad50 DNA repair complex on its head: lessons from SMC protein hinges, dynamic coiled-coil movements and DNA loop-extrusion?

Zabolotnaya, E., Mela, I., Henderson, R. M., & Robinson, N. P. (2020) · Biochemical Society Transactions · doi:10.1042/bst20170168 · Cited by 12

Moving beyond PARP Inhibition: Current State and Future Perspectives in Breast Cancer

Palleschi, M., Tedaldi, G., Sirico, M., Virga, A., Ulivi, P., & Giorgi, U. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157884 · Cited by 13

Impact on breast cancer susceptibility and clinicopathological traits of common genetic polymorphisms in TP53, MDM2 and ATM genes in Sardinian women

Floris, M., Pira, G., Castiglia, P., Idda, M. L., Steri, M., Miglio, M. R. D., Piana, A. F., Cossu, A., Azara, A., Arru, C., et al. (2022) · Oncology Letters · doi:10.3892/ol.2022.13451 · Cited by 12

TRIP13 Participates in Immediate-Early Sensing of DNA Strand Breaks and ATM Signaling Amplification through MRE11

Jeong, H., Wie, M., Baek, I., Sohn, G., Um, S.-H., Lee, S., Seo, Y., Ra, J., Lee, E. A., Kim, S., et al. (2022) · Cells · doi:10.3390/cells11244095 · Cited by 12

Intracellular calprotectin (S100A8/A9) facilitates DNA damage responses and promotes apoptosis in head and neck squamous cell carcinoma

Argyris, P. P., Saavedra, F. M., Malz, C., Stone, I. A., Wei, Y., Boyle, W. S., Johnstone, K. F., Khammanivong, A., & Herzberg, M. C. (2023) · Oral Oncology · doi:10.1016/j.oraloncology.2022.106304 · Cited by 12

Aneuploidy-Associated Gene Expression Signatures Characterize Malignant Transformation in Ulcerative Colitis

Gerling, M., Nousiainen, K., Hautaniemi, S., Krüger, S., Fritzsche, B., Homann, N., Bruch, H., Auer, G., Roblick, U. J., Ried, T., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e31827eeaa4 · Cited by 12

Structure–function relationships of the Mre11 protein in the control of DNA end bridging and processing

Marsella, A., Cassani, C., Casari, E., Tisi, R., & Longhese, M. P. (2018) · Current Genetics · doi:10.1007/s00294-018-0861-5 · Cited by 12

Prexasertib: an investigational checkpoint kinase inhibitor for the treatment of high-grade serous ovarian cancer

Evangelisti, G., Barra, F., Moioli, M., Sala, P., Stigliani, S., Gustavino, C., Costantini, S., & Ferrero, S. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1783238 · Cited by 12

Working together and apart: The twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression

Stracker, T. H., & Petrini, J. H. J. (2008) · Cell Cycle · doi:10.4161/cc.7.23.7064 · Cited by 12

hnRNP C1/C2 and Pur-beta proteins mediate induction of senescence by oligonucleotides homologous to the telomere overhang

Puri, N., Mulnix, R. E., Pitman, R., Retzer, A., Bertram, C., Arasi, K., Crees, Z. D., Girard, J., Uppada, S. B., & Stone, A. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s54575 · Cited by 12

Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases

Fan, H., Chi, C.-S., Cheng, S.-N., Lee, H.-F., Tsai, J., Lin, S., & Harn, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms17010026 · Cited by 12

Contribution of Double-strand Break Repair Gene Nijmegen Breakage Syndrome 1 Genotypes, Gender Difference and Smoking Status to Taiwanese Lung Cancer

Chuang, C.-L., Wang, C., Hsu, C., Hsiao, C.-L., Chen, G.-L., Yen, S.-T., Li, H.-T., CHANG, W.-S., Tsai, C.-W., WANG, S.-C., et al. (2017) · Anticancer Research · doi:10.21873/anticanres.11581 · Cited by 12

STK39-mediated amplification of γ-H2A.X promotes homologous recombination and contributes to PARP inhibitor resistance

Xu, Y., Li, C., Yin, H., Nowsheen, S., Xu, X., Kang, W., Liu, X., Chen, L., Lou, Z., Yi, J., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1099 · Cited by 11

ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stability

Shin, M. H., Yuan, M., Zhang, H., Margolick, J. B., & Kai, M. (2012) · Cell Cycle · doi:10.4161/cc.20161 · Cited by 11

ATM rules neurodevelopment and glutamatergic transmission in the hippocampus but not in the cortex

Focchi, E., Cambria, C., Pizzamiglio, L., Murru, L., Pelucchi, S., D’Andrea, L., Piazza, S., Mattioni, L., Passafaro, M., Marcello, E. E., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05038-7 · Cited by 12

Induction of a Cellular DNA Damage Response by Porcine Circovirus Type 2 Facilitates Viral Replication and Mediates Apoptotic Responses

Wei, L., Zhu, S., Wang, J., Quan, R., Yan, X., Li, Z., Hou, L., Wang, N., Yang, Y., Jiang, H., et al. (2016) · Scientific Reports · doi:10.1038/srep39444 · Cited by 11

Flow Cytometry Definition of Rat Mammary Epithelial Cell Populations and Their Distinct Radiation Responses

Kudo, K., Takabatake, M., Nagata, K., Nishimura, Y., Daino, K., Iizuka, D., Nishimura, M., Suzuki, K., Kakinuma, S., & Imaoka, T. (2020) · Radiation Research · doi:10.1667/rr15566.1 · Cited by 11

Marks to stop the clock: histone modifications and checkpoint regulation in the DNA damage responseThis paper is one of a selection of papers published in this Special Issue, entitled 29th Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.

Humpal, S. E., Robinson, D. A., & Krebs, J. E. (2009) · Biochemistry and Cell Biology · doi:10.1139/o08-109 · Cited by 11

Telomere Shortening Mechanisms

Grach, A. (2013) · InTech eBooks · doi:10.5772/55244 · Cited by 11

Distinct DNA damage determines differential phosphorylation of Chk2

Ouchi, M., & Ouchi, T. (2014) · Cancer Biology & Therapy · doi:10.4161/15384047.2014.972823 · Cited by 11

Sodium tungstate modulates ATM function upon DNA damage

Rodríguez-Hernández, C. J., Llorens-Agost, M., Calbó, J., Murguía, J. R., & Guinovart, J. J. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.04.003 · Cited by 11

Gamma/delta intraepithelial lymphocytes in the mouse small intestine

Ogata, M., & Itoh, T. (2016) · Anatomical Science International · doi:10.1007/s12565-016-0341-2 · Cited by 12

Mdc1 modulates the interaction between TopBP1 and the MRN complex during DNA damage checkpoint responses

Choi, S. H., & Yoo, H. Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.158 · Cited by 11

Ultrarare Variants in DNA Damage Repair Genes in Pediatric Acute-Onset Neuropsychiatric Syndrome or Acute Behavioral Regression in Neurodevelopmental Disorders

Cunningham, J. L., Frankovich, J., Dubin, R. A., Pedrosa, E., Baykara, R. N., Schlenk, N., Maqbool, S. B., Dolstra, H., Marino, J., Edinger, J., et al. (2024) · Developmental Neuroscience · doi:10.1159/000541908 · Cited by 10

Loperamide, an antidiarrheal agent, induces apoptosis and DNA damage in leukemia cells

He, X., Zhu, L., Li, S., Chen, Z., & Zhao, X. (2017) · Oncology Letters · doi:10.3892/ol.2017.7435 · Cited by 10

Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation

Kane, J. M., Magliocco, A. M., Zhang, Q., Wang, D., Klimowicz, A., Harris, J., Simko, J. P., DeLaney, T. F., Kraybill, W. G., & Kirsch, D. G. (2018) · Sarcoma · doi:10.1155/2018/8310950 · Cited by 10

Reversed halo sign in radiation induced organizing pneumonia: natural course of the underlying pathophysiology

Tzilas, V., Poletti, V. E., & Bouros, D. E. (2021) · Pulmonology · doi:10.1016/j.pulmoe.2020.12.015 · Cited by 10

Purified Tea (Camellia sinensis (L.) Kuntze) Flower Saponins Induce the p53-Dependent Intrinsic Apoptosis of Cisplatin-Resistant Ovarian Cancer Cells

Ren, N., Chen, L., Li, B., Rankin, G. O., Chen, Y., & Tu, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124324 · Cited by 10

Glycogen synthase kinase (GSK)-3 and mammalian target of rapamycin complex 1 (mTORC1) cooperate to regulate protein S6 kinase 1 (S6K1)

Shin, S., Wolgamott, L., & Yoon, S.-O. (2012) · Cell Cycle · doi:10.4161/cc.11.6.19784 · Cited by 10

Zeylenone synergizes with cisplatin in osteosarcoma by enhancing DNA damage, apoptosis, and necrosis via the Hsp90/ AKT / GSK3β and Fanconi anaemia pathway

Yang, S., Xiao, H., Sun, Y., & Cao, L. (2021) · Phytotherapy Research · doi:10.1002/ptr.7299 · Cited by 9

Novel Connections Between DNA Replication, Telomere Homeostasis, and the DNA Damage Response Revealed by a Genome-Wide Screen for TEL1/ATM Interactions in Saccharomyces cerevisiae

Piening, B., Huang, D., & Paulovich, A. G. (2013) · Genetics · doi:10.1534/genetics.113.149849 · Cited by 9

Age-Dependent Oxidative DNA Damage Does Not Correlate with Reduced Proliferation of Cardiomyocytes in Humans

Huang, Y., Hong, H., Li, M., Liu, J., Jiang, C., Zhang, H., Ye, L., & Zheng, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170351 · Cited by 9

The Carcinogenicity of Aflatoxin B1

Li, J., & Liu, M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88353 · Cited by 9

Inverse changes in telomere length between the blood and brain in depressive-like mice

Liu, Z., Han, R., Zhu, W., Xiu, J., Shen, Y., & Xu, Q. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.089 · Cited by 11

RYBP Sensitizes Cancer Cells to PARP Inhibitors by Regulating ATM Activity

Maybee, D. V., Psaras, A. M., Brooks, T. A., & Ali, M. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911764 · Cited by 9

Molecular Mechanisms of Senescence and Implications for the Treatment of Myeloid Malignancies

Ernst, P., & Heidel, F. H. (2021) · Cancers · doi:10.3390/cancers13040612 · Cited by 9

Myriad factors and pathways influencing tumor radiotherapy resistance

Mi, L., & Zhang, H. (2024) · Open Life Sciences · doi:10.1515/biol-2022-0992 · Cited by 8

GSTpi reduces DNA damage and cell death by regulating the ubiquitination and nuclear translocation of NBS1

Zhou, J., Gu, L., Shi, Y., Huang, T. H., Fan, X., Bi, X., Lü, S., Liang, J., Luo, L., Cao, P., et al. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04057-5 · Cited by 8

Towards Personalized Radiotherapy in Pelvic Cancer: Patient-Related Risk Factors for Late Radiation Toxicity

Nuijens, A. C., Oei, A. L., Franken, N. A. P., Rasch, C. R. N., & Stalpers, L. J. A. (2025) · Current Oncology · doi:10.3390/curroncol32010047 · Cited by 10

Evaluation of the Contribution of Homologous Recombination in DNA Double-Strand Break Repair in Human Fibroblasts after Exposure to Low and Intermediate Doses of X-ray Radiation

Grekhova, A., Pustovalova, M. V., Eremin, P. S., Ozerov, I. V., Максимова, О. А., Gordeev, A. V., Vorobyeva, N. Y., & Osipov, A. N. (2019) · Biology Bulletin · doi:10.1134/s1062359019110037 · Cited by 8

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Li, T., Zheng, Y., Li, T., Guo, M. Z., Wu, X., Liu, R., Liu, Q., You, X., Zeng, W., & Lv, Y. (2022) · Reproductive Toxicology · doi:10.1016/j.reprotox.2022.05.009 · Cited by 8

Recent Advances in ATM Inhibitors As Potential Therapeutic Agents

Dong, C., Wang, Y., Tu, Z., Yan, J., Jiang, Y., Lu, T., Chen, Y., & Liu, H. (2022) · Future Medicinal Chemistry · doi:10.4155/fmc-2022-0252 · Cited by 8

Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells

Vogt, L. M., Boekschoten, M. V., de Groot, P. J., Faas, M. M., & de Vos, P. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.08.011 · Cited by 8

Identification of ELAVL4 as a modulator of radiation sensitivity in A549 non-small cell lung cancer cells

Bae, S. (2011) · Oncology Reports · doi:10.3892/or.2011.1260 · Cited by 8

The Fission Yeast Rad32(Mre11)–Rad50–Nbs1 Complex Acts Both Upstream and Downstream of Checkpoint Signaling in the S-Phase DNA Damage Checkpoint

Willis, N. A., & Rhind, N. (2010) · Genetics · doi:10.1534/genetics.109.113019 · Cited by 9

Radiosensitivity of Human Breast Cancer Cell Lines Expressing the Breast Tumor Kinase (Brk)

Bourton, E. C. (2015) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000331 · Cited by 7

Adult Human Vascular Smooth Muscle Cells on 3D Silk Fibroin Nonwovens Release Exosomes Enriched in Angiogenic and Growth-Promoting Factors

Hu, P., Chiarini, A., Wu, J., Wei, Z., Armato, U., & Prà, I. D. (2022) · Polymers · doi:10.3390/polym14040697 · Cited by 7

Silence of URI in gastric cancer cells promotes cisplatin-induced DNA damage and apoptosis.

Bian, H., Gu, Y., Chen, C., Chen, J., Zhang, F., Xu, Z., Wang, Q., Mi, R., Wu, X., Lu, Y., et al. (2023) · PubMed Central · Cited by 7

Increased γ-H2A.X Intensity in Response to Chronic Medium-Dose-Rate γ-Ray Irradiation

Sugihara, T., Murano, H., & Tanaka, K. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045320 · Cited by 7

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Das, S. (2015) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2015/14120.6074 · Cited by 7

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Vassilakopoulou, M., Won, M., Curran, W. J., Souhami, L., Prados, M. D., Langer, C. J., Rimm, D. L., Hanna, J. A., Neumeister, V. M., Melian, E., et al. (2021) · Oncology · doi:10.1159/000516168 · Cited by 7

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Igotti, M. V., Pojidaeva, A. K., Филиппова, Е. А., Gnedina, O. O., Svetlikova, S. B., & Поспелов, В. А. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.03.031 · Cited by 6

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Florentino, P. T. V., Vitorino, F. N. D. L., Mendes, D., da Cunha, J. P. C., & Menck, C. F. M. (2022) · Journal of Proteomics · doi:10.1016/j.jprot.2022.104773 · Cited by 6

TCL1A and ATM are co-expressed in chronic lymphocytic leukemia cells without deletion of 11q

Garding, A., Bhattacharya, N., Haebe, S., Muller, F., Weichenhan, D., Idler, I. S., Ickstadt, K., Stilgenbauer, S., & Mertens, D. (2012) · Haematologica · doi:10.3324/haematol.2012.070623 · Cited by 6

ATM activation by DNA double-strand breaks through

Lee, J., & Paull, T. T. (2016)

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

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Lee, J. H. (2005) · Texas ScholarWorks (Texas Digital Library)

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Dupré, A., Boyer-Châtenet, L., & Gautier, J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1090 · Cited by 248

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2004) · Science · doi:10.1126/science.1091496 · Cited by 762