The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype
Open accessAbstract
The identification of cancer stem cells (CSCs) represents an important milestone in the understanding of chemodrug resistance and cancer recurrence. More specifically, some studies have suggested that potential metastasis-initiating cells (MICs) might be present within small CSC populations. The targeting and eradication of these cells represents a potential strategy for significantly improving clinical outcomes. A number of studies have suggested that dysregulation of Wnt/β-catenin signaling occurs in human breast cancer. Consistent with these findings, our previous data have shown that the relative level of Wnt/β-catenin signaling activity in breast cancer stem cells (BCSCs) is significantly higher than that in bulk cancer cells. These results suggest that BCSCs could be sensitive to therapeutic approaches targeting Wnt/β-catenin signaling pathway. In this context, abnormal Wnt/β-catenin signaling activity may be an important clinical feature of breast cancer and a predictor of poor survival. We therefore hypothesized that Wnt/β-catenin signaling might regulate self-renewal and CSC migration, thereby enabling metastasis and systemic tumor dissemination in breast cancer. Here, we investigated the effects of inhibiting Wnt/β-catenin signaling on cancer cell migratory potential by examining the expression of CSC-related genes and we examined how this pathway links metastatic potential with tumor formation in vitro and in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Prospective identification of tumorigenic breast cancer cells
Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,370
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M., Reinhard, F., Zhang, C. C., Shipitsin, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,672
Identification of human brain tumour initiating cells
Singh, S. K., Hawkins, C., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., Henkelman, R. M., Cusimano, M. D., & Dirks, P. B. (2004) · Nature · doi:10.1038/nature03128 · Cited by 7,433
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583
Ginestier, C., Hur, M. H., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M., Jacquemier, J., Viens, P., Kleer, C. G., Liu, S., et al. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.014 · Cited by 4,012
Identification and expansion of human colon-cancer-initiating cells
Ricci-Vitiani, L., Lombardi, D. G., Pilozzi, E., Biffoni, M., Todaro, M., Peschle, C., & De Maria, R. (2007) · Nature · doi:10.1038/nature05384 · Cited by 3,998
Wnt signalling in stem cells and cancer
Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666
Genes that mediate breast cancer metastasis to lung
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922
Hermann, P. C., Huber, S. L., Herrler, T., Aicher, A., Ellwart, J. W., Guba, M., Bruns, C. J., & Heeschen, C. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.06.002 · Cited by 2,897
A multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Kakonen, S. M., Cordón-Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,597
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., & Ben-Ze’ev, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5522 · Cited by 2,230
APC mutations occur early during colorectal tumorigenesis
Powell, S. M., Zilz, N., Beazer-Barclay, Y., Bryan, T. M., Hamilton, S. R., Thibodeau, S. N., Vogelstein, B., & Kinzler, K. W. (1992) · Nature · doi:10.1038/359235a0 · Cited by 1,924
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
Wellner, U., Schubert, J., Burk, U. C., Schmalhofer, O., Zhu, F., Sonntag, A., Waldvogel, B., Vannier, C., Darling, D., Hausen, A. Z., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1998 · Cited by 1,699
Applying the principles of stem-cell biology to cancer
Pardal, R., Clarke, M. F., & Morrison, S. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1232 · Cited by 1,624
Aslakson, C. J., & Miller, F. R. (1992) · PubMed · Cited by 1,234
Towards an integrated view of Wnt signaling in development
van Amerongen, R., & Nusse, R. (2009) · Development · doi:10.1242/dev.033910 · Cited by 1,175
Charafe-Jauffret, E., Ginestier, C., Iovino, F., Wicinski, J., Cervera, N., Finetti, P., Hur, M.-H., Diebel, M. E., Monville, F., Dutcher, J., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2741 · Cited by 1,173
Regulation of the actin cytoskeleton in cancer cell migration and invasion
Yamaguchi, H., & Condeelis, J. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.07.001 · Cited by 1,144
Fillmore, C. M., & Kuperwasser, C. (2008) · Breast Cancer Research · doi:10.1186/bcr1982 · Cited by 1,033
Sheridan, C., Kishimoto, H., Fuchs, R. K., Mehrotra, S., Bhat-Nakshatri, P., Turner, C. H., Goulet, R., Badve, S., & Nakshatri, H. (2006) · Breast Cancer Research · doi:10.1186/bcr1610 · Cited by 993
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene
Mori, Y., Nagse, H., Ando, H., Horii, A., Ichii, S., Nakatsuru, S., Aoki, T., Miki, Y., Mori, T., & Nakamura, Y. (1992) · Human Molecular Genetics · doi:10.1093/hmg/1.4.229 · Cited by 932
Ricardo, S., Vieira, A. F., Gerhard, R., Leitão, D., Pinto, R., Cameselle-Teijeiro, J. F., Milanezi, F., Schmitt, F., & Paredes, J. (2011) · Journal of Clinical Pathology · doi:10.1136/jcp.2011.090456 · Cited by 619
Wnt signaling and stem cell control
Nusse, R. (2008) · Cell Research · doi:10.1038/cr.2008.47 · Cited by 585
A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer
Pang, R., Law, W. L., Chu, A. C. Y., Poon, J. T., Lam, C. S. C., Chow, A. K. M., Ng, L., Cheung, L. W. H., Lan, X. R., Lan, H. Y., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.04.001 · Cited by 540
Liu, H., Patel, M. R., Prescher, J. A., Patsialou, A., Qian, D., Lin, J., Wen, S., Chang, Y.-F., Bachmann, M. H., Shimono, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006732107 · Cited by 465
Activation of the small GTP-binding proteins rho and rac by growth factor receptors
Nobes, C. D., Hawkins, P., Stephens, L., & Hall, A. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.1.225 · Cited by 438
Breast carcinoma: Pattern of metastasis at autopsy
Lee, Y. N. (. (1983) · Journal of Surgical Oncology · doi:10.1002/jso.2930230311 · Cited by 406
Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells
Grimshaw, M. J., Cooper, L., Papazisis, K., Coleman, J. A., Bohnenkamp, H. R., Chiapero-Stanke, L., Taylor-Papadimitriou, J., & Burchell, J. M. (2008) · Breast Cancer Research · doi:10.1186/bcr2106 · Cited by 339
Akt Participation in the Wnt Signaling Pathway through Dishevelled
Fukumoto, S., Hsieh, C.-M., Maemura, K., Layne, M. D., Yet, S.-F., Lee, K.-H., Matsui, T., Rosenzweig, A., Taylor, W. G., Rubin, J. S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000880200 · Cited by 334
Wnt signaling in triple negative breast cancer is associated with metastasis
Dey, N., Barwick, B. G., Moreno, C. S., Ordanic-Kodani, M., Chen, Z., Oprea-Ilies, G., Tang, W., Catzavelos, C., Kerstann, K. F., Sledge, G. W., et al. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-537 · Cited by 255
Veeck, J., Niederacher, D., An, H., Klopocki, E., Wiesmann, F., Betz, B., Galm, O., Camara, O., Dürst, M., Kristiansen, G., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209386 · Cited by 254
Nam, J.-S., Terabe, M., Kang, M.-J., Chae, H., Voong, N., Yang, Y.-A., Laurence, A., Michalowska, A., Mamura, M., Lonning, S., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0206 · Cited by 251
Self-citationID genes mediate tumor reinitiation during breast cancer lung metastasis
Gupta, G. P., Perk, J., Acharyya, S., de Candia, P., Mittal, V., Todorova-Manova, K., Gerald, W. L., Brogi, E., Benezra, R., & Massagué, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709185104 · Cited by 247
Mao, J., Fan, S., Ma, W., Fan, P., Wang, B., Zhang, J., Wang, H., Tang, B., Zhang, Q., Yu, X., et al. (2014) · Cell Death & Disease · doi:10.1038/cddis.2013.515 · Cited by 241
Gan, X.-Q., Wang, J.-Y., Xi, Y., Wu, Z.-L., Li, Y.-P., & Li, L. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710050 · Cited by 237
Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors
Klopocki, E., Kristiansen, G., Wild, P., Klaman, I., Castanos-Velez, E., Singer, G., Stöhr, R., Simon, R., Sauter, G., Leibiger, H., et al. (2004) · International Journal of Oncology · doi:10.3892/ijo.25.3.641 · Cited by 169
Pacheco-Pinedo, E. C., Durham, A. C., Stewart, K. M., Goss, A. M., Lu, M. M., DeMayo, F. J., & Morrisey, E. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44871 · Cited by 164
Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling.
van de Wetering, M., Barker, N., Harkes, I. C., van der Heyden, M. A. G., Dijk, N. J., Hollestelle, A., Klijn, J. G. M., Clevers, H. C., & Schutte, M. E. M. (2001) · PubMed · Cited by 151
Cytoplasmic Localization of β-Catenin is a Marker of Poor Outcome in Breast Cancer Patients
López‐Knowles, E., Zardawi, S. J., McNeil, C. M., Millar, E. K. A., Crea, P., Musgrove, E. A., Sutherland, R. L., & O'Toole, S. A. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0741 · Cited by 150
The NF-κB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1β
Kaler, P., Godasi, B. N., Augenlicht, L. H., & Klampfer, L. (2009) · Cancer Microenvironment · doi:10.1007/s12307-009-0030-y · Cited by 148
Charafe‐Jauffret, E., Ginestier, C., Bertucci, F., Cabaud, O., Wicinski, J., Finetti, P., Josselin, E., Adélaïde, J., Nguyen, T.-T., Monville, F., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4704 · Cited by 131
Ugolini, F., Adélaı̈de, J., Charafe‐Jauffret, E., Nguyen, C., Jacquemier, J. D., Jordan, B., Birnbaum, D., & Pébusque, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202739 · Cited by 124
Mouse Models for Tumor Metastasis
Yang, S., Zhang, J. J., & Huang, X.-Y. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-008-3_17 · Cited by 118
Breast Cancer Stem Cells: A Novel Therapeutic Target
Gangopadhyay, S., Nandy, A., Hor, P., & Mukhopadhyay, A. (2012) · Clinical Breast Cancer · doi:10.1016/j.clbc.2012.09.017 · Cited by 117
Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer.
Zardawi, S. J., O'Toole, S. A., Sutherland, R. L., & Musgrove, E. A. (2009) · PubMed · doi:10.14670/hh-24.385 · Cited by 114
Nam, J., Kang, M., Suchar, A. M., Shimamura, T., Kohn, E. A., Michalowska, A. M., Jordan, V. C., Hirohashi, S., & Wakefield, L. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0825 · Cited by 108
Self-citationKim, R., Park, J.-R., Roh, K., Choi, A.-R., Kim, S., Kim, P.-H., Yu, J. H., Lee, J. W., Ahn, S. H., Gong, G., et al. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.026 · Cited by 92
Self-citationSCA-1 Identifies the Tumor-Initiating Cells in Mammary Tumors of BALB-neuT Transgenic Mice
Grange, C., Lanzardo, S., Cavallo, F., Camussi, G., & Bussolati, B. (2008) · Neoplasia · doi:10.1593/neo.08902 · Cited by 86
Cancer stemness in Wnt-driven mammary tumorigenesis
Monteiro, J., Gaspar, C., Richer, W., Franken, P., Sacchetti, A., Joosten, R., Idali, A., Brandao, J., Decraene, C., & Fodde, R. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt279 · Cited by 55
Acute Myeloid Leukemia and the Wnt Pathway
Eaves, C. J., & Humphries, R. K. (2010) · New England Journal of Medicine · doi:10.1056/nejmcibr1003522 · Cited by 52
Tuck (2009) · International Journal of Oncology · doi:10.3892/ijo_00000340 · Cited by 45
Regulation of Breast Cancer-induced Bone Lesions by β-Catenin Protein Signaling
Chen, Y., Shi, H. Y., Stock, S. R., Stern, P. H., & Zhang, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.294595 · Cited by 35
Cited by
Stem cell programs in cancer initiation, progression, and therapy resistance
Huang, T., Song, X., Xu, D., Tiek, D., Goenka, A., Wu, B., Sastry, N., Hu, B., & Cheng, S.-Y. (2020) · Theranostics · doi:10.7150/thno.41648 · Cited by 524
Castagnoli, L., Cancila, V., Cordoba-Romero, S. L., Faraci, S., Talarico, G., Belmonte, B., Iorio, M. V., Milani, M., Volpari, T., Chiodoni, C., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0700-2 · Cited by 184
Tegavivint and the β-Catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma
Nomura, M., Rainusso, N., Lee, Y.-C., Dawson, B., Coarfa, C., Han, R., Larson, J. L., Shuck, R., Kurenbekova, L., & Yustein, J. T. (2019) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djz026 · Cited by 99
Targeting breast cancer stem cells by novel HDAC3-selective inhibitors
Hsieh, H.-Y., Chuang, H.-C., Shen, F.-H., Detroja, K., Hsin, L.-W., & Chen, C.-S. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.08.069 · Cited by 67
Human cancer stem cells are a target for cancer prevention using (−)-epigallocatechin gallate
Fujiki, H., Sueoka, E., Rawangkan, A., & Suganuma, M. (2017) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-017-2515-2 · Cited by 64
Metadata
- Authors
- Jang, G.-B., Kim, J.-Y., Cho, S.-D., Park, K.-S., Jung, J.-Y., Lee, H.-Y., Hong, I.-S., & Nam, J.-S.
- Venue
- Scientific Reports
- Published
- 2015-07-23
- Volume
- 5
- Issue
- 1
- Pages
- 12465-12465
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2407520682
- Cited by
- 328
- References
- 53
- FWCI
- 13.65
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
