Microbial Enterotypes, Inferred by the Prevotella-to-Bacteroides Ratio, Remained Stable during a 6-Month Randomized Controlled Diet Intervention with the New Nordic Diet

Roager, Henrik M.; Licht, Tine R.; Poulsen, Sanne K.; Larsen, Thomas M.; Bahl, Martin I.

doi:10.1128/aem.03549-13

Cited by 194Gut microbiota and healthOral microbiology and periodontitis researchNutritional Studies and Diet

Microbial Enterotypes, Inferred by the Prevotella-to-Bacteroides Ratio, Remained Stable during a 6-Month Randomized Controlled Diet Intervention with the New Nordic Diet

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Roager, Henrik M., Licht, Tine R., Poulsen, Sanne K., Larsen, Thomas M., Bahl, Martin I.·2014·Applied and Environmental Microbiology

DOI 10.1128/aem.03549-13PMC PMC3911217

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Abstract

It has been suggested that the human gut microbiota can be divided into enterotypes based on the abundance of specific bacterial groups; however, the biological significance and stability of these enterotypes remain unresolved. Here, we demonstrated that subjects (n = 62) 18 to 65 years old with central obesity and components of metabolic syndrome could be grouped into two discrete groups simply by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Furthermore, we showed that these groups remained stable during a 6-month, controlled dietary intervention, where the effect of consuming a diet in accord with the new Nordic diet (NND) recommendations as opposed to consuming the average Danish diet (ADD) on the gut microbiota was investigated. In this study, subjects (with and without stratification according to P/B ratio) did not reveal significant changes in 35 selected bacterial taxa quantified by quantitative PCR (ADD compared to NND) resulting from the dietary interventions. However, we found higher total plasma cholesterol within the high-P/B group than in the low-P/B group after the intervention. We propose that stratification of humans based simply on their P/B ratio could allow better assessment of possible effects of interventions on the gut microbiota and physiological biomarkers.

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Three distinct enterotypes have been proposed, each characterized by relatively high levels of a single microbial genus: Bacteroides, Prevotella, or Ruminococcus.
“three distinct enterotypes have been proposed, each of which is characterized by relatively high levels of a single microbial genus: Bacteroides., Prevotella.or Ruminococcus.(Arumugam et al., 2011;Roager et al., 2014).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Roager et al., 2014
The Prevotella:Bacteroides ratio in these subjects was higher than that reported for elderly Irish, American and Danish adults.
“Remarkably, the Prevotella:Bacteroides ratio in these subjects was higher than reported for elderly Irish subjects, 12 American 11 and Danish adults, 65”
From High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome (2016) · cites this paper as [65]

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Authors: Roager, H. M., Licht, T. R., Poulsen, S. K., Larsen, T. M., & Bahl, M. I.
Affiliations: Technical University of Denmark (DK)
University of Copenhagen (DK)
ORCID: Roager, Henrik M.
Licht, Tine R.
Larsen, Thomas M.
Bahl, Martin I.
Venue: Applied and Environmental Microbiology
Publisher: American Society for Microbiology
Published: 2014-02
Volume: 80
Issue: 3
Pages: 1142-1149
ISSN: 0099-2240 (ISSN-L)
1098-5336
DOI: 10.1128/aem.03549-13
PMC: PMC3911217
OpenAlex: W2165768293
Cited by: 194
References: 38
Citations by year: 2026: 7 · 2025: 16 · 2024: 18 · 2023: 14 · 2022: 27 · 2021: 26 · 2020: 16 · 2019: 16 · 2018: 16 · 2017: 14 · 2016: 10 · 2015: 9 · 2014: 5
FWCI: 3.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Applied and Environmental Microbiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, other-oa)
Funders: Nordea-fonden
Strategic Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: New Nordic Diet, dietary intervention, abdominal obesity, metabolic syndrome, serum cholesterol, bacterial taxa abundance, microbiome biomarkers
MeSH terms: Bacteroides, Cholesterol, Diet, Feces, Humans, Plasma, Prevotella, Gastrointestinal Tract, Metagenome, Real-Time Polymerase Chain Reaction

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Microbial Enterotypes, Inferred by the Prevotella-to-Bacteroides Ratio, Remained Stable during a 6-Month Randomized Controlled Diet Intervention with the New Nordic Diet

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