Cited by 285Gut microbiota and healthInfant Nutrition and HealthProbiotics and Fermented Foods

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Bifidobacteria exhibit social behavior through carbohydrate resource sharing in the gut

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Milani, Christian, Lugli, Gabriele Andrea, Duranti, Sabrina, Turroni, Francesca, Mancabelli, Leonardo, Ferrario, Chiara, Mangifesta, Marta, Hevia, Arancha, Viappiani, Alice, Scholz, Matthias, Arioli, Stefania, Sanchez, Borja, Lane, Jonathan, Ward, Doyle V., Hickey, Rita, Mora, Diego, Segata, Nicola, Margolles, Abelardo, van Sinderen, Douwe, Ventura, Marco·2015·Scientific Reports

DOI 10.1038/srep15782PMC PMC4623478

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Abstract

Bifidobacteria are common and frequently dominant members of the gut microbiota of many animals, including mammals and insects. Carbohydrates are considered key carbon sources for the gut microbiota, imposing strong selective pressure on the complex microbial consortium of the gut. Despite its importance, the genetic traits that facilitate carbohydrate utilization by gut microbiota members are still poorly characterized. Here, genome analyses of 47 representative Bifidobacterium (sub)species revealed the genes predicted to be required for the degradation and internalization of a wide range of carbohydrates, outnumbering those found in many other gut microbiota members. The glycan-degrading abilities of bifidobacteria are believed to reflect available carbon sources in the mammalian gut. Furthermore, transcriptome profiling of bifidobacterial genomes supported the involvement of various chromosomal loci in glycan metabolism. The widespread occurrence of bifidobacterial saccharolytic features is in line with metagenomic and metatranscriptomic datasets obtained from human adult/infant faecal samples, thereby supporting the notion that bifidobacteria expand the human glycobiome. This study also underscores the hypothesis of saccharidic resource sharing among bifidobacteria through species-specific metabolic specialization and cross feeding, thereby forging trophic relationships between members of the gut microbiota.

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Authors: Milani, C., Lugli, G. A., Duranti, S., Turroni, F., Mancabelli, L., Ferrario, C., Mangifesta, M., Hevia, A., Viappiani, A., Scholz, M., Arioli, S., Sanchez, B., Lane, J., Ward, D. V., Hickey, R., Mora, D., Segata, N., Margolles, A., van Sinderen, D., & Ventura, M.
Affiliations: University of Parma (IT)
National University of Ireland (IE)
Consejo Superior de Investigaciones Científicas (ES)
University of Trento (IT)
Teagasc - The Irish Agriculture and Food Development Authority (IE)
Broad Institute (US)
University of Milan (IT)
Corresponding author: Ventura, Marco
ORCID: Milani, Christian
Lugli, Gabriele Andrea
Duranti, Sabrina
Turroni, Francesca
Mancabelli, Leonardo
Ferrario, Chiara
Mangifesta, Marta
Hevia, Arancha
Scholz, Matthias
Arioli, Stefania
Lane, Jonathan
Ward, Doyle V.
Hickey, Rita
Mora, Diego
Segata, Nicola
Ventura, Marco
Venue: Scientific Reports
Publisher: Springer Science and Business Media LLC
Published: 2015-10-28
Volume: 5
Issue: 1
Pages: 15782-15782
ISSN: 2045-2322 (ISSN-L)
DOI: 10.1038/srep15782
PMC: PMC4623478
OpenAlex: W2302783498
Cited by: 284
References: 44
Citations by year: 2026: 8 · 2025: 19 · 2024: 20 · 2023: 25 · 2022: 33 · 2021: 25 · 2020: 49 · 2019: 39 · 2018: 22 · 2017: 27 · 2016: 15 · 2015: 1
FWCI: 9.40
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Scientific Reports (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
Funders: U.S. Department of Health and Human Services (HHSN272200900018C)
European Commission (618833)
Science Foundation Ireland (SFI/12/RC/, 12/RC/2273, 12/RC/, SFI/12/RC/2273., 08/SRC/B1393)
Ministero dell’Istruzione, dell’Università e della Ricerca
Fondazione Cassa Di Risparmio Di Trento E Rovereto
Alimentary Glycoscience Research Cluster (08/SRC/B1393)
National Institutes of Health (HHSN272200900018C)
APC Microbiome Institute (SFI/12/RC/2273)
National Institute of Allergy and Infectious Diseases (HHSN272200900018C)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: Bifidobacterium, gut microbiota, carbohydrate utilization, glycan degradation, cross-feeding, resource sharing, gene expression profiling, human faecal microbiota, insect gut microbiota, metabolic specialization
MeSH terms: Adult, Bifidobacterium, Carbohydrates, Feces, Humans, Infant, Gastrointestinal Tract, Carbohydrate Metabolism

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Bifidobacteria exhibit social behavior through carbohydrate resource sharing in the gut

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