Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice
Open accessAbstract
We investigated the relationship between gut health, visceral fat dysfunction and metabolic disorders in diet-induced obesity. C57BL/6J mice were fed control or high saturated fat diet (HFD). Circulating glucose, insulin and inflammatory markers were measured. Proximal colon barrier function was assessed by measuring transepithelial resistance and mRNA expression of tight-junction proteins. Gut microbiota profile was determined by 16S rDNA pyrosequencing. Tumor necrosis factor (TNF)-α and interleukin (IL)-6 mRNA levels were measured in proximal colon, adipose tissue and liver using RT-qPCR. Adipose macrophage infiltration (F4/80⁺) was assessed using immunohistochemical staining. HFD mice had a higher insulin/glucose ratio (P = 0.020) and serum levels of serum amyloid A3 (131%; P = 0.008) but reduced circulating adiponectin (64%; P = 0.011). In proximal colon of HFD mice compared to mice fed the control diet, transepithelial resistance and mRNA expression of zona occludens 1 were reduced by 38% (P<0.001) and 40% (P = 0.025) respectively and TNF-α mRNA level was 6.6-fold higher (P = 0.037). HFD reduced Lactobacillus (75%; P<0.001) but increased Oscillibacter (279%; P = 0.004) in fecal microbiota. Correlations were found between abundances of Lactobacillus (r = 0.52; P = 0.013) and Oscillibacter (r = -0.55; P = 0.007) with transepithelial resistance of the proximal colon. HFD increased macrophage infiltration (58%; P = 0.020), TNF-α (2.5-fold, P<0.001) and IL-6 mRNA levels (2.5-fold; P = 0.008) in mesenteric fat. Increased macrophage infiltration in epididymal fat was also observed with HFD feeding (71%; P = 0.006) but neither TNF-α nor IL-6 was altered. Perirenal and subcutaneous adipose tissue showed no signs of inflammation in HFD mice. The current results implicate gut dysfunction, and attendant inflammation of contiguous adipose, as salient features of the metabolic dysregulation of diet-induced obesity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Increased intestinal barrier permeability is related to the metabolic dysfunction of visceral adipose tissue.
“Increased intestinal barrier permeability is related to the metabolic dysfunction of visceral adipose tissue (Lam et al., 2012).”
From <i>Akkermansia muciniphila</i> alleviates <scp>high‐fat‐diet</scp> ‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids (2023) · cites this paper as Lam et al., 2012
Oscillibacter has been found to be associated with obesity, and its abundance is negatively correlated with intestinal barrier function.
“Oscillibacter has been found to be associated with obesity (Xu et al., 2017), and its abundance is negatively correlated with intestinal barrier function (Lam et al., 2012).”
From <i>Akkermansia muciniphila</i> alleviates <scp>high‐fat‐diet</scp> ‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids (2023) · cites this paper as Lam et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 20,966 · cited 3× · see citing works
“bTEFAP raw data were processed using Mothur [32] unless stated otherwise.”
MethodInfluentialA core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · cited 1× · see citing works
“Finally, there is an emerging body of literature demonstrating an association between altered gut microbiota profile and obesity in humans (see [14] and [15] for a recent review) which, from pioneering work on rodents [12,16,17], appears to be causative.”
BackgroundCani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · cited 5× · see citing works
“Impaired gut barrier function, along with gut inflammation, have also been observed in both genetic [11] and dietary [12,13] models of obesity.”
BackgroundInfluentialObesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · cited 1× · see citing works
“The increased transcriptional expression of pro-inflammatory factors in the mesenteric fat may be a consequence of the preferential infiltration of macrophages with a pro-inflammatory phenotype [60].”
BackgroundBacterial Community Variation in Human Body Habitats Across Space and Time
Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231 · cited 1× · see citing works
“Parameters used to filter sequences for analysis were based upon published studies [33,34].”
MethodMechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615 · cited 1× · see citing works
“Finally, there is an emerging body of literature demonstrating an association between altered gut microbiota profile and obesity in humans (see [14] and [15] for a recent review) which, from pioneering work on rodents [12,16,17], appears to be causative.”
BackgroundCani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068 · cited 1× · see citing works
“, appears to be causative. The cross-linkage between gut microbiota, metabolic dysfunction and the immune system is best illustrated in Toll-like receptor-5 knockout mice which develop spontaneous colitis, insulin resistance, hyperlipidemia and increased visceral fat deposition”
BackgroundDominant and diet-responsive groups of bacteria within the human colonic microbiota
Walker, A. W., Ince, J., Duncan, S. H., Webster, L. M., Holtrop, G., Ze, X., Brown, D., Stares, M. D., Scott, P., Bergerat, A., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2010.118 · Cited by 1,632 · cited 1× · see citing works
“diet-responsive in obese individuals [54] but to date little is known”
BackgroundFain, J. N., Madan, A. K., Hiler, M. L., Cheema, P. S., & Bahouth, S. W. (2004) · Endocrinology · doi:10.1210/en.2003-1336 · Cited by 1,571 · cited 1× · see citing works
“in the stromal-vascular fraction of fat depots [5,6].”
BackgroundMetabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Stockman, J. (2012) · doi:10.1016/j.yped.2010.12.040 · Cited by 1,053
Creely, S. J., McTernan, P. G., Kusminski, C. M., Fisher, F. M., Da Silva, N. F., Khanolkar, M., Evans, M., Harte, A. L., & Kumar, S. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00302.2006 · Cited by 1,043 · cited 1× · see citing works
“However, the recent report of bacterial translocation into the mesenteric fat of HFD mice [63] and of elevated circulating endotoxin levels in animal models of dietinduced obesity [12] and in obese and type 2 diabetic patients related to insulin resistance [64,65] are consistent with our hypothesized role of the gut i…”
BackgroundExploring Microbial Diversity and Taxonomy Using SSU rRNA Hypervariable Tag Sequencing
Huse, S. M., Dethlefsen, L., Huber, J. A., Welch, D. B. M., Relman, D. A., & Sogin, M. L. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000255 · Cited by 993 · cited 1× · see citing works
“Rarefaction curves at 95% sequence identity, considered to approximate genus level, showed that the rate of sampling was comparable across all samples and demonstrated sampling depth at this taxonomic resolution was comparable to previously reported studies (Figure S1) [35–37].”
ResultClaesson, M. J., O’Sullivan, Ó., Wang, Q., Nikkilä, J., Marchesi, J. R., Smidt, H., de Vos, W. M., Ross, R. P., & O’Toole, P. W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006669 · Cited by 880 · cited 1× · see citing works
“consistently detected in the microbial community of humans [52,53].”
BackgroundBrun, P., Castagliuolo, I., di Leo, V., Buda, A., Pinzani, M., Palù, G., & Martines, D. (2007) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00024.2006 · Cited by 877 · cited 1× · see citing works
“Impaired gut barrier function, along with gut inflammation, have also been observed in both genetic [11] and dietary [12,13] models of obesity.”
BackgroundAmar, J., Chabo, C., Waget, A., Klopp, P., Vachoux, C., Bermúdez‐Humarán, L. G., Smirnova, N. F., Bergé, M., Sulpice, T., Lahtinen, S. J., et al. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100159 · Cited by 837 · cited 1× · see citing works
“However, the recent report of bacterial translocation into the mesenteric fat of HFD mice [63] and of elevated circulating endotoxin levels in animal models of dietinduced obesity [12] and in obese and type 2 diabetic patients related to insulin resistance [64,65] are consistent with our hypothesized role of the gut i…”
BackgroundMa, T., Iwamoto, G. K., Hoa, N., Akotia, V., Pedram, A., Boivin, M., & Said, H. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00173.2003 · Cited by 811 · cited 1× · see citing works
“. In Caco-2 cell cultures, TNF-α reduced transepithelial resistance and ZO-1 protein expression via a NFκB-dependent pathway”
BackgroundCawthorn, W. P., & Sethi, J. K. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.051 · Cited by 792 · see citing works
Ding, S., Chi, M. M., Scull, B. P., Rigby, R., Schwerbrock, N. M. J., Magness, S., Jobin, C., & Lund, P. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012191 · Cited by 713 · cited 1× · see citing works
“In our study, and others using obesogenic diets, mice in the experimental groups had increased TNF-a mRNA expression [37] in the intestine.”
BackgroundKarczewski, J., Troost, F. J., Konings, I., Dekker, J., Kleerebezem, M., Brummer, R.-J. M., & Wells, J. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00327.2009 · Cited by 676 · cited 1× · see citing works
“affecting their transcriptional levels [49].”
Cancello, R., Tordjman, J., Poitou, C., Guilhem, G., Bouillot, J. L., Hugol, D., Coussieu, C., Basdevant, A., Hen, A. B., Bedossa, P., et al. (2006) · Diabetes · doi:10.2337/db06-0133 · Cited by 607 · cited 1× · see citing works
“sensitivity of obese individuals, whereas no such relationship was observed with subcutaneous fat [7].”
BackgroundAnderson, R. C., Cookson, A. L., McNabb, W. C., Park, Z., McCann, M. J., Kelly, W. J., & Roy, N. C. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-316 · Cited by 510 · cited 1× · see citing works
“not entirely clear and appears to be strain-specific [47,48].”
BackgroundGut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice
Membrez, M., Blancher, F., Jaquet, M., Bibiloni, R., Cani, P. D., Burcelin, R. G., Corthesy, I., Macé, K., & Chou, C. J. (2008) · The FASEB Journal · doi:10.1096/fj.07-102723 · Cited by 493 · cited 1× · see citing works
“Finally, there is an emerging body of literature demonstrating an association between altered gut microbiota profile and obesity in humans (see [14] and [15] for a recent review) which, from pioneering work on rodents [12,16,17], appears to be causative.”
BackgroundDowd, S. E., Sun, Y., Wolcott, R. D., Domingo, A., & Carroll, J. A. (2008) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2008.0107 · Cited by 417 · see citing works
Loss of the Tight Junction Protein ZO-1 in Dextran Sulfate Sodium Induced Colitis
Poritz, L. S., Garver, K. I., Green, C., Fitzpatrick, L. R., Ruggiero, F. M., & Koltun, W. A. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.07.050 · Cited by 414 · cited 1× · see citing works
“In an experimental model of colitis, the progressive increase in colonic permeability is associated with a corresponding reduction in ZO-1 protein expression [38].”
BackgroundLassenius, M., Pietiläinen, K., Kaartinen, K., Pussinen, P., Syrjänen, J., Forsblom, C., Pörsti, I., Rissanen, A., Kaprio, J., Mustonen, J., et al. (2011) · Diabetes Care · doi:10.2337/dc10-2197 · Cited by 404 · cited 1× · see citing works
“However, the recent report of bacterial translocation into the mesenteric fat of HFD mice [63] and of elevated circulating endotoxin levels in animal models of dietinduced obesity [12] and in obese and type 2 diabetic patients related to insulin resistance [64,65] are consistent with our hypothesized role of the gut i…”
BackgroundAnti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease
Suenaert, P., Bulteel, V., Lemmens, L., Noman, M., Geypens, B. J., Assche, G. V., Geboes, K. J., Ceuppens, J. L., & Rutgeerts, P. J. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05914.x · Cited by 402 · cited 1× · see citing works
“. There is also some evidence suggesting a direct effect of TNF-α on gut barrier integrity. Anti-TNF-α treatment improves gut barrier function in patients with Crohn's disease”
BackgroundForsyth, C. B., Farhadi, A., Jakate, S. M., Tang, Y., Shaikh, M. W., & Keshavarzian, A. (2009) · Alcohol · doi:10.1016/j.alcohol.2008.12.009 · Cited by 395 · see citing works
Ye, D., Ma, I., & Ma, T. (2006) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00318.2005 · Cited by 395 · cited 1× · see citing works
“to disorganization of tight-junction proteins at the intestinal barrier [41].”
BackgroundProbiotic lactobacilli and VSL#3 induce enterocyte β‐defensin 2
Schlee, M., Harder, J., Köten, B., Stange, E., Wehkamp, J., & Fellermann, K. (2008) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2007.03587.x · Cited by 393 · cited 1× · see citing works
“protection [50,51].”
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
Cénac, N., Coelho, A., Nguyen, C., Compton, S., Andrade-Gordon, P., MacNaughton, W., Wallace, J., Hollenberg, M., Bunnett, N., Garcia-Villar, R., et al. (2002) · American Journal of Pathology · doi:10.1016/s0002-9440(10)64466-5 · Cited by 386 · cited 1× · see citing works
“and is likely to be a consequence of the ‘leakage’ of gut luminal content. Cenac et al”
BackgroundAron‐Wisnewsky, J., Tordjman, J., Poitou, C., Darakhshan, F., Hugol, D., Basdevant, A., Aissat, A., Guerre-Millo, M., & Clément, K. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0925 · Cited by 379 · cited 1× · see citing works
“F4/80 cells were quantified by counting the number of adipocytes and F4/80 cells in 10 random areas at640 magnification and the abundance of F4/80 cells was normalized to 100 adipocytes [30].”
MethodThe environment within: how gut microbiota may influence metabolism and body composition
Vrieze, A., Holleman, F., Zoetendal, E. G., de Vos, W. M., Hoekstra, J. B. L., & Nieuwdorp, M. (2010) · Diabetologia · doi:10.1007/s00125-010-1662-7 · Cited by 347 · cited 1× · see citing works
“obesity and metabolic dysfunction [44].”
Youakim, A., & Ahdieh, M. (1999) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.5.g1279 · Cited by 340 · see citing works
Diamant, M., Blaak, E. E., & de Vos, W. M. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00797.x · Cited by 308 · cited 1× · see citing works
“Finally, there is an emerging body of literature demonstrating an association between altered gut microbiota profile and obesity in humans (see [14] and [15] for a recent review) which, from pioneering work on rodents [12,16,17], appears to be causative.”
BackgroundHolmes, J. L., Itallie, C. V. V., Rasmussen, J. E., & Anderson, J. (2006) · Gene Expression Patterns · doi:10.1016/j.modgep.2005.12.001 · Cited by 297 · cited 1× · see citing works
“Primer sequences for sterol regulatory element binding protein (SREBP)-1c [23], peroxisome proliferator-activated receptor (PPAR)-c [23], proglucagon [24], zona occludens (ZO)-1 [25], occludin [26] and IL-10 [27] have been published elsewhere.”
BackgroundFain, J. N. (2010) · Mediators of Inflammation · doi:10.1155/2010/513948 · Cited by 286 · cited 2× · see citing works
“in the stromal-vascular fraction of fat depots [5,6].”
BackgroundHighlighting new phylogenetic specificities of Crohn's disease microbiota
Mondot, S., Kang, S., Furet, J., de Cárcer, D. A., McSweeney, C., Morrison, M., Marteau, P., Doré, J., & Leclerc, M. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21436 · Cited by 283 · cited 1× · see citing works
“consistently detected in the microbial community of humans [52,53].”
BackgroundKumar, P., Brooker, M. R., Dowd, S. E., & Camerlengo, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020956 · Cited by 255 · cited 1× · see citing works
“Parameters used to filter sequences for analysis were based upon published studies [33,34].”
MethodAbdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus
Miyazaki, Y., Glass, L. C., Triplitt, C. L., Wajcberg, E., Mandarino, L. J., & DeFronzo, R. A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.0327.2001 · Cited by 251 · cited 1× · see citing works
“Visceral adiposity is strongly related to metabolic dysfunction including insulin resistance and systemic inflammation [1–3].”
BackgroundFunctional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice
Li, P., Lu, M. M., Nguyen, M. T., Bae, E. J., Chapman, J., Feng, D., Hawkins, M. A., Pessin, J. E., Sears, D. D., Nguyen, A.-K., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100263 · Cited by 238 · cited 3× · see citing works
“Serum concentrations of interleukin (IL)-1b, IL-10, monocyte chemotactic protein (MCP)-1, tumor necrosis factor (TNF)-a, IL-6, IL12p40 and plasminogen activator inhibitor (PAI)-1 were determined using commercially available cytokine kits and the xMAPH technology (Luminex Corporation, Austin, TX, USA).”
BackgroundThompson, C. L., Wang, B., & Holmes, A. J. (2008) · The ISME Journal · doi:10.1038/ismej.2008.29 · Cited by 223 · cited 1× · see citing works
“5 ml of homogenate using a bead beating method as described previously [31] and stored at 220uC.”
MethodSelf-citationAdipose tissue and the immune system.
Pond, C. (2005) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.005 · Cited by 210 · cited 1× · see citing works
“Equally, the presence of lymph nodes in mesenteric [61], but not epididymal, fat implies that immune cells other than macrophages, e.”
BackgroundThe obese healthy paradox: is inflammation the answer?
Barbarroja, N., López-Pedrera, C., Mayas, M. D., García‐Fuentes, E., Garrido‐Sánchez, L., Macías‐González, M., Bekay, R. E., Vidal‐Puig, A., & Tinahones, F. J. (2010) · Biochemical Journal · doi:10.1042/bj20100285 · Cited by 173 · cited 1× · see citing works
“Visceral adiposity is strongly related to metabolic dysfunction including insulin resistance and systemic inflammation [1–3].”
BackgroundTerra, X., Pallarès, V., Ardévol, A., Bladé, C., Fernández-Larrea, J., Pujadas, G., Salvadó, J., Arola, L., & Blay, M. (2011) · Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.03.006 · Cited by 162 · cited 1× · see citing works
“HFD mice had increased expression of TNF-a and IL6 and macrophage infiltration in mesenteric fat [13,56] and the role of TNF-a in the systemic dysmetabolism may be particularly critical [57].”
BackgroundAkt Mediates the Effect of Insulin on Epithelial Sodium Channels by Inhibiting Nedd4-2*
Lee, I.-H., Dinudom, A., Sánchez-Pérez, Á., Kumar, S., & Cook, D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701923200 · Cited by 153 · cited 1× · see citing works
“Experiments were carried out under current-clamp (open-circuit) conditions as described previously [22].”
MethodSelf-citationIntestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice.
Wang, Q., Fang, C.-H., & Hasselgren, P. (2001) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.3.r1013 · Cited by 136 · cited 1× · see citing works
“Assessment of gut permeability Gut permeability was measured as described by Wang et al [21] with minor modifications.”
MethodBifidobacterium exopolysaccharides fermented by human microbiota
Salazar, N., Fernández, M., Hernández-Barranco, A., Ruas-Madiedo, P., & Reyes-Gavilán, C. D. L. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00325-08 · Cited by 134 · cited 14× · see citing works
“HFD reduced Lactobacillus (75%; P,0.001) but increased Oscillibacter (279%; P = 0.004) in fecal microbiota.”
BackgroundInfluentialImmunomodulatory effects of Lactobacillus plantarum on human colon cancer cells
Paolillo, R., Carratelli, C. R., Sorrentino, S., Mazzola, N., & Rizzo, A. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.07.008 · Cited by 125 · cited 1× · see citing works
“protection [50,51].”
Relation of Abdominal Fat Depots to Systemic Markers of Inflammation in Type 2 Diabetes
Sam, S., Haffner, S., Davidson, M., D'Agostino, R., Feinstein, S., Kondos, G., Perez, A. T., & Mazzone, T. (2009) · Diabetes Care · doi:10.2337/dc08-1856 · Cited by 120 · cited 1× · see citing works
“Visceral adiposity is strongly related to metabolic dysfunction including insulin resistance and systemic inflammation [1–3].”
BackgroundZeyda, M., Gollinger, K., Kriehuber, E., Kiefer, F. W., Neuhofer, A., & Stulnig, T. M. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.103 · Cited by 109 · cited 2× · see citing works
“Fluorescence data were analyzed using the Rotor-Gene 6 software (version 6.0, Qiagen). mRNA expression was normalized to RPL-19 [24], UBC [28] and 18S rRNA [29] for colon, adipose tissue and liver respectively and reported as arbitrary units.”
MethodInfluentialIntestinal, adipose, and liver inflammation in diet-induced obese mice
Li, H., Lelliott, C. J., Håkansson, P., Ploj, K., Tuneld, A., Verolin-Johansson, M., Benthem, L., Carlsson, B., Storlien, L. H., & Michaëlsson, E. (2008) · Metabolism · doi:10.1016/j.metabol.2008.07.029 · Cited by 108 · cited 2× · see citing works
“HFD mice had increased expression of TNF-a and IL6 and macrophage infiltration in mesenteric fat [13,56] and the role of TNF-a in the systemic dysmetabolism may be particularly critical [57].”
BackgroundSelf-citationSachithanandan, N., Fam, B., Fynch, S., Dzamko, N., Watt, M., Wormald, S., Honeyman, J., Galic, S., Proietto, J., Andrikopoulos, S., et al. (2010) · Hepatology · doi:10.1002/hep.23861 · Cited by 100 · see citing works
Role of the gut in visceral fat inflammation and metabolic disorders
Lam, Y. Y., Mitchell, A. J., Holmes, A. J., Denyer, G. S., Gummesson, A., Caterson, I. D., Hunt, N. H., & Storlien, L. H. (2011) · Obesity · doi:10.1038/oby.2011.68 · Cited by 97 · cited 2× · see citing works
“Taken together the case can be made, see [19], that obesogenic diets induce gut dysfunction, which may lead to the stimulation of contiguous fat by an adverse microbial load and subsequently results in visceral fat inflammation and systemic metabolic dysregulation.”
BackgroundSelf-citationObesity, visceral fat and Crohnʼs disease
Bertin, B., Desreumaux, P., & Dubuquoy, L. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833cf0f4 · Cited by 91 · cited 1× · see citing works
“an expanded mesenteric fat depot characterized by an increased infiltration of immune cells [8].”
BackgroundMast cells and histamine contribute to bile acid-stimulated secretion in the mouse colon.
Gelbmann, C. M., Schteingart, C., Thompson, S., Hofmann, A. F., & Barrett, K. E. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117988 · Cited by 73 · cited 2× · see citing works
“After flushing with ice-cold bicarbonate buffer [20], segments of proximal colon (immediately below the cecum) were taken for assessment of gut permeability and gene expression (see below).”
MethodKim, O. Y., Lee, S.-M., Do, H., Moon, J., Lee, K.-H., Cha, Y., & Shin, M.-J. (2012) · Phytotherapy Research · doi:10.1002/ptr.3570 · Cited by 70 · see citing works
Mesenteric adipose tissue alterations resulting from experimental reactivated colitis
Gambero, A., Maróstica, M., Saad, M. A., & Pedrazzoli, J. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20222 · Cited by 65 · cited 1× · see citing works
“A causal relationship between gut inflammation and mesenteric fat dysfunction (notably a relative expansion in size and an increase in expression of macrophages and immune factors) has been demonstrated in animal models of experimental colitis [9,10].”
BackgroundAntimicrobial Aspects of Inflammatory Resolution in the Mucosa: A Role for Proresolving Mediators
Campbell, E. L., Serhan, C. N., & Colgan, S. P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100150 · Cited by 56 · cited 1× · see citing works
“pro-resolving mediators that are critical in maintaining immunological homeostasis of mucosal surface [66]) and manipulation of microbiota (e.”
BackgroundProtective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice
Volynets, V., Spruss, A., Kanuri, G., Wagnerberger, S., Bischoff, S. C., & Bergheim, I. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m007179 · Cited by 51 · cited 1× · see citing works
“Primer sequences for sterol regulatory element binding protein (SREBP)-1c [23], peroxisome proliferator-activated receptor (PPAR)-c [23], proglucagon [24], zona occludens (ZO)-1 [25], occludin [26] and IL-10 [27] have been published elsewhere.”
BackgroundPachikian, B., Neyrinck, A., Cani, P. D., Portois, L., Deldicque, L., de Backer, F. D., Bindels, L., Sohet, F., Malaisse, W., Francaux, M., et al. (2008) · BMC Physiology · doi:10.1186/1472-6793-8-21 · Cited by 49 · cited 1× · see citing works
“Primer sequences for sterol regulatory element binding protein (SREBP)-1c [23], peroxisome proliferator-activated receptor (PPAR)-c [23], proglucagon [24], zona occludens (ZO)-1 [25], occludin [26] and IL-10 [27] have been published elsewhere.”
BackgroundOliveira, M., Bosco, N., Perruisseau, G., Nicolas, J., Segura-Roggero, I., Duboux, S., Briand, M., Blum, S., & Benyacoub, J. (2011) · Clinical and Developmental Immunology · doi:10.1155/2011/807483 · Cited by 42 · cited 1× · see citing works
“not entirely clear and appears to be strain-specific [47,48].”
BackgroundEffect of Lactobacillus plantarum LP‐Onlly on gut flora and colitis in interleukin‐10 knockout mice
Xia, Y., Chen, H.-Q., Zhang, M., Jiang, Y.-Q., Hang, X., & Qin, H. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06498.x · Cited by 36 · cited 1× · see citing works
“ameliorate gut inflammation [45] and enhance barrier function”
BackgroundNovel anti-inflammatory role of SLPI in adipose tissue and its regulation by high fat diet
Adapala, V. J., Buhman, K. K., & Ajuwon, K. (2011) · Journal of Inflammation · doi:10.1186/1476-9255-8-5 · Cited by 20 · cited 1×
“Similar trends of depot-specific differences in the expression of pro-inflammatory cytokines have been reported previously in animal models of high-fat feeding [58,59].”
BackgroundThomaz, M. A., Acedo, S. C., de Oliveira, C. C., Pereira, J. A., Priolli, D. G., Saad, M. J. A., Pedrazzoli, J., & Gambero, A. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.05.003 · Cited by 20 · cited 2× · see citing works
“The increased macrophage infiltration and TNF-a expression in mesenteric fat of our HFD mice is consistent with results in rats with induced gut inflammation [9] and is likely to be a consequence of the ‘leakage’ of gut luminal content.”
BackgroundResultLam, Y. Y., Janovská, A., McAinch, A., Belobrajdic, D., Hatzinikolas, G., Game, P., & Wittert, G. (2011) · Obesity Research and Clinical Practice · doi:10.1016/j.orcp.2010.12.002 · Cited by 17 · cited 1× · see citing works
“[4].”
Self-citation
Flagged first, then by citations
6 of the 72 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [42]Al-Sadi R Ye D Said HM Ma TY 2010 IL-1[beta]-Induced Increase in Intestinal Epithelial Tight Junction Permeability Is Mediated by MEKK-1 Activation of Canonical NF-[kappa]B Pathway. The American Journal of Pathology 177 2310 2322 21048223 PMC2966790
- [55]Salazar N Gueimonde M Hernandez-Barranco AM Ruas-Madiedo P de los Reyes-Gavilan CG 2008 Exopolysaccharides produced by intestinal Bifidobacterium strains act as fermentable substrates for human intestinal bacteria. Appl Environ Microbiol 74 4737 4745 18539803 PMC2519331
Cited by
Sorted by citations
Intestinal permeability – a new target for disease prevention and therapy
Bischoff, S. C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J.-D., Serino, M., Tilg, H., Watson, A., & Wells, J. M. (2014) · BMC Gastroenterology · doi:10.1186/s12876-014-0189-7 · Cited by 1,755 · see citing works
“Also in peripheral blood and in adipose tissue bacteria or bacterial products can be observed following feeding with energy-rich Western style diet, an observation that might enable to define new bacterial biomarkers of intestinal barrier dysfunction in metabolic diseases [89,214].”
BackgroundAnhê, F. F., Roy, D., Pilon, G., Dudonné, S., Matamoros, S., Varin, T. V., Garofalo, C., Moine, Q., Desjardins, Y., Levy, E., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307142 · Cited by 1,137 · see citing works
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
Chang, C., Lin, C.-S., Lu, C., Martel, J., Ko, Y., Ojcius, D. M., Tseng, S., Wu, T.-R., Chen, Y. M., Young, J. D., et al. (2015) · Nature Communications · doi:10.1038/ncomms8489 · Cited by 1,251 · see citing works
Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance
Zhang, X., Shen, D., Fang, Z., Jie, Z., Qiu, X., Zhang, C., Chen, Y., & Ji, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071108 · Cited by 946 · see citing works
“It has frequently been reported that the fat and fiber content of diets can affect gut microbiota composition [22–24].”
BackgroundGut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2022) · Kompass Nutrition & Dietetics · doi:10.1159/000523712 · Cited by 79 · see citing works
“Populations of Lactobacillus are reduced in alcohol consumption and in high fat diet-induced obesity [55,195].”
BackgroundWang, J., Tang, H., Zhang, C., Zhao, Y., Derrien, M., Rocher, E., Vlieg, J. E. V. H., Strissel, K. J., Zhao, L., Obin, M. S., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.99 · Cited by 833 · see citing works
“…probiotic treatment reduced key phylotypes within Desulfovibrionaceae, Oscillibacter and Clostridium XIVa that were implicated in the development of obesity-related metabolic disorders (Zhang et al., 2010; Lam et al., 2012) or include pro-inflammatory bacterial species (Tuovinen et al., 2013).”
BackgroundImpact of Omega-3 Fatty Acids on the Gut Microbiota
Costantini, L., Molinari, R., Farinon, B., & Merendino, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122645 · Cited by 741 · see citing works
“Dysbiosis of the Firmicutes/Bacteroidetes ratio is associated with several conditions, such as weight gain and obesity [56], insulin resistance [56], high-fat diet [38,39], gut permeability [54], IBDs [21], and depression [88].”
BackgroundHigh-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review
Malesza, I. J., Malesza, M., Walkowiak, J., Mussin, N. M., Walkowiak, D., Aringazina, R. A., Bartkowiak-Wieczorek, J., & Mądry, E. (2021) · Cells · doi:10.3390/cells10113164 · Cited by 807 · see citing works
Roopchand, D. E., Carmody, R. N., Kuhn, P., Moskal, K., Rojas-Silva, P., Turnbaugh, P. J., & Raskin, I. (2015) · Diabetes · doi:10.2337/db14-1916 · Cited by 678 · see citing works
“GP Counteract HFD-Induced Effects in the Gastrointestinal Tract Interaction between the gut microbiota and HFD was reported to promote expression of proinflammatory cytokines in intestinal tissues before development of obesity and insulin resistance (4,5).”
BackgroundDel Chierico, F., Nobili, V., Vernocchi, P., Russo, A., De Stefanis, C., Gnani, D., Furlanello, C., Zandonà, A., Paci, P., Capuani, G., et al. (2017) · Hepatology · doi:10.1002/hep.28572 · Cited by 696 · see citing works
“In a study by Lam and coworkers,((32)) Oscillibacter-like organisms were TABLE 3.”
BackgroundNegative Effects of a High-Fat Diet on Intestinal Permeability: A Review
Rohr, M., Narasimhulu, C. A., Rudeski-Rohr, T., & Parthasarathy, S. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz061 · Cited by 766 · see citing works
“, directly correlating with depressed IEC expression of Tjp1 and gut barrier dysfunction (163).”
BackgroundParacellular permeability and tight junction regulation in gut health and disease
Horowitz, A., Chánez-Paredes, S. D., Haest, X., & Turner, J. R. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00766-3 · Cited by 725 · see citing works
Leaky Gut As a Danger Signal for Autoimmune Diseases
Mu, Q., Kirby, J. L., Reilly, C. M., & Luo, X. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00598 · Cited by 618 · see citing works
“Moreover, a diet high in saturated fat has been shown to greatly decrease Lactobacillus and increase Oscillibacter, and these changes were correlated with significantly increased permeability in the proximal colon (86).”
BackgroundGut microbiota and metabolic syndrome
Festi, D., Schiumerini, R., Eusebi, L. H., Marasco, G., Taddia, M., & Colecchia, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i43.16079 · Cited by 534 · see citing works
Microbiota-gut-brain axis: Modulator of host metabolism and appetite
van de Wouw, M., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.240481 · Cited by 461 · see citing works
“Obesity-associated increases in intestinal permeability can lead to an increased translocation of Gram-negative bacterial-derived LPS into the circulation, resulting in chronic low-grade systemic inflammation (273, 279, 280), in a condition called metabolic endotoxemia (281–283).”
BackgroundThe Intestinal Immune System in Obesity and Insulin Resistance
Winer, D. A., Luck, H., Tsai, S. J., & Winer, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.003 · Cited by 476 · see citing works
Probiotics improve gut microbiota dysbiosis in obese mice fed a high-fat or high-sucrose diet
Kong, C., Gao, R., Yan, X., Huang, L., & Qin, H. (2018) · Nutrition · doi:10.1016/j.nut.2018.10.002 · Cited by 491 · see citing works
Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review
Yang, Q., Liang, Q., Balakrishnan, B., Belobrajdic, D. P., Feng, Q.-J., & Zhang, W. Y. (2020) · Nutrients · doi:10.3390/nu12020381 · Cited by 475 · see citing works
Influence of Foods and Nutrition on the Gut Microbiome and Implications for Intestinal Health
Zhang, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179588 · Cited by 446 · see citing works
Gut microbiota, probiotics and diabetes
Gomes, A. C., Bueno, A. A., de Souza, R. G. M., & Mota, J. F. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-60 · Cited by 363 · see citing works
“T1D patients show perturbations in the structure of tight junctions as result of decreased zonulin expression, a protein related to the regulation of intestinal permeability [61], as well as increased paracellular space between intestinal epithelial cells [6].”
BackgroundThe Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release
Martin, A. M., Sun, E. W. L., Rogers, G. B., & Keating, D. J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00428 · Cited by 389 · see citing works
Noble, E. E., Hsu, T. M., & Kanoski, S. E. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00009 · Cited by 333 · see citing works
“Emerging research is revealing that gut microbiota have potent effects on gut permeability (Cani et al., 2007, 2008, 2009; Lam et al., 2012; Pendyala et al., 2012; Tulstrup et al., 2015; Maffeis et al., 2016; Mokkala et al., 2016; Müller et al., 2016) and bloodbrain barrier integrity (Braniste et…”
BackgroundConnecting the immune system, systemic chronic inflammation and the gut microbiome: the role of sex
Rizzetto, L., Fava, F., Tuohy, K. M., & Selmi, C. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.05.008 · Cited by 331 · see citing works
Gut microbiome composition may be an indicator of preclinical Alzheimer’s disease
Ferreiro, A. L., Choi, J., Ryou, J., Newcomer, E. P., Thompson, R., Bollinger, R. M., Hall-Moore, C. M., Ndao, I. M., Sax, L., Benzinger, T. L. S., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abo2984 · Cited by 369 · see citing works
Wang, B., Kong, Q., Xiu, L., Zhao, J., Zhang, H., Chen, W., & Wang, G. (2020) · Nutrients · doi:10.3390/nu12103197 · Cited by 336 · see citing works
The neurobiology of food intake in an obesogenic environment
Berthoud, H. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000602 · Cited by 305 · see citing works
Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review
Ma, T., Shen, X., Shi, X., Sakandar, H. A., Quan, K., Li, Y., Jin, H., Kwok, L., Zhang, H., & Sun, Z. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.06.013 · Cited by 344 · see citing works
Yamashiro, K., Tanaka, R., Urabe, T., Ueno, Y., Yamashiro, Y., Nomoto, K., Takahashi, T., Tsuji, H., Asahara, T., & Hattori, N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171521 · Cited by 318 · see citing works
Golubeva, A. V., Crampton, S., Desbonnet, L., Edge, D., O'Sullivan, O., Lomasney, K. W., Zhdanov, A. V., Crispie, F., Moloney, R. D., Borre, Y. E., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.002 · Cited by 283 · see citing works
“Positive associations between various pathological conditions and relative abundance of Anaerotruncus, Oscillibacter, Papillibacter and Mucispirillum bacteria have been similarly shown in other recent studies (Berry et al., 2012; Lam et al., 2012; Rooks et al., 2014; Wang et al., 2015).”
BackgroundResultThe effect of diet and exercise on intestinal integrity and microbial diversity in mice
Campbell, S. C., Wisniewski, P. J., Noji, M., McGuinness, L. R., Häggblom, M. M., Lightfoot, S. A., Joseph, L. B., & Kerkhof, L. J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0150502 · Cited by 268 · see citing works
Robertson, R. C., Seira Oriach, C., Murphy, K., Moloney, G. M., Cryan, J. F., Dinan, T. G., Paul Ross, R., & Stanton, C. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.145 · Cited by 268 · see citing works
Richards, J. L., Yap, Y. A., McLeod, K. H., Mackay, C. R., & Mariño, E. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.29 · Cited by 250 · see citing works
The association of periodontal diseases with metabolic syndrome and obesity
Jepsen, S. V., Suvan, J. E., & Deschner, J. (2020) · Periodontology 2000 · doi:10.1111/prd.12326 · Cited by 310 · see citing works
Kang, Y., Kang, X., Yang, H., Liu, H., Yang, X., Liu, Q., Tian, H., Xue, Y., Ren, P., Kuang, X., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.106020 · Cited by 281 · see citing works
Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue
Saxton, S. N., Clark, B., Withers, S., Eringa, E. C., & Heagerty, A. M. (2019) · Physiological Reviews · doi:10.1152/physrev.00034.2018 · Cited by 277 · see citing works
Fatty Acids Consumption: The Role Metabolic Aspects Involved in Obesity and Its Associated Disorders
Figueiredo, P. S., Inada, A. C., Marcelino, G., Cardozo, C. M. L., Freitas, K. D. C., Guimarães, R. D. C. A., de Castro, A. P., do Nascimento, V. A., & Hiane, P. A. (2017) · Nutrients · doi:10.3390/nu9101158 · Cited by 243 · see citing works
“Female rats Control group (10% kcal fat), high Fat (60% kcal fat, of which 34% was SFA) ↑ Firmicutes and ↓ Bacteroidetes ↑ Inflammatory citokines [100]”
BackgroundMethodWu, M.-N., Li, P.-Z., An, Y., Ren, J., Yan, D., Cui, J., Li, D., Li, M., Wang, M.-Y., & Zhong, G.-S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104489 · Cited by 230 · see citing works
Zinkernagel, M. S., Zysset-Burri, D. C., Keller, I., Berger, L. E., Leichtle, A. B., Largiadèr, C. R., Fiedler, G. M., & Wolf, S. (2017) · Scientific Reports · doi:10.1038/srep40826 · Cited by 229 · see citing works
Lam, Y. Y., Ha, C. W. Y., Hoffmann, J. M. A., Oscarsson, J., Dinudom, A., Mather, T. J., Cook, D. I., Hunt, N. H., Caterson, I. D., Holmes, A. J., et al. (2015) · Obesity · doi:10.1002/oby.21122 · Cited by 223 · see citing works
“Often referred to as the “leaky gut” hypothesis (2,18), bacteria and/or their metabolites are more likely to translocate across a compromised gut barrier to the adjacent mesenteric fat and trigger an inflammatory response (3,4), which induce visceral fat dysfunction and on to deleterious systemic metabolic sequelae.”
BackgroundMethodResultInfluentialSelf-citationPascale, A., Marchesi, N., Govoni, S. M., Coppola, A., & Gazzaruso, C. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.03.011 · Cited by 240 · see citing works
Plasma Lipopolysaccharide Is Closely Associated With Glycemic Control and Abdominal Obesity
Trøseid, M., Nestvold, T. K., Rudi, K., Thoresen, H., Nielsen, E. W., & Lappegård, K. T. (2013) · Diabetes Care · doi:10.2337/dc13-0451 · Cited by 215 · see citing works
“A recent study showed that increased gut permeability is associated with mesenteric fat inflammation and metabolic dysfunction in obese mice (30).”
BackgroundGut microbiota, diet, and obesity-related disorders: the good, the bad, and the future challenges
Portune, K. J., Benítez‐Páez, A., Del Pulgar, E. M. G., Cerrudo, V., & Sanz, Y. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600252 · Cited by 201 · see citing works
Oakley, B., & Kogut, M. (2016) · Frontiers in Veterinary Science · doi:10.3389/fvets.2016.00011 · Cited by 201 · see citing works
“Interestingly, Oscillibacter belongs to Clostridium cluster IV that produces valerate as an end product of fermentation and has been identified as a “healthy biomarker” in a study of human patients with Crohn’s disease (49) but also significantly associated with diet-induced obesity (50).”
BackgroundDamms-Machado, A., Louis, S., Schnitzer, A., Volynets, V., Rings, A., Basrai, M., & Bischoff, S. C. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.131110 · Cited by 195 · see citing works
“Previous animal experiments suggest increased intestinal permeability and subsequent lipopolysaccharide translocation are major mechanisms of fatty liver disease and other metabolic disorders accompanying obesity (6, 7, 42).”
BackgroundQu, W., Yuan, X., Zhao, J., Zhang, Y., Hu, J., Wang, J., & Li, J. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700118 · Cited by 195 · see citing works
Catry, E., Bindels, L. B., Tailleux, A., Lestavel, S., Neyrinck, A. M., Goossens, J.-F., Lobysheva, I., Plovier, H., Essaghir, A., Demoulin, J.-B., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313316 · Cited by 194 · see citing works
Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes
Massier, L., Chakaroun, R., Tabei, S., Crane, A., Didt, K. D., Fallmann, J., von Bergen, M., Haange, S.-B., Heyne, H., Stumvoll, M., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-320118 · Cited by 194 · see citing works
Bleau, C., Karelis, A. D., St‐Pierre, D. H., & Lamontagne, L. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2617 · Cited by 214 · see citing works
“the blood [7,8,61,70,75,84,85].”
Causality of small and large intestinal microbiota in weight regulation and insulin resistance
Scheithauer, T. P. M., Dallinga-Thie, G. M., de Vos, W. M., Nieuwdorp, M., & van Raalte, D. H. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.002 · Cited by 188 · see citing works
The role of the gut microbiota in metabolic health
Janssen, A. W. F., & Kersten, S. (2015) · The FASEB Journal · doi:10.1096/fj.14-269514 · Cited by 199 · see citing works
Inflammation links excess fat to insulin resistance: the role of the interleukin‐1 family
Tack, C. J., Stienstra, R., Joosten, L. A. B., & Netea, M. G. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01145.x · Cited by 192 · see citing works
“Alternatively, translocation of microbial products, including LPS, from the gut may have a more pronounced effect on the adipose tissue compartment that is reached before it can be cleared by the liver (113, 114).”
BackgroundDiet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints
Holmes, A. J., Chew, Y. V., Colakoglu, F., Cliff, J. B., Klaassens, E., Read, M. N., Solon-Biet, S. M., McMahon, A. C., Cogger, V. C., Ruohonen, K., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.021 · Cited by 183 · see citing works
Self-citationObesity, fatty liver disease and intestinal microbiota
Arslan, N. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i44.16452 · Cited by 191 · see citing works
Chen, G., Xie, M., Dai, Z., Wan, P., Ye, H., Zeng, X., & Sun, Y. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700485 · Cited by 189 · see citing works
Pretreatment gut microbiome predicts chemotherapy-related bloodstream infection
Montassier, E., Al-Ghalith, G., Ward, T. L., Corvec, S., Gastinne, T., Potel, G., Moreau, P., de la Cochetière, M., Batard, E., & Knights, D. (2016) · Genome Medicine · doi:10.1186/s13073-016-0301-4 · Cited by 176 · see citing works
“Oscillospira has also been reported to directly regulate components involved in the maintenance of gut barrier integrity [22].”
BackgroundShen, W., Gaskins, H. R., & McIntosh, M. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.009 · Cited by 161 · see citing works
Lai, Z.-L., Tseng, C.-H., Ho, H. J., Cheung, C., Lin, J.-Y., Chen, Y., Cheng, F.-C., Hsu, Y., Lin, J., El-Omar, E. M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33893-y · Cited by 192 · see citing works
Sellmann, C., Priebs, J., Landmann, M., Degen, C., Engstler, A., Jin, C. J., Gärttner, S., Spruss, A., Huber, O., & Bergheim, I. (2015) · Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.05.011 · Cited by 172 · see citing works
Maternal Obesity Is Associated with Alterations in the Gut Microbiome in Toddlers
Galley, J. D., Bailey, M. T., Dush, C. M. K., Schoppe‐Sullivan, S. J., & Christian, L. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113026 · Cited by 180 · see citing works
“Diet can substantially affect the composition of the gut microbiome [40,46,47].”
BackgroundPanwar, H., Rashmi, H. M., Batish, V. K., & Grover, S. (2013) · Diabetes/Metabolism Research Reviews · doi:10.1002/dmrr.2376 · Cited by 171 · see citing works
“reduced proportions of lactobacilli in gut microbial profile, reduced transepithelial resistance and increased metabolic edotoxemia in HFD mice [23].”
BackgroundThe Role of Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target
An, J., Liu, Y., Wang, Y., Fan, R., Hu, X., Zhang, F., Yang, J., & Chen, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.871713 · Cited by 191 · see citing works
“TLR2 recognizes and binds LPS, then promotes the secretion of the mucus layer and the transfer of ZO-1 to the top of cells to strengthen tight junctions through the TLR2 signaling pathway (61, 62).”
BackgroundInulin-type fructan improves diabetic phenotype and gut microbiota profiles in rats
Zhang, Q., Yu, H., Xiao, X., Hu, L., Xin, F., & Yu, X. (2018) · PeerJ · doi:10.7717/peerj.4446 · Cited by 184 · see citing works
“Oscillibacter is one species within the Ruminococcaceae family whose abundance is positively correlated with gut permeability, which can affect gut barrier integrity (Lam et al., 2012).”
BackgroundThe role of diet and intestinal microbiota in the development of metabolic syndrome
Santos-Marcos, J. A., Pérez‐Jiménez, F., & Camargo, A. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.03.017 · Cited by 185 · see citing works
Chen, H.-Q., Zhao, R., Wang, B., Cai, C., Zheng, L.-N., Wang, H., Wang, M., Ouyang, H., Zhou, X.-Y., Chai, Z., et al. (2017) · NanoImpact · doi:10.1016/j.impact.2017.07.005 · Cited by 164 · see citing works
Costa, F. R. C., Francozo, M., de Oliveira, G. G., Ignácio, A., Castoldi, Â., Zamboni, D. S., Ramos, S. G., Câmara, N. O. S., de Zoete, M. R., Palm, N. W., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20150744 · Cited by 173 · see citing works
Dietary cellulose prevents gut inflammation by modulating lipid metabolism and gut microbiota
Kim, Y., Hwang, S. W., Kim, S., Lee, Y., Kim, T., Lee, S.-H., Kim, S. J., Yoo, H. J., Kim, E. N., & Kweon, M. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1730149 · Cited by 192 · see citing works
“Oscillibacter, in the family Ruminococcaceae, reportedly has a negative correlation with barrier function parameters in the colon.(58) Our metabolite analysis showed that LCD-fed mice had higher levels of saturated fatty acids, including palmitic, stearic, and myristic, and ceramides (Figure 5c), which may be crucial…”
BackgroundLiu, T., Kern, J. T., Jain, U., Sonnek, N. M., Xiong, S., Simpson, K. F., VanDussen, K. L., Winkler, E. S., Haritunians, T., Malique, A., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.04.004 · Cited by 173 · see citing works
Straub, R. H., & Carsten Schradin, A. (2016) · Evolution Medicine and Public Health · doi:10.1093/emph/eow001 · Cited by 234 · see citing works
“The obesity-triggering microbiome has an increased capacity to harvest energy from the diet (95), but it is also linked to more inflammation in the gut and liver (96,97).”
BackgroundRegression analysis for microbiome compositional data
Shi, P., Zhang, A. R., & Li, H. (2016) · The Annals of Applied Statistics · doi:10.1214/16-aoas928 · Cited by 135 · see citing works
“A recent study also identified Oscillibacter-like organisms as a potentially important gut microbe that mediates high fat diet-induced gut dysfunction [Lam et al. (2012)].”
BackgroundJung, M., Lee, J., Shin, N., Kim, M., Hyun, D., Yun, J., Kim, P. S., Whon, T. W., & Bae, J. (2016) · Scientific Reports · doi:10.1038/srep30887 · Cited by 173 · see citing works
“Oscillibacter is positively correlated with gut permeability 43 , which can influence adiposity and systemic inflammation in obese prone donors and their GF recipients fed a HF diet 39 .”
Adipose-Tissue and Intestinal Inflammation – Visceral Obesity and Creeping Fat
Kredel, L. I., & Siegmund, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00462 · Cited by 157 · see citing works
“In trinitrobenzenesulfonic acid-induced colitis in mice and rats TNFα and IL-10 in the mesenteric fat is increased while leptin and adiponectin release is not altered compared to healthy animals (40, 41).”
BackgroundInfluentialThe Role of the Gut Microbiome in Diabetes and Obesity-Related Kidney Disease
Zaky, A. A., Glastras, S. J., Wong, M. Y. W., Pollock, C. A., & Saad, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179641 · Cited by 173 · see citing works
Ma, L., Kim, J.-W., Hatzenpichler, R., Karymov, M. A., Hubert, N., Hanan, I. M., Chang, E. B., & Ismagilov, R. F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404753111 · Cited by 158 · see citing works
“The genus Oscillibacter is frequently observed in the Most Wanted list (2) and other sequencing data sets (29 – 31), but no human-associated member of this genus has been cultivated yet.”
BackgroundDe Munck, T. J. I., Xu, P., Verwijs, H. J. A., Masclee, A. A. M., Jonkers, D., Verbeek, J., & Koek, G. H. (2020) · Liver International · doi:10.1111/liv.14696 · Cited by 145 · see citing works
Pathophysiological role of host microbiota in the development of obesity
Kobyliak, N. M., Virchenko, O., & Falalyeyeva, T. M. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0166-9 · Cited by 152 · see citing works
“037) expression in proximal colon was observed [78].”
BackgroundB Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance
Winer, D. A., Winer, S., Chng, M. H. Y., Shen, L., & Engleman, E. G. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1486-y · Cited by 144 · see citing works
Impact of Westernized Diet on Gut Microbiota in Children on Leyte Island
Nakayama, J., Yamamoto, A., Conde, L. A., Higashi, K., Sonomoto, K., Tan, J. D., & Lee, Y. K. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00197 · Cited by 163 · see citing works
“For instance, Oscillibacterlike bacteria are known as a potentially important gut microbe that mediates high-fat diet-induced gut dysfunction (Lam et al., 2012).”
BackgroundMethodInfluentialMechanistic links between gut microbial community dynamics, microbial functions and metabolic health
Ha, C. W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i44.16498 · Cited by 137 · see citing works
Self-citationPellegrini, S., Sordi, V., Bolla, A. M., Saita, D., Ferrarese, R., Canducci, F., Clementi, M., Invernizzi, F., Mariani, A., Bonfanti, R., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3222 · Cited by 153 · see citing works
“junctions (6) in rodent models (30, 31) and human subjects.”
BackgroundIntestinal epithelial barrier function in liver cirrhosis: an extensive review of the literature
Pijls, K. E., Jonkers, D. M. A. E., Elamin, E. E., Masclee, A., & Koek, G. H. (2013) · Liver International · doi:10.1111/liv.12271 · Cited by 123 · see citing works
High Fat Diet Causes Depletion of Intestinal Eosinophils Associated with Intestinal Permeability
Johnson, A. M. F., Costanzo, A. E., Gareau, M. G., Armando, A. M., Quehenberger, O., Jameson, J., & Olefsky, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122195 · Cited by 150 · see citing works
“Specifically, macrophage/DC IL-10 production and induction of regulatory T (Treg) cells can promote tolerance, whereas depletion of intestinal macrophages renders mice susceptible to bacterial penetration [17,18].”
BackgroundMethodInfluentialIntestinal microbiota and the immune system in metabolic diseases
Sittipo, P., Lobionda, S., Lee, Y. K., & Maynard, C. L. (2018) · The Journal of Microbiology · doi:10.1007/s12275-018-7548-y · Cited by 147 · see citing works
“(ZO-1, claudin-1, and occludin) expression were decreased (Lam et al., 2012; Shen et al., 2014).”
BackgroundPedersen, R., Ingerslev, H.-C., Sturek, M. S., Alloosh, M., Cirera, S., Christoffersen, B. Ø., Moesgaard, S. G., Larsen, N., & Boyé, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056612 · Cited by 129 · see citing works
“Together our results suggest that the obese Ossabaw minipigs’ gut microbiota display a profile that resembles the intestinal microbiota observed in obese mice and humans in response to HFD.”
InfluentialFleshner, M. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.08.012 · Cited by 126 · see citing works
Wu, W., Kaicen, W., Bian, X., Yang, L., Ding, S., Li, Y., Li, S., Zhuge, A., & Li, L. (2023) · Microbial Biotechnology · doi:10.1111/1751-7915.14293 · Cited by 129 · see citing works
Differential Analysis of Hypertension-Associated Intestinal Microbiota
Dan, X., Mushi, Z., Baili, W., Han, L., Enqi, W., Huanhu, Z., & Li, S. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.29322 · Cited by 157 · see citing works
“This genus might generate metabolites that directly regulate the integrity of epithelium, or it might have a double effect following changes in the overall composition of the microbiota [38].”
BackgroundVildagliptin increases butyrate-producing bacteria in the gut of diabetic rats
Zhang, Q., Xiao, X., Li, M., Yu, M., Ping, F., Zheng, J., Wang, T., & Wang, X. (2017) · PLOS ONE · doi:10.1371/journal.pone.0184735 · Cited by 124 · see citing works
Lai, W., Deng, W.-F., Xu, S., Zhao, J., Xu, D., Liu, Y., Guo, Y., Wang, M., He, F.-S., Ye, S.-W., et al. (2019) · Psychological Medicine · doi:10.1017/s0033291719003027 · Cited by 141 · see citing works
“demonstrated that Oscillibacter could produce anti-inflammatory metabolites and play a pivotal role in the maintenance of gut barrier integrity (Lam et al., 2012).”
BackgroundZhao, X., Jiang, Y., Xi, H., Chen, L., & Feng, X. (2020) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-1081-2036 · Cited by 124 · see citing works
“…Tremellen et al. [80] proposed that one of the pathogenic mechanisms of PCOS could be that obesity and a high-sugar, high-fat diet with low-dietary fiber encourages GM imbalance, thus destroying the junction between intestinal epithelial cells and reducing the expression of ZO-1 and occludin [81].”
Bested, A. C., Logan, A. C., & Selhub, E. M. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-3 · Cited by 121 · see citing works
“barrier and limit the detrimental effects of LPS [112-114].”
BackgroundToral, M., Gómez‐Guzmán, M., Jiménez, R., Romero, M., Sánchez, M., Utrilla, M. P., Garrido‐Mesa, N., Rodríguez‐Cabezas, M. E., Olivares, M. M., Gálvez, J., et al. (2014) · Clinical Science · doi:10.1042/cs20130339 · Cited by 134 · see citing works
Gruber, L., Kisling, S., Lichti, P., Martin, F., May, S., Klingenspor, M., Lichtenegger, M., Rychlik, M., & Haller, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071661 · Cited by 119 · see citing works
“In addition, animal studies indicate that high-fat diet (HFD)-induced obesity promotes intestinal inflammatory processes on a cellular level [5], and perturbs barrier function [6], but the underlying mechanisms remain largely unidentified.”
BackgroundRole of Obesity, Mesenteric Adipose Tissue, and Adipokines in Inflammatory Bowel Diseases
Bilski, J., Mazur-Biały, A. I., Wójcik-Grzybek, D., Surmiak, M., Magierowski, M., Śliwowski, Z., Pajdo, R., Kwiecień, S., Danielak, A., Ptak‐Belowska, A., et al. (2019) · Biomolecules · doi:10.3390/biom9120780 · Cited by 137 · see citing works
Cheng, Y., Luthuli, S., Hou, L., Jiang, H., Chen, P., Zhang, X., Wu, M., & Tong, H. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.04.040 · Cited by 135 · see citing works
Negi, S., Pahari, S., Bashir, H., & Agrewala, J. N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01142 · Cited by 116 · see citing works
“the translocation of gut bacteria derived products from the gut to blood circulation (51).”
BackgroundHigh dietary fat intake induces a microbiota signature that promotes food allergy
Hussain, M., Bonilla‐Rosso, G., Chung, C. K. C. K., Bäriswyl, L., Rodriguez, M. P., Kim, B., Engel, P., & Noti, M. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.01.043 · Cited by 133 · see citing works
Wang, J., Bose, S., Kim, G.-C., Hong, S.-U., Kim, J.-H., Kim, J.-E., & Kim, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086117 · Cited by 119 · see citing works
“This is in agreement with previous study suggesting that HFD triggers metabolic changes that impair gut barrier function, as reflected both by the decrease in TEER and gene expression of ZO-1 in the proximal colon [54].”
ResultImpaired Intestinal Barrier and Tissue Bacteria: Pathomechanisms for Metabolic Diseases
Massier, L., Blüher, M., Kovacs, P. L., & Chakaroun, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.616506 · Cited by 124 · see citing works
“intestinal permeability to inflammation (91, 92).”
Impairments to Thermoregulation in the Elderly During Heat Exposure Events
Millyard, A., Layden, J. D., Pyne, D. B., Edwards, A. M., & Bloxham, S. (2020) · Gerontology and Geriatric Medicine · doi:10.1177/2333721420932432 · Cited by 120 · see citing works
“Evidence suggests that with age there are alterations in the gut microbiota that lead to an increase in gut permeability and cytokine expression, and thus a reduced ability to repair damaged DNA (Guedj et al., 2020; Lam et al., 2012; Qi et al., 2017; Thevaranjan et al., 2017).”
BackgroundRole and Effective Therapeutic Target of Gut Microbiota in Heart Failure
Jia, Q., Li, H., Zhou, H., Zhang, X., Zhang, A., Xie, Y., Li, Y., Lv, S., & Zhang, J. (2019) · Cardiovascular Therapeutics · doi:10.1155/2019/5164298 · Cited by 118 · see citing works
- Authors
- Lam, Y. Y., Ha, C. W. Y., Campbell, C. R., Mitchell, A. J., Dinudom, A., Oscarsson, J., Cook, D. I., Hunt, N. H., Caterson, I. D., Holmes, A. J., & Storlien, L. H.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Lam, Yan Y.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-03-23
- Volume
- 7
- Issue
- 3
- Pages
- e34233
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3311621
- OpenAlex
- W2000450805
- Cited by
- 604
- References
- 72
- Citations by year
- 2026: 24 · 2025: 33 · 2024: 39 · 2023: 58 · 2022: 62 · 2021: 59 · 2020: 58 · 2019: 53 · 2018: 44 · 2017: 41 · 2016: 41 · 2015: 34 · 2014: 29 · 2013: 21 · 2012: 8
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- Medical Research Council
- National Health and Medical Research Council (633240)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- diet-induced obesity, high saturated fat diet, intestinal permeability, gut microbiota, mesenteric fat inflammation, visceral adipose tissue, metabolic dysfunction, tight junctions, ZO-1, TNF-α, interleukin-6, adipose tissue macrophages, Lactobacillus, Oscillibacter, adiponectin, serum amyloid A
- MeSH terms
- Animals, Diet, Female, Inflammation, Intestinal Mucosa, Intestines, Mesentery, Mice, Inbred C57BL, Permeability, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
