A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease
Open accessAbstract
The intestinal microbiome may have a critical roll in susceptibility or resistance to immune-mediated diseases. Alterations of the gut microflora after oral antibiotic treatment can regulate encephalomyelitis (EAE), an animal model for human multiple sclerosis (MS). We now show that a zwitterionic capsular polysaccharide A (PSA) of Bacteroides fragilis can protect against central nervous system demyelinating disease. Oral administration with purified PSA protected mice against EAE prophylactic and therapeutically. PSA treatment enhanced CD103 expressing dendritic cells (DCs) that accumulated in the cervical lymph nodes. Exposure of naïve DCs to PSA induced the conversion of naïve CD4(+) T cells into interleukin (IL)-10-producing FoxP3(+)Treg cells. Protection against EAE was completely abrogated in IL-10-deficient mice. Our results show an important role for a molecule from human commensal bacteria in protecting against EAE and suggest the possibility for protection in MS.
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Oral treatment with PSA could cause protection from experimental autoimmune encephalomyelitis in mice, when used as both prophylactic and therapeutic approach, via recruitment of CD103+ CD11chigh antigen-presenting cells and priming of IL-10-producing Treg cells in the cervical lymph nodes.
“They then concluded that oral treatment with PSA could cause protection from EAE in mice, when used as both prophylactic and therapeutic approach, via recruitment of CD103+ CD11chigh antigen-presenting cells and priming of IL-10–producing Treg cells in the cervical lymph-nodes (150).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [150]
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- Authors
- Ochoa-Repáraz, J., Mielcarz, D. W., Wang, Y., Begum-Haque, S., Dasgupta, S., Kasper, D. L., & Kasper, L. H.
- Affiliations
- Dartmouth College (US)
- Brigham and Women's Hospital (US)
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 3
- Issue
- 5
- Pages
- 487-495
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W2112948254
- Cited by
- 507
- References
- 39
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 26 · 2023: 48 · 2022: 29 · 2021: 42 · 2020: 36 · 2019: 39 · 2018: 47 · 2017: 43 · 2016: 37 · 2015: 29 · 2014: 33 · 2013: 20 · 2012: 20
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mucosal Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Multiple Sclerosis Society
- Teva Pharmaceutical Industries
- Dartmouth College
- Multiple Sclerosis Society
- National Center for Research Resources
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Bacteroides fragilis, multiple sclerosis, experimental autoimmune encephalomyelitis, demyelinating disease, gut microbiota, commensal bacteria, dendritic cells, CD103, regulatory T cells, IL-10, oral immunotherapy, gut-brain axis
- MeSH terms
- Administration, Oral, Animals, Bacteroides fragilis, Cell Differentiation, Cells, Cultured, Dendritic Cells, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Humans, Lymphocyte Activation, Mice, Inbred C57BL, Multiple Sclerosis, Polysaccharides, Bacterial, CD4-Positive T-Lymphocytes, Antigens, CD, Interleukin-10, Mice, Knockout, Integrin alpha Chains, T-Lymphocytes, Regulatory, Mice
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