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Plasma BDNF concentration, Val66Met genetic variant and depression- related personality traits
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Brain‐derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurogenesis, and BDNF plasma and serum levels have been associated with depression, Alzheimer's disease, and other psychiatric and neurodegenerative disorders. In a relatively large community sample, drawn from the Baltimore Longitudinal Study of Aging (BLSA), we examine whether BDNF plasma concentration is associated with the Val66Met functional polymorphism of the BDNF gene (n = 335) and with depression‐related personality traits assessed with the NEO‐PI‐R (n = 391). Plasma concentration of BDNF was not associated with the Val66Met variant in either men or women. However, in men, but not in women, BDNF plasma level was associated with personality traits linked to depression. Contrary to the notion that low BDNF is associated with negative outcomes, we found lower plasma levels in men who score lower on depression and vulnerability to stress (two facets of Neuroticism) and higher on Conscientiousness and Extraversion. These findings challenge the prevailing hypothesis that lower peripheral levels of BDNF are a marker of depression.
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rs6265 has been associated with occurrence of major depressive disorder, anxiety disorders, suicidal tendencies, and depressive episodes in bipolar disorder and in patients with Alzheimer's disease.
“This SNP has also been associated with the occurrence of major depressive disorder, anxiety disorders, suicidal tendencies, and depressive episodes in bipolar disorder and in patients with Alzheimer's disease (Kim et al., 2008; Terracciano et al., 2010).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Terracciano et al., 2010
The Introduction (page unavailable) identifies rs6265 as Val66Met and reports associations with mood and other neuropsychiatric disorders, while cautioning that replication has often been inconclusive. It does not specify associations with anxiety disorders, suicidal tendencies, or depressive episodes in bipolar disorder or patients with Alzheimer’s disease. The Discussion’s mention of Alzheimer’s disease concerns a personality trait, not an rs6265 association. (LLM, conf=0.86)
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Metadata
- Authors
- Terracciano, A., Martin, B., Ansari, D., Tanaka, T., Ferrucci, L., Maudsley, S., Mattson, M. P., & Costa, P. T.
- Affiliations
- National Institutes of Health (US)
- National Institute on Aging (US)
- MedStar Health Research Institute (US)
- Corresponding author
- Terracciano, A.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2010-07
- Volume
- 9
- Issue
- 5
- Pages
- 512-518
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- PMC
- PMC2907437
- OpenAlex
- W2052597507
- Cited by
- 63
- References
- 16
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 3 · 2021: 1 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 8
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 AG999999)
- National Institute on Aging (ZIAAG000197, ZIAAG000196)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, depression, personality traits, neuroticism, stress vulnerability, conscientiousness, extraversion, sex differences
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Depression, Female, Humans, Male, Middle Aged, Personality, Reference Values, Sex Factors, Genetic Variation, Biomarkers, Statistics, Nonparametric, Brain-Derived Neurotrophic Factor, Polymorphism, Single Nucleotide
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