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Cited by 304

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Sex differences in recent first-onset depression in an epidemiological sample of adolescents

Open access
Breslau, J, Gilman, S E, Stein, B D, Ruder, T, Gmelin, T, Miller, E·2017·Translational Psychiatry
DOI 10.1038/tp.2017.105
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Abstract

Prior studies provide limited and contradictory evidence regarding sex differences in the incidence of depression during adolescence, a critical period for development of the disorder. Data from six consecutive years (2009-2014) of a national survey of US adolescents aged 12-17 (N=101 685) are used to characterize sex differences in the incidence of depression by age and to compare recent first-onset and persistent depression with respect to impairment, suicide attempts, conduct problems and academic functioning. Projecting from age-specific incidence proportions, the cumulative incidence of depression between the ages of 12 and 17 is 13.6% among male and 36.1% among female subjects. The sex difference in incidence is significant at the age of 12 years (5.2% in female versus 2.0% in male subjects, P<0.0001), and it is significantly larger at ages of 13 through 17 years than at the age of 12 years (P-values<0.05). Depression-related impairment is lower in recent first-onset than in persistent depression among female but not among male subjects. The prevalence of conduct problems and poor academic functioning is higher in both recent first-onset and persistent depression relative to those with no depression for both male and female subjects. The incidence of depression during adolescence is higher than that suggested by prior studies based on retrospective recall. Contrary to prior studies, evidence suggests that the sex difference in depression originates during childhood and grows in magnitude during adolescence. High levels of impairment, suicide attempts, conduct problems and poor academic functioning argue against a 'wait and see' approach to clinical treatment of recent first-onset depression.

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Metadata

Authors
Breslau, J., Gilman, S. E., Stein, B. D., Ruder, T., Gmelin, T., & Miller, E.
Venue
Translational Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2017-05-30
Volume
7
Issue
5
Pages
e1139-e1139
ISSN
2158-3188 (ISSN-L)
DOI
10.1038/tp.2017.105
OpenAlex
W2617360094
Cited by
304
References
21
FWCI
23.39
Type
journal article
Language
en
Open access
gold

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