Depression from childhood into late adolescence: Influence of gender, development, genetic susceptibility, and peer stress.

Hankin, Benjamin L.; Young, Jami F.; Abela, John R. Z.; Smolen, Andrew; Jenness, Jessica L.; Gulley, Lauren D.; Technow, Jessica R.; Gottlieb, Andrea Barrocas; Cohen, Joseph R.; Oppenheimer, Caroline W.

doi:10.1037/abn0000089

Cited by 448Child and Adolescent Psychosocial and Emotional DevelopmentAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeurotransmitter Receptor Influence on Behavior

Depression from childhood into late adolescence: Influence of gender, development, genetic susceptibility, and peer stress.

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Hankin, Benjamin L., Young, Jami F., Abela, John R. Z., Smolen, Andrew, Jenness, Jessica L., Gulley, Lauren D., Technow, Jessica R., Gottlieb, Andrea Barrocas +2 more·2015·Journal of Abnormal Psychology

DOI 10.1037/abn0000089PMC PMC4662048

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Abstract

Depression is a debilitating mental illness with clear developmental patterns from childhood through late adolescence. Here, we present data from the Gene Environment Mood (GEM) study, which used an accelerated longitudinal cohort design with youth (N = 665) starting in 3rd, 6th, and 9th grades, and a caretaker, who were recruited from the general community, and were then assessed repeatedly through semistructured diagnostic interviews every 6 months over 3 years (7 waves of data) to establish and then predict trajectories of depression from age 8 to 18. First, we demonstrated that overall prevalence rates of depression over time, by age, gender, and pubertal status, in the GEM study closely match those trajectories previously obtained in past developmental epidemiological research. Second, we tested whether a genetic vulnerability-stress model involving 5-HTTLPR and chronic peer stress was moderated by developmental factors. Results showed that older aged adolescents with SS/SL genotype, who experienced higher peer chronic stress over 3 years, were the most likely to be diagnosed with a depressive episode over time. Girls experiencing greater peer chronic stress were the most likely to develop depression. This study used repeated assessments of diagnostic interviewing in a moderately large sample of youth over 3 years to show that depression rates increase in middle to late adolescence, or postpubertally, and that the gender difference in depression emerges earlier in adolescence (age 12.5), or postpubertally. Additionally, genetically susceptible older adolescents who experience chronic peer stress were the most likely to become depressed over time.

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Biological sex differences occur earlier in development for SAS (at least by 4th grade, or 9 years of age, in the current investigation) than for depressive symptoms (8th grade, or about 13 years of age).
“Biologi -cal sex differences occur earlier in development for SAS (at least by 4th grade or 9 years-of-age in the current investi -gation) than depressive symptoms (8th grade or about 13 years-of-age, [26, 28]).”
From Co-Development of Anxious Solitude and Social Anxiety Symptoms from Middle Childhood Through Early Adolescence: Increased Transactions After the Middle School Transition (2026) · cites this paper as [28]
The Results (Preliminary Descriptive Results; page unavailable) report that the gender difference in depression diagnoses emerged at age 12.5, broadly supporting the cited age of about 13. The paper does not establish an eighth-grade onset for depressive symptoms: it measures diagnoses, and its grade analysis identifies significant differences in the sixth- and ninth-grade cohorts. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Younger emerging adults and older adolescent students are more prone to depressive moods.
“Several studies have shown that younger emerging adults and older adolescent students are more prone to depressive moods (Bayram and Bilgel 2008; Hankin et al. 2015)”
From Problematic online behaviors among adolescents and emerging adults: associations between cyberbullying perpetration, problematic social media use, and psychosocial factors (2019) · cites this paper as Hankin et al. 2015
Depressive feelings and problematic behaviors may peak around the last years of high school.
“it has been suggested that depressive feelings and problematic behaviors may peak around the last years of high school (Bayram and Bilgel 2008; Hankin et al. 2015).”
From Problematic online behaviors among adolescents and emerging adults: associations between cyberbullying perpetration, problematic social media use, and psychosocial factors (2019) · cites this paper as Hankin et al. 2015
Evidence from other pre-COVID studies indicates that middle and late adolescents are likely to experience more heightened levels of distress than their younger peers.
“This is also consistent with evidence from other pre-COVID studies indicating that middle and late adolescents are likely to experience more heightened levels of distress than their younger peers [65,66].”
From Exploring the Impact of COVID-19 on Mental Health Outcomes in Children and Adolescents: A Systematic Review (2020) · cites this paper as [66]

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“For example, in an accelerated longitudinal cohort design, Hankin et al. (2015) recently reported that the gender difference in clinical depression emerges at age 12.5, slightly younger than the findings from the current study.”
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Authors: Hankin, B. L., Young, J. F., Abela, J. R. Z., Smolen, A., Jenness, J. L., Gulley, L. D., Technow, J. R., Gottlieb, A. B., Cohen, J. R., & Oppenheimer, C. W.
Affiliations: University of Denver (US)
Rutgers, The State University of New Jersey (US)
University of Colorado Boulder (US)
University of Pittsburgh (US)
ORCID: Hankin, Benjamin L.
Young, Jami F.
Smolen, Andrew
Jenness, Jessica L.
Gulley, Lauren D.
Cohen, Joseph R.
Oppenheimer, Caroline W.
Venue: Journal of Abnormal Psychology
Publisher: American Psychological Association (APA)
Published: 2015-11
Volume: 124
Issue: 4
Pages: 803-816
ISSN: 0021-843X (ISSN-L)
1939-1846
DOI: 10.1037/abn0000089
PMC: PMC4662048
OpenAlex: W2174766270
Cited by: 443
References: 116
Citations by year: 2026: 33 · 2025: 48 · 2024: 34 · 2023: 45 · 2022: 35 · 2021: 60 · 2020: 51 · 2019: 46 · 2018: 51 · 2017: 22 · 2016: 16 · 2015: 1
FWCI: 37.25
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
www.apa.org/pubs/journals/resources/open-access.aspx (am, 387 d)
Locations: Journal of Abnormal Psychology (publishedVersion, other-oa)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Digital Commons - DU (University of Denver) (submittedVersion)
Funders: National Institute of Mental Health (R01-MH 077195 and R01-MH 077178)
Topics: Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: adolescent depression, depression trajectories, childhood depression, gender differences in depression, pubertal stage, 5-HTTLPR, genetic susceptibility, accelerated longitudinal design, developmental epidemiology
MeSH terms: Adolescent, Child, Depressive Disorder, Female, Genotype, Humans, Interpersonal Relations, Life Change Events, Longitudinal Studies, Male, Peer Group, Sex Factors, Social Environment, Stress, Psychological, Prevalence, Genetic Predisposition to Disease, Serotonin Plasma Membrane Transport Proteins, Gene-Environment Interaction

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Depression from childhood into late adolescence: Influence of gender, development, genetic susceptibility, and peer stress.

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