Cited by 162Fungal and yeast genetics researchProtein Kinase Regulation and GTPase SignalingCellular transport and secretion

Rho GTPases: regulation of cell polarity and growth in yeasts

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Perez, Pilar, Rincón, Sergio A.·2010·Biochemical Journal

Abstract

Eukaryotic cells display a wide range of morphologies important for cellular function and development. A particular cell shape is made via the generation of asymmetry in the organization of cytoskeletal elements, usually leading to actin localization at sites of growth. The Rho family of GTPases is present in all eukaryotic cells, from yeast to mammals, and their role as key regulators in the signalling pathways that control actin organization and morphogenetic processes is well known. In the present review we will discuss the role of Rho GTPases as regulators of yeasts' polarized growth, their mechanism of activation and signalling pathways in Saccharomyces cerevisiae and Schizosaccharomyces pombe. These two model yeasts have been very useful in the study of the molecular mechanisms responsible for cell polarity. As in other organisms with cell walls, yeast's polarized growth is closely related to cell-wall biosynthesis, and Rho GTPases are critical modulators of this process. They provide the co-ordinated regulation of cell-wall biosynthetic enzymes and actin organization required to maintain cell integrity during vegetative growth.

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  • The Rho family of GTPases performs myriad functions in diverse cellular processes through different effector molecules.

    “The Rho family of GTPases is known to perform myriad functions in diverse cellular processes through different effector molecules partly due to the target specificities, functional diversities, and individual regulation of their GAPs (26,54).”

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Authors
Perez, P., & Rincón, S. A.
Affiliations
  • Instituto de Microbiología Bioquímica, Consejo Superior de Investigaciones Científicas (CSIC)/Universidad de Salamanca, Edificio Departamental, 37007 Salamanca, Spain
  • Consejo Superior de Investigaciones Científicas (ES)
Venue
Biochemical Journal
Published
2010-02-24
Volume
426
Issue
3
Pages
243-253
ISSN
  • 0264-6021 (ISSN-L)
  • 1470-8728
OpenAlex
W2061879227
Cited by
162
References
157
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 8 · 2021: 12 · 2020: 2 · 2019: 7 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 17 · 2013: 20 · 2012: 18
FWCI
1.88
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Biochemical Journal (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
Rho GTPases, cell polarity, polarized growth, yeast, Saccharomyces cerevisiae, Schizosaccharomyces pombe, actin organization, cell wall biosynthesis, cell integrity, GTPase activation, morphogenesis, signal transduction
MeSH terms
Cell Division, Cytoskeleton, Models, Biological, Saccharomyces cerevisiae, Schizosaccharomyces, rho GTP-Binding Proteins, cdc42 GTP-Binding Protein, MAP Kinase Signaling System, Saccharomyces cerevisiae Proteins, Schizosaccharomyces pombe Proteins

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