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Repression of the RHOH gene by JunD

Delestré, Laure, Berthon, Céline, Quesnel, Bruno, Figeac, Martin, Kerckaert, Jean-Pierre, Galiègue-Zouitina, Sylvie, Shelley, Carl Simon·2011·Biochemical Journal
DOI 10.1042/bj20100829
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Abstract

RhoH is a member of the Rho family of small GTP-binding proteins that lacks GTPase activity. Since RhoH is constantly bound by GTP, it is thought to be constitutively active and controlled predominantly by changes in quantitative expression. RhoH is produced specifically in haematopoietic cells and aberrant expression has been linked to various forms of leukaemia. Transcription of the RHOH gene is the first level at which the quantitative levels of the RhoH protein are regulated. Previous studies have demonstrated that RHOH gene transcription is initiated by three distinct promoter regions designated P1, P2 and P3 that define the 5′ end of exons 1, 2 and 4 respectively. In the present study we report that the P3 promoter is largely responsible for RHOH gene transcription in the B-lymphocytic cell line Raji. The P3 promoter contains a minimal promoter region and a repressor region extending from −236 to +67 and +68 to +245 respectively, relative to the 5′ end of exon 4. Chromatin immunoprecipitation demonstrated that two AP1 (activator protein 1) sites in the minimal promoter region bind JunD. When JUND is overexpressed, the endogenous RHOH gene is repressed; however, when JUND is inhibited, expression of endogenous RHOH is induced both in the Raji cell line and AML (acute myeloid leukaemia) cells. In the HCL (hairy cell leukaemia) cell line JOK-1, induction of RHOH increases expression of the α isoform of protein kinase C. This downstream target of RHOH is also induced in AML cells by JUND inhibition. Collectively, these data indicate that JunD is an inhibitor of RHOH gene expression.

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Research works printed but not linked: 60

  1. Lahousse, 2004, Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5′-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation, Gene, 343, 55, 10.1016/j.gene.2004.08.022 · DOI · Paper page
  2. Gu, 2005, RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration, and engraftment of hematopoietic progenitor cells, Blood, 105, 1467, 10.1182/blood-2004-04-1604 · DOI · Paper page
  3. Dorn, 2007, RhoH is important for positive thymocyte selection and T-cell receptor signaling, Blood, 109, 2346, 10.1182/blood-2006-04-019034 · DOI · Paper page
  4. Matsumoto, 2009, Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signalling pathways, Proteomics, 9, 3549, 10.1002/pmic.200900011 · DOI
  5. Cherry, 2004, RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes, Nat. Immunol., 5, 961, 10.1038/ni1103 · DOI · Paper page
  6. Wang, 2010, RhoH plays distinct roles in T-cell migrations induced by different doses of SDF1α, Cellular Signalling, 22, 1022, 10.1016/j.cellsig.2010.02.005 · DOI · Paper page
  7. Dallery, 1995, TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3,4) chromosomal translocation, Oncogene, 10, 2171
  8. Preudhomme, 2000, Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in nonHodgkin's lymphoma and multiple myeloma, Oncogene, 19, 2023, 10.1038/sj.onc.1203521 · DOI · Paper page
  9. Aamot, 2005, G-banding and molecular cytogenetic analyses of marginal zone lymphoma, Brit. J. Haematol., 130, 890, 10.1111/j.1365-2141.2005.05706.x · DOI
  10. Bernicot, 2006, Rearrangement of the RHOH gene in a case of splenic lymphoma with villous lymphocytes, Cancer Genet. Cytogenet., 170, 78, 10.1016/j.cancergencyto.2006.04.004 · DOI
  11. Gaidano, 2003, Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma, Blood, 102, 1833, 10.1182/blood-2002-11-3606 · DOI · Paper page
  12. Pasqualucci, 2001, Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas, Nature, 412, 341, 10.1038/35085588 · DOI · Paper page
  13. Hiraga, 2007, Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma, Leukemia, 21, 1846, 10.1038/sj.leu.2404717 · DOI · Paper page
  14. Vakiani, 2008, Genetic and phenotypic analysis of B-cell post-transplant lymphoproliferative disorders provides insights into disease biology, Hematol. Oncol., 26, 199, 10.1002/hon.859 · DOI
  15. Montesinos-Rongen, 2004, Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation, Blood, 103, 1869, 10.1182/blood-2003-05-1465 · DOI · Paper page
  16. Deutsch, 2007, MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation, Blood, 109, 3500, 10.1182/blood-2006-06-030494 · DOI
  17. Dijkman, 2006, Primary cutaneous follicular center lymphoma and primary cutaneous large B-cell lymphoma, leg type, are both targeted by aberrant somatic hypermutation but demonstrate differential expression of AID, Blood, 107, 4926, 10.1182/blood-2005-08-3443 · DOI
  18. Iwasaki, 2008, Prognostic implication and biological roles of RhoH in acute myeloid leukaemia, Eur. J. Haematol., 81, 454, 10.1111/j.1600-0609.2008.01132.x · DOI · Paper page
  19. Nicolaou, 2003, CD11c gene expression in hairy-cell leukemia is dependent upon activation of the proto-oncogenes ras and junD, Blood, 101, 4033, 10.1182/blood-2002-01-0324 · DOI · Paper page
  20. Detry, 2008, CREB-1 and AP-1 transcription factors JunD and Fra-2 regulate bone sialoprotein gene expression in human breast cancer cells, Bone, 42, 422, 10.1016/j.bone.2007.10.016 · DOI
  21. Gabert, 2003, Standardization and quality control studies of “real-time” quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia – a Europe Against Cancer program, Leukemia, 17, 2318, 10.1038/sj.leu.2403135 · DOI · Paper page
  22. Olschewski, 2006, Impact of TASK-1 in human pulmonary artery smooth muscle cells, Circ. Res., 98, 1072, 10.1161/01.RES.0000219677.12988.e9 · DOI
  23. Couronne, 2003, Strategies and tools for whole-genome alignments, Genome Res., 13, 73, 10.1101/gr.762503 · DOI · Paper page
  24. Bray, 2003, AVID: a global alignment program, Genome Res., 13, 97, 10.1101/gr.789803 · DOI
  25. Barrett, 2009, NCBI GEO: archive for high-throughput functional genomic data, Nucleic Acids Res., 37, D5, 10.1093/nar/gkn764 · DOI
  26. Edgar, 2002, Gene Expression Omnibus: NCBI gene expression and hybridization array data repository, Nucleic Acids Res., 30, 207, 10.1093/nar/30.1.207 · DOI · Paper page
  27. Yagi, 2003, Identification of a gene expression signature associated with pediatric AML prognosis, Blood, 102, 1849, 10.1182/blood-2003-02-0578 · DOI
  28. Haslinger, 2004, Microarray gene expression profiling of B-cell chronic lymphocytic leukemia subgroups defined by genomic aberrations and VH mutation status, J. Clinical Oncol., 22, 3937, 10.1200/JCO.2004.12.133 · DOI
  29. Su, 2002, Large-scale analysis of the human and mouse transcriptomes, Proc. Natl. Acad. Sci. U.S.A., 99, 4465, 10.1073/pnas.012025199 · DOI · Paper page
  30. An, 2005, The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrest, J. Biol. Chem., 280, 3862, 10.1074/jbc.M407435200 · DOI
  31. Brune, 2008, Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis, J. Exp. Med., 205, 2251, 10.1084/jem.20080809 · DOI
  32. Basso, 2004, Gene expression profiling of hairy cell leukemia reveals a phenotype related to memory B cells with altered expression of chemokine and adhesion receptors, J. Exp. Med., 199, 59, 10.1084/jem.20031175 · DOI
  33. Jabrane-Ferrat, 1994, Ets-1 activates the DRA promoter in B cells, Mol. Cell. Biol., 14, 7314
  34. Monticelli, 2002, NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription, Eur. J. Immunol., 32, 2971, 10.1002/1521-4141(2002010)32:10<2971::AID-IMMU2971>3.0.CO;2-G · DOI
  35. Geltinger, 1996, TATA box and Sp1 sites mediate the activation of c-myc promoter P1 by immunoglobulin kappa enhancers, Gene Expr., 6, 113
  36. Lelièvre, 2001, The Ets family contains transcriptional activators and repressors involved in angiogenesis, Int. J. Biochem. Cell. Biol., 33, 391, 10.1016/S1357-2725(01)00025-5 · DOI
  37. Schreiber, 1999, Control of cell cycle progression by c-Jun is p53 dependent, Genes Dev., 13, 607, 10.1101/gad.13.5.607 · DOI
  38. Wierenga, 1999, Evidence for suppressed activity of the transcription factor NFAT1 at its proximal binding element P0 in the IL-4 promoter associated with enhanced IL-4 gene transcription in T cells of atopic patients, Int. Immunol., 11, 297, 10.1093/intimm/11.2.297 · DOI
  39. Carvalho, 2007, The NFAT1 transcription factor is a repressor of cyclin A2 gene expression, Cell Cycle, 6, 1789, 10.4161/cc.6.14.4473 · DOI
  40. Aronson, 1997, Groucho-dependent and -independent repression activities of Runt domain proteins, Mol. Cell. Biol., 17, 5581, 10.1128/MCB.17.9.5581 · DOI
  41. Levanon, 1998, Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors, Proc. Natl. Acad. Sci. U.S.A., 95, 11590, 10.1073/pnas.95.20.11590 · DOI
  42. Elagib, 2007, Regulation of RUNX1 transcriptional function by GATA-1, Crit. Rev. Eukaryot. Gene Expr., 17, 271, 10.1615/CritRevEukarGeneExpr.v17.i4.20 · DOI
  43. Koipally, 1999, Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes, EMBO J., 18, 3090, 10.1093/emboj/18.11.3090 · DOI
  44. Pei, 1990, Transcriptional activation and repression by cellular DNA-binding protein C/EBP, J. Virol., 64, 1517, 10.1128/jvi.64.4.1517-1522.1990 · DOI
  45. Hromas, 1996, Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1, Curr. Top. Microbiol. Immunol., 211, 159
  46. Shaulian, 2001, AP-1 in cell proliferation and survival, Oncogene, 20, 2390, 10.1038/sj.onc.1204383 · DOI
  47. Short, 2002, Translational regulation of the JunD messenger RNA, J. Biol. Chem., 277, 32697, 10.1074/jbc.M204553200 · DOI
  48. Takahashi, 1998, Structure and transcriptional regulation of the human cystatin A gene. The 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive element-2 site (−272 to −278) on cystatin A gene is critical for TPA-dependent regulation, J. Biol. Chem., 273, 17375, 10.1074/jbc.273.28.17375 · DOI
  49. Takahashi, 1998, The alpha and eta isoforms of protein kinase C stimulate transcription of human involucrin gene, J. Invest. Dermatol., 110, 218, 10.1046/j.1523-1747.1998.00110.x · DOI
  50. Soh, 2003, Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes, J. Biol. Chem., 278, 34709, 10.1074/jbc.M302016200 · DOI
  51. Frost, 1997, Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins, EMBO J., 16, 6426, 10.1093/emboj/16.21.6426 · DOI
  52. Li, 2002, Ultraviolet-induced junD activation and apoptosis in myeloblastic leukemia ML-1 cells, J. Biol. Chem., 277, 32668, 10.1074/jbc.M203519200 · DOI
  53. Dallery-Prudhomme, 1997, Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization, Genomics, 1, 89, 10.1006/geno.1997.4788 · DOI · Paper page
  54. Nicolaides, 1992, The Jun family members, c-Jun and JunD, transactivate the human c-myb promoter via an Ap1-like element, J. Biol. Chem., 267, 19665, 10.1016/S0021-9258(18)41826-1 · DOI
  55. Clark, 2002, Modulation of the human protein kinase Cα gene promoter by activator protein-2, Biochemistry, 41, 11847, 10.1021/bi025600k · DOI
  56. Dupasquier, 2009, A new mechanism of SOX9 action to regulate PKCα expression in the intestine epithelium, J. Cell Sci., 122, 2191, 10.1242/jcs.036483 · DOI
  57. Dieter, 2000, Protein kinase C-α and -β play antagonistic roles in the differentiation process of THP-1 cells, Cell. Signalling, 12, 297, 10.1016/S0898-6568(00)00069-3 · DOI
  58. Kim, 2008, Interferon-α enhances artemisinin-induced differentiation of HL-60 leukemia cells via a PKCα/ERK pathway, Eur. J. Pharmacol., 587, 65, 10.1016/j.ejphar.2008.03.036 · DOI
  59. Nakagawa, 2006, Subversion of protein kinase Cα signaling in hematopoietic progenitor cells results in the generation of a B-cell chronic lymphocytic leukemia-like population in vivo, Cancer Res., 66, 527, 10.1158/0008-5472.CAN-05-0841 · DOI
  60. Abrams, 2007, B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII, Blood, 109, 1193, 10.1182/blood-2006-03-012021 · DOI

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Metadata

Authors
Delestré, L., Berthon, C., Quesnel, B., Figeac, M., Kerckaert, J.-P., Galiègue-Zouitina, S., & Shelley, C. S.
Affiliations
  • Institut National de la Santé et de la Recherche Médicale U.837, Centre Jean-Pierre Aubert, Institut pour la Recherche sur le Cancer de Lille and Université Lille Nord de France, UDSL, 59000 Lille, France
  • Université Lille Nord de France, UDSL, Université de Lille 2, 59045 Lille, France
  • Gundersen Lutheran Medical Foundation, La Crosse, WI 54601, U.S.A.
Venue
Biochemical Journal
Publisher
Portland Press Ltd.
Published
2011-06-14
Volume
437
Issue
1
Pages
75-88
ISSN
  • 0264-6021
  • 1470-8728
DOI
10.1042/bj20100829
Cited by
13
References
10
Language
en

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CoChat. (2026). Citation check: Repression of the RHOH gene by JunD. https://app.cochat.ai/papers/10.1042/bj20100829
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Delestré, L., Berthon, C., Quesnel, B., Figeac, M., Kerckaert, J.-P., Galiègue-Zouitina, S., & Shelley, C. S. (2011). Repression of the RHOH gene by JunD. Biochemical Journal. https://doi.org/10.1042/bj20100829