Cited by 406Mitochondrial Function and PathologyATP Synthase and ATPases ResearchMetabolism, Diabetes, and Cancer

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The efficiency and plasticity of mitochondrial energy transduction.

Brand, M.D.·2005·Biochemical Society Transactions

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Abstract

Since it was first realized that biological energy transduction involves oxygen and ATP, opinions about the amount of ATP made per oxygen consumed have continually evolved. The coupling efficiency is crucial because it constrains mechanistic models of the electron-transport chain and ATP synthase, and underpins the physiology and ecology of how organisms prosper in a thermodynamically hostile environment. Mechanistically, we have a good model of proton pumping by complex III of the electron-transport chain and a reasonable understanding of complex IV and the ATP synthase, but remain ignorant about complex I. Energy transduction is plastic: coupling efficiency can vary. Whether this occurs physiologically by molecular slipping in the proton pumps remains controversial. However, the membrane clearly leaks protons, decreasing the energy funnelled into ATP synthesis. Up to 20% of the basal metabolic rate may be used to drive this basal leak. In addition, UCP1 (uncoupling protein 1) is used in specialized tissues to uncouple oxidative phosphorylation, causing adaptive thermogenesis. Other UCPs can also uncouple, but are tightly regulated; they may function to decrease coupling efficiency and so attenuate mitochondrial radical production. UCPs may also integrate inputs from different fuels in pancreatic beta-cells and modulate insulin secretion. They are exciting potential targets for treatment of obesity, cachexia, aging and diabetes.

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Authors: Brand, M. D.
Affiliations: MRC Mitochondrial Biology Unit (GB)
Corresponding author: Brand, M.D.
ORCID: Brand, M.D.
Venue: Biochemical Society Transactions
Publisher: Portland Press Ltd.
Published: 2005-10-26
Volume: 33
Issue: 5
Pages: 897-904
ISSN: 0300-5127 (ISSN-L)
1470-8752
DOI: 10.1042/bst0330897
OpenAlex: W2021952329
Cited by: 406
References: 57
Citations by year: 2026: 12 · 2025: 17 · 2024: 8 · 2023: 25 · 2022: 17 · 2021: 19 · 2020: 22 · 2019: 20 · 2018: 19 · 2017: 30 · 2016: 21 · 2015: 23 · 2014: 27 · 2013: 12 · 2012: 27
FWCI: 0.91
Type: journal article
Language: en
Open access: closed
Locations: Biochemical Society Transactions (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: mitochondrial energy transduction, coupling efficiency, electron transport chain, complex I, ATP synthase, proton leak, UCP1, thermogenesis, mitochondrial uncoupling, mitochondrial reactive oxygen species, beta-cell insulin secretion, obesity, cachexia, aging, diabetes mellitus
MeSH terms: Adenosine Triphosphate, Animals, Energy Metabolism, Mitochondria, Models, Biological, Oxygen Consumption, Uncoupling Agents

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The efficiency and plasticity of mitochondrial energy transduction.

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