Cited by 172Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanismsNerve injury and regeneration

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Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre

Mason, J. L., Langaman, C., Morell, P., Suzuki, K., Matsushima, G. K.·2001·Neuropathology and Applied Neurobiology

DOI 10.1046/j.0305-1846.2001.00301.x

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Abstract

Exposure of young adult C57BL/6 mice to cuprizone in the diet initiated profound and synchronous demyelination of the corpus callosum, which was virtually complete by 4 weeks of exposure. Interestingly, even in the face of a continued exposure to cuprizone, there was spontaneous remyelination 2 weeks later. This remyelination preferentially involved smaller calibre axons. There was a suggestion of yet another cycle of demyelination (at 10 weeks) and remyelination (at 12 weeks), but by 16 weeks of exposure, the regenerative capacity was exhausted and the animals were near death. The relapsing–remitting pattern suggests this may be a useful model for certain human demyelinating disorders. In contrast to the above chronic model, the corpus callosum from mice exposed to cuprizone for only 6 weeks continued to remyelinate, with 67% of the axons being myelinated or remyelinated at 10 weeks. Interestingly, a significant reduction in the mean value for axonal diameter was observed during acute demyelination. Upon remyelination, however, the axonal calibre distribution returned to near‐normal. In contrast, when mice were maintained on a cuprizone diet for 16 weeks, the mean value for axonal diameter was reduced to 60% of normal. These results provide further evidence that the interactions between oligodendrocytes and axons alter axonal calibre.

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Authors: Mason, J. L., Langaman, C., Morell, P., Suzuki, K., & Matsushima, G. K.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Matsushima, G. K.
ORCID: Suzuki, K.
Venue: Neuropathology and Applied Neurobiology
Publisher: Wiley
Published: 2001-02
Volume: 27
Issue: 1
Pages: 50-58
ISSN: 0305-1846 (ISSN-L)
1365-2990
DOI: 10.1046/j.0305-1846.2001.00301.x
OpenAlex: W2156549416
Cited by: 172
References: 27
Citations by year: 2026: 3 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 13 · 2018: 6 · 2017: 8 · 2016: 13 · 2015: 12 · 2014: 9 · 2013: 6 · 2012: 4
FWCI: 3.32
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 323 d)
Locations: Neuropathology and Applied Neurobiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Multiple Sclerosis Society
National Institutes of Health (RG2754A1, 5r01ns011615-29, 5r01ns037815-05, 5r29ns035372-05)
National Institute of Neurological Disorders and Stroke (NS 24453, NS37815, R01NS024453, NS-11615, NS-35372)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: cuprizone, demyelination, remyelination, axon diameter, corpus callosum, demyelinating disease, C57BL/6 mice
MeSH terms: Amidines, Animals, Axons, Central Nervous System, Chronic Disease, Corpus Callosum, Cuprizone, Demyelinating Diseases, Disease Models, Animal, Fluorescent Dyes, Mice, Inbred C57BL, Microscopy, Electron, Nerve Fibers, Myelinated, Recurrence, Remission, Spontaneous, Cell Size, Mice

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Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre

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