Cited by 129Fatty Acid Research and HealthEdible Oils Quality and AnalysisInflammatory mediators and NSAID effects

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Pro- and anti-inflammatory cytokines in healthy volunteers fed various doses of fish oil for 1 year

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BLOK, W. L., DESLYPERE, J.‐P., DEMACKER, P. N. M., VAN DER VEN‐JONGEKRIJG, J., HECTORS, M. P. C., VAN DER MEER, J. W. M., KATAN, M. B.·1997·European Journal of Clinical Investigation

DOI 10.1046/j.1365-2362.1997.2240775.x

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Abstract

Dietary supplementation with n-3 fatty acids from fish oil alleviates inflammation in various chronic inflammatory disease states. Reductions in the production of pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) have been seen in humans after short-term n-3 fatty acid supplementation. We investigated long-term effects of dietary n-3 fatty acids on circulating cytokine concentrations and on ex vivo stimulated whole-blood production of IL-1 beta, TNF-alpha and interleukin 1 receptor antagonist (IL-1Ra), the naturally occurring antagonist of IL-1. A total of 58 monks with a mean age of 56 years were randomized into four groups and their diets were supplemented with 0, 3, 6, or 9 g of fish oil, providing 0, 1.06, 2.13 or 3.19 g of n-3 fatty acids per day. Subjects received equal amounts of saturated fatty acids, vitamin E and cholesterol. Compliance was excellent and erythrocyte fatty acid profiles closely reflected the amounts of n-3 fatty acids ingested. In the group receiving 9 g of fish oil per day, no influence of n-3 fatty acids on circulating cytokine concentrations was observed relative to placebo. Endotoxin-stimulated whole-blood cytokine production was measured at 26 and 52 weeks after the start and at 4, 8 and 26 weeks after cessation of supplementation. In all groups, the production of IL-1 beta and IL-1Ra was higher during supplementation than afterwards. However, no differences in cytokine production were noted between the placebo group and the various treatment groups at any point in time. Our results suggest that long-term supplementation of fish oil does not affect ex vivo cytokine production in man.

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Authors: BLOK, W. L., DESLYPERE, J. ‐., DEMACKER, P. N. M., VAN DER VEN‐JONGEKRIJG, J., HECTORS, M. P. C., VAN DER MEER, J. W. M., & KATAN, M. B.
Affiliations: Radboud University Nijmegen (NL)
Ghent University Hospital (BE)
Wageningen University & Research (NL)
Corresponding author: DEMACKER, P. N. M.
ORCID: KATAN, M. B.
Venue: European Journal of Clinical Investigation
Publisher: Wiley
Published: 1997-12
Volume: 27
Issue: 12
Pages: 1003-1008
ISSN: 0014-2972 (ISSN-L)
1365-2362
DOI: 10.1046/j.1365-2362.1997.2240775.x
OpenAlex: W2104625208
Cited by: 129
References: 35
Citations by year: 2026: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 1 · 2012: 7
FWCI: 1.89
Type: journal article
Language: en
Open access: green
research.vu.nl
Licence: other-oa
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2158 d)
Locations: European Journal of Clinical Investigation (publishedVersion)
PubMed (publishedVersion)
VU Research Portal (publishedVersion, other-oa)
Socio-Environmental Systems Modeling (acceptedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords: fish oil, omega-3 fatty acids, dietary supplementation, inflammatory cytokines, anti-inflammatory cytokines, IL-1β, TNF-α, interleukin-6, interleukin-1 receptor antagonist, whole blood cytokine production, endotoxin stimulation, erythrocyte fatty acids, long-term supplementation, healthy volunteers
MeSH terms: Adult, Aged, Aged, 80 and over, Fish Oils, Humans, Inflammation, Interleukin-1, Male, Middle Aged, Patient Compliance, Sialoglycoproteins, Tumor Necrosis Factor-alpha, Cytokines, Dietary Supplements, Interleukin 1 Receptor Antagonist Protein

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Pro- and anti-inflammatory cytokines in healthy volunteers fed various doses of fish oil for 1 year

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