Corticotrophin‐releasing factor produces a long‐lasting enhancement of synaptic efficacy in the hippocampus

Wang, H. L.; Wayner, M. J.; Chai, C. Y.; Lee, E. H. Y.

doi:10.1046/j.1460-9568.1998.00352.x

Cited by 97Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsStress Responses and Cortisol

Corticotrophin‐releasing factor produces a long‐lasting enhancement of synaptic efficacy in the hippocampus

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Wang, H. L., Wayner, M. J., Chai, C. Y., Lee, E. H. Y.·1998·European Journal of Neuroscience

DOI 10.1046/j.1460-9568.1998.00352.x

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Abstract

We have previously demonstrated that intra-hippocampal injection of corticotrophin-releasing factor improved memory retention of an inhibitory avoidance learning in rats; while the electrophysiological effects corticotrophin-releasing factor produces on hippocampal neurons are largely uncharacterized. In the present study, we found that corticotrophin-releasing factor injected into the dentate gyrus of hippocampus produced a dose-dependent and long-lasting enhancement in synaptic efficacy of these neurons, as measured by an increase in the amplitude and slope of population excitatory postsynaptic potentials, as well as the amplitude of population spike. The onset of corticotrophin-releasing factor-induced potentiation was slow. It was observed approximately 40-60 min after corticotrophin-releasing factor administration and lasted for more than 5 h. This effect of corticotrophin-releasing factor was blocked by pretreatment with the cyclase-adenosine-3,5-monophosphate (cAMP) inhibitor Rp-adenosine-3,5-cyclic monophosphothiolate triethylamine (Rp-cAMPS) and partially blocked by the N-methyl-D-aspartate receptor antagonist MK-801. Further, pretreatment with corticotrophin-releasing factor receptor antagonist dose-dependently diminished tetanization-induced long-term potentiation, and corticotrophin-releasing factor and tetanic stimuli had an additive effect on hippocampal neuron excitation. Moreover, direct injection of corticotrophin-releasing factor increased cAMP level in the dentate gyrus. These results together suggest that corticotrophin-releasing factor-induced potentiation simulates the late phase of tetanization-induced long-term potentiation and cAMP seems to be the messenger mediating this effect. Moreover, corticotrophin-releasing factor-induced potentiation and long-term potentiation may share some similar mechanisms, and corticotrophin-releasing factor is probably involved in the neural circuits underlying long-term potentiation. Thus, corticotrophin-releasing factor may play an important role in modulating synaptic plasticity in the hippocampus.

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The initial component (1A) involves the rapid activation of the hippocampus by the amygdala, in conjunction with local increases in levels of neuromodulators such as CRH, acetylcholine, dopamine, and norepinephrine.
“The initial component (1A) would involve the rapid activation of the hippocampus by the amygdala, in conjunction with local increases in levels of neuromodulators, such as corticotrophin-releasing hormone (CRH) (Adamec et al. [225]; Wang et al. [226]; Wang et al. [227]; Blank et al. [228]; Chen et al. [229]), acetylcholine (Ye et al. [247]; Ovsepian et al. [248]), dopamine (Li et al. [204]; Lisman”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Wang et al. [226]

Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965 · see citing works
Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904 · see citing works
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640 · see citing works
Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4 · Cited by 3,423 · see citing works
Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352 · see citing works
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons
Frey, U., Huang, Y.-Y., & Kandel, E. R. (1993) · Science · doi:10.1126/science.8389057 · Cited by 1,218 · see citing works
NMDA receptors - their role in long-term potentiation
Collingridge, G. L., & Bliss, T. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90175-5 · Cited by 1,174 · see citing works
Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
Nguyen, P. V., Abel, T., & Kandel, E. R. (1994) · Science · doi:10.1126/science.8066450 · Cited by 888 · see citing works
Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro
Frey, U., Krug, M., Reymann, K. G., & Matthies, H. (1988) · Brain Research · doi:10.1016/0006-8993(88)90008-x · Cited by 806 · see citing works
D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus.
Huang, Y.-Y., & Kandel, E. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2446 · Cited by 544 · see citing works
Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats
Krug, M., Lössner, B., & Ott, T. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90005-4 · Cited by 509 · see citing works
Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization.Preprint
Huang, Y.-Y., & Kandel, E. R. (1994) · Learning & Memory · doi:10.1101/lm.1.1.74 · Cited by 476 · see citing works
Synthetic Competitive Antagonists of Corticotropin-Releasing Factor: Effect on ACTH Secretion in the Rat
Rivier, J., RIVIER, C. L., & Vale, W. (1984) · Science · doi:10.1126/science.6326264 · Cited by 471 · see citing works
Corticotropin-releasing factor receptors in the rat central nervous system: characterization and regional distribution
Souza, E. B. D. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-01-00088.1987 · Cited by 338 · see citing works
Corticotropin Releasing Factor Decreases Postburst Hyperpolarizations and Excites Hippocampal Neurons
Aldenhoff, J. B., Gruol, D. L., Rivier, J., Vale, W., & Siggins, G. R. (1983) · Science · doi:10.1126/science.6603658 · Cited by 309 · see citing works
Physiological identification and analysis of dentate granule cell responses to stimulation of the medial and lateral perforant pathways in the rat
McNaughton, B. L., & Barnes, C. A. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901750404 · Cited by 280 · see citing works
A Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation Requiring cAMP in the Medial Perforant Pathway of Rat Hippocampal Slices
Nguyen, P., & Kandel, E. R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03189.1996 · Cited by 275 · see citing works
Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately post-tetanization
Otani, S., Marshall, C. J., Tate, W. P., Goddard, G. V., & Abraham, W. C. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90001-8 · Cited by 274 · see citing works
Rat Corticotropin-Releasing Hormone Gene: Sequence and Tissue-Specific Expression*
Thompson, R. C., Seasholtz, A. F., & Herbert, E. (1987) · Molecular Endocrinology · doi:10.1210/mend-1-5-363 · Cited by 214 · see citing works
Intra-amygdala injections of corticotropin releasing factor facilitate inhibitory avoidance learning and reduce exploratory behavior in rats
Liang, K., & Lee, E. H. Y. (1988) · Psychopharmacology · doi:10.1007/bf00177566 · Cited by 174 · see citing works
Self-citation
Effects of corticotropin releasing factor on locomotor activity in hypophysectomized rats
Eaves, M., Thatcher-Britton, K., Rivier, J., Vale, W., & Koob, G. F. (1985) · Peptides · doi:10.1016/0196-9781(85)90323-7 · Cited by 143 · see citing works
The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist
Baram, T. Z., Chalmers, D. T., Chen, C., Koutsoukos, Y., & Souza, E. B. D. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00759-2 · Cited by 109 · see citing works
Corticotropin-Releasing Factor Synapses within the Paraventricular Nucleus of the Hypothalamus
Silverman, A., Hou-Yu, A., & Chen, W. (2008) · Neuroendocrinology · doi:10.1159/000125131 · Cited by 95 · see citing works
Corticotropin-Releasing Factor Binding to Peripheral Tissue and Activation of the Adenylate Cyclase-Adenosine 3′,5′-Monophosphate System
Dave, J. R., Eiden, L. E., & Eskay, R. L. (1985) · Endocrinology · doi:10.1210/endo-116-6-2152 · Cited by 91 · see citing works
Hippocampal CRF, NE, and NMDA system interactions in memory processing in the rat
Lee, E. H. Y., Lee, C. P., Wang, H. I., & Lin, W. R. (1993) · Synapse · doi:10.1002/syn.890140207 · Cited by 88 · see citing works
Self-citation
Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain
Strijbos, P. J. L. M., Relton, J. K., & Rothwell, N. J. (1994) · Brain Research · doi:10.1016/0006-8993(94)91485-0 · Cited by 87 · see citing works
Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus
Smith, M. A., Weiss, S. R. B., Berry, R. L., Zhang, L., Clark, M., Massenburg, G. S., & Post, R. M. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01157-2 · Cited by 75 · see citing works
2-Amino-4-phosphonobutyrate selectively eliminates late phases of long-term potentiation in rat hippocampus
Reymann, K. G., & Matthies, H. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90504-1 · Cited by 65 · see citing works
Protein synthesis in the hippocampus associated with memory facilitation by corticotropin-releasing factor in rats
Lee, E. H. Y., Hung, H.-C., Lu, K., Chen, W. H., & Chen, H. Y. (1992) · Peptides · doi:10.1016/0196-9781(92)90051-4 · Cited by 61 · see citing works
Self-citation
Ethanol and diazepam inhibition of hippocampal LTP is mediated by angiotensin II and AT1 receptors
Wayner, M. J., Armstrong, D. L., Polan-Curtain, J. L., & Denny, J. B. (1993) · Peptides · doi:10.1016/0196-9781(93)90129-5 · Cited by 48 · see citing works
Self-citation
Antisense oligonucleotides to corticotropin-releasing factor impair memory retention and increase exploration in rats
Wu, H., Chen, K., Lee, W. Y., & Lee, E. H. Y. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00533-7 · Cited by 34 · see citing works
Self-citation
Spermine facilitates the generation of long-term potentiation of evoked potential in the dentate gyrus of anesthetized rats
Chida, N., Saitō, H., & Abe, K. (1992) · Brain Research · doi:10.1016/0006-8993(92)91263-e · Cited by 33 · see citing works
CRF facilitates NE release from the hippocampus: a microdialysis study
Lee, E. H. Y., Chang, S., & Chen, A. Y. J. (1994) · Neuroscience Research · doi:10.1016/0168-0102(94)90045-0 · Cited by 29 · see citing works
Self-citation
Enhanced hippocampal corticotropin-releasing factor gene expression associated with memory consolidation and memory storage in rats.
Lee, E. H. Y., Huang, A., Tsuei, K. S., & Lee, W. Y. (1996) · PubMed · Cited by 19 · see citing works
Self-citation
The effect of 'Astressin', a novel antagonist of corticotropin releasing hormone (CRH), on CRH-induced seizures in the infant rat: comparison with two other antagonists.
Baram, T., Koutsoukos, Y., Schultz, L., & Rivier, J. (1996) · PubMed · Cited by 18 · see citing works
Nicotine Blocks Angiotensin II Inhibition of LTP in the Dentate Gyrus
Wayner, M. J., Armstrong, D. L., & Phelix, C. F. (1996) · Peptides · doi:10.1016/s0196-9781(96)00179-9 · Cited by 15 · see citing works
Self-citation
Role of cyclic AMP in corticotropin releasing factor mediated ACTH release
Sobel, D. O. (1985) · Peptides · doi:10.1016/0196-9781(85)90158-5 · Cited by 12 · see citing works
Injections of corticotropin-releasing factor into the periaqueductal gray enhance Pavlovian fear conditioning
Tershner, S. A., & Helmstetter, F. J. (1996) · Psychobiology · doi:10.3758/bf03331953 · Cited by 6 · see citing works

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Central nervous regulation of the hypothalamic-pituitary-adrenal axis and its impact on fertility, immunity, metabolism and animal welfare – a review
Manteuffel, G. (2002) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-45-575-2002 · Cited by 58 · see citing works
Corticotropin-Releasing Hormone (CRH) Depresses N-Methyl-d-Aspartate Receptor-Mediated Current in Cultured Rat Hippocampal Neurons via CRH Receptor Type 1
Sheng, H., Zhang, Y., Sun, J., Gao, L., Ma, B., Lu, J., & Ni, X. (2007) · Endocrinology · doi:10.1210/en.2007-1378 · Cited by 46 · see citing works
Focal Adhesion Kinase Is Required, But Not Sufficient, for the Induction of Long-Term Potentiation in Dentate Gyrus NeuronsIn Vivo
Yang, Y. C., Ma, Y., Chen, S., Wang, C. W., & Lee, E. H. Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04072.2003 · Cited by 43 · see citing works
Self-citation
The neuroprotective actions of corticotropin releasing hormone
Bayatti, N., & Behl, C. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.02.004 · Cited by 40 · see citing works
Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion channels
Kratzer, S., Mattusch, C., Metzger, M. W., Dedic, N., Noll‐Hussong, M., Kafitz, K. W., Eder, M., Deussing, J. M., Holsboer, F., Kochs, E. F., et al. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00091 · Cited by 40 · see citing works
Modulation of social learning in rats by brain corticotropin-releasing factor.
Heinrichs, S. (2003) · Brain Research · doi:10.1016/j.brainres.2003.09.028 · Cited by 41 · see citing works
Fibromyalgia Syndrome: A Central Role for the Hippocampus—A Theoretical Construct
Wood, P. B. (2004) · Journal of Musculoskeletal Pain · doi:10.1300/j094v12n01_04 · Cited by 38 · see citing works
Linear and Non-Linear Dose-Response Functions Reveal a Hormetic Relationship between Stress and Learning
Zoladz, P. R., & Diamond, D. M. (2008) · Dose-Response · doi:10.2203/dose-response.08-015.zoladz · Cited by 37 · see citing works
Ovarian hormones influence corticotropin releasing factor receptor colocalization with delta opioid receptors in CA1 pyramidal cell dendrites
Williams, T. J., Akama, K. T., Knudsen, M. G., McEwen, B. S., & Milner, T. A. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.04.012 · Cited by 36 · see citing works
Mild stress facilitates learning and exercise improves retention in aged mice
Adlard, P. A., Engesser‐Cesar, C., & Cotman, C. W. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.10.001 · Cited by 37 · see citing works
Anxiety-like behavior in the elevated-plus maze tests and enhanced IL-1β, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats
Škurlová, M., Štofková, A., & Jur̀čovičová, J. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.10.032 · Cited by 34 · see citing works
Functional blocking of integrin-associated protein impairs memory retention and decreases glutamate release from the hippocampus
Chang, H., Ma, Y., Wan, F. J., Tsai, L. Y., Lindberg, F. P., & Lee, E. H. Y. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00478-4 · Cited by 34 · see citing works
Self-citation
Post-training administration of corticotropin-releasing hormone (CRH) enhances retention of a spatial memory through a noradrenergic mechanism in male rats
Row, B. W., & Dohanich, G. P. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.10.008 · Cited by 28 · see citing works
Time-dependent changes in CRH concentrations and release in discrete brain regions following global ischemia: effects of MK-801 pretreatment
Khan, S. A., Milot, M. R., Lecompte-Collin, J., & Plamondon, H. (2004) · Brain Research · doi:10.1016/j.brainres.2004.04.062 · Cited by 28 · see citing works
Delta opioid receptors colocalize with corticotropin releasing factor in hippocampal interneurons
Williams, T. J., & Milner, T. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.01.034 · Cited by 26 · see citing works
The behavioural and electrophysiological effects of CRF in rat frontal cortex
Zieba, B. A., Grzegorzewska, M., Brański, P., Domin, H., Wierońska, J. M., Hess, G., & Śmiałowska, M. (2008) · Neuropeptides · doi:10.1016/j.npep.2008.05.004 · Cited by 25 · see citing works
Molecular Determinants Mediating Effects of Acute Stress on Hippocampus-Dependent Synaptic Plasticity and Learning
Blank, T., Nijholt, I. M., & Spiess, J. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:2:131 · Cited by 25 · see citing works
Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2
Guan, X., Zhang, R., Xu, Y., & Li, S. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.035 · Cited by 24 · see citing works
Central amygdala CRF+ neurons promote heightened threat reactivity following early life adversity in mice
Demaestri, C., Pisciotta, M., Altunkeser, N., Berry, G., Hyland, H., Breton, J., Darling, A., Williams, B. L., & Bath, K. G. (2024) · Nature Communications · doi:10.1038/s41467-024-49828-3 · Cited by 23 · see citing works
Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy
Ali, I. Y., O’Brien, P., Kumar, G., Zheng, T. W., Jones, N. C., Pinault, D., French, C. R., Morris, M. J., Salzberg, M. R., & O'Brien, T. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066962 · Cited by 23 · see citing works
Chronic corticotropin-releasing hormone and vasopressin regulate corticosteroid receptors in rat hippocampus and anterior pituitary
Hügin-Flores, M. E., Steimer, T. J., Schulz, P., Vallotton, M. B., & Aubert, M. L. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02585-x · Cited by 23 · see citing works
Sex Differences in the Subcellular Distribution of Corticotropin-Releasing Factor Receptor 1 in the Rat Hippocampus following Chronic Immobilization Stress
McAlinn, H. R., Reich, B., Contoreggi, N. H., Poulton‐Kamakura, R., Dyer, A. G., McEwen, B. S., Waters, E. M., & Milner, T. A. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.007 · Cited by 20 · see citing works
Corticotropin-releasing hormone stimulates SGK-1 kinase expression in cultured hippocampal neurons via CRH-R1
Sheng, H., Sun, T., Cong, B., He, P., Zhang, Y., Yan, J., Lu, C., & Ni, X. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90462.2008 · Cited by 21 · see citing works
MRNA differential display identification of thyroid hormone‐responsive protein (THRP) gene in association with early phase of long‐term potentiation
Tang, Y. P., Ma, Y., Chen, S., & Lee, E. H. Y. (2001) · Hippocampus · doi:10.1002/hipo.1078 · Cited by 19 · see citing works
Self-citation
Challenge Point Framework and Efficient Learning of Golf
Guadagnoli, M. A., & Lindquist, K. (2007) · International Journal of Sports Science & Coaching · doi:10.1260/174795407789705505 · Cited by 18 · see citing works
Effects of Blocking GABA Degradation on Corticotropin‐Releasing Hormone Gene Expression in Selected Brain Regions
Tran, V., Hatalski, C. G., Yan, X., & Baram, T. Z. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb00847.x · Cited by 18 · see citing works
Effects of corticotropin-releasing factor on plasticity of optically recorded neuronal activity in the substantia gelatinosa of rat spinal cord slices
Ikeda, H., Kusudo, K., Ryu, P. D., & Murase, K. (2003) · Pain · doi:10.1016/j.pain.2003.08.004 · Cited by 14 · see citing works
Behavioral consequences of altered corticotropin-releasing factor activation in brain: a functionalist view of affective neuroscience
Heinrichs, S. C. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80012-4 · Cited by 7 · see citing works
Gene expression in the forebrain of dexamethasone-treated pigs: effects on stress neuropeptides in the hypothalamus and hippocampus and glutamate receptor subunits in the hippocampus
Vellucci, S. V., & Parrott, R. F. (2000) · Research in Veterinary Science · doi:10.1053/rvsc.2000.0380 · Cited by 7 · see citing works
Corticotrophin-releasing hormone decreases synaptic transmission in rat sensorimotor cortex in vivo
Froc, D. J., & Christie, B. R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.004 · Cited by 7 · see citing works
Neuromodulators of LTP and NCAMs in the amygdala and hippocampus in response to stress
Guterman, A., & Richter‐Levin, G. (2006) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7772-4_7 · Cited by 7 · see citing works
Interactions between CRF and acetylcholine in the modulation of cognitive behaviour
Warnock, G., Prickaerts, J., & Steckler, T. (2006) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7772-4_3 · Cited by 6 · see citing works
Amphetamine exposure alters behaviors, and neuronal and neurochemical activation in the brain of female prairie voles
Liu, Y., Pan, Y., Curtis, T. J., & Wang, Z. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.06.033 · Cited by 5 · see citing works
Estrogen Effects on Hippocampal Synapses
Milner, T. A., McEwen, B. S., & Waters, E. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418675-0.00007-9 · Cited by 5 · see citing works
The effects of CRF and the urocortins on the hippocampal acetylcholine release in rats
Pintér, D., Balangó, B., Simon, B., Palotai, M., Csabafi, K., Dobó, É., Ibos, K. E., & Bagosi, Z. (2021) · Neuropeptides · doi:10.1016/j.npep.2021.102147 · Cited by 4 · see citing works
Childhood abuse and EEG source localization in crack cocaine dependence
Alper, K., Shah, J., Howard, B., John, E. R., & Prichep, L. S. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.01.008 · Cited by 4 · see citing works
Hormetic and Non-Hormetic Dose-Response Functions in Stress Effects on Memory and Synaptic Plasticity: Issues and Mechanisms
Zoladz, P. R., & Diamond, D. M. (2008) · American Journal of Pharmacology and Toxicology · doi:10.3844/ajptsp.2008.111.124 · Cited by 4 · see citing works
Genetics of Endocrine-Behavior Interactions
Müller, M. B., Keck, M. E., Steckler, T., & Holsboer, F. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50093-7 · Cited by 4 · see citing works
Enhancement of learning and memory performance
Heinrichs, S. C. (2007) · Elsevier eBooks · doi:10.1016/b978-012372540-0/50018-2 · Cited by 3 · see citing works
Effects of PACAP-38 and an analog, acetyl-[Ala15, Ala20] PACAP-38-propylamide, on memory consolidation in the detection of spatial novelty task in rats
Ladjimi, M. H., Barbouche, R., Rhouma, K. B., Sakly, M., Tebourbi, O., & Save, É. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146858 · Cited by 3 · see citing works
Hippocampal gene expression in the pig: upregulation of corticotrophin releasing hormone mRNA following central administration of the peptide
Vellucci, S. V., & Parrott, R. F. (2000) · Neuropeptides · doi:10.1054/npep.2000.0818 · Cited by 3 · see citing works
Enteric Neurobiology of Stress
Liu, S., & Wood, J. D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00075-0 · Cited by 3 · see citing works
Corticotropin releasing factor modulates excitatory synaptic transmission
Joshi, N., McAree, M., & Chandler, D. J. (2020) · Vitamins and hormones · doi:10.1016/bs.vh.2020.04.003 · Cited by 3 · see citing works
Evolutionary, Historical and Mechanistic Perspectives on How Stress Affects Memory and Hippocampal Synaptic Plasticity
Farmer, G. E., Park, C. R., Bullard, L. A., & Diamond, D. M. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1056-4_10 · Cited by 2 · see citing works
Peptide and steroid hormone receptors as drug targets for enhancement of learning and memory performance
Martinez, J. L., Thompson, K. J., Leussis, M. P., & Heinrichs, S. C. (2004) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7867-8_9 · Cited by 2 · see citing works
Detrimental Role of Corticotropin-Releasing Factor on the Decrease of CA1 Field Potential Induced by In Vitro Ischemia in Rat Hippocampal Slices
Kagamiishi, Y., Yamamoto, T., & Watanabe, S. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.94.39 · Cited by 1 · see citing works
The Effects of Corticotropin-Releasing Factor on Anoxia-Induced Changes in Evoked Potentials in Living Slices of Rat Olfactory Cortex
Lyubimov, Y. E., Emel’yanov, N. A., & Izvarina, N. L. (2004) · Neuroscience and Behavioral Physiology · doi:10.1023/b:neab.0000028284.55405.8f · Cited by 1 · see citing works
The Effects of Corticoliberin at Different Concentrations on Long-Term Potentiation in Slices of Rat Olfactory Cortex
Lyubimov, Y. E., Nl, I., Emel’yanov, N. A., Chikhman, V. N., & Солнушкин, С. Д. (2002) · Neuroscience and Behavioral Physiology · doi:10.1023/a:1020457627521
Neuronal Mechanisms Mediating Acute Food Deprivation-Induced Reinstatement of Heroin Seeking
Tobin, S. W. (2012) · Spectrum Research Repository (Concordia University)
The Antidepressant Drug Tianeptine Blocks Working Memory Errors: Pharmacological and Endocrine Manipulations of Stress-Induced Amnesia in Rats
Campbell, A. M. (2004) · Digital Commons - University of South Florida (University of South Florida)
Characterization of the role of corticotropin-releasing hormone and opioid peptides on hippocampal neurodegeneration and functional recovery following global cerebral ischemia in rats
Charron, C. (2007) · uO Research (University of Ottawa) · doi:10.20381/ruor-19832
Involvement of the Nociceptin-OrphaninFQ-NOP system in the deleterious impact of chronic stress on memory and hippocampus plasticity
da Silva, F. D. (2022) · doi:10.70675/cb56c039z8744z4bc9zb0fczcd8ce5bc6a54

Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices
Rebaudo, R., Melani, R., Balestrino, M., & Izvarina, N. L. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03160-2 · Cited by 33 · see citing works
Corticotropin-Releasing Factor Produces a Protein Synthesis–Dependent Long-Lasting Potentiation in Dentate Gyrus Neurons
Wang, H. L., Tsai, L. Y., & Lee, E. H. Y. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.1.343 · Cited by 66 · see citing works
Self-citation
Hippocampal CRF, NE, and NMDA system interactions in memory processing in the rat
Lee, E. H. Y., Lee, C. P., Wang, H. I., & Lin, W. R. (1993) · Synapse · doi:10.1002/syn.890140207 · Cited by 88 · see citing works
Self-citation
Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2
Guan, X., Zhang, R., Xu, Y., & Li, S. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.035 · Cited by 24 · see citing works
Corticosterone inhibits generation of long-term potentiation in rat hippocampal slice: involvement of brain-derived neurotrophic factor
Zhou, J., Zhang, F., & Zhang, Y. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02934-6 · Cited by 64 · see citing works

Authors: Wang, H. L., Wayner, M. J., Chai, C. Y., & Lee, E. H. Y.
Affiliations: National Defense Medical Center (TW)
The University of Texas at San Antonio (US)
Institute of Biomedical Sciences, Academia Sinica (TW)
Corresponding author: Lee, E. H. Y.
ORCID: Lee, E. H. Y.
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 1998-11
Volume: 10
Issue: 11
Pages: 3428-3437
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1046/j.1460-9568.1998.00352.x
OpenAlex: W2073697680
Cited by: 97
References: 38
Citations by year: 2024: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 4 · 2013: 4 · 2012: 5
FWCI: 1.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1150 d)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Council
Academia Sinica
Institute of Biomedical Sciences, Academia Sinica
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: corticotropin-releasing factor, hippocampus, dentate gyrus, synaptic potentiation, long-term potentiation, cAMP signaling, NMDA receptor, synaptic plasticity, excitatory postsynaptic potentials, memory consolidation, passive avoidance
MeSH terms: Action Potentials, Cyclic AMP, Animals, Corticotropin-Releasing Hormone, Hippocampus, Male, Neurons, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Long-Term Potentiation, Dentate Gyrus, Rats

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Corticotrophin‐releasing factor produces a long‐lasting enhancement of synaptic efficacy in the hippocampus

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