The dopaminergic hyper-responsiveness of the shell of the nucleus accumbens is hormone-dependent
Abstract
The dopaminergic projection to the shell of the nucleus accumbens is the most reactive to stress, reward and drugs of abuse and this subregion of the nucleus accumbens is also considered a target of therapeutic effects of atypical antipsychotic drugs (APD). In this report we show, by means of in vivo microdialysis and Fos immunohistochemistry, that the hyper-responsiveness which characterizes the dopaminergic transmission to the shell is dependent on glucocorticoid hormones. In Sprague-Dawley rats, after suppression of endogenous glucocorticoids by adrenalectomy, extracellular dopamine levels selectively decreased in the shell, whilst they remained unchanged in the core. This effect was observed in basal conditions, after a mild stress (vehicle injection), as well as after subcutaneous administration of morphine (2 mg/kg, s.c. ) or intraperitoneal injection of cocaine (15 mg/kg, i.p.). The decrease in dopamine observed in the shell had a postsynaptic impact, as shown by less induction of Fos-like proteins selectively in the shell in response to cocaine. However, the induction of Fos-like proteins by the full D1 agonist SKF82958 (1.5 mg/kg, i.p.) remained unchanged after adrenalectomy, suggesting that the changes in Fos expression after cocaine injection were likely to depend on changes in extracellular dopamine levels rather than on changes in postsynaptic sensitivity to dopamine. The effects of adrenalectomy were glucocorticoid-specific given that they were prevented by corticosterone treatment. This anatomical specificity in the control of neuronal activity by a hormonal input highlights the role of steroid hormones in shaping the functional activity of the brain.
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Extracellular basal dopamine levels in the medial shell, but not the core, decrease after adrenalectomy, which diminishes plasma glucocorticoids.
“Interestingly, extracellular basal dopamine levels in the medial shell, but not the core, decrease after adrenalectomy, which diminishes plasma glucocorticoids (Barrot et al., 2000).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Barrot et al., 2000
Diminishment of glucocorticoids induced by adrenalectomy blunts increased dopamine concentration in the medial shell, but not the core, induced by morphine or cocaine administration.
“Moreover, diminishment of glucocorticoids induced by adrenalectomy blunts increased dopamine concentration in the medial shell, but not the core, induced by morphine or cocaine administration (Barrot et al., 2000).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Barrot et al., 2000
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- Authors
- Barrot, M., Marinelli, M., Abrous, D. N., Rougé‐Pont, F., Le Moal, M., & Piazza, P. V.
- Affiliations
- Inserm (FR)
- Corresponding author
- Piazza, Pier Vincenzo
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2000-03
- Volume
- 12
- Issue
- 3
- Pages
- 973-979
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1967379165
- Cited by
- 210
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 8 · 2018: 7 · 2017: 16 · 2016: 9 · 2015: 7 · 2014: 10 · 2013: 10 · 2012: 8
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nucleus accumbens shell, dopamine signaling, glucocorticoids, adrenalectomy, extracellular dopamine, Fos expression, cocaine, morphine, stress, dopamine D1 receptor, corticosterone, atypical antipsychotics
- MeSH terms
- Adrenalectomy, Animals, Benzazepines, Cocaine, Corticosterone, Dopamine, Glucocorticoids, Immunohistochemistry, Male, Synaptic Transmission, Nucleus Accumbens, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Receptors, Dopamine D1, Microdialysis, Dopamine Agonists, Dopamine Uptake Inhibitors, Rats
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