Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

A new mathematical model for relative quantification in real-time RT-PCR

Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735

Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathway

Huang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113

Hapten-Induced Model of Chronic Inflammation and Ulceration in the Rat Colon

Morris, G. P., Beck, P. L., Herridge, M. S., Depew, W. T., Szewczuk, M. R., & Wallace, J. L. (1989) · Gastroenterology · doi:10.1016/s0016-5085(89)80079-4 · Cited by 1,832

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

Salceda, S., & Caro, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22642 · Cited by 1,674

Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression

Wenger, R. H. (2002) · The FASEB Journal · doi:10.1096/fj.01-0944rev · Cited by 1,135

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

Maxwell, P. H., Dachs, G. U., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., & Ratcliffe, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8104 · Cited by 1,084

HIF-1, O2, and the 3 PHDs

Semenza, G. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00518-9 · Cited by 940

Untitled work

(2002) · PubMed · Cited by 840

Inflammatory bowel disease

Abraham, C., & Cho, J. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804647 · Cited by 2,712

Hypoxia and inflammation

Eltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061

Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function

Kelly, C. J., Zheng, L., Campbell, E. L., Saeedi, B., Scholz, C. C., Bayless, A. J., Wilson, K. E., Glover, L. E., Kominsky, D. J., Magnuson, A., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.005 · Cited by 1,716

HIF transcription factors, inflammation, and immunity

Palazon, A., Goldrath, A. W., Nizet, V., & Johnson, R. S. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.008 · Cited by 1,195

Wound healing essentials: Let there be oxygen

Sen, C. K. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00436.x · Cited by 738

Purinergic Signaling during Inflammation

Eltzschig, H. K., Sitkovsky, M. V., & Robson, S. C. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1205750 · Cited by 739

Regulation of Immunity and Inflammation by Hypoxia in Immunological Niches

Taylor, C. T., & Colgan, S. P. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.103 · Cited by 713

Interdependence of hypoxic and innate immune responses

Nizet, V., & Johnson, R. S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2607 · Cited by 708

Purinergic Signaling during Inflammation

Eltzschig, H. K., Mv, S., & Robson, S. C. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1300259 · Cited by 609

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

Losman, J.-A., & Kaelin, W. G. (2013) · Genes & Development · doi:10.1101/gad.217406.113 · Cited by 570

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

Clambey, E. T., McNamee, E. N., Westrich, J. A., Glover, L. E., Campbell, E. L., Jedlicka, P., de Zoeten, E. F., Cambier, J. C., Stenmark, K. R., Colgan, S. P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202366109 · Cited by 560

The updated biology of hypoxia-inducible factor

Greer, S. N., Metcalf, J. L., Wang, Y., & Ohh, M. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.125 · Cited by 545

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

Campbell, E. L., Bruyninckx, W. J., Kelly, C. J., Glover, L. E., McNamee, E. N., Bowers, B., Bayless, A. J., Scully, M. M., Saeedi, B. J., Golden‐Mason, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.020 · Cited by 481

Hypoxia: an alarm signal during intestinal inflammation

Colgan, S. P., & Taylor, C. T. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.39 · Cited by 461

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

Fearon, U., Canavan, M., Biniecka, M., & Veale, D. J. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.69 · Cited by 455

The resolution of inflammation: Principles and challenges

Headland, S. E., & Norling, L. V. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.014 · Cited by 429

Metabolic Shifts in Immunity and Inflammation

Kominsky, D. J., Campbell, E. L., & Colgan, S. P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903002 · Cited by 422

Hypoxia-Inducible Factor-1 Is Central to Cardioprotection

Eckle, T. D. L. G., Köhler, D., Lehmann, R., Kasmi, K. C. E., & Eltzschig, H. K. (2008) · Circulation · doi:10.1161/circulationaha.107.758516 · Cited by 410

Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

Rosenberger, P., Schwab, J. M., Mirakaj, V., Masekowsky, E., Mager, A., Morote–Garcia, J. C., Unertl, K. E., & Eltzschig, H. K. (2009) · Nature Immunology · doi:10.1038/ni.1683 · Cited by 406

Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine

Singhal, R., & Shah, Y. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011188 · Cited by 401

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

Eltzschig, H. K., Bratton, D. L., & Colgan, S. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4422 · Cited by 364

Interdependent roles for hypoxia inducible factor and nuclear factor‐κB in hypoxic inflammation

Taylor, C. T. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.157669 · Cited by 354

Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis

Konisti, S., Kiriakidis, S., & Paleolog, E. M. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.205 · Cited by 342

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

Fraisl, P., Aragonés, J., & Carmeliet, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2761 · Cited by 326

Hypoxia and gastrointestinal disease

Taylor, C. T., & Colgan, S. P. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0277-z · Cited by 313

Pharmacologic Targeting of Hypoxia-Inducible Factors

Semenza, G. L. (2019) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021637 · Cited by 288

ROS in gastrointestinal inflammation: Rescue Or Sabotage?

Aviello, G., & Knaus, U. G. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13428 · Cited by 284

Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

Meng, X., Grötsch, B., Luo, Y., Knaup, K. X., Wiesener, M. S., Chen, X., Jantsch, J., Fillatreau, S., Schett, G. A., & Bözec, A. (2018) · Nature Communications · doi:10.1038/s41467-017-02683-x · Cited by 280

Wound healing of intestinal epithelial cells

Iizuka, M. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i17.2161 · Cited by 281

Control and dysregulation of redox signalling in the gastrointestinal tract

Campbell, E. L., & Colgan, S. P. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0079-5 · Cited by 267

Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research

Gonzalez, L. M., Moeser, A. J., & Blikslager, A. T. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00112.2013 · Cited by 255

Adenosine: An Old Drug Newly Discovered

Eltzschig, H. K., Warner, D. S., & Warner, M. A. A. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181b060f2 · Cited by 253

Targeting hypoxia-inducible factors: therapeutic opportunities and challenges

Yuan, X., Ruan, W., Bobrow, B., Carmeliet, P., & Eltzschig, H. K. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00848-6 · Cited by 245

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L. C. J., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., et al. (2016) · Nature Communications · doi:10.1038/ncomms13312 · Cited by 247

Inflammation and Hypoxia: HIF and PHD Isoform Selectivity

Watts, E., & Walmsley, S. R. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.10.006 · Cited by 248

Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function

McNamee, E. N., Korns Johnson, D., Homann, D., & Clambey, E. T. (2013) · Immunologic Research · doi:10.1007/s12026-012-8349-8 · Cited by 234

HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity

Saeedi, B. J., Kao, D. J., Kitzenberg, D., Dobrinskikh, E., Schwisow, K. D., Masterson, J. C., Kendrick, A. A., Kelly, C. J., Bayless, A. J., Kominsky, D. J., et al. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-07-1194 · Cited by 235

Hypoxia and inflammation are two sides of the same coin

Bartels, K., Grenz, A., & Eltzschig, H. K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318345110 · Cited by 218

Hypoxia-dependent regulation of inflammatory pathways in immune cells

Taylor, C. T., Doherty, G. A., Fallon, P. G., & Cummins, E. P. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84433 · Cited by 224

Metabolic control of the Treg/Th17 axis

Barbi, J. J., Pardoll, D. M., & Pan, F. (2013) · Immunological Reviews · doi:10.1111/imr.12029 · Cited by 227

Anti-CD73 in Cancer Immunotherapy: Awakening New Opportunities

Antonioli, L., Yegutkin, G. G., Pacher, P., Blandizzi, C., & Haskó, G. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.01.003 · Cited by 218

Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip

Jalili-Firoozinezhad, S., Prantil-Baun, R., Jiang, A., Potla, R., Mammoto, T., Weaver, J. C., Ferrante, T. C., Kim, H. J., Cabral, J. M. S., Levy, O., et al. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0304-8 · Cited by 209

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

Tambuwala, M. M., Cummins, E. P., Lenihan, C. R., Kiss, J., Stauch, M., Scholz, C. C., Fraisl, P., Lasitschka, F., Mollenhauer, M., Saunders, S. P., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.068 · Cited by 204

Hypoxia-inducible factors: a central link between inflammation and cancer

Triner, D., & Shah, Y. M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84430 · Cited by 199

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways

Scholz, C. C., Cavadas, M. A. S., Tambuwala, M. M., Hams, E., Rodríguez, J., Kriegsheim, A. V., Cotter, P., Bruning, U., Fallon, P. G., Cheong, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309718110 · Cited by 186

Hypoxia-Inducible Factor–Dependent Repression of Equilibrative Nucleoside Transporter 2 Attenuates Mucosal Inflammation During Intestinal Hypoxia

Morote–Garcia, J. C., Rosenberger, P., Nivillac, N. M. I., Coe, I. R., & Eltzschig, H. K. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.037 · Cited by 183

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2 S ,4 R )-1-(( S )-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy- N -(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Soares, P., Gadd, M. S., Frost, J., Galdeano, C., Ellis, L. C. J., Epemolu, O., Rocha, S., Read, K. D., & Ciulli, A. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00675 · Cited by 182

The Role of NF‐κB in Hypoxia‐Induced Gene Expression

Taylor, C. T., & Cummins, E. P. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05024.x · Cited by 175

Oxygen metabolism and barrier regulation in the intestinal mucosa

Glover, L. E., Lee, J. S., & Colgan, S. P. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84429 · Cited by 173

Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice

Xue, X., Ramakrishnan, S. K., Anderson, E. R., Taylor, M. J., Zimmermann, E. M., Spence, J. R., Huang, S., Greenson, J. K., & Shah, Y. M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.010 · Cited by 174

Hypoxia-inducible factor-2α-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization

Paliege, A., Rosenberger, C., Bondke, A., Sciesielski, L. K., Shina, A., Heyman, S. N., Flippin, L. A., Arend, M., Klaus, S. J., & Bachmann, S. (2009) · Kidney International · doi:10.1038/ki.2009.460 · Cited by 171

Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction

Fricker, M., Goggins, B. J., Mateer, S. W., Jones, B., Kim, R., Gellatly, S. L., Jarnicki, A., Powell, N., Oliver, B. G. G., Radford‐Smith, G. L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.94040 · Cited by 172

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

Shah, Y. M., Ito, S., Morimura, K., Chen, C., Yim, S., Haase, V. H., & Gonzalez, F. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.009 · Cited by 168

Inhibition of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Oxygen Sensors: Tricking the Body into Mounting Orchestrated Survival and Repair Responses

Rabinowitz, M. H. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400386j · Cited by 166

Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions

Pral, L. P., Fachi, J. L., Corrêa, R. O., Colonna, M., & Vinolo, M. A. R. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.05.004 · Cited by 174

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

Xie, C., Yagai, T., Luo, Y., Liang, X., Chen, T., Wang, Q., Sun, D., Zhao, J., Ramakrishnan, S. K., Sun, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4412 · Cited by 162

Hypoxia and Innate Immunity: Keeping Up with the HIFsters

Colgan, S. P., Furuta, G. T., & Taylor, C. T. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-100819-121537 · Cited by 167

Targeting the HIF pathway in inflammation and immunity

Scholz, C. C., & Taylor, C. T. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.04.009 · Cited by 161

Cd73: An Emerging Checkpoint for Cancer Immunotherapy

Chen, S., Wainwright, D. A., Wu, J. D., Wan, Y., Matei, D. E., Zhang, Y., & Zhang, B. (2019) · Immunotherapy · doi:10.2217/imt-2018-0200 · Cited by 154

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

Bernhardt, W. M., Göttmann, U., Doyon, F., Buchholz, B., Câmpean, V., Schödel, J., Reisenbuechler, A., Klaus, S. J., Arend, M., Flippin, L. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903978106 · Cited by 150

Stabilized fermentation product of Cetobacterium somerae improves gut and liver health and antiviral immunity of zebrafish

Xie, M., Xie, Y., Li, Y., Zhou, W., Zhang, Z., Yang, Y., Olsen, R. E., Ringø, E., Ran, C., & Zhou, Z. (2021) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2021.11.017 · Cited by 144

Green tea extract prevents obesity in male mice by alleviating gut dysbiosis in association with improved intestinal barrier function that limits endotoxin translocation and adipose inflammation

Dey, P., Sasaki, G. Y., Wei, P. Y., Li, J., Wang, L., Zhu, J., McTigue, D. M., Yu, Z., & Bruno, R. S. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.01.017 · Cited by 145

Radiation damage and radioprotectants: new concepts in the era of molecular medicine

Koukourakis, M. I. (2012) · British Journal of Radiology · doi:10.1259/bjr/16386034 · Cited by 142

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

Olenchock, B. A., Moslehi, J. J., Baik, A. H., Davidson, S. M., Williams, J., Gibson, W. J., Chakraborty, A. A., Pierce, K. A., Miller, C. M., Hanse, E. A., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.006 · Cited by 145

Radioprotective Agents: Strategies and Translational Advances

Kamran, M. Z., Ranjan, A., Kaur, N., Sur, S., & Tandon, V. (2016) · Medicinal Research Reviews · doi:10.1002/med.21386 · Cited by 144

HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury

Feinman, R., Deitch, E. A., Watkins, A. C., Abungu, B., Colorado, I., Kannan, K. B., Sheth, S. U., Caputo, F. J., Lu, Q., Ramanathan, M., et al. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00065.2010 · Cited by 138

Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

Forristal, C. E., Winkler, I. G., Nowlan, B., Barbier, V., Walkinshaw, G., & Lévesque, J.-P. (2012) · Blood · doi:10.1182/blood-2012-02-408419 · Cited by 133

Hypoxia and Mucosal Inflammation

Colgan, S. P., Campbell, E. L., & Kominsky, D. J. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044231 · Cited by 137

Mechanisms and Consequences of Oxygen and Carbon Dioxide Sensing in Mammals

Cummins, E. P., Strowitzki, M. J., & Taylor, C. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00003.2019 · Cited by 140

Fundamental role for HIF-1α in constitutive expression of human β defensin-1

Kelly, C. J., Glover, L. E., Campbell, E. L., Kominsky, D., Ehrentraut, S., Bowers, B., Bayless, A. J., Saeedi, B. J., & Colgan, S. P. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.6 · Cited by 133

The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens

Zeitouni, N. E., Chotikatum, S., von Köckritz‐Blickwede, M., & Naim, H. Y. (2016) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-016-0041-y · Cited by 138

HIF2α signaling inhibits adherens junctional disruption in acute lung injury

Gong, H., Rehman, J., Tang, H., Wary, K. K., Mittal, M., Chatturvedi, P., Zhao, Y., Komorova, Y. A., Vogel, S. M., & Malik, A. B. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77701 · Cited by 136

Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis

Aherne, C. M., Collins, C. B., Masterson, J. C., Tizzano, M., Boyle, T. A., Westrich, J. A., Parnes, J. A., Furuta, G. T., Rivera–Nieves, J., & Eltzschig, H. K. (2011) · Gut · doi:10.1136/gutjnl-2011-300012 · Cited by 129

Pharmacological targeting of the HIF hydroxylases – A new field in medicine development

Chan, M. C., Holt‐Martyn, J. P., Schofield, C. J., & Ratcliffe, P. J. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.01.001 · Cited by 128

Hypoxia and Metabolic Factors That Influence Inflammatory Bowel Disease Pathogenesis

Glover, L. E., & Colgan, S. P. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.056 · Cited by 126

Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD

Welden, S. V., Selfridge, A. C., & Hindryckx, P. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.101 · Cited by 128

Adenosine and Hypoxia-Inducible Factor Signaling in Intestinal Injury and Recovery

Colgan, S. P., & Eltzschig, H. K. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153230 · Cited by 123

Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease

Poth, J. M., Brodsky, K. S., Ehrentraut, H., Grenz, A., & Eltzschig, H. K. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0988-7 · Cited by 125

Hypoxia and sterile inflammation in cystic fibrosis airways: mechanisms and potential therapies

Montgomery, S., Mall, M. A., Kicic, A., & Stick, S. M. (2016) · European Respiratory Journal · doi:10.1183/13993003.00903-2016 · Cited by 130

Prolyl 4‐hydroxylases, master regulators of the hypoxia response

Myllyharju, J. (2013) · Acta Physiologica · doi:10.1111/apha.12096 · Cited by 123

Ability of prebiotic polysaccharides to activate a HIF1α-antimicrobial peptide axis determines liver injury risk in zebrafish

Zhang, Z., Ran, C., Ding, Q., Liu, H.-L., Xie, M., Yang, Y., Xie, Y.-D., Gao, C., Zhang, H., & Zhou, Z. (2019) · Communications Biology · doi:10.1038/s42003-019-0526-z · Cited by 118

The hypoxia-adenosine link during inflammation

Bowser, J. L., Lee, J. W., Yuan, X., & Eltzschig, H. K. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00101.2017 · Cited by 118

Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury

Kapitsinou, P. P., Jaffe, J. T., Michael, M., Swan, C. E., Duffy, K. J., Erickson‐Miller, C. L., & Haase, V. H. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00667.2011 · Cited by 117

Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis

Flück, K., Breves, G., Fandrey, J., & Winning, S. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.67 · Cited by 114

Role of Extracellular Adenosine in Acute Lung Injury

Eckle, T. D. L. G., Koeppen, M., & Eltzschig, H. K. (2009) · Physiology · doi:10.1152/physiol.00022.2009 · Cited by 114

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review

Hirota, K. (2021) · Biomedicines · doi:10.3390/biomedicines9050468 · Cited by 115

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis

Keely, S., Campbell, E. L., Baird, A. W., Hansbro, P. M., Shalwitz, R. A., Kotsakis, A., McNamee, E. N., Eltzschig, H. K., Kominsky, D., & Colgan, S. P. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.29 · Cited by 111

Myeloid Cell-Derived Hypoxia-Inducible Factor Attenuates Inflammation in Unilateral Ureteral Obstruction-Induced Kidney Injury

Kobayashi, H., Gilbert, V., Liu, Q., Kapitsinou, P. P., Unger, T. L., Rha, J., Rivella, S., Schlöndorff, D., & Haase, V. H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103377 · Cited by 111

Pathogenesis of Crohn's disease

Boyapati, R. K., Satsangi, J. J., & Ho, G. (2015) · F1000Prime Reports · doi:10.12703/p7-44 · Cited by 117

Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function

Manresa, M. C., & Taylor, C. T. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.02.004 · Cited by 107

Hypoxia-Inducible Factor and Its Role in the Management of Anemia in Chronic Kidney Disease

Kaplan, J., Sharma, N., & Dikdan, S. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020389 · Cited by 108

Adora2b Adenosine Receptor Engagement Enhances Regulatory T Cell Abundance during Endotoxin-Induced Pulmonary Inflammation

Ehrentraut, H., Westrich, J. A., Eltzschig, H. K., & Clambey, E. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032416 · Cited by 104

Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury

Hirota, S. A., Fines, K., Ng, J., Traboulsi, D., Lee, J., Ihara, E., Li, Y., Willmore, W. G., Chung, D. C., Scully, M. M., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.045 · Cited by 100

Anastomotic leak in colorectal cancer patients: New insights and perspectives

Foppa, C., Ng, S. C., Montorsi, M., & Spinelli, A. (2020) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2020.02.027 · Cited by 101

Hypoxia/HIF Modulates Immune Responses

Chen, Y., & Gaber, T. (2021) · Biomedicines · doi:10.3390/biomedicines9030260 · Cited by 100

Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection

Harten, S. K., Ashcroft, M. A., & Maxwell, P. H. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2870 · Cited by 99

Hypoxia-Induced Inflammation in the Lung

Fröhlich, S., Boylan, J. F., & McLoughlin, P. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0137tr · Cited by 100

Role of Intestinal HIF-2α in Health and Disease

Ramakrishnan, S. K., & Shah, Y. M. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105202 · Cited by 100

Mucosal protection by hypoxia‐inducible factor (HIF) prolyl hydroxylase inhibition

Keeley, S., Furuta, G. T., & Colgan, S. P. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.328.3 · Cited by 3

ucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase nhibition

Robinson, N. (2007) · Cited by 1

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis

Karhausen, J., Furuta, G. T., Tomaszewski, J. E., Johnson, R. S., Colgan, S. P., & Haase, V. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421086 · Cited by 655

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis

Keely, S., Campbell, E. L., Baird, A. W., Hansbro, P. M., Shalwitz, R. A., Kotsakis, A., McNamee, E. N., Eltzschig, H. K., Kominsky, D., & Colgan, S. P. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.29 · Cited by 111

Hypoxia and gastrointestinal disease

Taylor, C. T., & Colgan, S. P. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0277-z · Cited by 313