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Cited by 152Pancreatic and Hepatic Oncology ResearchMRI in cancer diagnosisPancreatitis Pathology and Treatment

The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.

Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation

Vasen, Hans F.A., Wasser, Martin, van Mil, Anneke, Tollenaar, Rob A., Konstantinovski, Marja, Gruis, Nelleke A., Bergman, Wilma, Hes, Frederik J., Hommes, Daniel W., Offerhaus, G. Johan A., Morreau, Hans, Bonsing, Bert A., de Vos tot Nederveen Cappel, Wouter H.·2011·Gastroenterology
DOI 10.1053/j.gastro.2010.11.048
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Abstract

Background & aims Surveillance of high-risk groups for pancreatic cancer might increase early detection and treatment outcomes. Individuals with germline mutations in p16-Leiden have a lifetime risk of 15% to 20% of developing pancreatic cancer. We assessed the feasibility of detecting pancreatic cancer at an early stage and investigated the outcomes of patients with neoplastic lesions.Methods Individuals with germline mutations in p16-Leiden (N = 79; 31 male; mean age, 56 years; range, 39-72 years) were offered annual surveillance by magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography (MRCP). Those found to have neoplastic lesions were offered options for surgery or intensive follow-up. Individuals found to have possible neoplastic lesions were examined again by MRI/MRCP within 2 to 4 months.Results After a median follow-up period of 4 years (range, 0-10 years), pancreatic cancer was diagnosed in 7 patients (9%). The mean age at diagnosis was 59 years (range, 49-72 years). Three of the tumors were present at the first examination, and 4 were detected after a negative result in the initial examination. All 7 patients had a resectable lesion; 5 underwent surgery, 3 had an R0 resection, and 2 had lymph node metastases. Possible precursor lesions (ie, duct ectasias, based on MRCP) were found in 9 individuals (11%).Conclusions MRI/MRCP detects small, solid pancreatic tumors and small duct ectasias. Although surveillance increases the rate of resectability, carriers of a p16-Leiden mutation develop aggressive tumors.

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Crossref · 10.1053/j.gastro.2010.11.048

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Metadata

Authors
Vasen, H. F. A., Wasser, M., van Mil, A., Tollenaar, R. A., Konstantinovski, M., Gruis, N. A., Bergman, W., Hes, F. J., Hommes, D. W., Offerhaus, G. J. A., Morreau, H., Bonsing, B. A., & de Vos tot Nederveen Cappel, W. H.
Affiliations
  • Leiden University Medical Center (NL)
  • University Medical Center Utrecht (NL)
Corresponding author
Vasen, Hans F.A.
ORCID
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2011-03
Volume
140
Issue
3
Pages
850-856
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2010.11.048
OpenAlex
W2066851924
Cited by
152
References
19
Citations by year
2026: 3 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 10 · 2021: 5 · 2020: 7 · 2019: 11 · 2018: 13 · 2017: 11 · 2016: 14 · 2015: 16 · 2014: 17 · 2013: 9 · 2012: 19
FWCI
5.37
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Keywords
pancreatic cancer, germline mutation carriers, cancer surveillance, early detection, magnetic resonance imaging, magnetic resonance cholangiopancreatography, duct ectasia, tumor resectability, lymph node metastasis
MeSH terms
Adenocarcinoma, Adult, Aged, Feasibility Studies, Female, Humans, Magnetic Resonance Imaging, Male, Mass Screening, Middle Aged, Neoplasm Staging, Netherlands, Pancreas, Pancreatic Neoplasms, Phenotype, Precancerous Conditions, Predictive Value of Tests, Prognosis, Registries, Time Factors, Germ-Line Mutation, Genes, p16, Genetic Predisposition to Disease, Cholangiopancreatography, Magnetic Resonance, Early Detection of Cancer

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