Prevalence and progression of pancreatic cystic precursor lesions differ between groups at high risk of developing pancreatic cancer
Open accessAbstract
OBJECTIVES: The aim of this study was to compare the prevalence of cystic pancreatic lesions and their natural behavior in 2 distinct high-risk groups for developing pancreatic ductal adenocarcinoma (PDAC): (1) carriers of a mutation that predisposes to PDAC and (2) individuals without a known gene mutation but with a family history of PDAC (familial pancreatic cancer [FPC]). METHODS: Pancreatic surveillance by annual magnetic resonance imaging and endoscopic ultrasound was performed in individuals with an estimated lifetime risk of developing PDAC of 10% or greater. Progression of a lesion was defined as growth 4 mm or greater or the development of worrisome features. RESULTS: We included 186 individuals: 98 mutation carriers and 88 FPC individuals (mean follow-up, 51 months). Individuals with FPC were significantly more likely than mutation carriers to have a pancreatic cyst 10 mm or greater (16% vs 5%, P = 0.045). Pancreatic cysts detected in mutation carriers, however, were significantly more likely to progress than those in FPC individuals (16% vs 2%, P = 0.050). CONCLUSIONS: This study provides evidence that the prevalence and growth characteristics of pancreatic cysts differ between distinct high-risk groups: individuals with FPC have a higher prevalence of pancreatic cysts 10 mm or greater, whereas cysts in mutation carriers are more likely to progress. These observations may help to develop more optimally tailored surveillance strategies in specific high-risk populations.
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Germline testing should be considered for individuals eligible for pancreatic cancer surveillance.
“Therefore, germline testing should be considered for individuals eligible for pancreatic cancer surveillance.”
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- Authors
- Konings, I. C. A. W., Harinck, F., Poley, J.-W., Aalfs, C. M., van Rens, A., Krak, N. C., Wagner, A., Nio, C. Y., Sijmons, R. H., van Dullemen, H. M., Vleggaar, F. P., Ausems, M. G. E. M., Fockens, P., van Hooft, J. E., & Bruno, M. J.
- Affiliations
- University Medical Center Groningen (NL)
- Corresponding author
- Konings, Ingrid C. A. W.
- ORCID
- Venue
- Pancreas
- Published
- 2017-01
- Volume
- 46
- Issue
- 1
- Pages
- 28-34
- ISSN
- 0885-3177 (ISSN-L)
- OpenAlex
- W2555079950
- Cited by
- 41
- References
- 28
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 6
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- Locations
- Pancreas (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- Rijksuniversiteit Groningen
- Universitair Medisch Centrum Groningen
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Keywords
- pancreatic cysts, pancreatic ductal adenocarcinoma, familial pancreatic cancer, hereditary cancer predisposition, pancreatic cancer surveillance, cyst growth, lesion progression, vulnerable populations, lifetime cancer risk
- MeSH terms
- Adult, Aged, Female, Humans, Male, Middle Aged, Mutation, Netherlands, Pancreatic Cyst, Pancreatic Neoplasms, Prospective Studies, Prevalence, Disease Progression, Risk Assessment, Cyclin-Dependent Kinase Inhibitor p16, Carcinoma, Pancreatic Ductal, BRCA2 Protein, Early Detection of Cancer
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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