Cited by 28Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and TreatmentGlobal Cancer Incidence and Screening

Surveillance for neoplasia in the pancreas

Open access
Overbeek, Kasper A., Cahen, Djuna L., Canto, Marcia Irene, Bruno, Marco J.·2016·Best Practice & Research Clinical Gastroenterology

Abstract

Despite its low incidence in the general population, pancreatic cancer is one of the leading causes of cancer-related mortality. Survival greatly depends on operability, but most patients present with unresectable disease. Therefore, there is great interest in the early detection of pancreatic cancer and its precursor lesions by surveillance. Worldwide, several programs have been initiated for individuals at high risk for pancreatic cancer. Their first results suggest that surveillance in high-risk individuals is feasible, but their effectiveness in decreasing mortality remains to be proven. This review will discuss which individuals are eligible for surveillance, which lesions are aimed to be detected, and which surveillance modalities are being used in current clinical practice. Furthermore, it addresses the management of abnormalities found during surveillance and topics for future research.

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Crossref · 10.1016/j.bpg.2016.10.013

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  • Pancreatic intraepithelial neoplasias (PanINs) are the most frequently observed precursor lesions and are microscopic, not visible on abdominal imaging.

    “Pancreatic Intraepithelial Neoplasia (PanINs) are the most frequently observed precursor lesions and are, by definition, microscopic lesions that cannot be observed on abdominal imaging scans24.”

    From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [24]

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Authors
Overbeek, K. A., Cahen, D. L., Canto, M. I., & Bruno, M. J.
Affiliations
  • Erasmus MC (NL)
  • Johns Hopkins University (US)
Corresponding author
Overbeek, Kasper A.
Venue
Best Practice & Research Clinical Gastroenterology
Publisher
Elsevier BV
Published
2016-12
Volume
30
Issue
6
Pages
971-986
ISSN
1521-6918 (ISSN-L)
OpenAlex
W2547583190
Cited by
28
References
147
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 6
FWCI
0.27
Type
journal article
Language
en
Open access
Locations
  • Best Practice & Research Clinical Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • PubMed Central (acceptedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK089502)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
Keywords
pancreatic cancer, surveillance (medicine), early detection, high-risk individuals, precursor lesions, pancreatic neoplasia, surveillance programs, cancer mortality
MeSH terms
Humans, Neoplastic Syndromes, Hereditary, Pancreatic Neoplasms, Population Surveillance, Risk Factors, Genetic Predisposition to Disease, Early Detection of Cancer

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