The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Frequent Detection of Pancreatic Lesions in Asymptomatic High-Risk Individuals
Open accessAbstract
Background & aims The risk of pancreatic cancer is increased in patients with a strong family history of pancreatic cancer or a predisposing germline mutation. Screening can detect curable, noninvasive pancreatic neoplasms, but the optimal imaging approach is not known. We determined the baseline prevalence and characteristics of pancreatic abnormalities using 3 imaging tests to screen asymptomatic, high-risk individuals (HRIs).Methods We screened 225 asymptomatic adult HRIs at 5 academic US medical centers once, using computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasonography (EUS). We compared results in a blinded, independent fashion.Results Ninety-two of 216 HRIs (42%) were found to have at least 1 pancreatic mass (84 cystic, 3 solid) or a dilated pancreatic duct (n = 5) by any of the imaging modalities. Fifty-one of the 84 HRIs with a cyst (60.7%) had multiple lesions, typically small (mean, 0.55 cm; range, 2-39 mm), in multiple locations. The prevalence of pancreatic lesions increased with age; they were detected in 14% of subjects younger than 50 years old, 34% of subjects 50-59 years old, and 53% of subjects 60-69 years old (P < .0001). CT, MRI, and EUS detected a pancreatic abnormality in 11%, 33.3%, and 42.6% of the HRIs, respectively. Among these abnormalities, proven or suspected neoplasms were identified in 85 HRIs (82 intraductal papillary mucinous neoplasms and 3 pancreatic endocrine tumors). Three of 5 HRIs who underwent pancreatic resection had high-grade dysplasia in less than 3 cm intraductal papillary mucinous neoplasms and in multiple intraepithelial neoplasias.Conclusions Screening of asymptomatic HRIs frequently detects small pancreatic cysts, including curable, noninvasive high-grade neoplasms. EUS and MRI detect pancreatic lesions better than CT.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The question of what imaging modality to use was addressed in part by a comparative study by the Rotterdam group showing that MRI was better for pancreatic cyst detection, and EUS was better for solid lesions.74”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [74]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“A 3-way blinded comparison of EUS, MRI, and CT also showed that EUS and MRI had higher comparable diagnostic yield.75”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [75]
In the citing paper
“The preference for EUS and MRI/MRCP rather than CT is based on their superiority at detecting subcentimetre pancreatic cysts, and avoidance of ionising radiation.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tanaka, M., Chari, S. T., Adsay, V. N., Carlos, F.-D., Falconi, M., Shimizu, M., Yamaguchi, K., Yamao, K., & Matsuno, S. (2005) · Pancreatology · doi:10.1159/000090023 · Cited by 2,042
Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., Cavallini, G., Ammann, R., Lankisch, P. G., Andersen, J. R., DiMagno, E. P., Andrén‐Sandberg, Å., & Domellöf, L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282001 · Cited by 1,753
Very high risk of cancer in familial Peutz–Jeghers syndrome
Giardiello, F. M., Brensinger, J. D., Tersmette, A. C., Goodman, S. N., Petersen, G. M., Booker, S. V., Cruz–Correa, M., & Offerhaus, G. J. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.20228 · Cited by 1,435
Self-citationCancer risks in BRCA2 mutation carriers.
Olsson, H. (1999) · Journal of the National Cancer Institute · doi:10.1093/jnci/91.15.1310 · Cited by 1,404
Cancer Incidence in BRCA1 mutation carriers.
Thompson, D., & Easton, D. (2002) · Journal of the National Cancer Institute · doi:10.1093/jnci/94.18.1358 · Cited by 1,231
Hruban, R. H., Takaori, K., Klimstra, D. S., Adsay, N. V., Albores-Saavedra, J., Biankin, A. V., Biankin, S. A., Compton, C., Fukushima, N., Furukawa, T., et al. (2004) · American Journal of Surgical Pathology · doi:10.1097/01.pas.0000126675.59108.80 · Cited by 1,091
Self-citationIntraductal Papillary Mucinous Neoplasms of the Pancreas: An Updated Experience
Sohn, T., Yeo, C., Cameron, J., Hruban, R., Fukushima, N., Campbell, K., & Lillemoe, K. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000128306.90650.aa · Cited by 915
Self-citationPrevalence of Unsuspected Pancreatic Cysts on MDCT
Laffan, T. A., Horton, K. M., Klein, A. P., Berlanstein, B. P., Siegelman, S. S., Kawamoto, S., Johnson, P. T., Fishman, E. K., & Hruban, R. H. (2008) · American Journal of Roentgenology · doi:10.2214/ajr.07.3340 · Cited by 882
Self-citationExomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene
Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C.-H., Palmisano, E., Brune, K., Jaffee, E. M., et al. (2009) · Science · doi:10.1126/science.1171202 · Cited by 826
Self-citationSalvia, R., Castillo, C., Bassi, C., Thayer, S., Falconi, M., Mantovani, W., Pederzoli, P., & Warshaw, A. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000124386.54496.15 · Cited by 783
Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds
Klein, A. P., Brune, K. A., Petersen, G. M., Goggins, M., Tersmette, A. C., Offerhaus, G. J. A., Griffin, C., Cameron, J. L., Yeo, C. J., Kern, S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3823 · Cited by 678
Self-citationIncreased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16INK4Mutations
Goldstein, A. M., Fraser, M. C., Struewing, J. P., Hussussian, C. J., Ranade, K., Zametkin, D. P., Fontaine, L. S., Organic, S. M., Dracopoli, N. C., Clark, W. H., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510123331504 · Cited by 620
Risk of Pancreatic Cancer in Families With Lynch Syndrome
Kastrinos, F. (2009) · JAMA · doi:10.1001/jama.2009.1529 · Cited by 544
High Prevalence of Pancreatic Cysts Detected by Screening Magnetic Resonance Imaging Examinations
de Jong, K., Nio, C. Y., Hermans, J. J., Dijkgraaf, M. G. W., Gouma, D. J., van Eijck, C. H. J., van Heel, E., Klaß, G., Fockens, P., & Bruno, M. J. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.05.017 · Cited by 533
Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study
Canto, M. I., Goggins, M., Hruban, R. H., Petersen, G. M., Giardiello, F. M., Yeo, C., Fishman, E. K., Brune, K., Axilbund, J., Griffin, C., et al. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.02.005 · Cited by 524
Self-citationBRCA2 germline mutations in familial pancreatic carcinoma
Hahn, S. A., Greenhalf, B., Ellis, I., Sina-Frey, M., Rieder, H., Korte, B., Gerdes, B., Kress, R., Ziegler, A., Raeburn, J. A., et al. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.3.214 · Cited by 480
Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach
Canto, M. I., Goggins, M., Yeo, C. J., Griffin, C., Axilbund, J. E., Brune, K., Ali, S. Z., Jagannath, S., Petersen, G. M., Fishman, E. K., et al. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00244-7 · Cited by 448
Self-citationHruban, R. H., Pitman, M. B., & Klimstra, D. S. (2007) · American Registry of PathologyWashington, DC eBooks · doi:10.55418/9781933477022 · Cited by 424
Self-citationAnalysis of small cystic lesions of the pancreas
Kimura, W., Nagai, H., Kuroda, A., Muto, T., & Esaki, Y. (1995) · International Journal of Pancreatology · doi:10.1007/bf02784942 · Cited by 419
Cancer risks in BRCA2 families: estimates for sites other than breast and ovary
van Asperen, C. J., Brohet, R. M., Meijers-Heijboer, E. J., Hoogerbrugge, N., Verhoef, S., Vasen, H. F. A., Ausems, M. G. E. M., Menko, F. H., Gómez-García, E. B., Klijn, J. G. M., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.028829 · Cited by 419
Brentnall, T. A., Bronner, M. P., Byrd, D. R., Haggitt, R. C., & Kimmey, M. B. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-4-199908170-00003 · Cited by 391
(2006) · PubMed · Cited by 347
Self-citationSahai, A. V., Zimmerman, M., Aabakken, L., Tarnasky, P. R., Cunningham, J. T., Velse, A. V., Hawes, R. H., & Hoffman, B. J. (1998) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(98)70123-3 · Cited by 316
PALB2 mutations in European familial pancreatic cancer families
Slater, E., Langer, P., Niemczyk, E., Strauch, K., Butler, J., Habbe, N., Neoptolemos, J., Greenhalf, W., & Bartsch, D. (2010) · Clinical Genetics · doi:10.1111/j.1399-0004.2010.01425.x · Cited by 278
The Prevalence of BRCA2 Mutations in Familial Pancreatic Cancer
Couch, F. J., Johnson, M. R., Rabe, K. G., Brune, K. A., de Andrade, M., Goggins, M., Rothenmund, H., Gallinger, S., Klein, A. P., Petersen, G. M., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0783 · Cited by 273
Self-citationPoley, J. W., Kluijt, I., Gouma, D. J., Harinck, F., Wagner, A., Aalfs, C., van Eijck, C. H. J., Cats, A., Kuipers, E. J., Nio, Y., et al. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.276 · Cited by 257
Importance of Age of Onset in Pancreatic Cancer Kindreds
Brune, K. A., Lau, B., Palmisano, E., Canto, M., Goggins, M. G., Hruban, R. H., & Klein, A. P. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp466 · Cited by 257
Self-citationLanger, P., Kann, P. H., Fendrich, V., Habbe, N., Schneider, M., Sina‐Frey, M., Slater, E. P., Heverhagen, J. T., Gress, T. M., Rothmund, Μ., et al. (2009) · Gut · doi:10.1136/gut.2008.171611 · Cited by 249
Lal, G., Liu, G., Schmocker, B., Kaurah, P., Özçelik, H., Narod, S. A., Redston, M. S., & Gallinger, S. (2000) · PubMed · Cited by 233
Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients
Shi, C., Klein, A. P., Goggins, M., Maitra, A., Canto, M. I., Ali, S. Z., Schulick, R. D., Palmisano, E., & Hruban, R. H. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0004 · Cited by 210
Self-citationVerna, E. C., Hwang, C., Stevens, P. D., Rotterdam, H., Stavropoulos, S. N., Sy, C. D., Prince, M. A., Chung, W. K., Fine, R. L., Chabot, J. A., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3209 · Cited by 201
Tischkowitz, M. D., Sabbaghian, N., Hamel, N., Borgida, A., Rosner, C., Taherian, N., Srivastava, A., Holter, S., Rothenmund, H., Ghadirian, P., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.055 · Cited by 187
Feasibility and Yield of Screening in Relatives From Familial Pancreatic Cancer Families
Ludwig, E., Olson, S. H., Bayuga, S., Simon, J. A., Schattner, M. A., Gerdes, H., Allen, P. J., Jarnagin, W. R., & Kurtz, R. C. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.65 · Cited by 165
Vasen, H. F. A., Wasser, M., van Mil, A., Tollenaar, R. A., Konstantinovski, M., Gruis, N. A., Bergman, W., Hes, F. J., Hommes, D. W., Offerhaus, G. J. A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.11.048 · Cited by 152
Pancreatic Cancer Genetic Epidemiology Consortium
Petersen, G. M., de Andrade, M., Goggins, M., Hruban, R. H., Bondy, M. L., Korczak, J. F., Gallinger, S., Lynch, H. T., Syngal, S., Rabe, K. G., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0734 · Cited by 141
Self-citationHollerbach, S., Klamann, A., Topalidis, T., & Schmiegel, W. (2001) · Endoscopy · doi:10.1055/s-2001-17337 · Cited by 130
The prognosis of intraductal papillary mucinous tumors of the pancreas.
Yamao, K., Ohashi, K., Nakamura, T., Suzuki, T., Shimizu, Y., Nakamura, Y., Horibe, Y., Yanagisawa, A., Nakao, A., Nimuara, Y., et al. (2000) · PubMed · Cited by 100
Flagged first, then by citations
1 of the 38 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Slater, 2010, PALB2 mutations in European familial pancreatic cancer families, Clin Genet, 78, 490, 10.1111/j.1399-0004.2010.01425.x · DOI · Paper page
- Canto, 2004, Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach, Clin Gastroenterol Hepatol, 2, 606, 10.1016/S1542-3565(04)00244-7 · DOI · Paper page
- Poley, 2009, The yield of first-time endoscopic ultrasonography in screening individuals at a high risk of developing pancreatic cancer, Am J Gastroenterol, 104, 2175, 10.1038/ajg.2009.276 · DOI · Paper page
- Vasen, 2011, Magnetic resonance imaging surveillance detects early-stage pancreatic cancer in carriers of a p16-Leiden mutation, Gastroenterology, 140, 850, 10.1053/j.gastro.2010.11.048 · DOI · Paper page
Cited by
Sorted by citations
Mizrahi, J. D., Surana, R., Valle, J. W., & Shroff, R. T. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30974-0 · Cited by 2,559
Ryan, D. P., Hong, T. S., & Bardeesy, N. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1404198 · Cited by 2,348
Syngal, S., Brand, R. E., Church, J. M., Giardiello, F. M., Hampel, H. L., & Burt, R. W. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.435 · Cited by 1,662
Self-citationPancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors
Klein, A. P. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00457-x · Cited by 1,258
Self-citationLin, J. S., Bowles, E. J. A., Williams, S. B., & Morrison, C. C. (2017) · JAMA · doi:10.1001/jama.2017.0562 · Cited by 1,082
Metadata
- Authors
- Canto, M. I., Hruban, R. H., Fishman, E. K., Kamel, I. R., Schulick, R., Zhang, Z., Topazian, M., Takahashi, N., Fletcher, J., Petersen, G., Klein, A. P., Axilbund, J., Griffin, C., Syngal, S., Saltzman, J. R., Mortele, K. J., Lee, J., Tamm, E., Vikram, R., Bhosale, P., Margolis, D., Farrell, J., & Goggins, M.
- Affiliations
- Johns Hopkins University (US)
- Mayo Clinic (US)
- Brigham and Women's Hospital (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of California, Los Angeles (US)
- Corresponding author
- Canto, Marcia Irene
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 142
- Issue
- 4
- Pages
- 796-804
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC3321068
- OpenAlex
- W2055276888
- Cited by
- 648
- References
- 38
- Citations by year
- 2026: 21 · 2025: 22 · 2024: 42 · 2023: 42 · 2022: 39 · 2021: 47 · 2020: 37 · 2019: 52 · 2018: 55 · 2017: 65 · 2016: 54 · 2015: 63 · 2014: 39 · 2013: 43 · 2012: 27
- FWCI
- 27.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P50 CA62924)
- Lustgarten Foundation
- Olympus
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- pancreatic cancer screening, high-risk individuals, pancreatic cysts, intraductal papillary mucinous neoplasm, pancreatic neuroendocrine tumors, pancreatic duct dilatation, endoscopic ultrasound, magnetic resonance imaging, computed tomography, pancreatic neoplasms, familial pancreatic cancer, germline mutations, intraepithelial neoplasia, pancreatic resection
- MeSH terms
- Academic Medical Centers, Aged, Diagnostic Imaging, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Pancreatic Cyst, Pancreatic Neoplasms, Pedigree, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Factors, Tomography, X-Ray Computed, United States, Prevalence, Multivariate Analysis, Chi-Square Distribution, Logistic Models, Risk Assessment, Endosonography, Genetic Predisposition to Disease, Heredity, Asymptomatic Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
