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Cited by 114Treatment of Major DepressionSleep and related disordersCircadian rhythm and melatonin

Sleep deprivation combined with consecutive sleep phase advance as a fast-acting therapy in depression: an open pilot trial in medicated and unmedicated patients

Thomas Berger, Jochen Vollmann, Fritz Hohagen, Armin König, Hanns Lohner, Ulrich Voderholzer, Dieter Wilhelm Riemann·1997·American Journal of Psychiatry
DOI 10.1176/ajp.154.6.870
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Abstract

OBJECTIVE: The authors' goal was to test the hypothesis that the antidepressant effect of total sleep deprivation can be maintained by initially avoiding sleep during a supposedly "critical" time period in the early morning. METHOD: They studied 33 inpatients with major depression, melancholic type, all of whom responded positively to total sleep deprivation. Twelve of the patients were men and 21 were women; their mean age was 46.7 years (SD = 13.7). After total sleep deprivation, the patients started a sleep schedule from 5:00 p.m. to 12:00 midnight, which then was shifted back by 1 hour each day until a sleep time of 11:00 p.m. to 6:00 a.m. was reached. RESULTS: Twenty (61%) of the 33 patients who responded to total sleep deprivation with an improved state of mood maintained this improvement during sleep phase advance therapy. Drug-free and medicated patients did not differ from each other. CONCLUSIONS: The rapid amelioration of mood observed with total sleep deprivation can be preserved with a succeeding phase shift of the sleep period.

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Crossref · 10.1176/ajp.154.6.870

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  • Shifts in the timing of circadian rhythms relative to the timing of sleep have been shown to cause switches from depression to mania.

    “This type of shift in the timing of circadian rhythms relative to the timing of sleep has been shown to cause switches from depression to mania”

    From Bipolar mood cycles and lunar tidal cycles (2018) · cites this paper as [26]

  • Follow-up treatment with daily light therapy or a short phase advance in the sleep/wake cycle can prevent relapse after total sleep deprivation.

    “Furthermore, follow up treatment with daily light therapy or a short phase advance in the sleep/wake cycle can also prevent relapse (Berger et al., 1997; Riemann et al., 1999; Wirz-Justice et al., 2005).”

    From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Berger et al., 1997

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Authors
Berger, T., Vollmann, J., Hohagen, F., König, A., Lohner, H., Voderholzer, U., & Riemann, D. W.
Affiliations
University of Freiburg (DE)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
1997-06-01
Volume
154
Issue
6
Pages
870-872
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/ajp.154.6.870
OpenAlex
W123333088
Cited by
114
References
6
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 7 · 2012: 6
FWCI
3.91
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
total sleep deprivation, sleep phase advance, major depressive disorder, endogenous depression, circadian rhythm, mood improvement
MeSH terms
Antidepressive Agents, Circadian Rhythm, Combined Modality Therapy, Depressive Disorder, Female, Hospitalization, Humans, Male, Middle Aged, Pilot Projects, Sleep, Sleep Deprivation, Sleep Stages, Treatment Outcome

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