Developmental Studies of Artemisia annua: Flowering and Artemisinin Production Under Greenhouse and Field Conditions
Abstract
Cuttings of a clone of A. annua L. (Asteraceae), grown under 16 h photoperiod for 55 days were transferred to six photoperiod treatments in the greenhouse. Under short photoperiods (8, 10, or 12 h), plants flowered after two weeks; plants under long photoperiods (16, 20, or 24 h) remained vegetative until termination of treatment after 10 weeks. When plants grown under long photoperiod treatments were transferred to 8-h photoperiod, flowering occurred 2 weeks later. Flower induction in plants grown under field conditions occurred when the photoperiod was determined to the 13.3 h. Artemisinin levels in all studies were found to be highest at anthesis. Artemisinin content was 4- to 11-fold higher in inflorescences than in leaves.
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Several authors have reported that the artemisinin content is highest just before flowering.
“Several authors have reported that the artemisinin content is highest just before flowering [326,327,328]”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [328]
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Regulation of essential oil production in plants
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“Flower induction in plants grown under field conditions occurred when the photoperiod was 13.3 h ( Ferreira et al. 1995 ), but impact of the treatments on essential oil production has not been assessed.”
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“…levels of ADS and CYP71AV1 were high in inflorescences, moderate in young leaves, and low in mature leaves and stems (Figure 2A)—a pattern that was consistent with the report that artemisinin content was 4–11-fold higher in inflorescences than in leaves of A. annua L. (Ferreira et al., 1995).”
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Self-citationResearch to Improve Artemisinin Production for use in the Preparation of Anti-Malarial Drugs
Bouwmeester, H. J., Bertea, C. M., Jan-Willem, K. D., Verstappen, F. W. A., & Franssen, M. C. R. (2007) · Springer eBooks · doi:10.1007/1-4020-5449-1_20 · Cited by 6 · see citing works
Actividad de infusiones de Artemisia annua sobre epimastigotes de Trypanosoma cruzi
Berrizbeitia, M., Cariaco, Y., Buiza, J. I., & Lutgen, P. (2016) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/j.eimc.2016.09.011 · Cited by 6 · see citing works
Artemisinin the Nobel Molecule
Weathers, P. J., Cambra, H. M., Desrosiers, M. R., Rassias, D., & Towler, M. J. (2017) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63931-8.00005-9 · Cited by 6 · see citing works
Lee, J. H., Lee, S. H., Park, C.-G., Park, C. B., Kim, O.-T., Choi, A. J., Kim, Y., & Cha, S. W. (2013) · Korean Journal of Medicinal Crop Science · doi:10.7783/kjmcs.2013.21.6.433 · Cited by 5 · see citing works
“개 똥쑥의 Artemisinin은 생육시기별 또는 부위별에 따라 함량이 달라지는 것으로 보고되고 있으며 (Ferreira et al., 1995; Abdin et al., 2003), 부위별 Artemisinin의 함량은 두화에서 0.199㎎/g로 가장 높게 나타났다.”
InfluentialDetecting the Antimalarial Artemisinin in Plant Extracts Using Near-infrared Spectroscopy
Dowell, F. E., Wang, D., Wu, X., et al. (2013) · American journal of agricultural science and technology · doi:10.7726/ajast.2014.1001 · Cited by 5 · see citing works
“The artemisinin concentration in the plants is highest at approximately the time of flowering (Ferreira et al., 1995); thus, the inclusion of younger and older plants should provide a range of artemisinin contents.”
BackgroundRam, M., Jain, D. C., Mishra, H., Mandal, S., & Abdin, M. Z. (2013) · Springer eBooks · doi:10.1007/978-3-642-41027-7_11 · Cited by 5 · see citing works
“Selection for high-producing lines and traditional breeding, and research on the effects of environmental conditions and cultural practices could perhaps lead to an improvement of artemisinin content (Delabays et al. 1993; Ferreira et al. 1995; Gupta et al. 1996).”
BackgroundLee, J. W., Han, Z., Kang, W. H., et al. (2021) · Horticulture Environment and Biotechnology · doi:10.1007/s13580-021-00335-0 · Cited by 5 · see citing works
Introduction ofArtemisiaSpecies into the Egyptian Cultivation
Omer, E. A., Hendawy, S., Hussein, E. A. A., Gendy, A. E. G. E., & El-Din, A. A. E. (2016) · Journal of Essential Oil Bearing Plants · doi:10.1080/0972060x.2016.1203268 · Cited by 4 · see citing works
Chen, J., Wu, W., Ding, X., Zhang, D., Dai, C., Pan, H., Shi, P., Wu, C., Zhang, J., Zhao, J., et al. (2023) · BMC Genomics · doi:10.1186/s12864-023-09786-4 · Cited by 4 · see citing works
Strategies for Enhancing Artemisinin Production in Artemisia annua Under Changing Environment
Naeem, M., Aftab, T., & Khan, M. M. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-68717-9_13 · Cited by 4 · see citing works
Artemisia annua: A Miraculous Herb to Cure Malaria
Naeem, M., Idrees, M., Singh, M., Khan, M. M. A., & Moinuddin, M. (2013) · Springer eBooks · doi:10.1007/978-3-642-41027-7_3 · Cited by 5 · see citing works
“Naturally, the plant is pollinated by insects and wind (Ferreira et al. 1995; WHO 2006).”
BackgroundInfluentialKang, W. H., Han, Z., Lee, S. J., et al. (2018) · Protected horticulture and Plant Factory · doi:10.12791/ksbec.2018.27.1.94 · Cited by 3 · see citing works
Artemisia Annua L.: Agro-Techniques for Semi-Arid Environments
Scarcella, M., Grassi, F., & Mastrorilli, M. (2011) · Italian Journal of Agronomy · doi:10.4081/ija.2011.e26 · Cited by 3 · see citing works
“…during pre-flowering stages (Acton et al., 1985; Liersch et al., 1986; El-Sohly, 1990; Woerdenbag et al., 1991), whereas other results showed that artemisinin reaching its peak during flowering (Singh et al., 1988; Pras et al., 1991; Morales et al., 1993; Ferreira et al., 1995; Laughlin, 1995).”
ResultElsayed, G. (2020) · African Entomology · doi:10.4001/003.028.0055 · Cited by 3 · see citing works
“It attacks the potato tuber in the field and in storage (Ferreire et al. 1994).”
BackgroundCarlen, C., Koch, S., Christ, B., & Simonnet, X. (2023) · Acta Horticulturae · doi:10.17660/actahortic.2023.1358.13 · Cited by 3 · see citing works
- Authors
- Ferreira, J., Simon, J., & Janick, J.
- Affiliations
- Purdue University West Lafayette (US)
- ORCID
- Ferreira, Jorge
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1995-04
- Volume
- 61
- Issue
- 02
- Pages
- 167-170
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2092641756
- Cited by
- 128
- References
- 0
- Citations by year
- 2024: 6 · 2023: 8 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 11 · 2014: 3 · 2013: 13 · 2012: 7
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Flowering Plant Growth and Cultivation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Keywords
- Artemisia annua, flowering, artemisinin production, photoperiod, floral induction, inflorescence, anthesis, vegetative growth, plant development
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