Influence of age and gender on the occurrence and presentation of reflex syncope
Abstract
Background The clinical history is the cornerstone of diagnosing patients with transient loss of consciousness (TLOC). Reflex syncope is the most common cause of TLOC in patients across all ages. Knowledge of the variation in incidence and clinical features of reflex syncope by age and gender provides important background information to acquire an accurate diagnosis.Methods In a cohort of 503 patients presenting with TLOC we established a final diagnosis after systematic evaluation and two years of follow-up. The occurrence of prodromal signs, symptoms, and triggers in patients with reflex syncope was analyzed by both age (< 40 yrs, 40-59 yrs and > or = 60 years) and gender.Results Reflex syncope was the most frequently obtained diagnosis (60.2%) in patients of all ages presenting with TLOC. Its occurrence was higher in patients under 40 years (73.4%), than above 60 years of age (45.3%). Pallor (79.9%), dizziness (73.4%), and diaphoresis (63.0%) were the most frequently reported prodromal signs and symptoms. Most triggers and prodromal signs and symptoms were more common in patients under 40 years of age and in women.Conclusions Reflex syncope is nearly twice as common in patients under 40 years of age than in patients aged 60 years or above. Typical signs and symptoms of reflex syncope are more common in younger patients and in women. Therefore, age and gender provide important diagnostic information and can help to decide whether additional testing is necessary.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Comorbidity influences the diagnosis of syncope and management decisions.
“Comorbidity influences the diagnosis of syncope and management decisions. 33,375”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [375]
Cites
Incidence and Prognosis of Syncope
Soteriades, E. S., Evans, J. C., Larson, M. G., Chen, M. H., Chen, L., Benjamin, E. J., & Levy, D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012407 · Cited by 1,364 · see citing works
Guidelines on management (diagnosis and treatment) of syncope
Brignole, M. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2739 · Cited by 951 · see citing works
Guidelines on Management (diagnosis and treatment) of syncope ? update 2004
Brignole, M., Alboni, P., Benditt, D. G., Bergfeldt, L., Blanc, J., Thomsen, P. E. B., van Dijk, J. G., Fitzpatrick, A. P., Hohnloser, S. H., Janousek, J., et al. (2004) · EP Europace · doi:10.1016/j.eupc.2004.08.008 · Cited by 648 · see citing works
Self-citationDiagnostic value of history in patients with syncope with or without heart disease
Alboni, P., Brignole, M., Menozzi, C., Raviele, A., Del Rosso, A., Dinelli, M., Solano, A., & Bottoni, N. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01241-4 · Cited by 444 · see citing works
Historical criteria that distinguish syncope from seizures
Sheldon, R., Rose, S., Ritchie, D., Connolly, S. J., Koshman, M.-L., Lee, M. A., Frenneaux, M., Fisher, M., & Murphy, W. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01940-x · Cited by 398 · see citing works
Neurogenic Orthostatic Hypotension
Freeman, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmcp074189 · Cited by 384 · see citing works
Prevalence and triggers of syncope in medical students
Ganzeboom, K. S., Colman, N., Reitsma, J. B., Shen, W. K., & Wieling, W. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00127-9 · Cited by 366 · see citing works
Self-citationGender role expectations of pain: relationship to experimental pain perception
Wise, E. A., Price, D. D., Myers, C. D., Heft, M. W., & Robinson, M. E. (2002) · Pain · doi:10.1016/s0304-3959(01)00473-0 · Cited by 359 · see citing works
Syncope in Children and Adolescents
Driscoll, D. J., Jacobsen, S. J., Porter, C.-B. J., & Wollan, P. C. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00020-x · Cited by 283 · see citing works
Prospective evaluation of patients with syncope: a population-based study
Sarasin, F., Louis‐Simonet, M., Carballo, D., Slama, S., Rajeswaran, A., Metzger, J., Lovis, C., Unger, P.-F., & Junod, A.-F. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00797-5 · Cited by 280 · see citing works
Dynamic Regulation of Middle Cerebral Artery Blood Flow Velocity in Aging and Hypertension
Lipsitz, L. A., Mukai, S., Hamner, J. W., Gagnon, M. M., & Babikian, V. L. (2000) · Stroke · doi:10.1161/01.str.31.8.1897 · Cited by 276 · see citing works
Calkins, H. G., Shyr, Y., Frumin, H., Schork, A. M., & Morady, F. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80315-5 · Cited by 231 · see citing works
Vasovagal syncope in medical students and their first-degree relatives
Serletis, A., Rose, S., Sheldon, A. G., & Sheldon, R. S. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl147 · Cited by 229 · see citing works
Hemodynamics of orthostatic intolerance: implications for gender differences
Fu, Q., Arbab‐Zadeh, A., Perhonen, M. A., Zhang, R., Zuckerman, J. H., & Levine, B. D. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00735.2002 · Cited by 220 · see citing works
Transient loss of consciousness: the value of the history for distinguishing seizure from syncope
Hoefnagels, W. A. J., Padberg, G. W., Overweg, J., Velde, E. A., & Roos, R. A. C. (1991) · Journal of Neurology · doi:10.1007/bf00319709 · Cited by 187 · see citing works
VAN DIJK, N., BOER, K. R., COLMAN, N., BAKKER, A., STAM, J., VAN GRIEKEN, J. J. M., WILDE, A. A. M., LINZER, M., REITSMA, J. B., & WIELING, W. (2008) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.00984.x · Cited by 164 · see citing works
Self-citationReflex syncope in children and adolescents
Wieling, W., Ganzeboom, K. S., & Saul, J. P. (2004) · Heart · doi:10.1136/hrt.2003.022996 · Cited by 155 · see citing works
Self-citationRelation of clinical presentation of syncope to the age of patients
Del Rosso, A., Alboni, P., Brignole, M., Menozzi, C., & Raviele, A. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.07.047 · Cited by 138 · see citing works
HAINSWORTH, R. (2004) · Clinical Autonomic Research · doi:10.1007/s10286-004-1004-2 · Cited by 137 · see citing works
Miller, C., & Newton, S. E. (2006) · Pain Management Nursing · doi:10.1016/j.pmn.2006.09.004 · Cited by 133 · see citing works
Value of Tongue Biting in the Diagnosis of Seizures
Benbadis, S. R. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430210096015 · Cited by 127 · see citing works
Diagnosis and characteristics of syncope in older patients referred to geriatric departments
Ungar, A., Mussi, C., Del Rosso, A., Noro, G., Abete, P., Ghirelli, L., Cellai, T., Landi, A., Salvioli, G., Rengo, F., et al. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00891.x · Cited by 127 · see citing works
Neurocardiovascular Instability in Cognitive Impairment and Dementia
Kenny, R. A., Kalaria, R. N., & Ballard, C. G. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04816.x · Cited by 105 · see citing works
Recognizing Syncope: Pitfalls and Surprises
Lempert, T. (1996) · Journal of the Royal Society of Medicine · doi:10.1177/014107689608900705 · Cited by 86 · see citing works
Cardiovascular Responses to Postural Changes: Differences with Age for Women and Men
Frey, M. A. B., Tomaselli, C. M., & Hoffler, W. G. (1994) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1994.tb04979.x · Cited by 77 · see citing works
Clinical spectrum of neurally mediated reflex syncopes
Alboni, P. (2003) · EP Europace · doi:10.1016/j.eupc.2003.09.003 · Cited by 75 · see citing works
Defining and classifying syncope
Thijs, R. D., Wieling, W., Kaufmann, H., & van Dijk, G. (2004) · Clinical Autonomic Research · doi:10.1007/s10286-004-1002-4 · Cited by 74 · see citing works
Self-citationA study of 178 consecutive vasovagal syncopal reactions from the perspective of safety
Newman, B. H., & Graves, S. (2001) · Transfusion · doi:10.1046/j.1537-2995.2001.41121475.x · Cited by 66 · see citing works
Diagnostic value of history taking in reflex syncope
Colman, N., Nahm, K., van Dijk, J. G., Reitsma, J. B., Wieling, W., & Kaufmann, H. (2004) · Clinical Autonomic Research · doi:10.1007/s10286-004-1006-0 · Cited by 65 · see citing works
Self-citationImholz, B. P. M., Dambrink, J. H. A., Karemaker, J. M., & Wieling, W. (1990) · Clinical Science · doi:10.1042/cs0790073 · Cited by 64 · see citing works
Self-citationVerheyden, B., Gisolf, J., Beckers, F., Karemaker, J. M., Wesseling, K. H., Aubert, A. E., & Wieling, W. (2007) · Clinical Science · doi:10.1042/cs20070042 · Cited by 58 · see citing works
Self-citationWieling, W., Veerman, D. P., Dambrink, J. H. A., & Imholz, B. P. M. (1992) · Clinical Science · doi:10.1042/cs0830149 · Cited by 58 · see citing works
Self-citationThe head and neck discomfort of autonomic failure: An unrecognized aetiology of headache
Robertson, D., Kincaid, D. W., Haile, V., & Robertson, R. M. (1994) · Clinical Autonomic Research · doi:10.1007/bf01845772 · Cited by 52 · see citing works
Haemodynamic changes early in prodromal symptoms of vasovagal syncope
Alboni, P. (2002) · EP Europace · doi:10.1053/eupc.2002.0241 · Cited by 42 · see citing works
Clinical studies in the use of myanesin
Schlesinger, E. B., Drew, A. L., & Wood, B. R. (1948) · The American Journal of Medicine · doi:10.1016/0002-9343(48)90253-8 · Cited by 39 · see citing works
Stepwise evaluation of syncope: A prospective population-based controlled study
Sarasin, F., Pruvot, E. J., Louis‐Simonet, M., Hügli, O., Sztajzel, J. M., Schläpfer, J., Herrera, M., Graz, J., Berchier, C., Mischler, C., et al. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.04.077 · Cited by 32 · see citing works
Porges, O. (1947) · The American Journal of Medicine · doi:10.1016/0002-9343(47)90146-0 · Cited by 12 · see citing works
Morillo, C. A. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi663 · Cited by 12 · see citing works
Nanthakumar, K., Bergfeldt, L., & Darpö, B. (1999) · EP Europace · doi:10.1053/eupc.1998.0010 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Developed in collaboration with, European Heart Rhythm Association (EHRA), Heart Failure Association (HFA), and Heart Rhythm Society (HRS), societies, E. B. T. F., European Society of Emergency Medicine (EuSEM), European Federation of Internal Medicine (EFIM), European Union Geriatric Medicine Society (EUGMS), American Geriatrics Society (AGS), European Neurological Society (ENS), et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp298 · Cited by 2,040 · see citing works
Self-citation2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya, A., de Lange, F. J., Deharo, J.-C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martín, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy037 · Cited by 1,951 · see citing works
2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya‐Mitjans, À., de Lange, F. J., Deharo, J., Elliot, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martiın, A., et al. (2018) · Kardiologia Polska · doi:10.5603/kp.2018.0161 · Cited by 474 · see citing works
Newman‐Toker, D. E., & Edlow, J. A. (2015) · Neurologic Clinics · doi:10.1016/j.ncl.2015.04.011 · Cited by 303 · see citing works
Guía de práctica clínica para el diagnóstico y manejo del síncope (versión 2009)
Moya‐Mitjans, À., Sutton, R., Ammirati, F., Blanc, J., Brignole, M., Dahm, J. B., Deharo, J., Gajek, J. J., Gjesdal, K., Krahn, A. D., et al. (2009) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(09)73541-8 · Cited by 277 · see citing works
Self-citationSymptoms and signs of syncope: a review of the link between physiology and clinical clues
Wieling, W., Thijs, R. D., van Dijk, N., Wilde, A. A. M., Benditt, D. G., & van Dijk, J. G. (2009) · Brain · doi:10.1093/brain/awp179 · Cited by 265 · see citing works
Self-citationA New Diagnostic Approach to the Adult Patient with Acute Dizziness
Edlow, J. A., Gurley, K. L., & Newman‐Toker, D. E. (2018) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2017.12.024 · Cited by 136 · see citing works
A guide to disorders causing transient loss of consciousness: focus on syncope
van Dijk, J. G., Thijs, R. D., Benditt, D. G., & Wieling, W. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.99 · Cited by 134 · see citing works
Self-citationEpidemiology of Syncope/Collapse in Younger and Older Western Patient Populations
Kenny, R. A., Bhangu, J., & King-Kallimanis, B. L. (2013) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2012.11.006 · Cited by 131 · see citing works
Dynamic cerebral autoregulation is attenuated in young fit women
Labrecque, L., Rahimaly, K., Imhoff, S., Paquette, M., Blanc, O. L., Malenfant, S., Drapeau, A., Smirl, J. D., Bailey, D. M., & Brassard, P. (2019) · Physiological Reports · doi:10.14814/phy2.13984 · Cited by 90 · see citing works
Saklani, P., Krahn, A. D., & Klein, G. J. (2013) · Circulation · doi:10.1161/circulationaha.112.138396 · Cited by 89 · see citing works
Atkinson, G., Jones, H., & Ainslie, P. N. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1243-y · Cited by 70 · see citing works
Symptoms and Signs of Neuro-otologic Disorders
Newman‐Toker, D. E. (2012) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000421618.33654.8a · Cited by 57 · see citing works
Romme, J. J. C. M., van Dijk, N., Boer, K. R., Bossuyt, P. M. M., Wieling, W., & Reitsma, J. B. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp314 · Cited by 55 · see citing works
Self-citationEdgell, H., Robertson, A. D., & Hughson, R. L. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01204.2011 · Cited by 47 · see citing works
Prospective evaluation of non-pharmacological treatment in vasovagal syncope
Romme, J. J. C. M., Reitsma, J. B., Go-Schon, I. K., Harms, M. P. M., Ruiter, J. H., Luitse, J. S. K., Lenders, J. W. M., Wieling, W., & van Dijk, N. (2010) · Europace · doi:10.1093/europace/eup414 · Cited by 47 · see citing works
Self-citationThe different clinical presentations of vasovagal syncope
Alboni, P. (2015) · Heart · doi:10.1136/heartjnl-2014-307096 · Cited by 46 · see citing works
Lewis, N. C. S., Atkinson, G., Lucas, S. J. E., Grant, E. J. M., Jones, H., Tzeng, Y., Horsman, H. M., & Ainslie, P. N. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00030.2010 · Cited by 42 · see citing works
Slow breathing as a means to improve orthostatic tolerance: a randomized sham-controlled trial
Lucas, S. J. E., Lewis, N. C. S., Sikken, E. L. G., Thomas, K. N., & Ainslie, P. N. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00128.2013 · Cited by 40 · see citing works
Clinical history in management of suspected syncope: A powerful diagnostic tool
Sutton, R., van Dijk, N., & Wieling, W. (2014) · Cardiology Journal · doi:10.5603/cj.2014.0097 · Cited by 39 · see citing works
Self-citationBrien, H. O., & Kenny, R. A. (2014) · European Cardiology Review · doi:10.15420/ecr.2014.9.1.28 · Cited by 39 · see citing works
Physiological Phenomenology of Neurally-Mediated Syncope with Management Implications
Schroeder, C., Tank, J., Heusser, K., Diedrich, A., Luft, F. C., & Jordan, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026489 · Cited by 39 · see citing works
Genetic aspects of vasovagal syncope: a systematic review of current evidence
Nordkamp, L. R. A. O., Wieling, W., Zwinderman, A. H., Wilde, A. A. M., & van Dijk, N. (2008) · EP Europace · doi:10.1093/europace/eun387 · Cited by 29 · see citing works
Self-citationEdvardsson, N., Garutti, C., Rieger, G., Linker, N. J., & for the PICTURE Study Investigators (2014) · Clinical Cardiology · doi:10.1002/clc.22300 · Cited by 28 · see citing works
The relationship between syncope, depression and anti-depressant use in older adults
Bhangu, J. S., King-Kallimanis, B., Cunningham, C., & Kenny, R. A. (2014) · Age and Ageing · doi:10.1093/ageing/afu003 · Cited by 28 · see citing works
Investigation on the Incidence of Syncope in Children and Adolescents Aged 2–18 Years in Changsha
Hu, E., Liu, X., Chen, Q., & Wang, C. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.638394 · Cited by 28 · see citing works
Summers, R. L., Platts, S. H., Myers, J. G., & Coleman, T. G. (2010) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-7-8 · Cited by 28 · see citing works
A New Approach to the Diagnosis of Acute Dizziness in Adult Patients
Edlow, J. A. (2016) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2016.06.004 · Cited by 27 · see citing works
Syndromes of orthostatic intolerance and syncope in young adults
Hamrefors, V., Spahic, J. M., Nilsson, D., Senneby, M., Sutton, R., Melander, O., & Fedorowski, A. (2017) · Open Heart · doi:10.1136/openhrt-2016-000585 · Cited by 23 · see citing works
Are women really more affected by vasovagal syncope than men?
Alboni, P., Messop, A. C., Lauri, A., & Furlan, R. (2020) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000001009 · Cited by 22 · see citing works
Identical pattern of cerebral hypoperfusion during different types of syncope
Thomas, K. N., Galvin, S., Williams, M. J. A., Willie, C. K., & Ainslie, P. N. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2009.93 · Cited by 21 · see citing works
Syncope in Dental Practices: A Systematic Review on Aetiology and Management
Hutse, I., Coppens, M. J., Herbelet, S., Seyssens, L., & Marks, L. A. M. (2021) · Journal of Evidence Based Dental Practice · doi:10.1016/j.jebdp.2021.101581 · Cited by 21 · see citing works
Towards Understanding the Genetic Nature of Vasovagal Syncope
Matveeva, N. A., Titov, B. V., Bazyleva, E. A., Певзнер, А. В., & Favorova, O. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910316 · Cited by 18 · see citing works
Pérez-Denia, L., Claffey, P., Byrne, L., Rice, C. P., Kenny, R. A., & Finucane, C. (2022) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17810 · Cited by 18 · see citing works
Torabi, P., Hamrefors, V., Sutton, R., Brignole, M., & Fedorowski, A. (2023) · EP Europace · doi:10.1093/europace/euad247 · Cited by 17 · see citing works
Sheikh, N. A., Phillips, A. A., Ranada, S., Lloyd, M., Kogut, K., Bourne, K. M., Jorge, J. G., Lei, L. Y., Sheldon, R. S., Exner, D. V., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.18580 · Cited by 17 · see citing works
Sleep syncope: Important clinical associations with phobia and vagotonia
Busweiler, L. A. D., Jardine, D. L., Frampton, C. M., & Wieling, W. (2010) · Sleep Medicine · doi:10.1016/j.sleep.2010.04.013 · Cited by 17 · see citing works
Self-citationMurrell, C., Cotter, J. D., George, K., Shave, R., Wilson, L. C., Thomas, K. N., Williams, M. J. A., & Ainslie, P. N. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.06.004 · Cited by 17 · see citing works
Recurrent syncope: differential diagnosis and management
Bennett, M. T., Leader, N., & Krahn, A. D. (2015) · Heart · doi:10.1136/heartjnl-2014-306627 · Cited by 16 · see citing works
Lewis, N. C. S., Atkinson, G., Lucas, S. J. E., Grant, E. J. M., Jones, H., Tzeng, Y., Horsman, H. M., & Ainslie, P. N. (2011) · Chronobiology International · doi:10.3109/07420528.2010.536283 · Cited by 15 · see citing works
Téllez, M. J., Norcliffe‐Kaufmann, L., Lenina, S., Voustianiouk, A., & Kaufmann, H. (2009) · Clinical Autonomic Research · doi:10.1007/s10286-009-0039-9 · Cited by 15 · see citing works
Transient loss of consciousness in young adults
Providencia, R. A., Silva, J., Mota, P. C., Nascimento, J. H. M., & Leitão‐Marques, A. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.07.064 · Cited by 15 · see citing works
Pascual, J. F., Rivas‐Gándara, N., Bach-Oller, M., Badia-Molins, C., Ballesteros, M. M., Benito, B., Pérez‐Rodon, J., Santos‐Ortega, A., Sambola, A., Roca‐Luque, I., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.838473 · Cited by 14 · see citing works
Teste de inclinação (Tilt-test): do necessário ao imprescindível
Macedo, P. G., Leite, L. R., dos Santos‐Neto, L. L., & HACHUL, D. T. (2011) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2011005000006 · Cited by 14 · see citing works
Review of the Evaluation and Treatment of Vasovagal Reactions in Outpatient Procedures
Wu, W. J., Goldberg, L. H., Rubenzik, M. K., & Zelickson, B. R. (2018) · Dermatologic Surgery · doi:10.1097/dss.0000000000001598 · Cited by 14 · see citing works
Ghariq, M., Thijs, R. D., Bek, L. M., van Zwet, E. W., Benditt, D. G., & van Dijk, J. G. (2020) · Clinical Autonomic Research · doi:10.1007/s10286-020-00666-5 · Cited by 14 · see citing works
Tajdini, M., Tavolinejad, H., Aminorroaya, A., Aryan, Z., Jalali, A., Alaeddini, F., Sadeghian, S., Yadangi, S., Vasheghani‐Farahani, A., Kalhor, P., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.027272 · Cited by 13 · see citing works
Tilt-induced cardioinhibitory syncope: a follow-up study in 16 patients
Guaraldi, P., Buonaura, G. C., Terlizzi, R., Cecere, A., Solieri, L., Barletta, G., & Cortelli, P. (2011) · Clinical Autonomic Research · doi:10.1007/s10286-011-0153-3 · Cited by 13 · see citing works
Management of orthostatic intolerance in children: the state of the art
Tao, C., Jin, H., & Du, J. (2020) · World Journal of Pediatrics · doi:10.1007/s12519-019-00329-0 · Cited by 11 · see citing works
Classification of orthostatic intolerance through data analytics
Gilmore, S. J., Hart, J., Geddes, J. R., Olsen, C. H., Mehlsen, J., Gremaud, P. A., & Olufsen, M. S. (2021) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-021-02314-0 · Cited by 11 · see citing works
The Effect of Time-of-Day and Sympathetic α1-Blockade on Orthostatic Tolerance
Lewis, N. C. S., Ainslie, P. N., Atkinson, G., Jones, H., Grant, E. J. M., & Lucas, S. J. E. (2012) · Chronobiology International · doi:10.3109/07420528.2012.699121 · Cited by 11 · see citing works
Cymes, I., Jalali, R., Glińska‐Lewczuk, K., Dragańska, E., Giergielewicz-Januszko, B., & Romaszko, J. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145376 · Cited by 10 · see citing works
Syncope and the aging patient: Navigating the challenges
Hatoum, T., & Sheldon, R. S. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102919 · Cited by 10 · see citing works
Gillick, B. T., Rich, T. L., Chen, M., & Meekins, G. D. (2015) · BMC Neurology · doi:10.1186/s12883-015-0510-2 · Cited by 10 · see citing works
Fainting, emancipation and the ‘weak and sensitive’ sex
van Dijk, N., & Wieling, W. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.174672 · Cited by 10 · see citing works
Self-citationManaging Syncope in the Elderly: The Not So Simple Faint in Aging Patients
Solbiati, M., Sheldon, R. S., & Seifer, C. M. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.04.005 · Cited by 10 · see citing works
Epidemiology and Economic Impact of Cardiac Syncope in Western Countries
Sutton, R., & Benditt, D. G. (2012) · Future Cardiology · doi:10.2217/fca.12.17 · Cited by 10 · see citing works
Sheikh, N. A., Ranada, S. I., Lloyd, M. G., McCarthy, D., Kogut, K., Bourne, K. M., Jorge, J. G., Lei, L. Y., Sheldon, R. S., Exner, D. V., et al. (2022) · Heart Rhythm · doi:10.1016/j.hrthm.2021.12.030 · Cited by 9 · see citing works
Guía de práctica clínica para el diagnóstico y manejo del síncope (versión 2009)
Moya‐Mitjans, À., Sutton, R., Ammirati, F., Blanc, J., Brignole, M., Dahm, J. B., Deharo, J., Gajek, J. J., Gjesdal, K., Krahn, A. D., et al. (2009) · Revista Española de Cardiología · doi:10.1016/s0300-8932(09)73132-x · Cited by 22 · see citing works
Self-citationVasovagal Syncope during Office Hysteroscopy—A Frequently Overlooked Unpleasant Complication
Rodriguez, S., Haimovich, S., Vitale, S. G., Pacheco, L. A., & Carugno, J. A. (2022) · Medicina · doi:10.3390/medicina58111626 · Cited by 8 · see citing works
Mitro, P., Šimurda, M., & Müller, E. (2017) · Wiener klinische Wochenschrift · doi:10.1007/s00508-017-1197-8 · Cited by 6 · see citing works
Falls Due to Loss of Consciousness are Associated With Maxillofacial Fracture Severity
Ito, R., Kubota, K., Yaguchi, S., Furudate, K., Tanaka, Y., & Kobayashi, W. (2019) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2019.10.023 · Cited by 8 · see citing works
Syncope: risk stratification and clinical decision making.
Peeters, S., Hoek, A. E., Mollink, S. M., & Huff, J. S. (2014) · PubMed · Cited by 7 · see citing works
Takano, T., Hirose, M., Yamasaki, Y., Hara, M., Okada, T., & Kunishima, H. (2022) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2022.02.002 · Cited by 6 · see citing works
Evaluation of the Patient With Spells
Cornes, S. B., & Shih, T. (2011) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000407056.94789.2d · Cited by 6 · see citing works
New hemodynamic criteria to separate classical orthostatic hypotension from vasovagal syncope
Ghariq, M., Kerkhof, F. I., Reijntjes, R. H. A. M., Thijs, R. D., & van Dijk, J. G. (2021) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51412 · Cited by 6 · see citing works
Head Up Tilt Testing: An Appraisal of Its Current Role in the Management of Patients with Syncope.
Macedo, P. G., Leite, L. R., Asirvatham, S. J., HACHUL, D. T., dos Santos‐Neto, L. L., & Shen, W. K. (2011) · Europe PMC (PubMed Central) · doi:10.4022/jafib.333 · Cited by 6 · see citing works
Babaei, M., Tajdini, M., Bozorgi, A., Sadeghian, S., Taebi, M., Tavolinejad, H., Mahalleh, M., Taheri, H., Rader, F., Boris, J. R., et al. (2025) · European Heart Journal Open · doi:10.1093/ehjopen/oeaf061 · Cited by 5 · see citing works
Du, X., Tao, C., Wang, Y., Sun, Y., Zhang, Q., Zhang, C., Liu, P., Wang, Y., Liao, Y., Du, J., et al. (2022) · Children · doi:10.3390/children9070992 · Cited by 5 · see citing works
Sleep syncope—A systematic review
Raj, P. L., Sheldon, R. S., Lorenzetti, D., Jardine, D. L., Raj, S. R., & Vandenberk, B. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.973368 · Cited by 5 · see citing works
Sau, A., Mereu, R., Taraborrelli, P., Dhutia, N. M., Willson, K., Hayat, S. A., Francis, D. P., Sutton, R., & Lim, P. B. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.10.090 · Cited by 5 · see citing works
Bhagat, J. A., Sakthi, S., Balasubramaniyan, N., Durairaj, D., & Thennarasu, A. R. (2023) · Cureus · doi:10.7759/cureus.34488 · Cited by 4 · see citing works
Hensel, K. O., Roskopf, M., Schneyder, F. E. A., & Heusch, A. (2018) · BMC Cardiovascular Disorders · doi:10.1186/s12872-018-0826-0 · Cited by 4 · see citing works
Kenny, R. A. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6231-8.10046-7 · Cited by 4 · see citing works
Guida, P., Iacoviello, M., Forleo, C., Sorrentino, S., Puzzovivo, A., Rodio, M., PASCALIS, F. D., Balducci, C., SARLO, M., & Favale, S. (2010) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2010.02791.x · Cited by 4 · see citing works
Braimah, R. O., Ali-Alsuliman, D., Taiwo, A., Alyami, B., Ibikunle, A., Alwalah, A., Almunajjim, H., & Alalharith, A. (2022) · Scientific Dental Journal · doi:10.4103/sdj.sdj_25_22 · Cited by 3 · see citing works
Song, J., Tao, C., Chen, G., Chen, S. Y., Xu, W., Du, J., Yang, Y., & Huang, Y. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00098 · Cited by 3 · see citing works
Alboni, P., Coppola, P., & Stucci, N. (2015) · Cardiology Clinics · doi:10.1016/j.ccl.2015.04.002 · Cited by 3 · see citing works
Clinical Presentation and Diagnosis of Vasovagal Syncope
Alboni, P., Dipaola, F., Coppola, P., & Furlan, R. (2014) · Springer eBooks · doi:10.1007/978-3-319-09102-0_11 · Cited by 2 · see citing works
Head-up tilt test – a rationale for using in diagnosis of syncope
Stańczyk, A. (2020) · Heart Vessels and Transplantation · doi:10.24969/hvt.2020.225 · Cited by 2 · see citing works
Sex and age impact prevalence and symptoms of vasovagal syncope: Implications for accurate diagnosis
Gregson, H., & Ivkov, A. (2021) · STEM Fellowship Journal · doi:10.17975/sfj-2021-008 · Cited by 2 · see citing works
Predicting therapeutic efficacy of oral rehydration salts in children with vasovagal syncope
Du, X., Tao, C., Li, X., Du, J., Liao, Y., & Jin, H. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1164304 · Cited by 2 · see citing works
Alboni, P., Coppola, P., & Stucci, N. (2013) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2013.08.002 · Cited by 1 · see citing works
Witnessing loss of consciousness during TMS – Syncope in contrast to seizure
Riedel, P., Korb, F. M., Karcz, T., & Smolka, M. N. (2016) · Clinical Neurophysiology Practice · doi:10.1016/j.cnp.2016.09.002 · Cited by 1 · see citing works
2018 KHRS guideline for the evaluation and management of syncope-Part 1
Park, J., Cha, M.-J., Kim, D. H., Kim, Y. R., Mun, H. S., Bae, E. J., Seo, D. W., Song, M. K., Ahn, J., Yoon, H. D., et al. (2018) · International Journal of Arrhythmia · doi:10.18501/arrhythmia.2018.009 · Cited by 1 · see citing works
2018 KHRS guideline for the evaluation and management of syncope-Part 2
Kim, Y. R., Chun, K. J., Kim, J. S., Mun, H. S., Park, J., Seo, D. W., Song, M. K., Ahn, J. H., Yoon, H. J., Lee, D. I., et al. (2018) · International Journal of Arrhythmia · doi:10.18501/arrhythmia.2018.010 · Cited by 1 · see citing works
Amioka, N., Nakamura, K., Matsuo, N., Watanabe, A., Kotani, Y., Kasahara, S., & Ito, H. (2022) · Texas Heart Institute Journal · doi:10.14503/thij-21-7677 · Cited by 1 · see citing works
Aydoğdu, Ö., Burgu, B., Teber, S., Altugan, S., Gökçe, İ., Deda, G., & Soygür, T. (2011) · PubMed · Cited by 1 · see citing works
Neuro-otologic Emergencies: A Practical Approach
Gurley, K. L., & Edlow, J. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-28072-7_4 · Cited by 1 · see citing works
The Outcome of Head up Tilt Test in Older Adults with Typical versus Atypical Features of Syncope
Mishra, R., Mathews, P., & Gopinath, K. (2022) · Journal of The Indian Academy of Geriatrics · doi:10.4103/jiag.jiag_22_22 · Cited by 1 · see citing works
Initial Evaluation of the Patient with Transient Loss of Consciousness
Alboni, P., Dipaola, F., Stucci, N., & Furlan, R. (2014) · Springer eBooks · doi:10.1007/978-3-319-09102-0_10
Epidemiology of Vasovagal Syncope
Solbiati, M., & Sheldon, R. S. (2014) · Springer eBooks · doi:10.1007/978-3-319-09102-0_4
Neurally-mediated reflex syncope: diagnosis and treatment
Romme, J. J. C. M. (2010) · UvA-DARE (University of Amsterdam)
Self-citationRisk Stratification and Prognosis of Vasovagal Syncope in the Emergency Department
Reed, M. J., & Costantino, G. (2014) · Springer eBooks · doi:10.1007/978-3-319-09102-0_18
Beleslin, B., Deljanin, M., Kanjuh, V., Parapid, B. J., Giga, V. L., Prostran, M. S., Angelkov, L., Balinovac, J., Bikicki, M., Ambrosio, G., et al. (2013)
Preventing and Treating Vasovagal Reactions
Kalogeropoulos, A. S., & Lindsay, A. C. (2016) · Springer eBooks · doi:10.1007/978-1-4471-4959-0_1
O’Brien, B., Zafar, H., & Sharif, F. (2017) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-017-1643-7
Dizziness: An Evidence-Based Approach (Better than MRI?)
Edlow, J. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-64523-0_6
- Authors
- Romme, J. J. C. M., van Dijk, N., Boer, K. R., Dekker, L. R. C., Stam, J., Reitsma, J. B., & Wieling, W.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Romme, Jacobus J. C. M.
- Venue
- Clinical Autonomic Research
- Published
- 2008-04-30
- Volume
- 18
- Issue
- 3
- Pages
- 127-133
- ISSN
- 0959-9851 (ISSN-L)
- 1619-1560
- OpenAlex
- W2155882327
- Cited by
- 115
- References
- 39
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 15 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 10 · 2013: 6 · 2012: 5
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Clinical Autonomic Research (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- TU/e Research Portal (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- reflex syncope, transient loss of consciousness, age differences, gender differences, prodromal symptoms, syncope triggers, pallor, dizziness, diaphoresis, syncope diagnosis
- MeSH terms
- Adult, Age Factors, Aged, Diagnosis, Differential, Epilepsy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Sex Factors, Syncope, Cohort Studies, Incidence, Multivariate Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
