EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib
Kobayashi, Susumu, Boggon, Titus J., Dayaram, Tajhal, Jänne, Pasi A., Kocher, Olivier, Meyerson, Matthew, Johnson, Bruce E., Eck, Michael J. +2 more·2005·New England Journal of Medicine
Cited by (154)
Items 101–154 of 154
- EGFR-mutated lung cancer: a paradigm of molecular oncologyZhang, Zhenfeng, Stiegler, Amy L., Boggon, Titus J., Kobayashi, Susumu, Halmos, Balazs · 2010 · Oncotarget
- Drugging Ras GTPase: a comprehensive mechanistic and signaling structural viewLu, Shaoyong, Jang, Hyunbum, Gu, Shuo, Zhang, Jian, Nussinov, Ruth · 2016 · Chemical Society Reviews
- Epidermal Growth Factor Receptor Mutants from Human Lung Cancers Exhibit Enhanced Catalytic Activity and Increased Sensitivity to GefitinibMulloy, Roseann, Ferrand, Audrey, Kim, Youngjoo, Sordella, Raffaella, Bell, Daphne W., Haber, Daniel A., Anderson, Karen S., Settleman, Jeffrey · 2007 · Cancer Research
- Rebiopsy of non–small cell lung cancer patients with acquired resistance to epidermal growth factor receptor‐tyrosine kinase inhibitor: Comparison between T790M mutation‐positive and mutation‐negative populationsHata, Akito, Katakami, Nobuyuki, Yoshioka, Hiroshige, Takeshita, Jumpei, Tanaka, Kosuke, Nanjo, Shigeki, Fujita, Shiro, Kaji, Reiko, Imai, Yukihiro, Monden, Kazuya et al. · 2013 · Cancer
- Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): A better mousetrap? A review of the clinical evidenceOu, Sai-Hong Ignatius · 2012 · Critical Reviews in Oncology/Hematology
- A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint componentsNilsson, Monique B., Sun, Huiying, Robichaux, Jacqulyne, Pfeifer, Matthias, McDermott, Ultan, Travers, Jon, Diao, Lixia, Xi, Yuanxin, Tong, Pan, Shen, Li et al. · 2020 · Science Translational Medicine
- Patients with Exon 19 Deletion Were Associated with Longer Progression-Free Survival Compared to Those with L858R Mutation after First-Line EGFR-TKIs for Advanced Non-Small Cell Lung Cancer: A Meta-AnalysisZhang, Yaxiong, Sheng, Jin, Kang, Shiyang, Fang, Wenfeng, Yan, Yue, Hu, Zhihuang, Hong, Shaodong, Wu, Xuan, Qin, Tao, Liang, Wenhua et al. · 2014 · PLoS ONE
- A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer.Su, Zengliu, Dias-Santagata, Dora, Duke, MarKeesa, Hutchinson, Katherine, Lin, Ya-Lun, Borger, Darrell R., Chung, Christine H., Massion, Pierre P., Vnencak-Jones, Cindy L., Iafrate, A. John et al. · 2011 · The Journal of Molecular Diagnostics
- Effects of Erlotinib in <i>EGFR</i> Mutated Non-Small Cell Lung Cancers with Resistance to GefitinibCosta, Daniel B., Nguyen, Kim-Son H., Cho, Byoung C., Sequist, Lecia V., Jackman, David M., Riely, Gregory J., Yeap, Beow Y., Halmos, Balázs, Kim, Joo H., Jänne, Pasi A. et al. · 2008 · Clinical Cancer Research
- Functional Analysis of Epidermal Growth Factor Receptor (EGFR) Mutations and Potential Implications for EGFR Targeted TherapyKancha, Rama Krishna, von Bubnoff, Nikolas, Peschel, Christian, Duyster, Justus · 2009 · Clinical Cancer Research
- Advances in the preclinical testing of cancer therapeutic hypothesesCaponigro, Giordano, Sellers, William R. · 2011 · Nature Reviews Drug Discovery
- Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochipsEarhart, Christopher M., Hughes, Casey E., Gaster, Richard S., Ooi, Chin Chun, Wilson, Robert J., Zhou, Lisa Y., Humke, Eric W., Xu, Lingyun, Wong, Dawson J., Willingham, Stephen B. et al. · 2014 · Lab Chip
- Safety, Efficacy, and Pharmacokinetics of Almonertinib (HS-10296) in Pretreated Patients With EGFR-Mutated Advanced NSCLC: A Multicenter, Open-label, Phase 1 TrialYang, James Chih-Hsin, Camidge, D. Ross, Yang, Cheng-Ta, Zhou, Jianying, Guo, Renhua, Chiu, Chao-Hua, Chang, Gee-Chen, Shiah, Her-Shyong, Chen, Yuan, Wang, Chin-Chou et al. · 2020 · Journal of Thoracic Oncology
- <i>In vitro</i> modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant <i>EGFR</i> mutants in non-small-cell lung cancerHirano, Toshiyuki, Yasuda, Hiroyuki, Tani, Tetsuo, Hamamoto, Junko, Oashi, Ayano, Ishioka, Kota, Arai, Daisuke, Nukaga, Shigenari, Miyawaki, Masayoshi, Kawada, Ichiro et al. · 2015 · Oncotarget
- Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancersCosta, Daniel B., Kobayashi, Susumu, Tenen, Daniel G., Huberman, Mark S. · 2007 · Lung Cancer
- Molecular mechanisms of resistance in epidermal growth factor receptor-mutant lung adenocarcinomasCortot, Alexis B., Jänne, Pasi A. · 2014 · European Respiratory Review
- Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockersNilsson, Monique B., Sun, Huiying, Diao, Lixia, Tong, Pan, Liu, Diane, Li, Lerong, Fan, Youhong, Poteete, Alissa, Lim, Seung-Oe, Howells, Kathryn et al. · 2017 · Science Translational Medicine
- Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutationsYamamoto, Chizuko, Basaki, Yuji, Kawahara, Akihiko, Nakashima, Kazutaka, Kage, Masayoshi, Izumi, Hiroto, Kohno, Kimitoshi, Uramoto, Hidetaka, Yasumoto, Kosei, Kuwano, Michihiko et al. · 2010 · Cancer Research
- Co-delivery of oxygen and erlotinib by aptamer-modified liposomal complexes to reverse hypoxia-induced drug resistance in lung cancerLi, Fengqiao, Mei, Hao, Gao, Yu, Xie, Xiaodong, Nie, Huifang, Li, Tao, Zhang, Huijuan, Jia, Lee · 2017 · Biomaterials
- Effect of epidermal growth factor receptor tyrosine kinase domain mutations on the outcome of patients with non-small cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitorsJänne, Pasi A., Johnson, Bruce E. · 2006 · Clinical Cancer Research
- Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non–Small Cell Lung Cancer Harboring
<i>K-RAS</i>
MutationsKonstantinidou, Georgia, Bey, Erik A., Rabellino, Andrea, Schuster, Katja, Maira, Michael S., Gazdar, Adi F., Amici, Augusto, Boothman, David A., Scaglioni, Pier Paolo · 2009 · Cancer Research
- Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptorYoshikawa, S, Kukimoto-Niino, M, Parker, L, Handa, N, Terada, T, Fujimoto, T, Terazawa, Y, Wakiyama, M, Sato, M, Sano, S et al. · 2013 · Oncogene
- Battling Btk mutants with noncovalent inhibitors that overcome Cys481 and Thr474 mutationsJohnson, Adam R., Kohli, Pawan Bir, Katewa, Arna, Gogol, Emily, Belmont, Lisa D., Choy, Regina, Penuel, Elicia, Burton, Luciana, Eigenbrot, Charles, Yu, Christine et al. · 2016 · ACS Chemical Biology
- Afatinib restrains K-RAS–driven lung tumorigenesisMoll, Herwig P., Pranz, Klemens, Musteanu, Monica, Grabner, Beatrice, Hruschka, Natascha, Mohrherr, Julian, Aigner, Petra, Stiedl, Patricia, Brcic, Luka, Laszlo, Viktoria et al. · 2018 · Science Translational Medicine
- Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerizationCho, Jeonghee, Chen, Liang, Sangji, Naveen, Okabe, Takafumi, Yonesaka, Kimio, Francis, Joshua M., Flavin, Richard J., Johnson, William, Kwon, Jihyun, Yu, Soyoung et al. · 2013 · Cancer Research
- Finding the tumor copycat: Therapy fails, patients don’tEllis, Lee M, Fidler, Isaiah J · 2010 · Nature Medicine
- Uncommon Epidermal Growth Factor Receptor mutations in non-small cell lung cancer and their mechanisms of EGFR tyrosine kinase inhibitors sensitivity and resistanceMassarelli, Erminia, Johnson, Faye M., Erickson, Heidi S., Wistuba, Ignacio I., Papadimitrakopoulou, Vassiliki · 2013 · Lung Cancer
- Targeting EGFR in Lung Cancer: Current Standards and DevelopmentsDíaz-Serrano, Asunción, Gella, Pablo, Jiménez, Elisabeth, Zugazagoitia, Jon, Paz-Ares Rodríguez, Luis · 2018 · Drugs
- Next-generation epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor -mutant non-small cell lung cancerTan, Chee-Seng, Cho, Byoung-Chul, Soo, Ross A. · 2016 · Lung Cancer
- Resistance is futile: overcoming resistance to targeted therapies in lung adenocarcinomaNeel, Dana S., Bivona, Trever G. · 2017 · npj Precision Oncology
- Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLCArasada, Rajeswara Rao, Shilo, Konstantin, Yamada, Tadaaki, Zhang, Jianying, Yano, Seiji, Ghanem, Rashelle, Wang, Walter, Takeuchi, Shinji, Fukuda, Koji, Katakami, Nobuyuki et al. · 2018 · Nature Communications
- Noncovalent Wild-type–Sparing Inhibitors of EGFR T790MLee, Ho-June, Schaefer, Gabriele, Heffron, Timothy P., Shao, Lily, Ye, Xiaofen, Sideris, Steve, Malek, Shiva, Chan, Emily, Merchant, Mark, La, Hank et al. · 2013 · Cancer Discovery
- AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer PatientsXu, Xiao, Mao, Long, Xu, Wanhong, Tang, Wei, Zhang, Xiaoying, Xi, Biao, Xu, Rongda, Fang, Xin, Liu, Jia, Fang, Ce et al. · 2016 · Molecular Cancer Therapeutics
- Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitorsYuza, Yuki, Glatt, Karen A., Jiang, Jingrui, Greulich, Heidi, Minami, Yuko, Woo, Michele S., Shimamura, Takeshi, Shapiro, Geoffrey I., Lee, Jeffrey C., Ji, Hongbin et al. · 2007 · Cancer Biology & Therapy
- Opportunities and challenges in combination gene cancer therapyNastiuk, Kent L., Krolewski, John J. · 2016 · Advanced Drug Delivery Reviews
- High T790M detection rate in TKI-naive NSCLC with EGFR sensitive mutation: truth or artifact?Ye, Xin, Zhu, Zhong-Zheng, Zhong, Lei, Lu, Yachao, Sun, Yun, Yin, Xiaolu, Yang, Zhenfan, Zhu, Guanshan, Ji, Qunsheng · 2013 · Journal of Thoracic Oncology
- Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challengesTang, Daolin, Kroemer, Guido, Kang, Rui · 2021 · Molecular Cancer
- Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLCZeng, Hao, Castillo-Cabrera, Johnny, Manser, Mika, Lu, Bo, Yang, Zinger, Strande, Vaik, Begue, Damien, Zamponi, Raffaella, Qiu, Shumei, Sigoillot, Frederic et al. · 2019 · eLife
- Toward a More Precise Future for OncologyMurciano-Goroff, Yonina R., Taylor, Barry S., Hyman, David M., Schram, Alison M. · 2020 · Cancer Cell
- Molecular pathways: sensitivity and resistance to anti-EGFR antibodiesBertotti, Andrea, Sassi, Francesco · 2015 · Clinical Cancer Research
- EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse modelsVenugopalan, Abhilash, Lee, Min-Jung, Niu, Gang, Medina-Echeverz, José, Tomita, Yusuke, Lizak, Martin J., Cultraro, Constance M., Simpson, Robert Mark, Chen, Xiaoyuan, Trepel, Jane B. et al. · 2016 · Oncotarget
- A phase I study of AST1306, a novel irreversible EGFR and HER2 kinase inhibitor, in patients with advanced solid tumorsZhang, Jian, Cao, Junning, Li, Jin, Zhang, Yifan, Chen, Zhiyu, Peng, Wei, Sun, Si, Zhao, Naiqing, Wang, Jiachen, Zhong, Dafang et al. · 2014 · Journal of Hematology & Oncology
- Continuing EGFR inhibition beyond progression in advanced non-small cell lung cancerYap, Timothy A., Macklin-Doherty, Aislinn, Popat, Sanjay · 2017 · European Journal of Cancer
- Recent advances in the development of RIPK2 modulators for the treatment of inflammatory diseasesPham, Anh-Tuan, Ghilardi, Amanda Franceschini, Sun, Lijun · 2023 · Frontiers in Pharmacology
- Combining Erlotinib and Cetuximab Is Associated with Activity in Patients with Non–Small Cell Lung Cancer (Including Squamous Cell Carcinomas) and Wild-Type<i>EGFR</i>or Resistant MutationsWheler, Jennifer J., Tsimberidou, Apostolia M., Falchook, Gerald S., Zinner, Ralph G., Hong, David S., Fok, Jansina Y., Fu, Siqing, Piha-Paul, Sarina A., Naing, Aung, Kurzrock, Razelle · 2013 · Molecular Cancer Therapeutics
- SH-1028, An Irreversible Third-Generation EGFR TKI, Overcomes T790M-Mediated Resistance in Non-Small Cell Lung CancerHan, Luwei, Zhang, Xiaomeng, Wang, Zhiqiang, Zhang, Xian, Zhao, Liwen, Fu, Wei, Liang, Xiaobo, Zhang, Zhibo, Wang, Yong · 2021 · Frontiers in Pharmacology
- BIM deletion polymorphisms in Hispanic patients with non-small cell lung cancer carriers of EGFR mutationsCardona, Andrés F., on behalf of the CLICaP, Rojas, Leonardo, Wills, Beatriz, Arrieta, Oscar, Carranza, Hernán, Vargas, Carlos, Otero, Jorge, Corrales-Rodriguez, Luis, Martín, Claudio et al. · 2016 · Oncotarget
- The AhR‐SRC axis as a therapeutic vulnerability in BRAFi‐resistant melanomaParis, Anaïs, Tardif, Nina, Baietti, Francesca M, Berra, Cyrille, Leclair, Héloïse M, Leucci, Eleonora, Galibert, Marie‐Dominique, Corre, Sébastien · 2022 · EMBO Molecular Medicine
- Dynamic monitoring of EGFR mutations in circulating cell-free DNA for EGFR-mutant metastatic patients with lung cancer: Early detection of drug resistance and prognostic significanceNi, Jianjiao, Weng, Linqian, Liu, Yi, Sun, Zhao, Bai, Chunmei, Wang, Yingyi · 2017 · Oncology Letters
- The origins of cancer cell dormancyMorales-Valencia, Jorge, David, Gregory · 2022 · Current Opinion in Genetics & Development
- Overcoming Resistance to AC0010, a Third Generation of EGFR Inhibitor, by Targeting c-MET and BCL-2Xu, Wanhong, Tang, Wei, Li, Tingting, Zhang, Xiaoying, Sun, Yi · 2019 · Neoplasia
- The status of immunosuppression in patients with stage IIIB or IV non-small-cell lung cancer correlates with the clinical characteristics and response to chemotherapyWang, Yuan, Hu, Guo-fang, Wang, Zhehai · 2017 · OncoTargets and Therapy
- Clinical activity of <scp>ASP</scp>8273 in Asian patients with non‐small‐cell lung cancer with <scp>EGFR</scp> activating and T790M mutationsMurakami, Haruyasu, Nokihara, Hiroshi, Hayashi, Hidetoshi, Seto, Takashi, Park, Keunchil, Azuma, Koichi, Tsai, Chun‐Ming, Yang, James Chih‐Hsin, Nishio, Makoto, Kim, Sang‐We et al. · 2018 · Cancer Science
- Clinical usefulness of gefitinib for non-small-cell lung cancer with a double epidermal growth factor receptor mutationOIKAWA, TAKEFUMI, OHIRA, TATSUO, OTANI, KEISHI, HAGIWARA, MASARU, KONAKA, CHIMORI, IKEDA, NORIHIKO · 2015 · Molecular and Clinical Oncology