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Cited by 1,339

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

Piot, Christophe, Croisille, Pierre, Staat, Patrick, Thibault, Hélène, Rioufol, Gilles, Mewton, Nathan, Elbelghiti, Rachid, Cung, Thien Tri, Bonnefoy, Eric, Angoulvant, Denis, Macia, Christophe, Raczka, Franck, Sportouch, Catherine, Gahide, Gerald, Finet, Gérard, André-Fouët, Xavier, Revel, Didier, Kirkorian, Gilbert, Monassier, Jean-Pierre, Derumeaux, Geneviève, Ovize, Michel·2008·New England Journal of Medicine
DOI 10.1056/nejmoa071142
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Abstract

BACKGROUND: Experimental evidence suggests that cyclosporine, which inhibits the opening of mitochondrial permeability-transition pores, attenuates lethal myocardial injury that occurs at the time of reperfusion. In this pilot trial, we sought to determine whether the administration of cyclosporine at the time of percutaneous coronary intervention (PCI) would limit the size of the infarct during acute myocardial infarction. METHODS: We randomly assigned 58 patients who presented with acute ST-elevation myocardial infarction to receive either an intravenous bolus of 2.5 mg of cyclosporine per kilogram of body weight (cyclosporine group) or normal saline (control group) immediately before undergoing PCI. Infarct size was assessed in all patients by measuring the release of creatine kinase and troponin I and in a subgroup of 27 patients by performing magnetic resonance imaging (MRI) on day 5 after infarction. RESULTS: The cyclosporine and control groups were similar with respect to ischemia time, the size of the area at risk, and the ejection fraction before PCI. The release of creatine kinase was significantly reduced in the cyclosporine group as compared with the control group (P=0.04). The release of troponin I was not significantly reduced (P=0.15). On day 5, the absolute mass of the area of hyperenhancement (i.e., infarcted tissue) on MRI was significantly reduced in the cyclosporine group as compared with the control group, with a median of 37 g (interquartile range, 21 to 51) versus 46 g (interquartile range, 20 to 65; P=0.04). No adverse effects of cyclosporine administration were detected. CONCLUSIONS: In our small, pilot trial, administration of cyclosporine at the time of reperfusion was associated with a smaller infarct by some measures than that seen with placebo. These data are preliminary and require confirmation in a larger clinical trial.

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Metadata

Authors
Piot, C., Croisille, P., Staat, P., Thibault, H., Rioufol, G., Mewton, N., Elbelghiti, R., Cung, T. T., Bonnefoy, E., Angoulvant, D., Macia, C., Raczka, F., Sportouch, C., Gahide, G., Finet, G., André-Fouët, X., Revel, D., Kirkorian, G., Monassier, J.-P., Derumeaux, G., & Ovize, M.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2008-07-31
Volume
359
Issue
5
Pages
473-481
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa071142
OpenAlex
W2153298328
Cited by
1,339
References
5
FWCI
69.94
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.