Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969

A haplotype map of the human genome

The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858

The Future of Genetic Studies of Complex Human Diseases

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Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”

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Axonal transection in the lesions of multiple sclerosis

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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

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A genome-wide association study identifies novel risk loci for type 2 diabetes

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753

Revised diagnostic criteria for neuromyelitis optica

Wingerchuk, D. M., Lennon, V. A., Pittock, S. J., Lucchinetti, C. F., & Weinshenker, B. G. (2006) · Neurology · doi:10.1212/01.wnl.0000216139.44259.74 · Cited by 2,568

Beyond Regulatory T Cells: The Potential Role for IL-2 to Deplete T-Follicular Helper Cells and Treat Autoimmune Diseases

Ballesteros‐Tato, A. (2014) · Immunotherapy · doi:10.2217/imt.14.83 · Cited by 33

Pathogenesis of Pediatric Multiple Sclerosis

Vargas-Lowy, D., & Chitnis, T. (2012) · Journal of Child Neurology · doi:10.1177/0883073812456084 · Cited by 37

The genetics of multiple sclerosis and its experimental models

Olsson, T. P., & Hillert, J. A. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3282fd10cc · Cited by 34

Presence of CSF oligoclonal bands (OCB) is associated with the HLA-DRB1 genotype in a West Australian multiple sclerosis cohort

Wu, J.-S., Qiu, W., Castley, A. S. L., JAMES, I. R., Joseph, J. P., Christiansen, F., Carroll, W. M., Mastaglia, F. L., & Kermode, A. G. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.10.005 · Cited by 35

The Effect of Single Nucleotide Polymorphisms from Genome Wide Association Studies in Multiple Sclerosis on Gene Expression

Handel, A. E., Handunnetthi, L., Berlanga‐Taylor, A. J., Watson, C. T., Morahan, J. M., & Ramagopalan, S. V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010142 · Cited by 35

IL7RAPolymorphisms and Susceptibility to Multiple Sclerosis

O’Doherty, C., Kantarci, O. H., & Vandenbroeck, K. (2008) · New England Journal of Medicine · doi:10.1056/nejmc0707553 · Cited by 35

A Multiple Sclerosis–Associated Variant of CBLB Links Genetic Risk with Type I IFN Function

Stürner, K. H., Borgmeyer, U., Schulze, C., Pleß, O., & Martinꝉ, R. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303077 · Cited by 33

A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility

Bush, W. S., McCauley, J. L., DeJager, P. L., DUDEK, S. M., Hafler, D. A., Gibson, R. A., Matthews, P. M., Kappos, L., Naegelin, Y., Polman, C. H., et al. (2011) · Genes and Immunity · doi:10.1038/gene.2011.3 · Cited by 34

Human Endogenous Retrovirus HERV-Fc1 Association with Multiple Sclerosis Susceptibility: A Meta-Analysis

de la Hera, B., Varadé, J., Montojo, M. G., Alcina, A., Fedetz, M., Alloza, I., Astobiza, I., Leyva, L., Fernández, Ó., Izquierdo, G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090182 · Cited by 34

Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk

Lill, C. M., Schjeide, B. M., Graetz, C., Liu, T., Damotte, V., Akkad, D. A., Blaschke, P., Gerdes, L.-A., Kroner, A., Luessi, F., et al. (2013) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101411 · Cited by 34

Sequencing and analysis of a South Asian-Indian personal genome

Gupta, R. K., Ratan, A., Rajesh, C., Chen, R., Kim, H. L., Burhans, R. C., Miller, W., Santhosh, S., Davuluri, R. V., Butte, A. J., et al. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-440 · Cited by 34

Association between seasonal factors and multiple sclerosis

Watad, ‬., Azrielant, S., Soriano, A., Bracco, D., Abu‐Much, A., & Amital, H. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0165-3 · Cited by 34

Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease

Tandon, A., Singh, S. J., & Chaturvedi, R. K. (2018) · BioMed Research International · doi:10.1155/2018/1483791 · Cited by 36

Genetic factors for susceptibility to and manifestations of neuromyelitis optica

Matsushita, T., Masaki, K., Isobe, N., Sato, S., Yamamoto, K., Nakamura, Y., Watanabe, M., Suenaga, T., & Kira, J. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51147 · Cited by 35

Genetics and functional genomics of multiple sclerosis

Kim, W., & Patsopoulos, N. A. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-021-00907-3 · Cited by 39

Autoimmune Thyroid Disease in the Use of Alemtuzumab for Multiple Sclerosis: A Review

Aranha, A. A., Amer, S., Reda, E. S., Broadley, S., & Davoren, P. M. (2013) · Endocrine Practice · doi:10.4158/ep13020.ra · Cited by 35

Multiple sclerosis associated genetic variants ofCD226impair regulatory T cell function

Piédavent, M., Willing, A., Engler, J. B., Steinbach, K., Bauer, S., Eggert, B., Ufer, F., Kursawe, N., Wehrmann, S., Jäger, J., et al. (2015) · Brain · doi:10.1093/brain/awv256 · Cited by 36

Genetics and familial distribution of multiple sclerosis: A review

Balcerac, A., & Louapre, C. (2022) · Revue Neurologique · doi:10.1016/j.neurol.2021.11.009 · Cited by 35

HLA‐DRB1: genetic susceptibility and disability progression in a Spanish multiple sclerosis population

Romero-Pinel, L., Pujal, J. M., Martínez‐Yélamos, S., Gubieras, L., Matas, E., Bau, L., Torrabadella, M., Azqueta, C., & Arbizu, T. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03148.x · Cited by 33

Lentiviral Vector-Mediated Gene Transfer and RNA Silencing Technology in Neuronal Dysfunctions

Dreyer, J. (2010) · Molecular Biotechnology · doi:10.1007/s12033-010-9334-x · Cited by 35

GWAS-identified multiple sclerosis risk loci involved in immune response: Validation in Russians

Bashinskaya, V. V., Кулакова, О. Г., Сергеевич, К. И., Baulina, N., Favorov, A. V., Boyko, A. N., Tsareva, E., & Favorova, O. O. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.03.015 · Cited by 33

Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians

Fang, L., Isobe, N., Yoshimura, S., Yonekawa, T., Matsushita, T., Masaki, K., Doi, H., Ochi, K., Miyamoto, K., Kawano, Y., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821f466c · Cited by 33

Association of Macrophage Migration Inhibitory Factor Gene Promoter Polymorphisms with Multiple Sclerosis in Turkish Patients

Akçalı, A., Pehlıvan, S., Pehlıvan, M., Sever, T., & Neyal, M. (2010) · Journal of International Medical Research · doi:10.1177/147323001003800108 · Cited by 32

Reduced axonal motor protein expression in non-lesional grey matter in multiple sclerosis

Hares, K. M., Kemp, K. C., Rice, C. M., Gray, E., Scolding, N. J., & Wilkins, A. (2013) · Multiple Sclerosis Journal · doi:10.1177/1352458513508836 · Cited by 34

Genome‐wide association studies (GWAS): impact on elucidating the aetiology of diabetes

Hakonarson, H. H., & Grant, S. F. A. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1221 · Cited by 34

Pharmacogenomics strategies to optimize treatments for multiple sclerosis: Insights from clinical research

Grossman, I., Knappertz, V. A., Laifenfeld, D., Ross, C. J., Zeskind, B., Kolitz, S. E., Ladkani, D., Hayardeny, L., Loupe, P. S., Laufer, R., et al. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.02.001 · Cited by 34

Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C

Martin, P., McGovern, A., Massey, J., Schoenfelder, S., Duffus, K., Yarwood, A., Barton, A. C., Worthington, J., Fraser, P., Eyre, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166923 · Cited by 32

Genetic Predisposition to Rosacea

Awosika, O., & Oussedik, E. (2017) · Dermatologic Clinics · doi:10.1016/j.det.2017.11.002 · Cited by 33

N-Glycan Branching Decouples B Cell Innate and Adaptive Immunity to Control Inflammatory Demyelination

Mortales, C., Lee, S.-U., Manousadjian, A., Hayama, K. L., & Demetriou, M. (2020) · iScience · doi:10.1016/j.isci.2020.101380 · Cited by 31

The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation

Benallegue, N., Kébir, H., Kapoor, R., Crockett, A. M., Li, C., Cheslow, L., Abdel-Hakeem, M. S., Gesualdi, J., Miller, M. C., Wherry, E. J., et al. (2021) · Brain · doi:10.1093/brain/awab083 · Cited by 31

Genome-wide association studies in neurology.

Tan, M., Jiang, T., Tan, L., & Yu, J. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2014.11.12 · Cited by 35

Risk conferring genes in multiple sclerosis

Nischwitz, S., Müller‐Myhsok, B., & Weber, F. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.037 · Cited by 35

Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain

Swaminathan, B., Matesanz, F., Cavanillas, M. L., Alloza, I., Otaegui, D., Olascoaga, J., Cénit, M. C., Heras, V. D. L., Barcina, M. G., Arroyo, R., et al. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.03.020 · Cited by 31

Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants

Li, C. F., Zhou, R. W., Mkhikian, H., Newton, B. L., Yu, Z., & Demetriou, M. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.12.008 · Cited by 37

Genomic regulation of CTLA4 and Multiple Sclerosis

Palacios, R., Comas, D., Elorza, J., & Villoslada, P. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.06.021 · Cited by 33

Finding disease candidate genes by liquid association

Li, K.-C., Palotie, A. V., Yuan, S., Bronnikov, D., Chen, D., Wei, X., Choi, O., Saarela, J., & Peltonen, L. (2007) · Genome biology · doi:10.1186/gb-2007-8-10-r205 · Cited by 33

Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects: Figure 1

Lill, C. M., Liu, T., Schjeide, B. M., Roehr, J. T., Akkad, D. A., Damotte, V., Alcina, A., Ortiz, M. A., Arroyo, R., de Lapuente, A. L., et al. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101175 · Cited by 33

Calcitriol Modulates the CD46 Pathway in T Cells

Kickler, K., Choileáin, S. N., Williams, A., Richards, A., & Astier, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048486 · Cited by 33

Response to interferon-beta treatment in multiple sclerosis patients: a genome-wide association study

Mahurkar, S., Moldovan, M. V., Suppiah, V., Sorosina, M., Clarelli, F., Liberatore, G., Malhotra, S., Montalbán, X., Antigüedad, A. R., Krupa, M., et al. (2016) · The Pharmacogenomics Journal · doi:10.1038/tpj.2016.20 · Cited by 33

Multiple Sclerosis: An Overview

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Identification of Shared Genes and Pathways: A Comparative Study of Multiple Sclerosis Susceptibility, Severity and Response to Interferon Beta Treatment

Mahurkar, S., Moldovan, M., Suppiah, V., & O'Doherty, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057655 · Cited by 22

Pharmacogenetics: A strategy for personalized medicine for autoimmune diseases

Tavakolpour, S., Darvishi, M., & Ghasemiadl, M. (2017) · Clinical Genetics · doi:10.1111/cge.13186 · Cited by 32

A Perspective of Coagulation Dysfunction in Multiple Sclerosis and in Experimental Allergic Encephalomyelitis

Plantone, D., Inglese, M., Salvetti, M., & Koudriavtseva, T. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2018.01175 · Cited by 32

Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese

Ogawa, K., Okuno, T., Hosomichi, K., Hosokawa, A., Hirata, J., Ken, S., Sakaue, S., Kinoshita, M., Asano, Y., Miyamoto, K., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1551-z · Cited by 32

Proinflammatory mucosal-associated invariant CD8+ T cells react to gut flora yeasts and infiltrate multiple sclerosis brain

Gargano, F., Guerrera, G., Piras, E., Serafini, B., Paola, M. D., Rizzetto, L., Buscarinu, M. C., Annibali, V., Vuotto, C., Bardi, M. D., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.890298 · Cited by 32

Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis

Blankenhorn, E. P., Butterfield, R. J., Case, L. K., Wall, E. H., del Río, R., Diehl, S. A., Krementsov, D. N., Saligrama, N., & Teuscher, C. (2011) · Annals of Neurology · doi:10.1002/ana.22642 · Cited by 32

IL-7Rα confers susceptibility to experimental autoimmune encephalomyelitis

Walline, C. C., Kanakasabai, S., & Bright, J. J. (2010) · Genes and Immunity · doi:10.1038/gene.2010.49 · Cited by 30

Increased Th17 response to myelin peptides in pediatric MS

Vargas-Lowy, D., Kivisäkk, P., Gandhi, R., Raddassi, K., Soltany, P., Gorman, M., Khoury, S. J., & Chitnis, T. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.12.008 · Cited by 32

Gene expression profiling in multiple sclerosis brain

Dutta, R., & Trapp, B. D. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.12.003 · Cited by 32

Substrain Differences Reveal Novel Disease-Modifying Gene Candidates That Alter the Clinical Course of a Rodent Model of Multiple Sclerosis

deLuca, L. S., Pikor, N. B., O’Leary, J., Galicia, G., Ward, L. A., Defreitas, D., Finlay, T. M., Ousman, S. S., Osborne, L. R., & Gommerman, J. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902881 · Cited by 31

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

Redmann, V., Lamb, C. A., Hwang, S., Orchard, R. C., Kim, S., Razi, M., Milam, A., Park, S., Yokoyama, C. C., Kambal, A., et al. (2016) · Scientific Reports · doi:10.1038/srep23326 · Cited by 31

Emerging Therapies for Relapsing Multiple Sclerosis

Cohen, J. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.104 · Cited by 31

A large candidate‐gene association study suggests genetic variants at IRF 5 and PRDM 1 to be associated with aggressive periodontitis

Schäefer, A. S., Jochens, A., Dommisch, H., Graetz, C., Jockel‐Schneider, Y., Harks, I., Staufenbiel, I., Meyle, J., Eickholz, P., Folwaczny, M., et al. (2014) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12314 · Cited by 31

The Role Of Glial–Neuronal Metabolic Cooperation in Modulating Progression of Multiple Sclerosis and Neuropathic Pain

Robinson, R. R., Dietz, A. K., Maroof, A. M., Asmis, R., & Forsthuber, T. G. (2019) · Immunotherapy · doi:10.2217/imt-2018-0153 · Cited by 33

The IL-7Rα Pathway Is Quantitatively and Functionally Altered in CD8 T Cells in Multiple Sclerosis

Kreft, K. L., Verbraak, E., Wierenga‐Wolf, A. F., van Meurs, M., Oostra, B. A., Laman, J. D., & Hintzen, R. Q. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102559 · Cited by 30

A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis

Ban, M., McCauley, J. L., Zuvich, R. L., Baker, A., Bergamaschi, L., Cox, M., Kemppinen, A., D’Alfonso, S., Guerini, F. R., Lechner‐Scott, J., et al. (2010) · Genes and Immunity · doi:10.1038/gene.2010.36 · Cited by 30

CD58 polymorphisms associated with the risk of neuromyelitis optica in a Korean population

Kim, Y., Bae, J. S., Kim, H. J., & Shin, H. D. (2014) · BMC Neurology · doi:10.1186/1471-2377-14-57 · Cited by 31

Both MHC and non-MHC genes regulate inflammation and T-cell response after traumatic brain injury

Nimer, F. A., Beyeen, A. D., Lindblom, R. P. F., Ström, M., Aeinehband, S., Lidman, O., & Piehl, F. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.10.017 · Cited by 31

The T244I variant of the interleukin‐7 receptor‐alpha gene and multiple sclerosis

Alcina, A., Fedetz, M., Ndagire, D., Fernández, Ó., Leyva, L., Guerrero, M., Arnal, C., Delgado, C., & Matesanz, F. (2008) · Tissue Antigens · doi:10.1111/j.1399-0039.2008.01075.x · Cited by 31

The tag SNP for HLA-DRB1⁎1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: Cost-effective high-throughput detection by real-time PCR

Živković, M., Stanković, A., Dinčić, E., Popović, M., Popovic, S., Raičević, R., & Alavantić, D. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.05.004 · Cited by 34

Dendritic Cells and Multiple Sclerosis: Disease, Tolerance and Therapy

Mohammad, M. G., Hassanpour, M., Tsai, V. W.-W., Li, H., Ruitenberg, M. J., Booth, D. R., Serrats, J., Hart, P. H., Symonds, G., Sawchenko, P. E., et al. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms14010547 · Cited by 34

How to Use an Article About Genetic Association

Attia, J., Ioannidis, J. P. A., Thakkinstian, A., McEvoy, M., Scott, R. J., Minelli, C., Thompson, J. R., Infante‐Rivard, C., & Guyatt, G. H. (2009) · Cited by 31

Neuroimmunotherapies Targeting T Cells: From Pathophysiology to Therapeutic Applications

Bittner, S., & Wiendl, H. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0405-3 · Cited by 32

Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions

de Boer, A., van den Bosch, A. M. R., Mekkes, N., Fransen, N. L., Dagkesamanskaia, E., Hoekstra, E., Hamann, J., Smolders, J., Huitinga, I., & Holtman, I. R. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02742-w · Cited by 30

Interleukin 2 in the Pathogenesis and Therapy of Type 1 Diabetes

Rosenzwajg, M., Churlaud, G., Hartemann, A., & Klatzmann, D. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0553-6 · Cited by 31

Multiple Sclerosis Genetics 2010

McElroy, J. P., & Oksenberg, J. R. (2011) · Neurologic Clinics · doi:10.1016/j.ncl.2010.12.002 · Cited by 30

HLA alleles as biomarkers of high-titre neutralising antibodies to interferon-β therapy in multiple sclerosis

Núñez, C., Cénit, M. C., Álvarez‐Lafuente, R., Río, J., Fernández‐Arquero, M., Arroyo, R., Montalbán, X., Fernández, Ó., Oliver‐Martos, B., Leyva, L., et al. (2014) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2014-102348 · Cited by 30

Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis

Öckinger, J., Stridh, P., Beyeen, A. D., Lundmark, F., Seddighzadeh, M., Oturai, A. B., Sørensen, P. S., Lorentzen, Å. R., Celius, E. G., Leppä, V., et al. (2009) · Genes and Immunity · doi:10.1038/gene.2009.82 · Cited by 30

Paediatric Multiple Sclerosis: Update on Diagnostic Criteria, Imaging, Histopathology and Treatment Choices

Chou, I., Wang, H.-S., Whitehouse, W. P., & Constantinescu, C. S. (2016) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-016-0663-4 · Cited by 30

One, No One, and One Hundred Thousand: T Regulatory Cells' Multiple Identities in Neuroimmunity

Sambucci, M., Gargano, F., Guerrera, G., Battistini, L., & Borsellino, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02947 · Cited by 31

Deleterious and Oncogenic Mutations in the IL7RA

Campos, L. W., Pissinato, L. G., & Yunes, J. A. (2019) · Cancers · doi:10.3390/cancers11121952 · Cited by 30

Associations of CD6 , TNFRSF1A and IRF8 polymorphisms with risk of inflammatory demyelinating diseases

Park, T. ‐., Kim, H. J., Kim, J. ‐., Bae, J. S., Cheong, H. S., Park, B. ‐., & Shin, H. D. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01304.x · Cited by 30

Genetic association between polymorphisms in the BTG1 gene and multiple sclerosis

Camiña-Tato, M., Morcillo-Suárez, C., Navarro, A., Fernández, M., Horga, A., Montalbán, X., & Comabella, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.05.010 · Cited by 31

Multiple sclerosis risk markers in HLA-DRA, HLA-C, and IFNG genes are associated with sex-specific childhood leukemia risk

Morrison, B. A., Ucisik-Akkaya, E., Flores, H., Alaez, C., Gorodezky, C., & Dorak, M. T. (2010) · Autoimmunity · doi:10.3109/08916930903567492 · Cited by 30

BAFF is a Biological Response Marker to IFN-β Treatment in Multiple Sclerosis

Gandhi, K. S., McKay, F. C., Schibeci, S. D., Arthur, J. W., Heard, R. N., Stewart, G. J., & Booth, D. R. (2008) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0007 · Cited by 30

HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain)

Fernández, Ó., Antigüedad, A. R., Pinto-Medel, M. J., Mendibe, M. M., Acosta, N., Oliver‐Martos, B., Guerrero, M., Papais-Alvarenga, M., Fernández-Sánchez, V. E., & Leyva, L. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5223-2 · Cited by 31

T-Cell Based Immunotherapy in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

O’Brien, K., Gran, B., & Rostami, A. M. (2009) · Immunotherapy · doi:10.2217/imt.09.61 · Cited by 31

Will we ever find the genes for addiction?

Buckland, P. R. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02285.x · Cited by 31

Genome-wide association studies in type 1 diabetes

Grant, S. F. A., & Hakonarson, H. H. (2009) · Current Diabetes Reports · doi:10.1007/s11892-009-0026-5 · Cited by 29

Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS

Kallio, S. P., Jakkula, E., Purcell, S., Suvela, M. H., Koivisto, K. J., Tienari, P. J., Elovaara, I., Pirttilä, T., Reunanen, M., Bronnikov, D., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp073 · Cited by 32

Emerging Role for Methylation in Multiple Sclerosis: Beyond DNA

Webb, L., & Guerau‐de‐Arellano, M. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.04.004 · Cited by 29

A Phenome-Wide Mendelian Randomization Study of Pancreatic Cancer Using Summary Genetic Data

Langdon, R., Richmond, R. C., Hemani, G., Zheng, J., Wade, K. H., Carreras‐Torres, R., Johansson, M., Brennan, P., Wootton, R. E., Munafo, M. R., et al. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-0036 · Cited by 30

Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus

Perera, D., Stankovich, J. M., Butzkueven, H., Taylor, B. V., Foote, S. J., Kilpatrick, T. J., & Rubio, J. P. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.03.010 · Cited by 30

Pharmacogenomics of multiple sclerosis: in search for a personalized therapy

Martínez‐Forero, I., Peláez, A., & Villoslada, P. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560802515553 · Cited by 29

Universal or Personalized Mesenchymal Stem Cell Therapies: Impact of Age, Sex, and Biological Source

Carp, D. M., & Liang, Y. (2022) · Cells · doi:10.3390/cells11132077 · Cited by 29

Iron metabolism disorder and multiple sclerosis: a comprehensive analysis

Tang, C. K., Yang, J., Zhu, C., Ding, Y., Yang, S., Xu, B., & He, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1376838 · Cited by 31

Next steps in regulatory T cells: Biology and clinical application

Zou, C., Li, P., Li, B., Sparwasser, T. D., & Yuan, J. (2026) · Cell · doi:10.1016/j.cell.2025.11.035 · Cited by 29

Fine-Mapping Resolves Eae23 into Two QTLs and Implicates ZEB1 as a Candidate Gene Regulating Experimental Neuroinflammation in Rat

Stridh, P., Hedreul, M. T., Beyeen, A. D., Adzemovic, M. Z., Lindahl, H., Gillett, A., Öckinger, J., Marta, M., Lassmann, H., Bečanović, K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012716 · Cited by 29

Multiple Sclerosis Re-Examined: Essential and Emerging Clinical Concepts

Zurawski, J. D., & Stankiewicz, J. M. (2017) · The American Journal of Medicine · doi:10.1016/j.amjmed.2017.11.044 · Cited by 30

Highly conserved extended haplotypes of the major histocompatibility complex and their relationship to multiple sclerosis susceptibility

Goodin, D. S., Khankhanian, P., Gourraud, P., & Vince, N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190043 · Cited by 30

Gender-Associated Differences of Perforin Polymorphisms in the Susceptibility to Multiple Sclerosis

Camiña-Tato, M., Morcillo-Suárez, C., Bustamante, M. F., Ortega, I. C., Navarro, A., Muntasell, A., López‐Botet, M., Sánchez‐Pla, Á., Carmona, P., Julià, E., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000102 · Cited by 29

A neurologist’s guide to genome-wide association studies

Mullen, S. A., Crompton, D. E., Carney, P. W., Helbig, I., & Berkovic, S. F. (2009) · Neurology · doi:10.1212/01.wnl.0000341942.29513.bd · Cited by 30

HLA-DRB1 allele heterogeneity influences multiple sclerosis severity as well as risk in Western Australia

Wu, J.-S., JAMES, I. R., Qiu, W., Castley, A. S. L., Christiansen, F., Carroll, W. M., Mastaglia, F. L., & Kermode, A. G. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.015 · Cited by 29

Potential Impact of B Cells on T Cell Function in Multiple Sclerosis

Ireland, S. J., & Monson, N. L. (2011) · Multiple Sclerosis International · doi:10.1155/2011/423971 · Cited by 29

Aberrant stress‐induced Hsp70 expression in immune cells in multiple sclerosis

Ćwiklińska, H., Mycko, M. P., Szymańska, B., Matysiak, M., & Selmaj, K. W. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22476 · Cited by 29

Multiple sclerosis etiology: beyond genes and environment

Mechelli, R., Annibali, V., Ristori, G., Vittori, D., Coarelli, G., & Salvetti, M. (2010) · Expert Review of Clinical Immunology · doi:10.1586/eci.10.11 · Cited by 29

IL2RA is associated with persistence of rheumatoid arthritis

van Steenbergen, H. W., van Nies, J. A. B., Ruyssen‐Witrand, A., Huizinga, T. W. J., Cantagrel, A., Berenbaum, F., & Mil, A. H. M. V. D. H. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0739-6 · Cited by 29

Regulatory T, natural killer T and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison

Ramos, S. B., Brenu, E., Broadley, S., Kwiatek, R., Ng, J., Nguyen, T. U., Freeman, S., Staines, D., & Marshall‐Gradisnik, S. (2016) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/ap0733 · Cited by 30

Genetic Association between the Interleukin-2 Receptor-α Gene and Mode of Onset of Type 1 Diabetes in the Japanese Population

Kawasaki, E., Awata, T., Ikegami, H., Kobayashi, T., Maruyama, T., Nakanishi, K., Shimada, A., Uga, M., Kurihara, S., Kawabata, Y., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1596 · Cited by 29

Dissection of the multiple sclerosis associated DR2 haplotype

Etzensperger, R., McMahon, R. M., Jones, E. Y., & Fugger, L. H. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.04.016 · Cited by 29

News in brief

(2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70214-4

Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

for the Multiple Sclerosis Genetics Group, Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., et al. (2007) · Nature Genetics · doi:10.1038/ng2103 · Cited by 657

Risk alleles for multiple sclerosis in multiplex families

D’Netto, M. J., Ward, H., Morrison, K., Ramagopalan, S. V., Dyment, D. A., DeLuca, G. C., Handunnetthi, L., Sadovnick, A. D., & Ebers, G. C. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a92c25 · Cited by 62

Decoding multiple sclerosis: an update on genomics and future directions

Oksenberg, J. R. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.865867 · Cited by 66

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

Zuvich, R. L., McCauley, J. L., Oksenberg, J. R., Sawcer, S. J., Jager, P. L. D., Aubin, C., Cross, A. H., Piccio, L. M., Aggarwal, N. T., Evans, D. A., et al. (2010) · Human Genetics · doi:10.1007/s00439-010-0789-4 · Cited by 65