Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

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A haplotype map of the human genome

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The Future of Genetic Studies of Complex Human Diseases

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Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”

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Axonal transection in the lesions of multiple sclerosis

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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

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A genome-wide association study identifies novel risk loci for type 2 diabetes

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

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Revised diagnostic criteria for neuromyelitis optica

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Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6

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A population-based case–control study on viral infections and vaccinations and subsequent multiple sclerosis risk

Ahlgren, C., Torén, K., Odén, A., & Andersen, O. (2009) · European Journal of Epidemiology · doi:10.1007/s10654-009-9367-2 · Cited by 47

Therapies for multiple sclerosis: considerations in the pediatric patient

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Insight from genome‐wide association studies in rheumatoid arthritis and multiple sclerosis

Suzuki, A., Kochi, Y., Okada, Y., & Yamamoto, K. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.025 · Cited by 45

Genetic determinants of risk and progression in multiple sclerosis

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Gender-based blood transcriptomes and interactomes in multiple sclerosis: Involvement of SP1 dependent gene transcription

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Multiple sclerosis incidence in the era of measles-mumps-rubella mass vaccinations

Ahlgren, C., Odén, A., Torén, K., & Andersen, O. (2008) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2008.01131.x · Cited by 45

Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients

Kreft, K. L., Verbraak, E., Wierenga‐Wolf, A. F., van Meurs, M., Oostra, B. A., Laman, J. D., & Hintzen, R. Q. (2012) · Genes and Immunity · doi:10.1038/gene.2012.34 · Cited by 46

Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis

Buck, D., Albrecht, E., Aslam, M., Goris, A., Hauenstein, N., Jochim, A., Cepok, S., Grummel, V., Dubois, B., Berthele, A., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23749 · Cited by 48

The human lexinome: Genes of language and reading

Gibson, C. J., & Gruen, J. R. (2008) · Journal of Communication Disorders · doi:10.1016/j.jcomdis.2008.03.003 · Cited by 48

Genome-Wide Association Study of Multiple Sclerosis Confirms a Novel Locus at 5p13.1

Matesanz, F., González‐Pérez, A., Lucas, M., Sanna, S., Gayán, J., Urcelay, E., Zara, I., Pitzalis, M., Cavanillas, M. L., Arroyo, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036140 · Cited by 45

Genome-wide association study identifies MAPT locus influencing human plasma tau levels

Chen, J., Yu, J., Wojta, K. J., Wang, H.-F., Zetterberg, H., Blennow, K., Yokoyama, J. S., Weiner, M. W., Kramer, J. H., Rosen, H. J., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000003615 · Cited by 46

Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS

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Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes

Rafiq, S., Melzer, D. R., Weedon, M. N., Lango, H., Saxena, R., Scott, L. J., Palmer, C. N. A., Morris, A. D., McCarthy, M. I., Ferrucci, L., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1160-3 · Cited by 47

Integrating genome-wide association studies and gene expression data highlights dysregulated multiple sclerosis risk pathways

Liu, G., Zhang, F., Jiang, Y., Hu, Y., Gong, Z., Liu, S., Chen, X., Jiang, Q., & Hao, J. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516649038 · Cited by 45

No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis

Ban, M., Caillier, S. J., Mero, I., Myhr, K., Celius, E. G., Aarseth, J. H., Torkildsen, Ø., Harbo, H. F., Oksenberg, J. R., Hauser, S. L., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23833 · Cited by 45

Interleukin 17 gene polymorphism is associated with anti-aquaporin 4 antibody-positive neuromyelitis optica in the Southern Han Chinese — A case control study

Wang, H., Zhong, X., Wang, K., Qiu, W., Li, J., Dai, Y., & Hu, X. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.11.005 · Cited by 45

From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A

Berge, T., Leikfoss, I., & Harbo, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14034476 · Cited by 45

Anti‐IL‐7 receptor α monoclonal antibody (GSK2618960) in healthy subjects – a randomized, double‐blind, placebo‐controlled study

Ellis, J., van Maurik, A., Fortunato, L., Gisbert, S., Chen, K., Schwartz, A. M., McHugh, S. M., Want, A., Franco, S. S., Oliveira, J., et al. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13748 · Cited by 45

Deconstructing and targeting the genomic architecture of human neurodegeneration

Jager, P. L. D., Yang, H., & Bennett, D. A. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0240-z · Cited by 46

Strategies for Neuroprotection in Multiple Sclerosis and the Role of Calcium

Enders, M., Heider, T., Ludwig, A., & Küerten, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051663 · Cited by 45

Variants in several genomic regions associated with asperger disorder

Salyakina, D., Ma, D. Q., Jaworski, J. M., Konidari, I., Whitehead, P. L., Henson, R., Martinez, D. M., Robinson, J. L., Sacharow, S. J., Wright, H. H., et al. (2010) · Autism Research · doi:10.1002/aur.158 · Cited by 44

Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus

Mero, I.-L., Ban, M., Lorentzen, Å. R., Smestad, C., Celius, E. G., Sæther, H. S., Saeedi, H., Viken, M. K., Skinningsrud, B., Undlien, D. E., et al. (2010) · Genes and Immunity · doi:10.1038/gene.2010.59 · Cited by 44

Replication of KIF21B as a susceptibility locus for multiple sclerosis: Table 1

Goris, A., Boonen, S., D'hooghe, M. B., & Dubois, B. (2010) · Journal of Medical Genetics · doi:10.1136/jmg.2009.075911 · Cited by 43

Epstein-barr virus in multiple sclerosis

Bagert, B. A. (2009) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-009-0059-9 · Cited by 43

Pathogenic mechanisms and experimental models of multiple sclerosis

Slavin, A., Modis, L. K., Labadia, M. E., Ryan, K. R., & Brown, M. L. (2010) · Autoimmunity · doi:10.3109/08916931003674733 · Cited by 45

A Sardinian Map for Multiple Sclerosis

Cossu, D., Masala, S., & Sechi, L. A. (2013) · Future Microbiology · doi:10.2217/fmb.12.135 · Cited by 45

Multiple sclerosis associates with LILRA3 deletion in Spanish patients

Ordóñez, D., Sánchez, A., Rodríguez, J., Cisneros, E., Ramil, E., Romo, N., Moraru, M., Munteis, E., López‐Botet, M., Roquer, J., et al. (2009) · Genes and Immunity · doi:10.1038/gene.2009.34 · Cited by 45

Potential Triggers of MS

Libbey, J. E., & Fujinami, R. S. (2009) · Results and problems in cell differentiation · doi:10.1007/400_2008_12 · Cited by 45

Expression analysis and functional activity of interleukin-7 splice variants

Vudattu, N. K., Magalhaes, I., Hoehn, H., Pan, D., & Maeurer, M. J. (2008) · Genes and Immunity · doi:10.1038/gene.2008.90 · Cited by 46

Study of the association between the CAPSL-IL7R locus and type 1 diabetes

Santiago, J. L., Alizadeh, B. Z., Martínez, A., Espino‐Paisán, L., de la Calle, H., Fernández‐Arquero, M., Figueredo, M. A., de la Concha, E. G., Roep, B. O., Koeleman, B. P. C., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1070-4 · Cited by 44

Variation Within DNA Repair Pathway Genes and Risk of Multiple Sclerosis

Briggs, F. B. S., Goldstein, B. A., McCauley, J. L., Zuvich, R. L., Jager, P. L. D., Rioux, J. D., Ivinson, A. J., Compston, A., Hafler, D. A., Hauser, S. L., et al. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq086 · Cited by 43

Systems biology approach to late‐onset Alzheimer's disease genome‐wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments

Mukherjee, S., Russell, J. C., Carr, D. T., Burgess, J. D., Allen, M., Serie, D. J., Boehme, K. L., Kauwe, J. S. K., Naj, A. C., Fardo, D. W., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.01.016 · Cited by 39

The interleukin‐7 receptor α chain contributes to altered homeostasis of regulatory T cells in multiple sclerosis

Haas, J., Korporal, M., Schwarz, A., Balint, B., & Wildemann, B. (2010) · European Journal of Immunology · doi:10.1002/eji.201041139 · Cited by 44

Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: mechanisms implicated

Perez‐Nievas, B. G., García‐Bueno, B., Madrigal, J. L. M., & Leza, J. C. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-60 · Cited by 43

The Genetics of Juvenile Idiopathic Arthritis: What Is New in 2010?

Angeles‐Han, S. T., & Prahalad, S. (2010) · Current Rheumatology Reports · doi:10.1007/s11926-010-0087-0 · Cited by 43

Role of dimethyl fumarate in oxidative stress of multiple sclerosis: A review

Suneetha, A., & Rajeswari, K. R. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.02.010 · Cited by 46

Genetic architecture differences between pediatric and adult-onset inflammatory bowel diseases in the Polish population

Ostrowski, J., Paziewska, A., Łazowska‐Przeorek, I., Ambrożkiewicz, F., Goryca, K., Kulecka, M., Rawa, T., Karczmarski, J., Dąbrowska, M., Żeber‐Lubecka, N., et al. (2016) · Scientific Reports · doi:10.1038/srep39831 · Cited by 43

Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

Huckins, L. M., Hatzikotoulas, K., Southam, L., Thornton, L. M., Steinberg, J., Aguilera-McKay, F., Treasure, J. L., Schmidt, U., Gunasinghe, C., Romero, A., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.88 · Cited by 44

Anti-heart autoantibodies in familial dilated cardiomyopathy

Caforio, A. L. P., Vinci, A., & Iliceto, S. (2008) · Autoimmunity · doi:10.1080/08916930802031546 · Cited by 44

Multiple Sclerosis and Autoimmunity: A Veiled Relationship

Barkhane, Z., Elmadi, J., Kumar, L. S., Pugalenthi, L. S., Ahmad, M., & Reddy, S. (2022) · Cureus · doi:10.7759/cureus.24294 · Cited by 44

Investigation of selected cytokine genes suggests that IL2RA and the TNF / LTA locus are risk factors for severe alopecia areata

Redler, S., Albert, F., Brockschmidt, F. F., Herold, C., Hanneken, S., Eigelshoven, S., Giehl, K. A., Kruse, R., Lutz, G., Wolff, H., et al. (2012) · British Journal of Dermatology · doi:10.1111/bjd.12004 · Cited by 42

The Role of Distinct Subsets of Macrophages in the Pathogenesis of MS and the Impact of Different Therapeutic Agents on These Populations

Radandish, M., Khalilian, P., & Esmaeil, N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.667705 · Cited by 41

Gene–environment interactions between HLA B7/A2, EBV antibodies are associated with MRI injury in multiple sclerosis

Zivadinov, R., Weinstock‐Guttman, B., Zorzon, M., Uxa, L., Serafin, M., Bosco, A., Bratina, A., Maggiore, C., Grop, A., Tommasi, M. A., et al. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.01.023 · Cited by 42

Refining the association of MHC with multiple sclerosis in African Americans

McElroy, J. P., Cree, B., Caillier, S. J., Gregersen, P. K., Herbert, J., Khan, O. A., Freudenberg, J., Lee, A., Bridges, S. L., Hauser, S. L., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq197 · Cited by 41

Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

Verma, A. (2008) · Yearbook of Neurology and Neurosurgery · doi:10.1016/s0513-5117(08)79017-3 · Cited by 42

Daclizumab (anti-CD25) in multiple sclerosis

Pfender, N., & Martinꝉ, R. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.04.015 · Cited by 44

IL7RA polymorphisms and chronic inflammatory arthropathies

O’Doherty, C., Alloza, I., Rooney, M., & Vandenbroeck, K. (2009) · Tissue Antigens · doi:10.1111/j.1399-0039.2009.01342.x · Cited by 42

Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection

Vandenbroeck, K., Alloza, I., Swaminathan, B., Antigüedad, A. R., Otaegui, D., Olascoaga, J., Barcina, M. G., Heras, V. D. L., Bartolomé, M., Fernández‐Arquero, M., et al. (2010) · Genes and Immunity · doi:10.1038/gene.2010.46 · Cited by 41

Cell-Based Modulation of Autoimmune Responses in Multiple Sclerosis and Experimental Autoimmmune Encephalomyelitis: Therapeutic Implications

Mastorodemos, V. C., Ιωάννου, Μ., & Verginis, P. (2014) · NeuroImmunoModulation · doi:10.1159/000362370 · Cited by 41

What Do Effective Treatments for Multiple Sclerosis Tell Us about the Molecular Mechanisms Involved in Pathogenesis?

Buzzard, K. A., Broadley, S., & Butzkueven, H. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131012665 · Cited by 51

Treating multiple sclerosis with monoclonal antibodies

Buttmann, M., & Rieckmann, P. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.3.433 · Cited by 41

Lipoprotein markers associated with disability from multiple sclerosis

Gafson, A. R., Thorne, T., McKechnie, C. I. J., Jimenez, B., Nicholas, R., & Matthews, P. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-35232-7 · Cited by 40

The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis

Peerlings, D. E. M., Mimpen, M., & Damoiseaux, J. G. M. C. (2021) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2021.100123 · Cited by 45

Crosstalk between dendritic cells and regulatory T cells: Protective effect and therapeutic potential in multiple sclerosis

Li, R., Li, H., Yang, X., Hu, H., Liu, P., & Liu, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.970508 · Cited by 42

Replication of top markers of a genome-wide association study in multiple sclerosis in Spain

Cavanillas, M. L., Fernández, Ó., Comabella, M., Alcina, A., Fedetz, M., Izquierdo, G., Lucas, M., Cénit, M. C., Arroyo, R., Vandenbroeck, K., et al. (2010) · Genes and Immunity · doi:10.1038/gene.2010.52 · Cited by 40

Comparing the CNS morphology and immunobiology of different EAE models in C57BL/6 mice – A step towards understanding the complexity of multiple sclerosis

Kuerten, S., & Angelov, D. N. (2008) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2007.11.001 · Cited by 40

Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus

Leikfoss, I. S., Mero, I.-L., Dahle, M. K., Lie, B. A., Harbo, H. F., Spurkland, A., & Berge, T. (2012) · Genes and Immunity · doi:10.1038/gene.2012.52 · Cited by 40

Genetic burden in multiple sclerosis families

Isobe, N., Damotte, V., Re, V. L., Ban, M., Pappas, D. J., Guillot‐Noël, L., Cournu‐Rebeix, I., Compston, A., Mack, T. M., Cozen, W., et al. (2013) · Genes and Immunity · doi:10.1038/gene.2013.37 · Cited by 38

Association of the Protein Tyrosine Phosphatase Nonreceptor 22 Haplotypes with Autoimmune Thyroid Disease in the Japanese Population

Ban, Y., Tozaki, T., Taniyama, M., Nakano, Y., Ban, Y., Ban, Y., & Hirano, T. (2010) · Thyroid · doi:10.1089/thy.2010.0104 · Cited by 39

The Genetics of Multiple Sclerosis

Didonna, A., & Oksenberg, J. R. (2017) · Codon Publications eBooks · doi:10.15586/codon.multiplesclerosis.2017.ch1 · Cited by 44

Interleukin-7 is required for CD4 + T cell activation and autoimmune neuroinflammation

Lawson, B. R., González‐Quintial, R., Eleftheriadis, T., Farrar, M. A., Miller, S. D., Sauer, K., McGavern, D. B., Kono, D. H., Baccalà, R., & Theofilopoulos, A. N. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.08.007 · Cited by 41

Opposing functions of IL-2 and IL-7 in the regulation of immune responses

Katzman, S. D., Hoyer, K. K., Dooms, H., Gratz, I. K., Rosenblum, M. D., Paw, J. S., Osum, S. H., & Abbas, A. K. (2011) · Cytokine · doi:10.1016/j.cyto.2011.07.005 · Cited by 41

Immunologic Aspects of Multiple Sclerosis

Boppana, S., Huang, H., Ito, K., & Dhib-Jalbut, S. S. (2011) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20249 · Cited by 40

Genetic association analysis: a primer on how it works, its strengths and its weaknesses

Rodriguez‐Murillo, L., & Greenberg, D. A. (2008) · International Journal of Andrology · doi:10.1111/j.1365-2605.2008.00896.x · Cited by 41

Old Suspects Found Guilty — The First Genome Profile of Multiple Sclerosis

Peltonen, L. (2007) · New England Journal of Medicine · doi:10.1056/nejme078147 · Cited by 40

Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes

Caron, B., Patin, É., Rotival, M., Charbit, B., Albert, M. L., Quintana‐Murci, L., Duffy, D., Rausell, A., Abel, L., Alcover, A., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01032-y · Cited by 43

Shared Molecular and Functional Frameworks among Five Complex Human Disorders: A Comparative Study on Interactomes Linked to Susceptibility Genes

Menon, R., & Farina, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018660 · Cited by 39

Exploiting differential expression of the IL-7 receptor on memory T cells to modulate immune responses

Zaunders, J., Lévy, Y., & Seddiki, N. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.012 · Cited by 39

Gender Disparities in Ocular Inflammatory Disorders*

Sen, H. N., Davis, J. L., Uçar, D., Fox, A. R., Chan, C. C., & Goldstein, D. A. (2014) · Current Eye Research · doi:10.3109/02713683.2014.932388 · Cited by 41

Circulating dendritic cells of multiple sclerosis patients are proinflammatory and their frequency is correlated with MS-associated genetic risk factors

Thewissen, K., Nuyts, A. H., Deckx, N., Wijmeersch, B. V., Nagels, G., D'hooghe, M. B., Willekens, B. M. P., Cras, P. P., Eijnde, B. O., Goossens, H., et al. (2013) · Multiple Sclerosis Journal · doi:10.1177/1352458513505352 · Cited by 39

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients

Downes, K., Marcovecchio, M. L., Pamela, C., Cooper, J. D., Ferreira, R. C., Howson, J. M. M., Jolley, J., Nutland, S. L., Stevens, H. E., Walker, N. M., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-3113-8 · Cited by 38

Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus

Monti, P., Heninger, A., & Bonifacio, E. E. (2009) · Current Diabetes Reports · doi:10.1007/s11892-009-0020-y · Cited by 39

Epistasis

Ramagopalan, S. V., & Ebers, G. C. (2009) · Neurology · doi:10.1212/01.wnl.0000341941.24967.e6 · Cited by 39

The efficacy and safety of daclizumab and its potential role in the treatment of multiple sclerosis

Milo, R. (2014) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285613504021 · Cited by 38

Immune Regulatory Functions of Macrophages and Microglia in Central Nervous System Diseases

Poppell, M., Hammel, G., & Ren, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065925 · Cited by 39

HLA-DRB1*1501 and Spinal Cord Magnetic Resonance Imaging Lesions in Multiple Sclerosis

Sombekke, M. H., Lukas, C., Crusius, J. B. A., Tejedor, D., Killestein, J., Arteta, D., Martínez, A., Uitdehaag, B. M. J., Knol, D. L., Peña, A. S., et al. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.278 · Cited by 37

Fingolimod alters the transcriptome profile of circulating CD4+ cells in multiple sclerosis

Friess, J., Hecker, M., Roch, L., Koczan, D., Fitzner, B., Angerer, I. C., Schröder, I., Flechtner, K., Thiesen, H., Winkelmann, A., et al. (2017) · Scientific Reports · doi:10.1038/srep42087 · Cited by 41

Environmental Influencers, MicroRNA, and Multiple Sclerosis

Mohammed, E. M. A. (2020) · Journal of Central Nervous System Disease · doi:10.1177/1179573519894955 · Cited by 39

Genetically determined myocarditis: clinical presentation and immunological characteristics

Caforio, A. L. P., & Iliceto, S. (2008) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3282fbf572 · Cited by 37

The dual nature of neuroinflammation in networked brain

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Polymorphisms in the IL2RA and IL2RB Genes in Inflammatory Bowel Disease Risk

Bouzid, D., Amouri, A., Fourati, H., Marques, I., Abida, O., Tahri, N., Penha‐Gonçalves, C., & Masmoudi, H. (2013) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2013.0291 · Cited by 37

Epistasis and immunity: the role of genetic interactions in autoimmune diseases

Rose, A. M., & Bell, L. C. K. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03623.x · Cited by 40

Genetics of multiple sclerosis

Hoppenbrouwers, I. A., & Hintzen, R. Q. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.09.017 · Cited by 39

Genetic variants in IL2RA and IL7R affect multiple sclerosis disease risk and progression

Traboulsee, A. L., Bernales, C. Q., Ross, J. P., Lee, J. D., Sadovnick, A. D., & Vilariño‐Güell, C. (2014) · Neurogenetics · doi:10.1007/s10048-014-0403-3 · Cited by 41

ALCAM and CD6 — multiple sclerosis risk factors

Wagner, M., Bilińska, M. M., Pokryszko‐Dragan, A., Sobczyński, M., Cyrul, M., Kuśnierczyk, P., & Jasek, M. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.08.621 · Cited by 37

Smoking is associated with increased disease activity during natalizumab treatment in multiple sclerosis

Petersen, E. R., Søndergaard, H. B., Laursen, J. H., Olsson, A., Börnsen, L. S., Sørensen, P. S., Sellebjerg, F. T., & Oturai, A. B. (2018) · Multiple Sclerosis Journal · doi:10.1177/1352458518791753 · Cited by 37

Interpreting Non-coding Genetic Variation in Multiple Sclerosis Genome-Wide Associated Regions

Paraboschi, E. M., Cardamone, G., Soldà, G., Duga, S., & Asselta, R. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00647 · Cited by 37

Changes in Th17 cells frequency and function after ozone therapy used to treat multiple sclerosis patients

Izadi, M., Tahmasebi, S., Pustokhina, I., Yumashev, A. V., Lakzaei, T., Alvanegh, A. G., Roshangar, L., Dadashpour, M., Yousefi, M., & Ahmadi, M. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102466 · Cited by 37

In Vivo Enhancement of Peptide Display by MHC Class II Molecules with Small Molecule Catalysts of Peptide Exchange

Call, M. J., Xing, X., Cuny, G. D., Seth, N. P., Altmann, D. M., Fugger, L. H., Krogsgaard, M., Stein, R. L., & Wucherpfennig, K. W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803464 · Cited by 37

‘Drug Reactions, Enzymes, and Biochemical Genetics‘: 50 years Later

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Multiple sclerosis is prominent in the Gulf states: Review

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Epstein-Barr Virus and Multiple Sclerosis

Lünemann, J. D., & Münz, C. (2007) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-007-0038-y · Cited by 36

Chemotherapeutics in the treatment of multiple sclerosis

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Tracing environmental markers of autoimmunity: introducing the infectome

Bogdanos, D. P., Smyk, D. S., Invernizzi, P., Rigopoulou, E. I., Blank, M., Sakkas, L. I., Pouria, S., & Shoenfeld, Y. (2013) · Immunologic Research · doi:10.1007/s12026-013-8399-6 · Cited by 38

Association of SNPs of CD40 Gene with Multiple Sclerosis in Russians

Sokolova, E. А., Malkova, N. A., Korobko, D. S., Rozhdestvenskiĭ, A. S., Kakulya, A. V., Ханох, Е. В., Ra, D., Платонов, Ф. А., Popova, T., Геннадьевна, А. Е., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061032 · Cited by 36

Plasmacytoid dendritic cells in multiple sclerosis: Chemokine and chemokine receptor modulation by interferon-beta

Aung, L. L., Fitzgerald-Bocarsly, P. A., Dhib-Jalbut, S. S., & Balashov, K. E. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.06.008 · Cited by 38

Clear and independent associations of several HLA-DRB1 alleles with differential antibody responses to hepatitis B vaccination in youth

Li, Y., Ni, R., Song, W., Shao, W., Shrestha, S., Ahmad, S., Cunningham, C. K., Flynn, P. M., Kapogiannis, B. G., Wilson, C. M., et al. (2009) · Human Genetics · doi:10.1007/s00439-009-0720-z · Cited by 36

The major cause of multiple sclerosis is environmental: genetics has a minor role - Yes

Taylor, B. V. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511421105 · Cited by 36

Autoimmunity risk alleles in costimulation pathways

Maier, L. M., & Hafler, D. A. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00777.x · Cited by 36

News in brief

(2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70214-4

Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

for the Multiple Sclerosis Genetics Group, Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., et al. (2007) · Nature Genetics · doi:10.1038/ng2103 · Cited by 657

Risk alleles for multiple sclerosis in multiplex families

D’Netto, M. J., Ward, H., Morrison, K., Ramagopalan, S. V., Dyment, D. A., DeLuca, G. C., Handunnetthi, L., Sadovnick, A. D., & Ebers, G. C. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a92c25 · Cited by 62

Decoding multiple sclerosis: an update on genomics and future directions

Oksenberg, J. R. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.865867 · Cited by 66

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

Zuvich, R. L., McCauley, J. L., Oksenberg, J. R., Sawcer, S. J., Jager, P. L. D., Aubin, C., Cross, A. H., Piccio, L. M., Aggarwal, N. T., Evans, D. A., et al. (2010) · Human Genetics · doi:10.1007/s00439-010-0789-4 · Cited by 65