Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969

A haplotype map of the human genome

The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858

The Future of Genetic Studies of Complex Human Diseases

Risch, N., & Merikangas, K. (1996) · Science · doi:10.1126/science.273.5281.1516 · Cited by 5,355

Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”

Polman, C. H., Reingold, S. C., Edan, G., Filippi, M., Hartung, H., Kappos, L., Lublin, F. D., Metz, L. M., McFarland, H. F., O'Connor, P. W., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20703 · Cited by 5,017

Axonal transection in the lesions of multiple sclerosis

Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039

A genome-wide association study identifies novel risk loci for type 2 diabetes

Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., et al. (2007) · Nature · doi:10.1038/nature05616 · Cited by 2,993

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753

Revised diagnostic criteria for neuromyelitis optica

Wingerchuk, D. M., Lennon, V. A., Pittock, S. J., Lucchinetti, C. F., & Weinshenker, B. G. (2006) · Neurology · doi:10.1212/01.wnl.0000216139.44259.74 · Cited by 2,568

Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis

Benešová, Y., Vašků, A., Štourač, P., Hladíková, M., Fiala, A., & Bednařík, J. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.10.014 · Cited by 28

Characterization of Multiple Sclerosis candidate gene expression kinetics in rat experimental autoimmune encephalomyelitis

Hedreul, M. T., Gillett, A., Olsson, T. P., Jagodic, M., & Harris, R. A. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.02.010 · Cited by 28

IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients

Couturier, N., Gourraud, P., Cournu‐Rebeix, I., Gout, C., Bucciarelli, F., Edan, G., Babron, M., Clerget‐Darpoux, F., Clanet, M., Fontaine, B., et al. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.259 · Cited by 27

Tempol ameliorates murine viral encephalomyelitis by preserving the blood–brain barrier, reducing viral load, and lessening inflammation

Tsuhako, M. H., Augusto, O., Linares, E., Chadi, G., Giorgio, S., & Pereira, C. A. D. B. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.013 · Cited by 28

Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CLBL genes

Varadé, J., Comabella, M., Ortiz, M. A., Arroyo, R., Fernández, O., Pinto-Medel, M. J., Fedetz, M., Izquierdo, G., Lucas, M., Gómez, C. L., et al. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458511432741 · Cited by 28

Effects of Acupuncture on Gait of Patients with Multiple Sclerosis

Criado, M. B., Santos, M. J., Machado, J. P., Gonçalves, A. M., & Greten, H. J. (2017) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2016.0355 · Cited by 30

HLA and non-HLA genes and familial predisposition to autoimmune diseases in families with a child affected by type 1 diabetes

Parkkola, A., Laine, A., Karhunen, M., Härkönen, T., Ryhänen, S. J., Ilonen, J., Knip, M., & Register, T. F. P. D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188402 · Cited by 28

The influence of the HLA‐DRB1 and HLA‐DQB1 allele heterogeneity on disease risk and severity in Iranian patients with multiple sclerosis

Kollaee, A., Ghaffarpor, M., Ghlichnia, H. A., Ghaffari, S. H., & Zamani, M. (2012) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2012.01104.x · Cited by 28

Splicing Regulation of Pro-Inflammatory Cytokines and Chemokines: At the Interface of the Neuroendocrine and Immune Systems

Shakola, F., Suri, P., & Ruggiu, M. (2015) · Biomolecules · doi:10.3390/biom5032073 · Cited by 28

Single nucleotide polymorphism in the MMP-9 gene is associated with susceptibility to develop multiple sclerosis in an Italian case-control study

Russa, A. L., Cittadella, R., Marco, E. V. D., Valentino, P., Andreoli, V., Trecroci, F., Latorre, V., Gambardella, A., & Quattrone, A. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.04.016 · Cited by 28

Fine Mapping and Functional Analysis of the Multiple Sclerosis Risk Gene CD6

Swaminathan, B., Cuapio, A., Alloza, I., Matesanz, F., Alcina, A., García‐Barcina, M., Fedetz, M., Fernández, Ó., Lucas, M., Órpez, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062376 · Cited by 30

Genetic loci linked to Type 1 Diabetes and Multiple Sclerosis families in Sardinia

Pitzalis, M., Zavattari, P., Murru, R., Deidda, E., Żołędziewska, M., Murru, D., Moi, L., Motzo, C., Orrù, V., Costa, G., et al. (2008) · BMC Medical Genetics · doi:10.1186/1471-2350-9-3 · Cited by 30

The variant methylenetetrahydrofolate reductase c.1298A>C (p.E429A) is associated with multiple sclerosis in a German case-control study

Klotz, L., Farkas, M., Bain, N., Keskitalo, S., Semmler, A., Ineichen, B. V., Jelčić, I., Klockgether, T., Kölsch, H., Weller, M., et al. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.10.057 · Cited by 28

Exploring the roles of CD8+ T lymphocytes in the pathogenesis of autoimmune demyelination

Johnson, T., Jirik, F. R., & Fournier, S. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0199-7 · Cited by 25

Immunologic mechanisms of multiple sclerosis.

Frohman, E., Eagar, T., Monson, N., Stüve, O., & Karandikar, N. (2008) · Neuroimaging clinics of North America · doi:10.1016/j.nic.2008.06.009 · Cited by 29

Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients

Schmied, M. C., Zehetmayer, S., Reindl, M., Ehling, R., Bajer-Kornek, B., Leutmezer, F., Zebenholzer, K., Hotzy, C., Lichtner, P., Meitinger, T., et al. (2012) · Neurogenetics · doi:10.1007/s10048-012-0316-y · Cited by 29

HLA-DQB1*0602 Determines Disease Susceptibility in a New “Humanized” Multiple Sclerosis Model in HLA-DR15 (DRB1*1501;DQB1*0602) Transgenic Mice

Kaushansky, N., Altmann, D. M., Ascough, S., David, C. S., Lassmann, H., & Ben‐Nun, A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900784 · Cited by 28

Genetic variation in the geneLRP2increases relapse risk in multiple sclerosis

Zhou, Y., Graves, J. S., Simpson, S., Charlesworth, J., van der Mei, I. A. F., Waubant, E. L., Barcellos, L. F., Belman, A. L., Krupp, L., Lucas, R. M., et al. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-315971 · Cited by 28

Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species

Rainbow, D. B., Esposito, L., Howlett, S., Hunter, K. M. D., Todd, J. A., Peterson, L. B., & Wicker, L. S. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360312 · Cited by 29

HLA-DRB1*15 allele influences the later course of relapsing remitting multiple sclerosis

Cournu‐Rebeix, I., Génin, E., Leray, E., Babron, M., Cohen, J. F., Gout, C., Alizadeh, M., Perdry, H., Sémana, G., Brassat, D., et al. (2008) · Genes and Immunity · doi:10.1038/gene.2008.52 · Cited by 29

Is the risk of multiple sclerosis related to the ‘biography’ of the immune system?

Krone, B., Oeffner, F., & Grange, J. M. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5068-8 · Cited by 28

IL2RA Gene Polymorphism rs2104286 A>G Seen in Multiple Sclerosis Is Associated with Intermediate Uveitis: Possible Parallel Pathways?

Lindner, E., Weger, M., Steinwender, G., Griesbacher, A., Posch, U., Ulrich, S., Wegscheider, B. J., Ardjomand, N., & El‐Shabrawi, Y. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8163 · Cited by 28

Daclizumab Therapy for Multiple SclerosisPreprint

Bielekova, B. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a034470 · Cited by 28

Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis

Alcina, A., Fernández, Ó., Gonzalez, J. R., Catalá-Rabasa, A., Fedetz, M., Ndagire, D., Leyva, L., Guerrero, M., Arnal, C., Delgado, C., et al. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.240 · Cited by 27

Genetics in primary sclerosing cholangitis

Folseraas, T., Melum, E., Franke, A., & Karlsen, T. H. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.09.010 · Cited by 27

Neurodevelopmental MACPFs: The vertebrate astrotactins and BRINPs

Berkowicz, S., Giousoh, A., & Bird, P. I. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.05.005 · Cited by 28

MS in self-identified Hispanic/Latino individuals living in the US

Amezcua, L., Oksenberg, J. R., & McCauley, J. L. (2017) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/2055217317725103 · Cited by 28

CLEC16A—An Emerging Master Regulator of Autoimmunity and Neurodegeneration

Pandey, R., Bakay, M. A., & Hakonarson, H. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098224 · Cited by 30

More CLEC16A gene variants associated with multiple sclerosis

Nischwitz, S., Cepok, S., Kroner, A., Wolf, C., Knop, M., Müller‐Sarnowski, F., Pfister, H., Rieckmann, P., Hemmer, B., Ising, M., et al. (2010) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2010.01421.x · Cited by 28

Identity-by-Descent Mapping to Detect Rare Variants Conferring Susceptibility to Multiple Sclerosis

Lin, R., Charlesworth, J., Stankovich, J. M., Perreau, V. M., Brown, M. A., & Taylor, B. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056379 · Cited by 27

Defining a new biomarker for the autoimmune component of Multiple Sclerosis: Th40 cells

Waid, D., Schreiner, T., Vaitaitis, G. M., Carter, J. R., Corboy, J. R., & Wagner, D. H. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.03.009 · Cited by 27

Custom CGH array profiling of copy number variations (CNVs) on chromosome 6p21.32 (HLA locus) in patients with venous malformations associated with multiple sclerosis

Ferlini, A., Bovolenta, M., Neri, M., Gualandi, F., Balboni, A., Yuryev, A., Salvi, F., Gemmati, D., Liboni, A., & Zamboni, P. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-64 · Cited by 27

Mesenchymal Stromal/Stem Cells Do Not Ameliorate Experimental Autoimmune Encephalomyelitis and Are Not Detectable in the Central Nervous System of Transplanted Mice

Abramowski, P., Krasemann, S., Ernst, T., Lange, C., Ittrich, H., Schweizer, M., Zander, A. R., Martinꝉ, R., & Fehse, B. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0020 · Cited by 29

Variants in the IL7RA gene confer susceptibility to multiple sclerosis in Caucasians: evidence based on 9734 cases and 10436 controls

Liu, H., Huang, J., Dou, M., Liu, Y., Xiao, B., Liu, X., & Huang, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-01345-8 · Cited by 28

A pharmacogenetic signature of high response to Copaxone in late-phase clinical-trial cohorts of multiple sclerosis

Ross, C. J., Towfic, F., Shankar, J., Laifenfeld, D., Thoma, M., Davis, M., Weiner, B., Kusko, R. L., Zeskind, B., Knappertz, V. A., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0436-y · Cited by 27

Genetic and gene expression signatures in multiple sclerosis

Patsopoulos, N. A., & Jager, P. L. D. (2020) · Multiple Sclerosis Journal · doi:10.1177/1352458519898332 · Cited by 27

IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups

Elghzaly, A. A., Metwally, S. S., El-Chennawi, F. A., Gayyar, M. A. E., Mosaad, Y. M., Eltoraby, E., Hegab, M. M., & Ibrahim, S. M. (2015) · Human Immunology · doi:10.1016/j.humimm.2015.06.001 · Cited by 27

The rs2030324 SNP of brain-derived neurotrophic factor (BDNF) is associated with visual cognitive processing in multiple sclerosis

Weinstock‐Guttman, B., Benedict, R. H. B., Tamaño‐Blanco, M., Ramasamy, D. P., Stosic, M., Polito, J., Zivadinov, R., & Ramanathan, M. K. (2010) · Pathophysiology · doi:10.1016/j.pathophys.2010.04.005 · Cited by 27

CCL genes in multiple sclerosis and systemic lupus erythematosus

Vyshkina, T., Sylvester, A., Sadiq, S. A., Bonilla, E., Perl, A., & Kálmán, B. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.05.016 · Cited by 26

Genome-wide association studies in multiple sclerosis: lessons and future prospects

Kemppinen, A., Sawcer, S. J., & Compston, A. (2011) · Briefings in Functional Genomics · doi:10.1093/bfgp/elr004 · Cited by 27

T helper cell- and CD40-dependent germline IgM prevents chronic virus-induced demyelinating disease

Gil‐Cruz, C., Perez‐Shibayama, C., Firner, S., Waisman, A., Bechmann, I., Thiel, V., Cervantes‐Barragán, L., & Ludewig, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115154109 · Cited by 26

Multiple loci comprising immune-related genes regulate experimental neuroinflammation

Marta, M., Stridh, P., Bečanović, K., Gillett, A., Öckinger, J., Lorentzen, J. C., Jagodic, M., & Olsson, T. P. (2009) · Genes and Immunity · doi:10.1038/gene.2009.62 · Cited by 26

Genomic, proteomic, and systems biology approaches in biomarker discovery for multiple sclerosis

Huizar, C. C., Raphael, I., & Forsthuber, T. G. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104219 · Cited by 26

TRPV1 Gates Tissue Access and Sustains Pathogenicity in Autoimmune Encephalitis

Paltser, G., Liu, X. J., Yantha, J., Winer, S., Tsui, H., Wu, P., Maezawa, Y., Cahill, L. S., Laliberté, C. L., Ramagopalan, S. V., et al. (2013) · Molecular Medicine · doi:10.2119/molmed.2012.00329 · Cited by 26

SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients

McElroy, J., Isobe, N., Gourraud, P., Caillier, S. J., Matsushita, T., Kohriyama, T., Miyamoto, K., Nakatsuji, Y., Miki, T., Hauser, S. L., et al. (2011) · Genes and Immunity · doi:10.1038/gene.2011.25 · Cited by 26

Using prior knowledge and genome-wide association to identify pathways involved in multiple sclerosis

Ritchie, M. D. (2009) · Genome Medicine · doi:10.1186/gm65 · Cited by 26

Genes associated with multiple sclerosis: 15 and counting

Habek, M., Brinar, V. V., & Borovečki, F. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.77 · Cited by 28

Further understanding of the immunopathology of multiple sclerosis: impact on future treatments

Bhise, V. V., & Dhib-Jalbut, S. S. (2016) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2016.1191351 · Cited by 28

Decrease of blood anti-α1,3 Galactose Abs levels in multiple sclerosis (MS) and clinically isolated syndrome (CIS) patients

Berre, L. L., Rousse, J., Gourraud, P., Imbert‐Marcille, B., Salama, A., Evanno, G., Sémana, G., Nicot, A. B., Dugast, E., Guérif, P., et al. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.05.006 · Cited by 26

The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility

Bahreini, S. A., Jabalameli, M. R., Saadatnia, M., & Zahednasab, H. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.08.002 · Cited by 27

Heightened Epstein-Barr virus immunity and potential cross-reactivities in multiple sclerosis

Thomas, O. G., Haigh, T. A., Croom-Carter, D. S. G., Leese, A. M., van Wijck, Y., Douglas, M. R., Rickinson, A. B., Brooks, J. M., & Taylor, G. S. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012177 · Cited by 25

Next generation sequencing for neurological diseases: New hope or new hype?

Keogh, M. J., & Chinnery, P. F. (2012) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2012.09.030 · Cited by 25

IL7Rα Contributes to Experimental Autoimmune Encephalomyelitis through Altered T Cell Responses and Nonhematopoietic Cell Lineages

Ashbaugh, J. J., Brambilla, R., Karmally, S., Cabello, C., Malek, T. R., & Bethea, J. R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203214 · Cited by 26

On the covariance of two correlated log‐odds ratios

Bagos, P. G. (2012) · Statistics in Medicine · doi:10.1002/sim.4474 · Cited by 25

Emerging Roles of Long Non-coding RNAs in Chronic Neuropathic Pain

Wu, W., Ji, X., & Zhao, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01097 · Cited by 25

Altered Plasma Metabolic Profiles in Chinese Patients With Multiple Sclerosis

Yang, F., Wu, S., Ling, Z., Shan, C., Zhang, L., Yan, X., He, L., Yu, L., & Zhao, N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.792711 · Cited by 25

Genetics of primary progressive multiple sclerosis

Cree, B. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52001-2.00042-x · Cited by 27

Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells

Leikfoss, I., Keshari, P., Gustavsen, M., Bjølgerud, A., Brorson, I. S., Celius, E., Spurkland, A., Bos, S., Harbo, H., & Berge, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132957 · Cited by 23

Meta-Analysis of Multiple Sclerosis Microarray Data Reveals Dysregulation in RNA Splicing Regulatory Genes

Paraboschi, E. M., Cardamone, G., Rimoldi, V., Gemmati, D., Spreafico, M., Duga, S., Soldà, G., & Asselta, R. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161023463 · Cited by 25

Protective role of the HLA–A*02 allele in Portuguese patients with multiple sclerosis

da Silva, B. M., Bettencourt, A., Pereira, C., Santos, E., Carvalho, C., Mendonça, D. M., Costa, P., Monteiro, L., & Martins, B. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509104588 · Cited by 25

Long-term daclizumab therapy in relapsing-remitting multiple sclerosis

Rojas, M. A., Carlson, N. G., Miller, T. L., & ROSE, J. W. (2009) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285609337992 · Cited by 25

Obesity Genes and Gene–Environment–Behavior Interactions: Recommendations for a Way Forward

Shuldiner, A. R. (2008) · Obesity · doi:10.1038/oby.2008.523 · Cited by 25

T cells and microglia as drivers of multiple sclerosis pathology

Friese, M. A., & Fugger, L. H. (2007) · Brain · doi:10.1093/brain/awm246 · Cited by 26

The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis

Martin, J.-E., Carmona, F. D., Broen, J. C. A., Simeón‐Aznar, C. P., Vonk, M. C., Carreira, P. E., Ríos-Fernández, R., Espinosa, G., Vicente‐Rabaneda, E. F., Tolosa-Vilella, C., et al. (2011) · Genes and Immunity · doi:10.1038/gene.2011.72 · Cited by 25

Small RNA Regulators of T Cell-Mediated Autoimmunity

Jeker, L. T., & Bluestone, J. A. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9392-7 · Cited by 27

Accurate measurement of gene copy number for human alpha-defensin DEFA1A3

Khan, F. F., Carpenter, D., Mitchell, L., Mansouri, O. A., Black, H. A., Tyson, J., & Armour, J. A. L. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-719 · Cited by 26

Multiple Sclerosis Therapies: Molecular Mechanisms and Future

da Fontoura, P. P., & Garren, H. (2009) · Results and problems in cell differentiation · doi:10.1007/400_2010_36 · Cited by 23

Defective expression of apoptosis-related molecules in multiple sclerosis patients is normalized early after autologous haematopoietic stem cell transplantation

de Oliveira, G. L. V., Ferreira, A. F., Gasparotto, E. P. L., Kashima, S. H., Covas, D. T., Guerreiro, C. T., Brum, D. G., Barreira, A. A., Voltarelli, J. C., Simões, B. P., et al. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12895 · Cited by 25

The gut microbiota perspective for interventions in MS

Żołędziewska, M. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.03.016 · Cited by 25

Association to the Glypican-5 gene in multiple sclerosis

Lorentzen, Å. R., Melum, E., Ellinghaus, E., Smestad, C., Mero, I., Aarseth, J. H., Myhr, K., Celius, E. G., Lie, B. A., Karlsen, T. H., et al. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.07.003 · Cited by 25

Genetic determinants of diabetes are similarly associated with other immune-mediated diseases

Duffy, D. L. (2007) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e3282f1dc99 · Cited by 25

The Biology of Persistent Infection: Inflammation and Demyelination Following Murine Coronavirus Infection of the Central Nervous System

Hosking, M., & Lane, T. E. (2009) · Current Immunology Reviews · doi:10.2174/157339509789504005 · Cited by 27

Meta-analysis of the association of IL2RA polymorphisms rs2104286 and rs12722489 with multiple sclerosis risk

Wang, X., & Chen, T. (2018) · Immunological Investigations · doi:10.1080/08820139.2018.1425699 · Cited by 25

Interleukin-2 receptor-α proximal promoter hypomethylation is associated with multiple sclerosis

Field, J., Fox, A., Jordan, M. A., Baxter, A. G., Spelman, T. D., Gresle, M., Butzkueven, H., Kilpatrick, T. J., & Rubio, J. P. (2017) · Genes and Immunity · doi:10.1038/gene.2016.50 · Cited by 27

Association of genomic variants at the human leukocyte antigen locus with cervical cancer risk, HPV status and gene expression levels

Ramachandran, D., Schürmann, P., Mao, Q., Wang, Y., Bretschneider, L., Speith, L., Hülse, F., Enßen, J., Bousset, K., Jentschke, M., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.33171 · Cited by 24

Neuroinflammation: Extinguishing a blaze of T cells

Benallegue, N., Kébir, H., & Alvarez, J. I. (2022) · Immunological Reviews · doi:10.1111/imr.13122 · Cited by 25

Role of T cell—glial cell interactions in creating and amplifying central nervous system inflammation and multiple sclerosis disease symptoms

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Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese

Ainiding, G., Kawano, Y., Sato, S., Isobe, N., Matsushita, T., Yoshimura, S., Yonekawa, T., Yamasaki, R., Murai, H., & Kira, J. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.11.037 · Cited by 24

Interleukin 7 Receptor Alpha Chain Haplotypes Vary in Their Influence on Multiple Sclerosis Susceptibility and Response to Interferon Beta

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Progress in Multiple Sclerosis Genetics

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Ordóñez, G., Romero-Cordoba, S. L., Orozco, L., Pineda, B., Jiménez‐Morales, S., Nieto, A., Garcia‐Ortíz, H., & Sotelo, J. (2014) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2014.11.026 · Cited by 24

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Multiple single nucleotide polymorphisms in the first intron of the IL2RA gene affect transcription factor binding and enhancer activity

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Systems biology approaches for the study of multiple sclerosis

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An integrated approach to design novel therapeutic interventions for demyelinating disorders

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IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis

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Next-generation sequencing in understanding complex neurological disease

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The Impact of the Human Genome Project on Complex Disease

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XVI European Charcot Foundation lecture: Nutrition and environment, can MS be prevented?

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Dynamic changes in the regulatory T-cell heterogeneity and function by murine IL-2 mutein

Lu, D., Wu, H., Driver, I. H., Ingersoll, S. A., Sohn, S. J., Wang, S., Li, C.-M., & Phee, H. (2020) · Life Science Alliance · doi:10.26508/lsa.201900520 · Cited by 25

From DNA human sequence to the chromatin higher order organisation and its biological meaning: Using biomolecular interaction networks to understand the influence of structural variation on spatial genome organisation and its functional effect

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The current standing of autologous haematopoietic stem cell transplantation for the treatment of multiple sclerosis

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Haplotype-based approach to known MS-associated regions increases the amount of explained risk

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Single nucleotide polymorphisms in multiple sclerosis: disease susceptibility and treatment response biomarkers

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Expression and Cellular Distribution of the Interleukin 2 Signaling System in Cortical Lesions From Patients With Focal Cortical Dysplasia

Guo, W., Zheng, D.-H., Sun, F., Yang, J.-Y., Zang, Z.-L., Liu, S., Yin, Q., Zhang, C., & Yang, H. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000042 · Cited by 23

Increasing Incidence in Relapsing-Remitting MS and High Rates among Young Women in Finland: A Thirty-Year Follow-Up

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Association Study of ITGAM, ITGAX, and CD58 Autoimmune Risk Loci in Systemic Sclerosis: Results from 2 Large European Caucasian Cohorts

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The genetic basis of multiple sclerosis: a model for MS susceptibility

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News in brief

(2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70214-4

Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

for the Multiple Sclerosis Genetics Group, Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., et al. (2007) · Nature Genetics · doi:10.1038/ng2103 · Cited by 657

Risk alleles for multiple sclerosis in multiplex families

D’Netto, M. J., Ward, H., Morrison, K., Ramagopalan, S. V., Dyment, D. A., DeLuca, G. C., Handunnetthi, L., Sadovnick, A. D., & Ebers, G. C. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a92c25 · Cited by 62

Decoding multiple sclerosis: an update on genomics and future directions

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Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

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