Cited by 1,746Multiple Sclerosis Research StudiesGenetic Associations and EpidemiologyPsoriasis: Treatment and Pathogenesis

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Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

The International Multiple Sclerosis Genetics Consortium·2007·New England Journal of Medicine

DOI 10.1056/nejmoa073493

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Abstract

Background Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis. Methods We used DNA microarray technology to identify common DNA sequence variants in 931 family trios (consisting of an affected child and both parents) and tested them for association. For replication, we genotyped another 609 family trios, 2322 case subjects, and 789 control subjects and used genotyping data from two external control data sets. A joint analysis of data from 12,360 subjects was performed to estimate the overall significance and effect size of associations between alleles and the risk of multiple sclerosis. Results A transmission disequilibrium test of 334,923 single-nucleotide polymorphisms (SNPs) in 931 family trios revealed 49 SNPs having an association with multiple sclerosis (P Conclusions Alleles of IL2RA and IL7RA and those in the HLA locus are identified as heritable risk factors for multiple sclerosis.

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Authors: The International Multiple Sclerosis Genetics Consortium
Corresponding author: The International Multiple Sclerosis Genetics Consortium
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2007-08-30
Volume: 357
Issue: 9
Pages: 851-862
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa073493
OpenAlex: W2164392039
Cited by: 1,746
References: 64
Citations by year: 2026: 26 · 2025: 38 · 2024: 40 · 2023: 32 · 2022: 55 · 2021: 49 · 2020: 57 · 2019: 53 · 2018: 66 · 2017: 74 · 2016: 75 · 2015: 97 · 2014: 109 · 2013: 112 · 2012: 145
FWCI: 132.85
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (076113)
National Institutes of Health (6u54rr020278-06)
National Institute of Allergy and Infectious Diseases (U19AI067152, AI-067152, P01AI039671)
National Institute of Neurological Disorders and Stroke (NS26799, NS032830, NS049477, NS2427, R01NS032830, R01NS026799, R01NS049477)
National Center for Research Resources (U54-RR020278-1)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: multiple sclerosis, genetic susceptibility, single nucleotide polymorphisms, family trios, transmission disequilibrium test, IL2RA, CD127, HLA-DRA, IL-2 receptor alpha, HLA locus, heritability
MeSH terms: Adolescent, Adult, Aged, Alleles, Female, HLA-DR Antigens, Humans, Male, Middle Aged, Multiple Sclerosis, Mutation, Risk Factors, Linkage Disequilibrium, Genome, Human, Genetic Predisposition to Disease, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Interleukin-2 Receptor alpha Subunit, Interleukin-7 Receptor alpha Subunit, HLA-DR alpha-Chains

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Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

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