A Molecular Basis for Nicotine as a Gateway Drug
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Such findings provide substantial support for a neurobiological sensitization mechanism.
“Such findings provide substantial support for a neurobiological sensitization mechanism (Kandel & Kandel, 2014).”
From <scp>N</scp> icotine and the adolescent brain (2015) · cites this paper as Kandel & Kandel, 2014
These effects result from inhibition of histone deacetylase.
“These effects are both unidirectional in that cocaine does not affect nicotine-induced responses and result from inhibition of histone deacetylase (Kandel & Kandel, 2014).”
From <scp>N</scp> icotine and the adolescent brain (2015) · cites this paper as Kandel & Kandel, 2014
These effects are unidirectional in that cocaine does not affect nicotine-induced responses.
“These effects are both unidirectional in that cocaine does not affect nicotine-induced responses and result from inhibition of histone deacetylase (Kandel & Kandel, 2014).”
From <scp>N</scp> icotine and the adolescent brain (2015) · cites this paper as Kandel & Kandel, 2014
At the molecular level, nicotine exerts a priming effect by enhancing cocaine's ability to induce FosB, a key mediator of addiction.
“At the molecular level, nicotine exerts a priming effect by enhancing the ability of cocaine to induce FosB, a key mediator of addiction.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [304]
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Smoking Intention and Progression From E-Cigarette Use to Cigarette Smoking
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Neurobiological Foundations of Behavioral Addictions
Vaccaro, A. G., & Potenza, M. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.016 · Cited by 45 · see citing works
The Prevention and Treatment of Gambling Disorders: Some Art, Some Science
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Sensitization of Incentive Salience and the Transition to Addiction
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Considering the Overlap and Nonoverlap of Compulsivity, Impulsivity, and Addiction
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Neurobiology of Substance Addictions
Christie, N. C., & Bechara, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.015 · Cited by 44 · see citing works
Mindfulness-Based Interventions Applied to Addiction Treatments
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Multiple Memory Systems, Addiction, and Health Habits: New Routes for Translational Science
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E-cigarette Use in Veterans Seeking Mental Health and/or Substance Use Services
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Behavioral Economics and Addictive Disorders
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Prevention and Treatment of Compulsive Buying Disorder
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Prevention and Treatment of “Food Addiction”
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Human Neurobiological Approaches to Hedonically Motivated Behaviors
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Feedback Models for Gambling Control: The Use and Efficacy of Online Responsible Gambling Tools
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Socioeconomic patterning of vaping by smoking status among UK adults and youth
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Neural correlates of adherence to extended-release naltrexone pharmacotherapy in heroin dependence
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UPPS-P impulsive personality traits and adolescent cigarette smoking: A meta-analysis
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Birth Cohorts Analysis of Adolescent Cigarette Smoking and Subsequent Marijuana and Cocaine Use
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Self-citationDevelopment and validation of the Sports Supplements Beliefs Scale
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Update on medicines for smoking cessation
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Denise Kandel's classic work on the gateway sequence of drug acquisition
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Harms of Electronic Cigarettes: What the Healthcare Provider Needs to Know
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- Authors
- Kandel, E. R., & Kandel, D. B.
- Affiliations
- Howard Hughes Medical Institute (US)
- New York State Psychiatric Institute (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-09-04
- Volume
- 371
- Issue
- 10
- Pages
- 932-943
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC4353486
- OpenAlex
- W2317172122
- Cited by
- 353
- References
- 32
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 18 · 2023: 21 · 2022: 18 · 2021: 31 · 2020: 72 · 2019: 32 · 2018: 26 · 2017: 27 · 2016: 33 · 2015: 45 · 2014: 6
- FWCI
- 24.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute on Drug Abuse (K-5 DA00081, K05DA000081, R01DA024001)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- nicotine, tobacco use, smoking initiation, nicotine dependence
- MeSH terms
- Animals, Brain, Cocaine, Humans, Learning, Nicotine, Substance-Related Disorders, Mice, Memory, Long-Term
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