Cited by 506RNA Research and SplicingRNA and protein synthesis mechanismsRNA regulation and disease

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Identification of a target RNA motif for RNA-binding protein HuR

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de Silanes, Isabel López, Zhan, Ming, Lal, Ashish, Yang, Xiaoling, Gorospe, Myriam·2004·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0306453101PMC PMC365732

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Abstract

HuR, a protein that binds to specific mRNA subsets, is increasingly recognized as a pivotal posttranscriptional regulator of gene expression. Here, HuR was immunoprecipitated under conditions that preserved HuR-RNA interactions, and HuR-bound target mRNAs were identified by cDNA array hybridization. Analysis of primary sequences and secondary structures shared among HuR targets led to the identification of a 17- to 20-base-long RNA motif rich in uracils. This HuR motif was found in almost all mRNAs previously reported to be HuR targets, was located preferentially within 3′ untranslated regions of all unigene transcripts examined, and was conserved in >50% of human and mouse homologous genes. Importantly, the HuR motif allowed the successful prediction and subsequent validation of novel HuR targets from gene databases. This study describes an HuR target RNA motif and presents a general strategy for identifying target motifs for RNA-binding proteins.

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Authors: de Silanes, I. L., Zhan, M., Lal, A., Yang, X., & Gorospe, M.
Affiliations: Laboratory of Cellular and Molecular Biology and Research Resources Branch, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224
Houston Methodist (US)
National Institutes of Health (US)
ORCID: Zhan, Ming
Lal, Ashish
Gorospe, Myriam
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2004-02-23
Volume: 101
Issue: 9
Pages: 2987-2992
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0306453101
PMC: PMC365732
OpenAlex: W2135070076
Cited by: 502
References: 48
Citations by year: 2026: 5 · 2025: 11 · 2024: 11 · 2023: 21 · 2022: 21 · 2021: 16 · 2020: 16 · 2019: 16 · 2018: 21 · 2017: 19 · 2016: 21 · 2015: 30 · 2014: 30 · 2013: 23 · 2012: 39
FWCI: 7.58
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: HuR, RNA-binding proteins, post-transcriptional regulation, mRNA targets, 3' untranslated region, target prediction, sequence conservation
MeSH terms: ELAV-Like Protein 1, Animals, Antigens, Surface, Base Sequence, Binding Sites, Carcinoma, Humans, Nucleic Acid Conformation, RNA, Messenger, Colorectal Neoplasms, RNA-Binding Proteins, 5' Untranslated Regions, Oligonucleotide Array Sequence Analysis, 3' Untranslated Regions, Cell Line, Tumor, Mice, ELAV Proteins

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Identification of a target RNA motif for RNA-binding protein HuR

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