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8-Nitroguanosines as chemical probes of the protein S-guanylation

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Protein damage from electrophiles and oxidants in lungs of mice chronically exposed to the tumor promoter butylated hydroxytoluene

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Tetrachlorobenzoquinone Activates Nrf2 Signaling by Keap1 Cross-Linking and Ubiquitin Translocation but Not Keap1-Cullin3 Complex Dissociation

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Oncogenic mutations in KEAP1 disturbing inhibitory Nrf2‐Keap1 interaction: Activation of antioxidative pathway in papillary thyroid carcinoma

Danilovic, D. L. S., de Mello, E. S., Frazzatto, E., Wakamatsu, A., Jorge, A. A. L., Hoff, A. O., & Marui, S. (2018) · Head & Neck · doi:10.1002/hed.25105 · Cited by 22

A Novel Pyrazolo[3,4-d]pyrimidine Induces Heme Oxygenase-1 and Exerts Anti-Inflammatory and Neuroprotective Effects

Lee, J. A., Kwon, Y., Kim, H. R., Shin, N., Son, H. J., Cheong, C. S., Kim, D. J., & Hwang, O. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0074 · Cited by 22

Identification and Characterization of Novel Nrf2 Inducers Designed to Target the Intervening Region of Keap1

Wu, J. H., Miao, W., Hu, L. G., & Batist, G. (2010) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2010.00955.x · Cited by 22

Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction

Kim, H. B., Shanu, A., Wood, S., Parry, S. N., Collet, M., McMahon, A., & Witting, P. K. (2011) · Free Radical Research · doi:10.3109/10715762.2011.590137 · Cited by 22

4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression

Park, S., Lee, M., Na, H., & Surh, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.10516 · Cited by 22

Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation

Badr, C. E., da Hora, C. C., Kirov, A. B., Tabet, E. I., Amante, R. J., Maksoud, S., Nibbs, A. E., Fitzsimons, E., Boukhali, M., Chen, J. W., et al. (2020) · ACS Chemical Biology · doi:10.1021/acschembio.0c00104 · Cited by 21

Iso-seco-tanapartholide activates Nrf2 signaling pathway through Keap1 modification and oligomerization to exert anti-inflammatory effects

Zhu, D., Xia, Y., Li, S., Kong, M., Chen, C., Xue, G., Kong, L., & Luo, J. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.12.259 · Cited by 21

The Regulatory Effects of JAK2/STAT3 on Spermatogenesis and the Redox Keap1/Nrf2 Axis in an Animal Model of Testicular Ischemia Reperfusion Injury

Alnajem, A., & Al‐Maghrebi, M. (2023) · Cells · doi:10.3390/cells12182292 · Cited by 21

Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication

Ariffianto, A., Deng, L., Abe, T., Matsui, C., Ito, M., Ryo, A., Aly, H. H., Watashi, K., Suzuki, T., Mizokami, M., et al. (2023) · Journal of Virology · doi:10.1128/jvi.01287-23 · Cited by 22

CUL3 and protein kinases: Insights from PLK1/KLHL22 interaction

Metzger, T., Kleiss, C., & Sumara, I. (2013) · Cell Cycle · doi:10.4161/cc.25369 · Cited by 21

Tussilagone inhibits dendritic cell functions via induction of heme oxygenase-1

Park, Y., Ryu, H. S., Lee, H. K., Kim, J. S., Yun, J., Kang, J. S., Hwang, B. Y., Hong, J. T., Kim, Y. S., & Han, S. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.07.023 · Cited by 21

The electrophilic character of quinones is essential for the suppression of Bach1

Su, C., Liu, Z., Wang, Y., Wang, Y., Song, E., & Song, Y. (2017) · Toxicology · doi:10.1016/j.tox.2017.06.006 · Cited by 21

Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells

Murray, J. R., de la Vega, L., Hayes, J. D., Duan, L., & Penning, T. M. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00399 · Cited by 21

Tissue-specific Nrf2 signaling protects against methylmercury toxicity in Drosophila neuromuscular development

Gunderson, J. T., Peppriell, A. E., Vorojeikina, D. P., & Rand, M. D. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02879-z · Cited by 21

3,3′-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts

Ernst, I. M. A., Schuemann, C., Wagner, A. E., & Rimbach, G. H. (2011) · Free Radical Research · doi:10.3109/10715762.2011.571683 · Cited by 21

Catechols in caffeic acid phenethyl ester are essential for inhibition of TNF‐mediated IP‐10 expression through NF‐κB‐dependent but HO‐1‐ and p38‐independent mechanisms in mouse intestinal epithelial cells

Mapesa, J. O., Waldschmitt, N., Schmoeller, I., Blume, C., Hofmann, T. F., Mahungu, S. M., Clavel, T., & Haller, D. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100105 · Cited by 21

Sticky spices

Caterina, M. J. (2007) · Nature · doi:10.1038/nature05565 · Cited by 21

Saucerneol D inhibits dendritic cell activation by inducing heme oxygenase-1, but not by directly inhibiting toll-like receptor 4 signaling

Ryu, H. S., Lee, H. K., Kim, J. S., Kim, Y. G., Pyo, M., Yun, J., Hwang, B. Y., Hong, J. T., Kim, Y. S., & Han, S. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.03.020 · Cited by 21

NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors

Seng, S., Avraham, H. K., Birrane, G., Jiang, S. S., Li, H., Katz, G., Bass, C. E., Zagożdżon, R., & Avraham, S. (2008) · Oncogene · doi:10.1038/onc.2008.396 · Cited by 21

3-Morpholinopropyl isothiocyanate is a novel synthetic isothiocyanate that strongly induces the antioxidant response element-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo

Keum, Y., Chang, P. P.-J., Kwon, K. H., Yuan, X., Li, W., Hu, L., & Kong, A.-N. T. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm208 · Cited by 21

Endocytosis of particulate matter induces cytokine production by neutrophil via Toll-like receptor 4

Miyake, T., Wang, D., Matsuoka, H., Morita, K., Yasuda, H., Yatera, K., Kanazawa, T., & Yoshida, Y. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.02.020 · Cited by 20

4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease

Yang, W., Chen, X., Wang, S., Hu, H., Cheng, X.-P., Xu, L., Ren, D., Wang, X., Zhao, B., Lou, H., et al. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.9b01265 · Cited by 20

κ Opioid Receptor Agonist Inhibits Myocardial Injury in Heart Failure Rats through Activating Nrf2/HO‐1 Pathway and Regulating Ca2+‐SERCA2a

Wu, T., Yao, H., Zhang, B., Zhou, S., Hou, P., & Chen, K. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/7328437 · Cited by 20

Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers

Holtzclaw, W. D., Dinkova‐Kostova, A. T., & Talalay, P. (2004) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2003.11.013 · Cited by 145

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

Eggler, A. L., Liu, G., Pezzuto, J. M., van Breemen, R. B., & Mesecar, A. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502402102 · Cited by 476

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

Talalay, P., Dinkova‐Kostova, A. T., & Holtzclaw, W. D. (2003) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(02)00038-9 · Cited by 289

NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation

He, X., & Ma, Q. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.058453 · Cited by 153