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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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Nuclear Factor (Erythroid-Derived 2)-Like 2 and Thioredoxin-1 in Atherosclerosis and Ischemia/Reperfusion Injury in the Heart

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Optimization of Vinyl Sulfone Derivatives as Potent Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Parkinson’s Disease Therapy

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Nrf2: Friend and Foe in Preventing Cigarette Smoking-Dependent Lung Disease

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Nrf2-Inducing Anti-Oxidation Stress Response in the Rat Liver - New Beneficial Effect of Lansoprazole

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The Ubiquitin-conjugating Enzyme UbcM2 Can Regulate the Stability and Activity of the Antioxidant Transcription Factor Nrf2

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Approaches to Prevent Dopamine Quinone-Induced Neurotoxicity

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Oxidative Stress Profiling:

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Regulation of Antioxidants and Phase 2 Enzymes by Shear-Induced Reactive Oxygen Species in Endothelial Cells

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Disorders of Endogenous and Exogenous Antioxidants in Neurological Diseases

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Nrf2‐mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ‐GSK3β pathway

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Ochratoxin A impairs Nrf2‐dependent gene expression in porcine kidney tubulus cells

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Dietary chemoprevention strategies for induction of phase II xenobiotic-metabolizing enzymes in lung carcinogenesis: A review

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NRF2 and the Phase II Response in Acute Stress Resistance Induced by Dietary Restriction

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Safeners coordinately induce the expression of multiple proteins and MRP transcripts involved in herbicide metabolism and detoxification in Triticum tauschii seedling tissues

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Mechanisms of Nrf2 and NF-κB pathways in diabetic wound and potential treatment strategies

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Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects

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Zerumbone Induces Heme Oxygenase-1 Expression in Mouse Skin and Cultured Murine Epidermal Cells through Activation of Nrf2

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Glutathione and Related Molecules in Parkinsonism

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Oxidative stress: A radical way to stop making bile

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Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer

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Optimal micronutrients delay mitochondrial decay and age-associated diseases

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An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms

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Protective effect of diphenyl diselenide against peroxynitrite-mediated endothelial cell death: A comparison with ebselen

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Initial Response and Cellular Protection through the Keap1/Nrf2 System during the Exposure of Primary Mouse Hepatocytes to 1,2-Naphthoquinone

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Zerumbone protects human skin keratinocytes against UVA-irradiated damages through Nrf2 induction

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Modulatory role of dietary polyunsaturated fatty acids in Nrf2-mediated redox homeostasis

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Major Oxidative and Antioxidant Mechanisms During Heat Stress-Induced Oxidative Stress in Chickens

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Long‐acting genipin derivative protects retinal ganglion cells from oxidative stress models in vitro and in vivo through the Nrf2/antioxidant response element signaling pathway

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Catechol Type Polyphenol Is a Potential Modifier of Protein Sulfhydryls: Development and Application of a New Probe for Understanding the Dietary Polyphenol Actions

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Pharmacogenomics of Phenolic Antioxidant Butylated Hydroxyanisole (BHA) in the Small Intestine and Liver of Nrf2 Knockout and C57BL/6J Mice

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Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation

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Molecular Mechanisms of Drug Transporter Regulation

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Ferulic acid prevents aflatoxin B1-induced liver injury in rats via inhibiting cytochrome P450 enzyme, activating Nrf2/GST pathway and regulating mitochondrial pathway

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The Role of the Keap1/Nrf2 Pathway in the Cellular Response to Methylmercury

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Quinone Formation as a Chemoprevention Strategy for Hybrid Drugs: Balancing Cytotoxicity and Cytoprotection

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Chemical Toxicology of Reactive Intermediates Formed by the Glutathione-Dependent Bioactivation of Halogen-Containing Compounds

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Keap1 modification and nuclear accumulation in response to S-nitrosocysteine

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Genipin up-regulates heme oxygenase-1 via PI3-kinase-JNK1/2-Nrf2 signaling pathway to enhance the anti-inflammatory capacity in RAW264.7 macrophages

Jeon, W.-K., Hong, H.-Y., & Kim, B.-C. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.05.016 · Cited by 60

Hydrogen Sulfide Levels and Nuclear Factor‐Erythroid 2‐Related Factor 2 (NRF2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI)

Islam, K. N., Polhemus, D. J., Donnarumma, E., Brewster, L. P., & Lefer, D. J. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.001986 · Cited by 61

20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway

Huang, J., Yuan, Y., Yan, J., Wang, Y., Chu, S., Zhu, C., Guo, Q., Shi, J., & Chen, N. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.154 · Cited by 60

Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery

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Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice

Nair, S., XU, C., Shen, G., Hebbar, V., Gopalakrishnan, A., Hu, R., JAIN, M., Liew, C. V., CHAN, J., & KONG, A. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.10.012 · Cited by 60

γ-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells

Zhang, H., Liu, H., Dickinson, D. A., Liu, R.-M., Postlethwait, E. M., Laperche, Y., & Forman, H. J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.11.005 · Cited by 60

Lipid Autacoids in Inflammation and Injury Responses: A Matter of Privilege

Gronert, K. (2008) · Molecular Interventions · doi:10.1124/mi.8.1.7 · Cited by 60

Seven in Absentia Homolog 2 (Siah2) Protein Is a Regulator of NF-E2-related Factor 2 (Nrf2)*

Baba, K., Morimoto, H., & Imaoka, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.438762 · Cited by 60

Chemical reactivity measurements: Potential for characterization of respiratory chemical allergens

Lalko, J., Kimber, I., Dearman, R. J., Gerberick, G. F., Sarlo, K. T., & Api, A. M. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.11.007 · Cited by 60

Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson’s Disease

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4-Hydroxynonenal Induces Rat γ-Glutamyl Transpeptidase through Mitogen-Activated Protein Kinase–Mediated Electrophile Response Element/Nuclear Factor Erythroid 2–Related Factor 2 Signaling

Zhang, H., Liu, H., Iles, K. E., Liu, R.-M., Postlethwait, E. M., Laperche, Y., & Forman, H. J. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0280oc · Cited by 60

Screening Method for the Discovery of Potential Cancer Chemoprevention Agents Based on Mass Spectrometric Detection of Alkylated Keap1

Liu, G., Eggler, A. L., Dietz, B. M., Mesecar, A. D., Bolton, J. L., Pezzuto, J. M., & van Breemen, R. B. (2005) · Analytical Chemistry · doi:10.1021/ac050892r · Cited by 59

Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population

Wang, X., Chen, H., Liu, J., Ouyang, Y., Wang, D., Bao, W., & Liu, L. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160716483 · Cited by 58

Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes

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PI3K, RSK, and mTOR Signal Networks for the GST Gene Regulation

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Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress

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Asiatic Acid Ameliorates Doxorubicin-Induced Cardiac and Hepato-Renal Toxicities with Nrf2 Transcriptional Factor Activation in Rats

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(−)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68

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Overexpression of Nrf2 Protects Cerebral Cortical Neurons from Ethanol-Induced Apoptotic Death

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Nrf2/HO-1 as a therapeutic target in renal fibrosis

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Keap1–Nrf2 signalling in pancreatic cancer

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The multifaceted mechanisms for coffee’s anti-tumorigenic effect on liver

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Induction of Heme Oxygenase I (HMOX1) by HPP-4382: A Novel Modulator of Bach1 Activity

Attucks, O. C., Jasmer, K. J., Hannink, M., Kassis, J. N., Zhong, Z., Gupta, S., Victory, S. F., Güzel, M., Rao, P. D., Andrews, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101044 · Cited by 55

Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury

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Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions

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Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites

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Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice

Chartoumpekis, D. V., Palliyaguru, D. L., Wakabayashi, N., Fazzari, M., Khoo, N. K. H., Schopfer, F. J., SIPULA, I. J., Yagishita, Y., Michalopoulos, G. K., O'Doherty, R. M., et al. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00311.2017 · Cited by 56

Roles of CNC Transcription Factors NRF1 and NRF2 in Cancer

Sekine, H., & Motohashi, H. (2021) · Cancers · doi:10.3390/cancers13030541 · Cited by 51

Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway

Liu, X., Goldring, C. E., Copple, I. M., Wang, H., Wei, W., Kitteringham, N. R., & Park, B. K. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.01.034 · Cited by 55

Differential Modulation of Keratin Expression by Sulforaphane Occurs via Nrf2-dependent and -independent Pathways in Skin Epithelia

Kerns, M. L., DePianto, D. J., Yamamoto, M. P., & Coulombe, P. A. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-02-0153 · Cited by 55

Two-Step Mechanism of Induction of the Gene Expression of a Prototypic Cancer-Protective Enzyme by Diphenols

Bensasson, R. V., Zoete, V., Dinkova‐Kostova, A. T., & Talalay, P. (2008) · Chemical Research in Toxicology · doi:10.1021/tx7002883 · Cited by 55

Electrophilic Chemicals but not UV Irradiation or Reactive Oxygen Species Activate Nrf2 in Keratinocytes In Vitro and In Vivo

Durchdewald, M., Beyer, T. A., Johnson, D. A., Johnson, J. A., Werner, S., & Keller, U. A. D. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700585 · Cited by 53

Redox Regulation of Lipopolysaccharide-mediated Sulfiredoxin Induction, Which Depends on Both AP-1 and Nrf2

Kim, H., Jung, Y., Shin, B. S., Kim, H., Song, H., Bae, S. H., Rhee, S. G., & Jeong, W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.126839 · Cited by 56

Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane

Emmert, S. W., Desai, D. H., Amin, S., & Richie, J. P. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.01.044 · Cited by 54

NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland

Ziros, P. G., Habeos, I. G., Chartoumpekis, D. V., Ntalampyra, E., Somm, E., Renaud, C. O., Bongiovanni, M., Trougakos, I. P., Yamamoto, M. P., Kensler, T. W., et al. (2018) · Thyroid · doi:10.1089/thy.2018.0018 · Cited by 53

Targeting Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2) for the Intervention of Vascular Cognitive Impairment and Dementia

Yang, T., & Zhang, F. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314804 · Cited by 52

Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice

Seedorf, K., Weber, C., Vinson, C., Berger, S., Vuillard, L.-M., Kiss, A., Creusot, S., Broux, O., Géant, A., Ilic, C., et al. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100651 · Cited by 54

Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes

Kim, S.-J., Hur, J. H., Park, C., Kim, H., Oh, G., Lee, J. N., Yoo, S.-J., Choe, S., So, H., LIM, D. J., et al. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.112 · Cited by 52

Ginsenoside Rd mitigates myocardial ischemia-reperfusion injury via Nrf2/HO-1 signaling pathway.

Zeng, X., Li, J., & Li, Z. (2015) · Europe PMC (PubMed Central) · Cited by 52

Neuroprotective effects of pramipexole transdermal patch in the MPTP-induced mouse model of Parkinson's disease

Wang, Y., Yu, X., Zhang, P., Ma, Y., Wang, L., Xu, H., & Sui, D. (2018) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2018.08.008 · Cited by 53

Role of Gα12 and Gα13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor

Cho, M. K., Kim, W., Ki, S. H., Hwang, J., Choi, S., Lee, C. H., & Kim, S. G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02065-06 · Cited by 54

Prevention of mutation, Cancer, and other Age-Associated diseases by optimizing micronutrient intake

Ames, B. N. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/725071 · Cited by 51

Effects of atrazine on the oxidative damage of kidney in Wister rats.

Liu, W., Du, Y., Liu, J., Wang, H., Sun, D., Liang, D., Zhao, L., & Shang, J. (2014) · PubMed Central · Cited by 51

Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymes

Shin, J. M., Lee, K.-M., Lee, H. J., Yun, J. H., & Nho, C. W. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2511-y · Cited by 51

Delayed Mechanism for Induction of γ-Glutamylcysteine Synthetase Heavy Subunit mRNA Stability by Oxidative Stress Involving p38 Mitogen-activated Protein Kinase Signaling

Song, I., Tatebe, S., Dai, W., & Kuo, M. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413103200 · Cited by 50

Role of the Nrf2-ARE pathway in acrylamide neurotoxicity

Zhang, L., Gavin, T., Barber, D. S., & LoPachin, R. M. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.04.011 · Cited by 50

Functional diversification of three delta‐class glutathione S‐transferases involved in development and detoxification in Tribolium castaneum

Song, X., Pei, L., Zhang, Y. E., Chen, X., Zhong, Q., Ji, Y., Tang, J., Feng, F., & Li, B. (2020) · Insect Molecular Biology · doi:10.1111/imb.12637 · Cited by 49

The Interaction Between NF-κB and Estrogen in Alzheimer’s Disease

Mishra, P., Davies, D. A., & Albensi, B. C. (2023) · Molecular Neurobiology · doi:10.1007/s12035-022-03152-3 · Cited by 51

Nrf2 Signaling in Renal Cell Carcinoma: A Potential Candidate for the Development of Novel Therapeutic Strategies

Schiavoni, V., Emanuelli, M., Milanese, G., Galosi, A. B., Pompei, V., Salvolini, E., & Campagna, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413239 · Cited by 51

Role of Catechin Quinones in the Induction of EpRE-Mediated Gene Expression

Muzolf-Panek, M., Gliszczyńska‐Świgło, A., de Haan, L., Aarts, J. M. M. J. G., Szymusiak, H., Vervoort, J. J. M., Tyrakowska, B., & Rietjens, I. M. C. M. (2008) · Chemical Research in Toxicology · doi:10.1021/tx8001498 · Cited by 49

Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers

Holtzclaw, W. D., Dinkova‐Kostova, A. T., & Talalay, P. (2004) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2003.11.013 · Cited by 145

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

Eggler, A. L., Liu, G., Pezzuto, J. M., van Breemen, R. B., & Mesecar, A. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502402102 · Cited by 476

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

Talalay, P., Dinkova‐Kostova, A. T., & Holtzclaw, W. D. (2003) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(02)00038-9 · Cited by 289

NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation

He, X., & Ma, Q. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.058453 · Cited by 153