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Bucillamine induces glutathione biosynthesis via activation of the transcription factor Nrf2

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Lansoprazole protects hepatic cells against cisplatin-induced oxidative stress through the p38 MAPK/ARE/Nrf2 pathway

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Tussilagonone-induced Nrf2 pathway activation protects HepG2 cells from oxidative injury

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The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System

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Dimethyl fumarate suppresses Theiler’s murine encephalomyelitis virus-induced demyelinating disease by modifying the Nrf2-Keap1 pathway

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Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti-inflammatory effects

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Methyl Methacrylate Activates the Gsta1 Promoter

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Effect of 2-Hydroxyethyl Methacrylate on Antioxidant Responsive Element-Mediated Transcription: A Possible Indication of Its Cytotoxicity

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Targeting the Nrf2-Prx1 Pathway with Selenium to Enhance the Efficacy and Selectivity of Cancer Therapy

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Nrf2 in Host Defense: Over the Rainbow

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Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress

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Exploring the oxidative stress response mechanism triggered by environmental water samples

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Region Specific Vulnerability to Lipid Peroxidation in the Human Central Nervous System

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Dysregulation of monocyte biology in metabolic syndrome

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Nrf2-Keap1 Activation, A Promising Strategy in the Prevention of Cancer

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The oxygen concentration in cultures modulates protein expression and enzymatic antioxidant responses in Metarhizium lepidiotae conidia

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Chronic Kidney disease and stroke: A Bi-directional risk cascade and therapeutic update

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Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells

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AMPK-Mediated Phosphorylation of Nrf2 at S374/S408/S433 Favors Its βTrCP2-Mediated Degradation in KEAP1-Deficient Cells

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Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

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Further structure–activity relationships study of substituted dithiolethiones as glutathione-inducing neuroprotective agents

Brown, D. A., Betharia, S., Yen, J.-H. J., Kuo, P., & Mistry, H. (2016) · Chemistry Central Journal · doi:10.1186/s13065-016-0210-z · Cited by 11

Activation of the Nrf2-antioxidant system by a novel cyclooxygenase-2 inhibitor furan-2-yl-3-pyridin-2-yl-propenone: implication in anti-inflammatory function by Nrf2 activator

Manandhar, S., You, A., Lee, E.-S., Kim, J., & Kwak, M. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.7.0009 · Cited by 11

Induction of lung glutathione and glutamylcysteine ligase by 1,4-phenylenebis(methylene)selenocyanate and its glutathione conjugate: Role of nuclear factor-erythroid 2-related factor 2

Emmert, S. W., El‐Bayoumy, K., Das, A., Sun, Y., Amin, S., Desai, D. H., Aliaga, C. A., & Richie, J. P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.018 · Cited by 11

The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD

Lemmens, K. J. A., van de Wier, B., Koek, G. H., Köhler, E. S., Drittij-Reijnders, M.-J., van der Vijgh, W. J. F., Bast, A., & Haenen, G. R. M. M. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.11.055 · Cited by 11

PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus

Burroughs, A. F., Eluhu, S., Whalen, D. S., Goodwin, J. S., Sakwe, A. M., & Arinze, I. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000490033 · Cited by 11

The role of miR-216a-mediated Nrf2 pathway in muscle oxidative stress of Siniperca chuatsi induced by cadmium

Li, H., Bao, L., Pan, Y., Zhu, X., Cheng, J. R., Zhang, J., & Chu, W. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116863 · Cited by 10

MiRNAs-Modulation of Nrf2 Signaling Networks in Regulation Oxidative Stress of Chinese Perch Skeletal Muscle After Fasting Treatment

Wu, P., Chen, L., Cheng, J. R., Pan, Y., Guo, X., Chu, W., Zhang, J., & Liu, X. (2020) · Marine Biotechnology · doi:10.1007/s10126-020-09982-3 · Cited by 10

Role of Nrf2 Pathway Activation in Neurological Disorder: A Brief Review

Baba, M. Z., Gomathy, S., & Wahedi, U. (2022) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.1177/0976500x221128855 · Cited by 10

Metabolic Activation of Chemical Carcinogens

Penning, T. M. (2010) · Humana Press eBooks · doi:10.1007/978-1-61737-995-6_7 · Cited by 10

Protective effect of coumarin-pi against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via enhanced Nrf2 signaling

Zhang, J., Feng, H., Lv, J., Zhao, L., Zhao, J., & Wang, L. Y. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03880-x · Cited by 10

Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1-Nitropyrene via Nitroreduction in Human Lung Cells

Su, A. L., & Penning, T. M. (2023) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00337 · Cited by 9

Nrf2, A Target for Precision Oncology in Cancer Prognosis and Treatment

Ngo, H. K. C., Le, H., & Surh, Y. (2023) · Journal of Cancer Prevention · doi:10.15430/jcp.2023.28.4.131 · Cited by 9

Induction of Phase II Enzymes Glutathione-S-Transferase and NADPH: Quinone Oxydoreductase 1 with Novel Sulforaphane Derivatives in Human Keratinocytes: Evaluation of the Intracellular GSH Level

Sikdar, S., Lallemand, B., & Dubois, J. (2014) · Pharmacology & Pharmacy · doi:10.4236/pp.2014.510105 · Cited by 9

Duality of n-3 Polyunsaturated Fatty Acids on Mcp-1 Expression in Vascular Smooth Muscle: A Potential Role of 4-Hydroxy Hexenal

Nagayama, K., Morino, K., Sekine, O., Nakagawa, F., Ishikado, A., Iwasaki, H., Okada, T., Tawa, M., Sato, D., Imamura, T., et al. (2015) · Nutrients · doi:10.3390/nu7095381 · Cited by 9

Evaluation of 2‐Thiothiazolidine‐4‐Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake

Palliyaguru, D. L., Salvatore, S. R., Schopfer, F. J., Cheng, X., Zhou, J., Kensler, T. W., & Wendell, S. G. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801029 · Cited by 9

Inhibition of sphingomyelin synthase 2 relieves hypoxia-induced cardiomyocyte injury by reinforcing Nrf2/ARE activation via modulation of GSK-3β

Jin, A., Cheng, H., Xia, L., Ye, S., & Yang, C. (2020) · Human & Experimental Toxicology · doi:10.1177/0960327120969958 · Cited by 9

Defective autophagy triggered by arterial cyclic stretch promotes neointimal hyperplasia in vein grafts via the p62/nrf2/slc7a11 signaling pathway

Chen, Y., Bao, M., Liu, J.-T., Bao, H., Zhang, S., Lou, Y., & Qi, Y. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.10.001 · Cited by 10

Regulatory Role of the COX-2 Pathway in the Nrf2-Mediated Anti-Inflammatory Response

Itoh, K., & Yamamoto, M. P. (2005) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.37.9 · Cited by 9

Vulnerability of Antioxidant Drug Therapies on Targeting the Nrf2-Trp53-Jdp2 Axis in Controlling Tumorigenesis

Lin, Y., Ku, C., Wuputra, K., Wu, D., & Yokoyama, K. K. (2024) · Cells · doi:10.3390/cells13191648 · Cited by 8

KRAS and NRF2 drive metabolic reprogramming in pancreatic cancer cells: the influence of oxidative and nitrosative stress

Rapozzi, V., Comuzzi, C., Giorgio, E. D., & Xodo, L. E. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1547582 · Cited by 9

The crosstalk between Nrf2 and pyroptosis in diseases

Wang, X., Monemi, M., Moghadam, F. M., Fazilat, A., Roshani, S., & Valilo, M. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156085 · Cited by 8

Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes

Kaleta, K., Janik, K., Rydz, L., Wróbel, M., & Jurkowska, H. (2024) · Biomolecules · doi:10.3390/biom14070746 · Cited by 8

Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers

Holtzclaw, W. D., Dinkova‐Kostova, A. T., & Talalay, P. (2004) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2003.11.013 · Cited by 145

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

Eggler, A. L., Liu, G., Pezzuto, J. M., van Breemen, R. B., & Mesecar, A. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502402102 · Cited by 476

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

Talalay, P., Dinkova‐Kostova, A. T., & Holtzclaw, W. D. (2003) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(02)00038-9 · Cited by 289

NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation

He, X., & Ma, Q. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.058453 · Cited by 153