Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Manipulating the mouse embryo: A laboratory manual

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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

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Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element

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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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The Evolving Concept of Oxidative Stress

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Nrf2 activation as a future target of therapy for chronic diseases

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The level of S-glutathionylated protein is a predictor for metastasis in colorectal cancer and correlated with those of Nrf2/Keap1 pathway

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Mechanisms of plant polyphenols anti-cancer effects I. Blockade of carcinogenesis initiation

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Expression of Nuclear Factor Erythroid 2 Protein in Malignant Cutaneous Tumors

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Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome

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Loading tea polyphenols enhances the repair of human umbilical cord mesenchymal stem cell sheet after spinal cord injury

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New paradigm of host defense against intracellular pathogens by nitric oxide

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Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements

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Glutathione S‐transferase A4 is a positive marker for rat hepatic foci induced by clofibrate and genotoxic carcinogens

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Cigarette Smoke-Induced Redox Signaling and Gene Expression in In Vitro and In Vivo Models

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NFE2L2 protects against Sorafenib-induced Ferroptosis and cardiotoxicity by activating the HO1/ferritin pathway

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Role of Reactive Oxygen Species in Epilepsy

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Cellular and Environmental Electrophiles: Balancing Redox Signaling, Inflammation, and Cell Death Pathways

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Sulfhydryl-Reactive Phytochemicals as Dual Activators of Transcription Factors NRF2 and HSF1

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Nrf2 Activation, an Innovative Therapeutic Alternative in Cerebral Ischemia

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Modulation of Cellular Redox and Metabolic Status by Lipoic Acid

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Smoking and COPD and Other Respiratory Diseases

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Plant Phenolic Compounds: Modulation of Cytoprotective Enzymes and Nrf2/ARE Signaling

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Keap1-resistant ΔN-Nrf2 isoform does not translocate to the nucleus upon electrophilic stressPreprint

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de Klerk, D. J., de Keijzer, M. J., Franchi, L. P., Tian, J., Gureev, M., Ge, Y., Mesquita, B. S., Saelman, G., herteryck, I. V., Dias, L. M., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117620 · Cited by 3

AKT2 deficiency alleviates doxorubicin-induced cardiac injury via alleviating oxidative stress in cardiomyocytes

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The KeratinoSens™ Assay for Skin Sensitization Screening

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Impact of Nuclear Receptors CAR, PXR, FXR, and VDR, and Their Ligands On Enzymes and Transporters

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Aflatoxins

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Research advances in the protective effect of sulforaphane against kidney injury and related mechanisms

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Anti-Proteolytic Peptide R7I Protects the Intestinal Barrier and Alleviates Fatty Acid Malabsorption in Salmonella typhimurium-Infected Mice

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Sulforaphane Enhances Protection and Repair of Gastric Mucosa against Oxidative Stress via Nrf2-Dependent Mechanisms

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Nuclear factor erythroid 2-related factor 2 and autophagy regulation in cancer development

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Chapter 3 Site-Specific Modification of the Electrophile Sensor Protein Keap1 and Activation of Nrf2-Dependent Gene Expression

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Lipoic Acid as an Inducer of Phase II Detoxification Enzymes through Activation of Nrf2-Dependent Gene Expression

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Efficacy of Lycium barbarum polysaccharide and synergism with paclitaxel/cisplatin in ovarian cancer in mice

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Interaction effect in the tank mixtures of herbicides diflufenican, metribuzin and carfentrazone

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Targeting NRF2 With Isoeugenol: A Promising Small Molecule for Neurodegenerative, Metabolic, and Chronic Inflammatory Disorders

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NRF2 as a Therapeutic Target in Dermatological Disorders: Mechanisms and Molecules

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Targeting NRF2 addiction in cancer: synthetic lethal strategies beyond direct inhibition

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Xenobiotic Sulforaphane in Head and Neck Cancer: Beyond the Nrf2 Pathway

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Selective estrogen receptor modulator BC-1 activates antioxidant signaling pathway in vitro via formation of reactive metabolites

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Considerations for antibody-based detection of NRF2 in human cells

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Identification and Structural Analysis of New Nrf2 Activators by Mechanism‐Based Chemical Transformation of 15‐Deoxy‐Δ12, 14‐PGJ2

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Oxidative Modifications of Proteins and Lipids by Cigarette Smoke (CS). A Central Role for Unsaturated Aldehydes in CS-Mediated Airway Inflammation

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Oxidative Stress and Respiratory Diseases: The Critical Role of Nrf2

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A1and A3adenosine receptors alter glutathione status in an organ-specific manner and influence the changes after inhibition ofγ-glutamylcysteine ligase

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Healing Sulfurous Thermal Waters in Health Resort Medicine: Therapies, Indications, and Contraindications

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The Keap1-Nrf2 Signaling Pathway in Lung Cancer

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Preventive Agents and Phytochemicals for Reducing the Adverse Health Effects of Arsenic

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The Keratinosens Assay: A High‐Throughput Screening Assay to Assess Chemical Skin Sensitization

Natsch, A. (2013) · doi:10.1002/9781118538203.ch8 · Cited by 2

Influence of oxidative stress on aryl hydrocarbon receptor signaling

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Thre role of Bach1 in ultraviolet-A mediated human heme oxygenase-1 gene regulation

Raval, C. M. (2008) · The University of Bath Online Publications Store (The University of Bath) · Cited by 2

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Benchmark of screening markers for KEAP1/NFE2L2 mutations and joint analysis with the K1N2-score

Arolt, C., Scheel, A. H., Dugan, M. H., Wild, R., Richartz, V., Holz, B., Brägelmann, J., Wagener‐Ryczek, S., Merkelbach‐Bruse, S., Wolf, J., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00744-1 · Cited by 1

Deciphering the quantitative relationship between NRF2 and SRXN1 through semi-mechanistic computational modeling

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The endemic Greek wines Χinomavro, Agiorgitiko, Αssyrtiko, and Malagouzia exert beneficial effects on human cells by upregulating the antioxidant defense mechanisms

Tekos, F., Vardakas, P., Skaperda, Z., Nechalioti, P.-M., Atsopardi, Κ., Xiftou, K., Patouna, A., Gkasdrogka, M., Veskoukis, A. S., Giakountis, A., et al. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.107088 · Cited by 1

EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge

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Limited Nrf2 activation and heterogeneous thyroidal effects in a 424-compound multi-assay screen call for rigorous testing of purported antioxidant and health-promoting supplements

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