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Cited by 222Sleep and Wakefulness ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Learning increases human electroencephalographic coherence during subsequent slow sleep oscillations

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Mölle, Matthias, Marshall, Lisa, Gais, Steffen, Born, Jan·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0402820101PMC PMC518860
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Abstract

Learning is assumed to induce specific changes in neuronal activity during sleep that serve the consolidation of newly acquired memories. To specify such changes, we measured electroencephalographic (EEG) coherence during performance on a declarative learning task (word pair associations) and subsequent sleep. Compared with a nonlearning control condition, learning performance was accompanied with a strong increase in coherence in several EEG frequency bands. During subsequent non-rapid eye movement sleep, coherence only marginally increased in a global analysis of EEG recordings. However, a striking and robust increase in learning-dependent coherence was found when analyses were performed time-locked to the occurrence of slow oscillations (<1 Hz). Specifically, the surface-positive half-waves of the slow oscillation resulting from widespread cortical depolarization were associated with distinctly enhanced coherence after learning in the slow-oscillatory, delta, slow-spindle, and gamma bands. The findings identify the depolarizing phase of the slow oscillations in humans as a time period particularly relevant for a reprocessing of memories in sleep.

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Crossref · 10.1073/pnas.0402820101

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  • In humans, intense learning of declarative memories (word pairs) enhanced amplitudes of the slow oscillation up-states as well as coherence in the SWA frequency band during succeeding SWS.

    “In humans, intense learning of declarative memories (word pairs) enhanced amplitudes of the slow oscillation up-states as well as coherence in the SWA frequency band during succeeding SWS (829, 831).”

    From About Sleep's Role in Memory (2013) · cites this paper as [831]

  • Slopes of the down-to-up state of the slow oscillations were steeper after learning.

    “Also, slopes of the down-to-up state of the slow oscillations were steeper after learning.”

    From About Sleep's Role in Memory (2013) · cites this paper as [831]

  • Generation of spindles in the thalamus and generation of SW-Rs in the hippocampus are distinctly suppressed during the down-phase of the slow oscillation, followed by a rebound in spindle and SW-R activity during the succeeding depolarizing up-state.

    “Generation of spindles in the thalamus and generation of SW-Rs in the hippocampus are distinctly suppressed during the down-phase of the slow oscillation, and this is followed by a rebound in spindle and SW-R activity during the succeeding depolarizing up-state (66, 215, 597, 829 -832, 925, 1088).”

    From About Sleep's Role in Memory (2013) · cites this paper as [831]

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Authors
Mölle, M., Marshall, L., Gais, S., & Born, J.
Affiliations
  • University of Lübeck (DE)
  • Department of Neuroendocrinology, University of Lübeck, Ratzeburger Allee 160, Haus 23a, 23538 Lübeck, Germany
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2004-09-08
Volume
101
Issue
38
Pages
13963-13968
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0402820101
PMC
PMC518860
OpenAlex
W2154249160
Cited by
222
References
7
Citations by year
2026: 7 · 2025: 9 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 12 · 2018: 7 · 2017: 11 · 2016: 8 · 2015: 13 · 2014: 16 · 2013: 19 · 2012: 12
FWCI
5.37
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
learning, sleep, slow oscillations, EEG coherence, memory consolidation, declarative learning, word pair association, NREM sleep, cortical depolarization, delta oscillations, gamma oscillations, memory reprocessing
MeSH terms
Adult, Brain Mapping, Cognition, Electroencephalography, Female, Humans, Learning, Male, Oscillometry, Sleep

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