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The role of the locus coeruleus in shaping adaptive cortical melodies

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Noradrenergic locus coeruleus activity functionally partitions NREM sleep to gatekeep the NREM-REM sleep cyclePreprint

Osorio-Forero, A., Foustoukos, G., Cardis, R., Cherrad, N., Devenoges, C., Fernandez, L. M. J., & Lüthi, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.20.541586 · Cited by 35 · see citing works

Locus Coeruleus Activation Patterns Differentially Modulate Odor Discrimination Learning and Odor Valence in Rats

Ghosh, A., Massaeli, F., Power, K. D., Omoluabi, T., Torraville, S. E., Pritchett, J. B., Sepahvand, T., Strong, V., Reinhardt, C., Chen, X., et al. (2021) · Cerebral Cortex Communications · doi:10.1093/texcom/tgab026 · Cited by 26 · see citing works

Blunted Glucocorticoid Responsiveness to Stress Causes Behavioral and Biological Alterations That Lead to Posttraumatic Stress Disorder Vulnerability

Monari, S., de Suduiraut, I. G., Grosse, J., Zanoletti, O., Walker, S. E., Mesquita, M. S., Wood, T., Cash, D., Astori, S., & Sandi, C. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.09.015 · Cited by 32 · see citing works

Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices

Tukker, J. J., Beed, P. S., Schmitz, D., Larkum, M. E., & Sachdev, R. N. S. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.00022 · Cited by 28 · see citing works

Spontaneous slow oscillation—slow spindle features predict induced overnight memory retention

Dehnavi, F., Koo, P. C., Ghorbani, M., & Marshall, L. (2021) · SLEEP · doi:10.1093/sleep/zsab127 · Cited by 31 · see citing works

Modulation of Prefrontal Cortex Slow Oscillations by Phasic Activation of the Locus Coeruleus

Durán, E., Yang, M., Neves, R. M., Logothetis, N. K., & Eschenko, O. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.028 · Cited by 29 · see citing works

Associations of 24-hour rest-activity rhythm fragmentation, cognitive decline, and postmortem locus coeruleus hypopigmentation in Alzheimer's disease

Van Egroo, M., van Someren, E. J. W., Grinberg, L. T., Bennett, D. A., & Jacobs, H. I. L. (2024) · Annals of Neurology · doi:10.1002/ana.26880 · Cited by 28 · see citing works

Rapid eye movement sleep and neuronal development

Wolfe, K. M., & Ralls, F. M. (2019) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000622 · Cited by 28 · see citing works

The Locus Coeruleus in Chronic Pain

España, J. C., Mohan, A., & Vanneste, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168636 · Cited by 26 · see citing works

Sleep’s contribution to memory formation

Lutz, N. D., Harkotte, M., & Jan Born, A. (2025) · Physiological Reviews · doi:10.1152/physrev.00054.2024 · Cited by 40 · see citing works

Sleep disturbances in autism spectrum disorder: Animal models, neural mechanisms, and therapeutics

Maurer, J. J., Choi, A., An, I., Sathi, N., & Chung, S. (2023) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2023.100095 · Cited by 28 · see citing works

Sleep spindle architecture associated with distinct clinical phenotypes in older adults at risk for dementia

Orlando, I. F., O’Callaghan, C., Lam, A. K. F., McKinnon, A. C., Tan, J. B., Michaelian, J. C., Kong, S. D. X., D'Rozario, A. L., & Naismith, S. L. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02335-1 · Cited by 25 · see citing works

The Molecular Relationship between Stress and Insomnia

Birch, J., & Vanderheyden, W. M. (2022) · Advanced Biology · doi:10.1002/adbi.202101203 · Cited by 24 · see citing works

The role of ascending arousal network in patients with chronic insomnia disorder

Gong, L., He, K., Fang, C., Deng, Z., Cheng, K., Zhang, X., Zhou, W., Ou, J., Wang, J., Zhang, B., et al. (2022) · Human Brain Mapping · doi:10.1002/hbm.26072 · Cited by 24 · see citing works

Optogenetic control of neural activity: The biophysics of microbial rhodopsins in neuroscience

Piatkevich, K. D., & Boyden, E. S. (2023) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583523000033 · Cited by 24 · see citing works

On the basis of sex and sleep: the influence of the estrous cycle and sex on sleep-wake behavior

Swift, K. M., Gary, N. C., & Urbanczyk, P. J. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1426189 · Cited by 30 · see citing works

Emerging Functions of Neuromodulation during Sleep

Sulaman, B. A., Zhang, Y., Matosevich, N., Kjærby, C., Foustoukos, G., Andersen, M., & Eban-Rothschild, A. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1277-24.2024 · Cited by 21 · see citing works

Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats

Matsuda, Y., Ozawa, N., Shinozaki, T., Aoki, K., Nihonmatsu-Kikuchi, N., Shinba, T., & Tatebayashi, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-96094-0 · Cited by 23 · see citing works

Altered norepinephrine transmission after spatial learning impairs sleep-mediated memory consolidation in rats

Durán, E., Pandinelli, M., Logothetis, N. K., & Eschenko, O. (2023) · Scientific Reports · doi:10.1038/s41598-023-31308-1 · Cited by 25 · see citing works

Sleep as a default state of cortical and subcortical networks

Bandarabadi, M., Vassalli, A., & Tafti, M. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.12.004 · Cited by 19 · see citing works

Delta Opioid Receptors and Enkephalinergic Signaling within Locus Coeruleus Promote Stress Resilience

Tkaczynski, J. A., Borodovitsyna, O., & Chandler, D. J. (2022) · Brain Sciences · doi:10.3390/brainsci12070860 · Cited by 17 · see citing works

Locus coeruleus activity while awake is associated with REM sleep quality in older individuals

Koshmanova, E., Berger, A., Beckers, E., Campbell, I., Mortazavi, N., Sharifpour, R., Paparella, I., Balda, F., Berthomier, C., Degueldre, C., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.172008 · Cited by 19 · see citing works

How do we create a healthier thermal environment for sleep? A review of sleep thermal comfort and sleep quality

Bai, Z., Han, Y., Zhuang, D., & Sun, C. T. (2024) · Building and Environment · doi:10.1016/j.buildenv.2024.112214 · Cited by 17 · see citing works

Eye movements during phasic versus tonic rapid eye movement sleep are biomarkers of dissociable electroencephalogram processes for the consolidation of novel problem-solving skills

van den Berg, N., Gibbings, A., Baena, D., Alyssa, P., Al-Kuwatli, J., Ray, L. B., & Fogel, S. M. (2023) · SLEEP · doi:10.1093/sleep/zsad151 · Cited by 17 · see citing works

Neurocognitive, mood changes, and sleepiness in patients with REM-predominant obstructive sleep apnea

BaHammam, A. S., Pirzada, A. R., & Pandi-Perumal, S. R. (2022) · Sleep And Breathing · doi:10.1007/s11325-022-02602-5 · Cited by 18 · see citing works

Diverse ancestral brainstem noradrenergic neuron activity across species and biological factorsPreprint

Kelberman, M. A., Rodberg, E. M., Munn, B. R., Arabzadeh, E., Bair-Marshall, C. J., Berridge, C. W., Berrocoso, E., Breton‐Provencher, V., Chandler, D. J., Che, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.14.618224 · Cited by 19 · see citing works

A time window for memory consolidation during NREM sleep revealed by cAMP oscillation

Deng, Z., Fei, X., Zhang, S., & Xu, M. (2025) · Neuron · doi:10.1016/j.neuron.2025.03.020 · Cited by 17 · see citing works

Norepinephrine depletion in the brain sex-dependently modulates aspects of spatial learning and memory in female and male rats

Gheidi, A., Davidson, C. J., Simpson, S. C., Yahya, M. A., Sadik, N., Mascarin, A. T., & Perrine, S. A. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06453-0 · Cited by 16 · see citing works

The Many Unknowns of Partial Sensory Disconnection during Sleep: A Review of the Literature

Cirelli, C., & Tononi, G. (2024) · Clinical and Translational Neuroscience · doi:10.3390/ctn8010009 · Cited by 15 · see citing works

Shining a Light on the Mechanisms of Sleep for Memory Consolidation

Frazer, M. A., Cabrera, Y., Guthrie, R. S., & Poe, G. R. (2021) · Current Sleep Medicine Reports · doi:10.1007/s40675-021-00204-3 · Cited by 15 · see citing works

Potential Interactions Between Cerebellar Dysfunction and Sleep Disturbances in Dystonia

Leon, L. E. S., & Sillitoe, R. V. (2022) · Dystonia · doi:10.3389/dyst.2022.10691 · Cited by 15 · see citing works

Lactobacillales derived from traditional Xizang dairy products improve insomnia and restore neurotransmitter-metabolic profiles via gut microbiota in PCPA-induced mice

Li, P., Yang, L., Shao, X., Zou, Z., Shi, H., Sun, Y., Wu, X., Li, Z., Li, Y., & Li, Z. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128276 · Cited by 14 · see citing works

Role of the Locus Coeruleus Arousal Promoting Neurons in Maintaining Brain Criticality across the Sleep–Wake Cycle

Huo, C., Lombardi, F., Blanco‐Centurion, C., Shiromani, P. J., & Ivanov, P. C. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1939-23.2024 · Cited by 14 · see citing works

Visual Plasticity in Adulthood: Perspectives from Hebbian and Homeostatic Plasticity

Bang, J. W., Hamilton-Fletcher, G., & Chan, K. C. (2021) · The Neuroscientist · doi:10.1177/10738584211037619 · Cited by 15 · see citing works

The Future of Insomnia Research—There's Still Work to Be Done

Dressle, R. J., Spiegelhalder, K., Schiel, J. E., Benz, F., Johann, A. F., Feige, B., Jernelöv, S., Perlis, M. L., & Riemann, D. W. (2025) · Journal of Sleep Research · doi:10.1111/jsr.70091 · Cited by 12 · see citing works

Noradrenergic dysregulation in the locus coeruleus: Implications for neuropsychiatric disease pathophysiology- A systematic review

Mir, F. A., Jha, S. K., & Nehs, C. J. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106442 · Cited by 16 · see citing works

Systems memory consolidation during sleep: oscillations, neuromodulators, and synaptic remodeling

Kim, J., & Park, M. (2025) · BMB Reports · doi:10.5483/bmbrep.2025-0033 · Cited by 14 · see citing works

Noradrenergic therapies in neurodegenerative disease: from symptomatic to disease modifying therapy?

Durcan, R., O’Callaghan, C., & Rowe, J. B. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf310 · Cited by 14 · see citing works

Monoaminergic signaling during mammalian NREM sleep - Recent insights and next-level questions

Foustoukos, G., & Lüthi, A. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103025 · Cited by 12 · see citing works

Disrupted sleep in dystonia depends on cerebellar function but not motor symptoms in mice

Leon, L. E. S., & Sillitoe, R. V. (2023) · Dystonia · doi:10.3389/dyst.2023.11487 · Cited by 11 · see citing works

Insomnia and intestinal microbiota: a narrative review

Liu, L., Zhu, J.-W., Wu, J.-L., Li, M., Lu, M.-L., Yu, Y., & Pan, L. (2024) · Sleep And Breathing · doi:10.1007/s11325-024-03206-x · Cited by 11 · see citing works

Neurophysiological effects of targeting sleep spindles with closed-loop auditory stimulation

Jourde, H. R., Sobral, M., Beltrame, G., & Coffey, E. B. J. (2025) · SLEEP Advances · doi:10.1093/sleepadvances/zpaf007 · Cited by 12 · see citing works

Cortical activity upon awakening from sleep reveals consistent spatio-temporal gradients across sleep stages in human EEG

Stephan, A., Cataldi, J., Virk, A. S., & Siclari, F. (2025) · Current Biology · doi:10.1016/j.cub.2025.06.064 · Cited by 11 · see citing works

Memory reactivations and consolidation: considering neuromodulators across wake and sleep

Samanta, A., Alonso, A., & Genzel, L. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.01.003 · Cited by 11 · see citing works

WaveSleepNet: An interpretable deep convolutional neural network for the continuous classification of mouse sleep and wake

Kam, K., Rapoport, D. M., Parekh, A., Ayappa, I. A., & Varga, A. W. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109224 · Cited by 11 · see citing works

Purkinje cell dysfunction causes disrupted sleep in ataxic mice

Leon, L. E. S., Brown, A. M., Kaku, H., & Sillitoe, R. V. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050379 · Cited by 10 · see citing works

Traumatic brain injury and sleep in military and veteran populations: A literature review

Landvater, J., Kim, S. Y., Caswell, K., Kwon, C., Odafe, E., Roe, G., Tripathi, A., Vukovics, C., Wang, J., Ryan, K., et al. (2024) · Neurorehabilitation · doi:10.3233/nre-230380 · Cited by 11 · see citing works

Sleep spindle density and temporal clustering are associated with sleep-dependent memory consolidation in Parkinson’s disease

Lahlou, S., Kamińska, M., Doyon, J., Carrier, J., & Sharp, M. E. (2024) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.11080 · Cited by 9 · see citing works

Single closed‐loop acoustic stimulation targeting memory consolidation suppressed hippocampal ripple and thalamo‐cortical spindle activity in mice

Aksamaz, S., Mölle, M., Akinola, E. O., Gromodka, E., Bazhenov, M., & Marshall, L. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16116 · Cited by 9 · see citing works

Sleep Changes Across the Female Hormonal Cycle Affecting Memory: Implications for Resilient Adaptation to Traumatic Experiences

Cabrera, Y., Holloway, J., & Poe, G. R. (2020) · Journal of Women s Health · doi:10.1089/jwh.2020.8332 · Cited by 8 · see citing works

Self-reported sleep relates to microstructural hippocampal decline in ß-amyloid positive Adults beyond genetic risk

Grydeland, H., Sederevičius, D., Wang, Y., David Bartrés-faz, A., Bertram, L., Dobričić, V., Düzel, S., Ebmeier, K. P., Lindenberger, U., Nyberg, L. H., et al. (2021) · SLEEP · doi:10.1093/sleep/zsab110 · Cited by 9 · see citing works

The effect of sleep restriction therapy for insomnia on REM sleep fragmentation: A secondary analysis of a randomised controlled trial

Maurer, L., Sharman, R. L., Espie, C. A., & Kyle, S. D. (2023) · Journal of Sleep Research · doi:10.1111/jsr.13982 · Cited by 8 · see citing works

Phasic Dopamine Release in the Nucleus Accumbens Influences REM Sleep Timing

Toth, B. A., & Burgess, C. R. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1374-24.2024 · Cited by 8 · see citing works

Experience alters hippocampal and cortical network communication via a KIBRA-dependent mechanism

Quigley, L. D., Pendry, R., Mendoza, M. L., Pfeiffer, B. E., & Volk, L. J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112662 · Cited by 8 · see citing works

Genetic risk for insomnia is associated with objective sleep measures in young and healthy good sleepers

Koshmanova, E., Muto, V., Chylinski, D., Mouraux, C., Reyt, M., Grinard, M., Talwar, P., Lambot, E., Berthomier, C., Brandewinder, M., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105924 · Cited by 8 · see citing works

Do all norepinephrine surges disrupt sleep?

Lüthi, A., Franken, P., Fulda, S., Siclari, F., & Someren, E. J. W. V. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01313-8 · Cited by 8 · see citing works

Sleeping through brain excitation and inhibition

Pereira, S. I. R., & Lewis, P. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0697-4 · Cited by 7 · see citing works

Noradrenaline Regulation of Brain-Body Communication

Fernandes, G., Lam, R. M., Park, J. H., Drummond, G. T., & Sur, M. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-89525-8_2 · Cited by 7 · see citing works

Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus

Cumpana, L., Zanoletti, O., Kankanamge, D., Copits, B. A., Sandi, C., & Astori, S. (2025) · Nature Communications · doi:10.1038/s41467-025-63118-6 · Cited by 7 · see citing works

Rethinking early Alzheimer’s disease: An impaired internal model updating disorder?

Antonioni, A. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106790 · Cited by 7 · see citing works

Do your troubles today seem further away than yesterday? On sleep’s role in mitigating the blushing response to a reactivated embarrassing episode

Reinhold, F. L., Gerlicher, A. M. V., Someren, E. J. W. V., & Kindt, M. (2022) · SLEEP · doi:10.1093/sleep/zsac220 · Cited by 7 · see citing works

Disruption of Sleep Microarchitecture Is a Sensitive and Early Marker of Parkinson’s Disease

Doppler, C. E. J., Smit, J. A. M., Hommelsen, M., Seger, A., Okkels, N., Horsager, J., Kinnerup, M. B., Hansen, A. K., Fedorova, T. D., Knudsen, K., et al. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-223442 · Cited by 6 · see citing works

Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents

Brunswick, C. A., Carpenter, C. M., Dennis, N. A., & Kwapis, J. L. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106195 · Cited by 8 · see citing works

The influence of peripheral glucose on sleep brain oscillations

Yu, L., Hallschmid, M., Jan Born, A., & Niethard, N. (2025) · SLEEP · doi:10.1093/sleep/zsaf151 · Cited by 6 · see citing works

Are the biomedical sciences ready for synthetic biology?

DeNies, M. S., Liu, A. P., & Schnell, S. D. (2020) · BioMolecular Concepts · doi:10.1515/bmc-2020-0003 · Cited by 6 · see citing works

Locus Coeruleus Optogenetic Stimulation and the Estrous Cycle Manipulate Sleep Characteristics and Memory Consolidation

Swift, K. A. (2019) · Deep Blue (University of Michigan)

Locus coeruleus activity during sleep for off-line memory consolidation

Sara, S. J. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/conf.neuro.08.2009.09.023

Ripple-triggered stimulation of the locus coeruleus during post-learning sleep disrupts ripple/spindle coupling and impairs memory consolidationPreprint

Novitskaya, Y., Sara, S., Logothetis, N., & Eschenko, O. (2016) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.040923.115 · Cited by 86 · see citing works

The Locus Coeruleus activity during hippocampal-cortical communication

Yang, M., Logothetis, N. K., Sara, S. J., & Eschenko, O. (2019) · MPG.PuRe (Max Planck Society)

Differential locus coeruleus–hippocampus interactions during offline states

Yang, M., & Eschenko, O. (2026) · eLife · doi:10.1101/2025.09.18.677005 · Cited by 1 · see citing works