The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators

Crunelli, Vincenzo; Hughes, Stuart W

doi:10.1038/nn.2445

Cited by 435Sleep and Wakefulness ResearchNeural dynamics and brain functionNeuroscience of respiration and sleep

The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators

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Crunelli, Vincenzo, Hughes, Stuart W·2010·Nature Neuroscience

DOI 10.1038/nn.2445PMC PMC2980822

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Abstract

The slow (<1 Hz) rhythm, the most important electroencephalogram (EEG) signature of non–rapid eye movement (NREM) sleep, is generally viewed as originating exclusively from neocortical networks. Here we argue that the full manifestation of this fundamental sleep oscillation in a corticothalamic module requires the dynamic interaction of three cardinal oscillators: one predominantly synaptically based cortical oscillator and two intrinsic, conditional thalamic oscillators. The functional implications of this hypothesis are discussed in relation to other EEG features of NREM sleep, with respect to coordinating activities in local and distant neuronal assemblies and in the context of facilitating cellular and network plasticity during slow-wave sleep.

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Somatostatin-positive interneurons inhibiting pyramidal dendrites appear to be specifically implicated in the induction of downstates, apart from thalamic afferents and cortical astrocytes.
“Apart from thalamic afferents and cortical astrocytes, somatostatin positive interneurons inhibiting pyramidal dendrites appear to be specifically implicated in the induction of downstates.161,172,173”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [173]
The Neocortex section (page unavailable) identifies layer-5 Martinotti cells as cells that intrinsically generate UP and DOWN states, providing limited support for interneuron involvement. It does not identify them as somatostatin-positive, describe inhibition of pyramidal dendrites, or specifically implicate them in inducing DOWN states; the passage instead discusses a current involved in generating their UP states. (LLM, conf=0.82)
Experimental — accuracy not yet measured
In naturally sleeping mice, spindles nesting into a SO upstate are characterized by a unique constellation of cortical microcircuit activity: inhibition by somatostatin-positive cells is released from dendrites of pyramidal cells that display strongly increased calcium activity, whereas effective somatic inhibition of pyramidal cells prevails when spindles occur without a SO.
“In vivo calcium imaging in naturally sleeping mice revealed that spindles, which nest into a SO upstate are characterized by a unique constellation of activity in cortical microcircuits, where inhibition (by somatostatin positive cells) is released from the dendrites of pyramidal cells that themselves display strongly increased calcium activity, whereas an effective somatic inhibition of the pyram”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [173]
Split into 2 atoms — 0 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
The slow oscillation is generated in cortical networks and can occur in isolated cortical slices.
“The slow oscillation is generated in cortical networks and can occur in isolated cortical slices (239, 1028, 1198).”
From About Sleep's Role in Memory (2013) · cites this paper as [239]
The slow oscillation of the intact brain likely reflects an interaction between cortical and thalamic networks.
“Nevertheless, the slow oscillation of the intact brain likely reflects an interaction between cortical and thalamic networks (239, 1196).”
From About Sleep's Role in Memory (2013) · cites this paper as [239]

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A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components
Steriade, M., Nunez, A., & Amzica, F. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03252.1993 · Cited by 1,903 · see citing works
Local sleep and learning
Huber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854 · see citing works
Boosting slow oscillations during sleep potentiates memory
Marshall, L., Helgadóttir, H., Mölle, M., & Born, J. (2006) · Nature · doi:10.1038/nature05278 · Cited by 1,792 · see citing works
Coordinated memory replay in the visual cortex and hippocampus during sleep
Ji, D., & Wilson, M. A. (2007) · Nature Neuroscience · doi:10.1038/nn1825 · Cited by 1,669 · see citing works
Cellular and network mechanisms of rhythmic recurrent activity in neocortex
Sanchez-Vives, M. V., & McCormick, D. A. (2000) · Nature Neuroscience · doi:10.1038/79848 · Cited by 1,539 · see citing works
Natural waking and sleep states: a view from inside neocortical neurons
Steriade, M., Timofeev, I., & Grenier, F. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.5.1969 · Cited by 1,296 · see citing works
Grouping of brain rhythms in corticothalamic systems
Steriade, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.029 · Cited by 1,296 · see citing works
Memory of sequential experience in the hippocampus during slow wave sleep
Lee, A. K., & Wilson, M. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)01096-6 · Cited by 1,296 · see citing works
The sleep slow oscillation as a traveling wave
Massimini, M., Huber, R., Ferrarelli, F., Hill, S., & Tononi, G. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1318-04.2004 · Cited by 1,221 · see citing works
Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity
McCormick, D. A. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90012-4 · Cited by 1,117 · see citing works
Turning on and off recurrent balanced cortical activity
Shu, Y., Hasenstaub, A., & McCormick, D. A. (2003) · Nature · doi:10.1038/nature01616 · Cited by 1,054 · see citing works
Neocortical Network ActivityIn VivoIs Generated through a Dynamic Balance of Excitation and Inhibition
Haider, B., Duque, A., Hasenstaub, A. R., & McCormick, D. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5297-05.2006 · Cited by 962 · see citing works
Replay and Time Compression of Recurring Spike Sequences in the Hippocampus
Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J., & Buzsáki, G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09497.1999 · Cited by 932 · see citing works
Communication between neocortex and hippocampus during sleep in rodents
Sirota, A., Csicsvari, J., Buhl, D., & Buzsáki, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437938100 · Cited by 930 · see citing works
Sleep spindles: an overview
Gennaro, L. D., & Ferrara, M. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0252 · Cited by 925 · see citing works
Intracellular analysis of relations between the slow (< 1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram
Steriade, M., Nunez, A., & Amzica, F. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03266.1993 · Cited by 894 · see citing works
Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
Vyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G. (2008) · Nature Neuroscience · doi:10.1038/nn2035 · Cited by 837 · see citing works
Are spatial memories strengthened in the human hippocampus during slow wave sleep?
Peigneux, P., Laureys, S., Fuchs, S., Collette, F., Perrin, F., Reggers, J., Phillips, C., Degueldre, C., Del Fiore, G., Aerts, J., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.007 · Cited by 766 · see citing works
Functional organization of thalamocortical relays
Sherman, S. M., & Guillery, R. W. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.3.1367 · Cited by 762 · see citing works
The slow (< 1 Hz) oscillation in reticular thalamic and thalamocortical neurons: scenario of sleep rhythm generation in interacting thalamic and neocortical networks
Steriade, M., Contreras, D., Dossi, R. C., & Núñez, Á. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03284.1993 · Cited by 723 · see citing works
Origin of Slow Cortical Oscillations in Deafferented Cortical Slabs
Timofeev, I. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.12.1185 · Cited by 710 · see citing works
Cellular basis of EEG slow rhythms: a study of dynamic corticothalamic relationships
Contreras, D., & Steriade, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00604.1995 · Cited by 700 · see citing works
Bursting of Thalamic Neurons and States of Vigilance
Llinás, R. R., & Steriade, M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00166.2006 · Cited by 682 · see citing works
Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
Petersen, C. C. H., Hahn, T. T. G., Mehta, M. R., Grinvald, A., & Sakmann, B. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235811100 · Cited by 673 · see citing works
Attractor dynamics of network UP states in the neocortex
Cossart, R., Aronov, D., & Yuste, R. (2003) · Nature · doi:10.1038/nature01614 · Cited by 659 · see citing works
Grouping of spindle activity during slow oscillations in human non-rapid eye movement sleep
Mölle, M., Marshall, L., Gais, S., & Born, J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10941.2002 · Cited by 617 · see citing works
Sleep as a fundamental property of neuronal assemblies
Krueger, J. M., Rector, D. M., Roy, S., Van Dongen, H. P. A., Belenky, G., & Panksepp, J. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2521 · Cited by 596 · see citing works
The Slow (4 Hz) Oscillation in Reticular Thalamic and Thalamocortical Neurons: Scenario of Sleep Rhythm Generation in Interacting Thalamic and Neocortical Networks
Steriade, M., Contreras, D., & Nuiiez, A. (1993) · Cited by 584 · see citing works
Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity
Huber, R., Ghilardi, M. F., Massimini, M., Ferrarelli, F., Riedner, B. A., Peterson, M. J., & Tononi, G. (2006) · Nature Neuroscience · doi:10.1038/nn1758 · Cited by 579 · see citing works
Low-frequency (<1Hz) oscillations in the human sleep electroencephalogram
Achermann, P., & Borbély, A. A. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00186-3 · Cited by 577 · see citing works
From waking to sleeping: neuronal and chemical substrates
Jones, B. E. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.09.009 · Cited by 577 · see citing works
Cellular bases of neocortical activation: modulation of neural oscillations by the nucleus basalis and endogenous acetylcholine
Metherate, R., Cox, C. L., & Ashe, J. H. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04701.1992 · Cited by 575 · see citing works
Spatiotemporal analysis of local field potentials and unit discharges in cat cerebral cortex during natural wake and sleep states
Destexhe, A., Contreras, D., & Steriade, M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04595.1999 · Cited by 573 · see citing works
Cellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model
Compte, A., Sanchez-Vives, M. V., McCormick, D. A., & Wang, X. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00845.2002 · Cited by 536 · see citing works
Sequential structure of neocortical spontaneous activity in vivo
Luczak, A., Barthó, P., Marguet, S. L., Buzsáki, G., & Harris, K. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605643104 · Cited by 515 · see citing works
The impact of 'bursting' thalamic impulses at a neocortical synapse
Swadlow, H. A., & Gusev, A. G. (2001) · Nature Neuroscience · doi:10.1038/86054 · Cited by 500 · see citing works
Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.
McCormick, D. A., & von Krosigk, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2774 · Cited by 500 · see citing works
Integration and Segregation of Activity in Entorhinal-Hippocampal Subregions by Neocortical Slow Oscillations
Isomura, Y., Sirota, A., Özen, S., Montgomery, S., Mizuseki, K., Henze, D. A., & Buzsáki, G. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.023 · Cited by 500 · see citing works
Imaging input and output of neocortical networks in vivo
Kerr, J. N. D., Greenberg, D., & Helmchen, F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506029102 · Cited by 474 · see citing works
Model of Thalamocortical Slow-Wave Sleep Oscillations and Transitions to Activated States
Bazhenov, M., Timofeev, I., Steriade, M., & B, T. J. S. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08691.2002 · Cited by 457 · see citing works
Spontaneous neural activity during human slow wave sleep
Dang‐Vu, T. T., Schabus, M., Desseilles, M., Albouy, G., Boly, M., Darsaud, A., Gais, S., Rauchs, G., Virginie Sterpenich, A., Vandewalle, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801819105 · Cited by 436 · see citing works
Synchronized activities of coupled oscillators in the cerebral cortex and thalamus at different levels of vigilance [published erratum appears in Cereb Cortex 1997 Dec;7(8):779]
Steriade, M. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.583 · Cited by 429 · see citing works
Modeling Sleep and Wakefulness in the Thalamocortical System
Hill, S., & Tononi, G. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00915.2004 · Cited by 417 · see citing works
Population imaging of ongoing neuronal activity in the visual cortex of awake rats
Greenberg, D. S., Houweling, A. R., & Kerr, J. N. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2140 · Cited by 408 · see citing works
Do all animals sleep?
Siegel, J. M. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.02.001 · Cited by 404 · see citing works
Synchronization of fast (30-40 Hz) spontaneous oscillations in intrathalamic and thalamocortical networks
Steriade, M., Contreras, D., Amzica, F., & Timofeev, I. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02788.1996 · Cited by 404 · see citing works
The Human K-Complex Represents an Isolated Cortical Down-State
Cash, S. S., Halgren, E., Dehghani, N., Rossetti, A. O., Thesen, T., Wang, C., Devinsky, O., Kuzniecky, R., Doyle, W., Madsen, J. R., et al. (2009) · Science · doi:10.1126/science.1169626 · Cited by 394 · see citing works
Internal Dynamics Determine the Cortical Response to Thalamic Stimulation
MacLean, J. N., Watson, B. O., Aaron, G. B., & Yuste, R. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.035 · Cited by 373 · see citing works
Spontaneous Subthreshold Membrane Potential Fluctuations and Action Potential Variability of Rat Corticostriatal and Striatal Neurons In Vivo
Stern, E. A., Kincaid, A. E., & Wilson, C. J. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.4.1697 · Cited by 362 · see citing works
The cortex as a central pattern generator
Yuste, R., MacLean, J. N., Smith, J., & Lansner, A. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1686 · Cited by 355 · see citing works
Are corticothalamic ‘up’ states fragments of wakefulness?
Destexhe, A., Hughes, S. W., Rudolph, M., & Crunelli, V. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.04.006 · Cited by 355 · see citing works
Self-citation
Low-frequency rhythms in the thalamus of intact-cortex and decorticated cats
Timofeev, I., & Steriade, M. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.6.4152 · Cited by 353 · see citing works
The K-complex: Its slow (<1-Hz) rhythmicity and relation to delta waves
Amzica, F., & Steriade, M. (1997) · Neurology · doi:10.1212/wnl.49.4.952 · Cited by 329 · see citing works
Spindle oscillation in cats: the role of corticothalamic feedback in a thalamically generated rhythm.
Contreras, D., & Steriade, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021133 · Cited by 329 · see citing works
Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm
Lörincz, M. L., Kékesi, K. A., Juhász, G. D., Crunelli, V., & Hughes, S. W. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.012 · Cited by 326 · see citing works
Self-citation
Precise Long-Range Synchronization of Activity and Silence in Neocortical Neurons during Slow-Wave Sleep
Volgushev, M., Chauvette, S., Mukovski, M., & Timofeev, I. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0279-06.2006 · Cited by 289 · see citing works
Synchronized Oscillations at α and θ Frequencies in the Lateral Geniculate Nucleus
Hughes, S. W., Lörincz, M. L., Cope, D. W., Blethyn, K. L., Kékesi, K. A., Parri, H. R., Juhász, G. D., & Crunelli, V. (2004) · Neuron · doi:10.1016/s0896-6273(04)00191-6 · Cited by 276 · see citing works
Self-citation
Inhibition Determines Membrane Potential Dynamics and Controls Action Potential Generation in Awake and Sleeping Cat Cortex
Rudolph, M., Pospischil, M., Timofeev, I., & Destexhe, A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4652-06.2007 · Cited by 247 · see citing works
Cellular Mechanisms of the Slow (<1 Hz) Oscillation in Thalamocortical Neurons In Vitro
Hughes, S. W., Cope, D. W., Blethyn, K. L., & Crunelli, V. (2002) · Neuron · doi:10.1016/s0896-6273(02)00623-2 · Cited by 243 · see citing works
Self-citation
Hippocampal Slow Oscillation: A Novel EEG State and Its Coordination with Ongoing Neocortical Activity
Wolansky, T., Clement, E., Peters, S. R., Palczak, M. A., & Dickson, C. T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5594-05.2006 · Cited by 226 · see citing works
Learning increases human electroencephalographic coherence during subsequent slow sleep oscillations
Mölle, M., Marshall, L., Gais, S., & Born, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402820101 · Cited by 222 · see citing works
Disconnection of intracortical synaptic linkages disrupts synchronization of a slow oscillation
Amzica, F., & Steriade, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04658.1995 · Cited by 221 · see citing works
The ‘window’ component of the low threshold Ca2+ current produces input signal amplification and bistability in cat and rat thalamocortical neurones
Williams, S. R., Toth, T. I., Turner, J. P., Hughes, S. W., & Crunelli, V. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.689ba.x · Cited by 219 · see citing works
Self-citation
T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites
Cueni, L., Canepari, M., Luján, R., Emmenegger, Y., Watanabe, M., Bond, C. T., Franken, P., Adelman, J. P., & Lüthi, A. (2008) · Nature Neuroscience · doi:10.1038/nn.2124 · Cited by 215 · see citing works
Cholinergic brainstem neurons modulate cortical gamma activity during slow oscillations
Mena‐Segovia, J., Sims, H. M., Magill, P. J., & Bolam, J. P. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.153874 · Cited by 205 · see citing works
Characterization of sensory and corticothalamic excitatory inputs to rat thalamocortical neurones in vitro
Turner, J. P., & Salt, T. E. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.829bj.x · Cited by 192 · see citing works
Cellular substrates and laminar profile of sleep K-complex
Amzica, F., & Steriade, M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00319-9 · Cited by 191 · see citing works
Neuronal metabolism governs cortical network response state.
Cunningham, M., Pervouchine, D., Racca, C., Kopell, N., Davies, C., Jones, R. S. G., Traub, R., & Whittington, M. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0600604103 · Cited by 174 · see citing works
Selective GABAergic Control of Higher-Order Thalamic Relays
Bokor, H., Frère, S. G. A., Eyre, M. D., Slézia, A., Ulbert, I., Lüthi, A., & Acsády, L. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.048 · Cited by 169 · see citing works
The ‘window’ T‐type calcium current in brain dynamics of different behavioural states
Crunelli, V., Toth, T. I., Cope, D. W., Blethyn, K. L., & Hughes, S. W. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.076273 · Cited by 167 · see citing works
Self-citation
The functional significance of K-complexes
Amzica, F., & Steriade, M. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2001.0181 · Cited by 161 · see citing works
Thalamic T-type Ca2+ channels and NREM sleep
Crunelli, V., Cope, D. W., & Hughes, S. W. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.04.022 · Cited by 151 · see citing works
Self-citation
Thalamocortical Up States: Differential Effects of Intrinsic and Extrinsic Cortical Inputs on Persistent Activity
Rigas, P., & Castro‐Alamancos, M. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0003-07.2007 · Cited by 147 · see citing works
Persistently active, pacemaker-like neurons in neocortex
Bon-Jégo, M. L. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.009.2007 · Cited by 146 · see citing works
Ultrastructural Localization Suggests that Retinal and Cortical Inputs Access Different Metabotropic Glutamate Receptors in the Lateral Geniculate Nucleus
Godwin, D. W., Horn, S. C. V., Erişir, A., Sesma, M. A., Romano, C., & Sherman, S. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-08181.1996 · Cited by 137 · see citing works
Neuronal Basis of the Slow (<1 Hz) Oscillation in Neurons of the Nucleus Reticularis ThalamiIn Vitro
Blethyn, K. L., Hughes, S. W., Toth, T. I., Cope, D. W., & Crunelli, V. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3607-05.2006 · Cited by 135 · see citing works
Self-citation
EEG Slow (∼1 Hz) Waves Are Associated With Nonstationarity of Thalamo-Cortical Sensory Processing in the Sleeping Human
Massimini, M., Rosanova, M., & Mariotti, M. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00373.2002 · Cited by 124 · see citing works
Control of Dendritic Outputs of Inhibitory Interneurons in the Lateral Geniculate Nucleus
Cox, C. L., & Sherman, S. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00069-6 · Cited by 119 · see citing works
All thalamocortical neurones possess a T‐type Ca2+‘window’ current that enables the expression of bistability‐mediated activities
Hughes, S. W., Cope, D. W., Toth, T. I., Williams, S. R., & Crunelli, V. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0805s.x · Cited by 109 · see citing works
Self-citation
Thalamocortical Bursts Trigger Recurrent Activity in Neocortical Networks: Layer 4 as a Frequency-Dependent Gate
Beierlein, M., Fall, C. P., Rinzel, J., & Yuste, R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09885.2002 · Cited by 104 · see citing works
Cellular mechanisms of burst firing‐mediated long‐term depression in rat neocortical pyramidal cells
Czarnecki, A., Birtoli, B., & Ulrich, D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.123588 · Cited by 99 · see citing works
Two distinct activity patterns of fast-spiking interneurons during neocortical UP states
Puig, M. V., Ushimaru, M., & Kawaguchi, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712219105 · Cited by 98 · see citing works
Synchronization of low-frequency rhythms in corticothalamic networks
Contreras, D., & Steriade, M. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00393-4 · Cited by 94 · see citing works
Properties and origin of spikelets in thalamocortical neurones in vitro
Hughes, S. W., Blethyn, K. L., Cope, D. W., & Crunelli, V. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00577-2 · Cited by 90 · see citing works
Self-citation
Impact of Cortical Network Activity on Short-term Synaptic Depression
Reig, R., Gallego, R., Nowak, L. G., & Sanchez-Vives, M. V. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj014 · Cited by 90 · see citing works
Role of Thalamic and Cortical Neurons in Augmenting Responses and Self-Sustained Activity: Dual Intracellular Recordings In Vivo
Steriade, M., Timofeev, I., Grenier, F., & Dürmüller, N. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06425.1998 · Cited by 89 · see citing works
A MEG study of sleep
Simon, N. R., Manshanden, I., & da Silva, F. H. L. (2000) · Brain Research · doi:10.1016/s0006-8993(00)01974-0 · Cited by 73 · see citing works
The Upshot of Up States in the Neocortex: From Slow Oscillations to Memory Formation
Hoffman, K., Battaglia, F., Harris, K., MacLean, J., Marshall, L., & Mehta, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3501-07.2007 · Cited by 72 · see citing works
Cortico-hippocampal interaction during up-down states and memory consolidation
Mehta, M. R. (2006) · Nature Neuroscience · doi:10.1038/nn0107-13 · Cited by 68 · see citing works
Cortical Plasticity Induced by Transcranial Magnetic Stimulation during Wakefulness Affects Electroencephalogram Activity during Sleep
De Gennaro, L., Fratello, F., Marzano, C., Moroni, F., Curcio, G., Tempesta, D., Pellicciari, M. C., Pirulli, C., Ferrara, M., & Rossini, P. M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002483 · Cited by 60 · see citing works
State-dependent fluctuations of low-frequency rhythms in corticothalamic networks
Contreras, D., & Steriade, M. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00392-2 · Cited by 54 · see citing works
Synaptic activation of the group I metabotropic glutamate receptor mGlu1 on the thalamocortical neurons of the rat dorsal Lateral Geniculate Nucleus in vitro
Turner, J. P., & Salt, T. E. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00280-3 · Cited by 52 · see citing works
Nucleus- and species-specific properties of the slow (<1 Hz) sleep oscillation in thalamocortical neurons
Zhu, L., Blethyn, K. L., Cope, D. W., Tsomaia, V., Crunelli, V., & Hughes, S. W. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.069 · Cited by 52 · see citing works
Self-citation
A role for low‐frequency, rhythmic synaptic potentials in the synchronization of cat thalamocortical cells.
Soltész, I., & Crunelli, V. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019377 · Cited by 50 · see citing works
Self-citation
Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensory cortical neurons: in vivo patch‐clamp analysis
Doi, A., Mizuno, M., Katafuchi, T., Furue, H., Koga, K., & Yoshimura, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05885.x · Cited by 35 · see citing works
Sleepy Dialogues between Cortex and Hippocampus: Who Talks to Whom?
Tononi, G., Massimini, M., & Riedner, B. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.11.014 · Cited by 29 · see citing works
Functional Synaptic Contacts by Intranuclear Axon Collaterals of Thalamic Relay Neurons
Cox, C. L., Reichova, I., & Sherman, S. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07642.2003 · Cited by 26 · see citing works
Analysis and biophysical interpretation of bistable behaviour in thalamocortical neurons
Toth, T. I., Hughes, S. W., & Crunelli, V. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00118-3 · Cited by 18 · see citing works
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About Sleep's Role in Memory
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
Wang, X.-J. (2010) · Physiological Reviews · doi:10.1152/physrev.00035.2008 · Cited by 1,939 · see citing works
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works
Regional Slow Waves and Spindles in Human Sleep
Nir, Y., Staba, R. J., Andrillon, T., Vyazovskiy, V. V., Cirelli, C., Fried, I., & Tononi, G. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.043 · Cited by 924 · see citing works
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
Electroencephalogram signatures of loss and recovery of consciousness from propofol
Purdon, P. L., Pierce, E. T., Mukamel, E. A., Prerau, M. J., Walsh, J. L., Wong, K. F. K., Salazar-Gomez, A. F., Harrell, P. G., Sampson, A. L., Cimenser, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221180110 · Cited by 854 · see citing works
Sleep promotes branch-specific formation of dendritic spines after learning
Yang, G., Lai, C. S. W., Cichon, J., Ma, L., Li, W., & Gan, W.-B. (2014) · Science · doi:10.1126/science.1249098 · Cited by 616 · see citing works
Fast and Slow Spindles during the Sleep Slow Oscillation: disparate Coalescence and engagement in Memory processing
Mölle, M., Bergmann, T. O., Marshall, L., & Born, J. (2011) · Sleep · doi:10.5665/sleep.1290 · Cited by 557 · see citing works
Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness
Lewis, L. D., Weiner, V. S., Mukamel, E. A., Donoghue, J., Eskandar, E. N., Madsen, J. R., Anderson, W. S., Hochberg, L. R., Cash, S. S., Brown, E. N., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210907109 · Cited by 387 · see citing works
Sleep and the single neuron: the role of global slow oscillations in individual cell rest
Vyazovskiy, V. V., & Harris, K. D. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3494 · Cited by 362 · see citing works
Impairments of neural circuit function in Alzheimer's disease
Busche, M. A., & Konnerth, A. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0429 · Cited by 360 · see citing works
Sleep—A brain-state serving systems memory consolidation
Brodt, S., Inostroza, M., Niethard, N., & Born, J. (2023) · Neuron · doi:10.1016/j.neuron.2023.03.005 · Cited by 343 · see citing works
Sleep Neurophysiological Dynamics Through the Lens of Multitaper Spectral Analysis
Prerau, M. J., Brown, R. E., Bianchi, M. T., Ellenbogen, J. M., & Purdon, P. L. (2016) · Physiology · doi:10.1152/physiol.00062.2015 · Cited by 308 · see citing works
Motor thalamus integration of cortical, cerebellar and basal ganglia information: implications for normal and parkinsonian conditions
Bosch‐Bouju, C., Hyland, B. I., & Parr‐Brownlie, L. C. (2013) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2013.00163 · Cited by 301 · see citing works
EEG microstates of wakefulness and NREM sleep
Brodbeck, V., Kuhn, A., von Wegner, F., Morzelewski, A., Tagliazucchi, E., Borisov, S. V., Michel, C. M., & Laufs, H. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.05.060 · Cited by 294 · see citing works
Cortical circuit activity underlying sleep slow oscillations and spindles
Niethard, N., Ngo, H.-V. V., Ehrlich, I., & Born, J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805517115 · Cited by 245 · see citing works
Oscillating circuitries in the sleeping brain
Adamantidis, A. R., Gutierrez Herrera, C., & Gent, T. C. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0223-4 · Cited by 281 · see citing works
Layer-Specific Physiological Features and Interlaminar Interactions in the Primary Visual Cortex of the Mouse
Senzai, Y., Fernández‐Ruiz, A., & Buzsáki, G. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.009 · Cited by 279 · see citing works
The Slow Oscillation in Cortical and Thalamic Networks: Mechanisms and Functions
Neske, G. T. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00088 · Cited by 283 · see citing works
Sleep slow wave changes during the middle years of life: Changes in slow waves with age
Carrier, J., Viens, I., Poirier, G., Robillard, R., Lafortune, M., Vandewalle, G., Martin, N., Barakat, M., Paquet, J., & Filipini, D. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07543.x · Cited by 269 · see citing works
Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation
Chauvette, S., Volgushev, M., & Timofeev, I. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq009 · Cited by 266 · see citing works
Neural correlates of consciousness in patients who have emerged from a minimally conscious state: a cross-sectional multimodal imaging study
Perri, C. D., Bahri, M. A., Amico, E., Thibaut, A., Heine, L., Antonopoulos, G., Charland‐Verville, V., Wannez, S., Gómez, F. A., Hustinx, R., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00111-3 · Cited by 260 · see citing works
Slow-wave sleep: From the cell to the clinic
Léger, D., Debellemanière, E., Rabat, A., Bayon, V., Benchenane, K., & Chennaoui, M. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.01.008 · Cited by 261 · see citing works
Making Waves: Initiation and Propagation of Corticothalamic Ca2+ Waves In Vivo
Stroh, A., Adelsberger, H., Groh, A., Rühlmann, C., Fischer, S., Schierloh, A., Deisseroth, K. A., & Konnerth, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.031 · Cited by 249 · see citing works
Facilitation of epileptic activity during sleep is mediated by high amplitude slow waves
Frauscher, B., von Ellenrieder, N., Ferrari-Marinho, T., Avoli, M., Dubeau, F., & Gotman, J. (2015) · Brain : a journal of neurology · doi:10.1093/brain/awv073 · Cited by 228 · see citing works
Laminar analysis of slow wave activity in humans
Csercsa, R., Dombovári, B., Fabó, D., Wittner, L., Erőss, L., Entz, L., Sólyom, A., Rásonyi, G., Szűcs, A., Kelemen, A., et al. (2010) · Brain · doi:10.1093/brain/awq169 · Cited by 239 · see citing works
Sleep Spindles
Lüthi, A. (2013) · The Neuroscientist · doi:10.1177/1073858413500854 · Cited by 233 · see citing works
Essential Thalamic Contribution to Slow Waves of Natural Sleep
David, F., Schmiedt, J. T., Taylor, H. L., Orbán, G., Giovanni, G. D., Uebele, V. N., Renger, J. J., Lambert, R. C., Leresche, N., & Crunelli, V. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3169-13.2013 · Cited by 223 · see citing works
Self-citation
Age-related changes in the cognitive function of sleep
Pace-Schott, E. F., & Spencer, R. M. C. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53752-2.00012-6 · Cited by 220 · see citing works
Rescue of long-range circuit dysfunction in Alzheimer's disease models
Busche, M. A., Kekuš, M., Adelsberger, H., Noda, T., Förstl, H., Nelken, I., & Konnerth, A. (2015) · Nature Neuroscience · doi:10.1038/nn.4137 · Cited by 215 · see citing works
The Ca V 3.3 calcium channel is the major sleep spindle pacemaker in thalamus
Astori, S., Wimmer, R. D., Prosser, H. M., Corti, C., Corsi, M., Liaudet, N., Volterra, A., Franken, P., Adelman, J. P., & Lüthi, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105115108 · Cited by 213 · see citing works
Thalamic reticular nucleus induces fast and local modulation of arousal state
Lewis, L. D., Voigts, J., Flores, F. J., Schmitt, L. I., Wilson, M. A., Halassa, M. M., & Brown, E. N. (2015) · eLife · doi:10.7554/elife.08760 · Cited by 204 · see citing works
The Neurobiology of Sleep and Wakefulness
Schwartz, M. D., & Kilduff, T. S. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.07.002 · Cited by 207 · see citing works
Brain state dependent activity in the cortex and thalamus
McCormick, D. A., McGinley, M. J., & Salkoff, D. B. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.10.003 · Cited by 189 · see citing works
Two distinct synchronization processes in the transition to sleep: a high-density electroencephalographic study
Siclari, F., Bernardi, G., Riedner, B. A., LaRocque, J. J., Benca, R. M., & Tononi, G. (2014) · Sleep · doi:10.5665/sleep.4070 · Cited by 181 · see citing works
The Impact of Cortical Deafferentation on the Neocortical Slow Oscillation
Lemieux, M., Chen, J., Lonjers, P., Bazhenov, M., & Timofeev, I. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1156-13.2014 · Cited by 177 · see citing works
Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness
Flores, F. J., Hartnack, K. E., Fath, A. B., Kim, S., Wilson, M. A., Brown, E. N., & Purdon, P. L. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700148114 · Cited by 169 · see citing works
Shaping the Default Activity Pattern of the Cortical Network
Sanchez-Vives, M. V., Massimini, M., & Mattia, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.015 · Cited by 167 · see citing works
Time Multiplexed Active Neural Probe with 1356 Parallel Recording Sites
Raducanu, B. C., Yazıcıoğlu, R. F., López, C. M., Ballini, M., Putzeys, J., Wang, S., Andrei, A., Rochus, V., Welkenhuysen, M., Helleputte, N. V., et al. (2017) · Sensors · doi:10.3390/s17102388 · Cited by 166 · see citing works
NREM and REM Sleep: Complementary Roles in Recovery after Wakefulness
Vyazovskiy, V. V., & Delogu, A. (2014) · The Neuroscientist · doi:10.1177/1073858413518152 · Cited by 169 · see citing works
Sleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients
Rosanova, M., Fecchio, M., Casarotto, S., Sarasso, S., Casali, A. G., Pigorini, A., Comanducci, A., Seregni, F., Devalle, G., Citerio, G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06871-1 · Cited by 167 · see citing works
Altered Neocortical Rhythmic Activity States inFmr1KO Mice Are Due to Enhanced mGluR5 Signaling and Involve Changes in Excitatory Circuitry
Hays, S. A., Huber, K. M., & Gibson, J. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3157-11.2011 · Cited by 167 · see citing works
Local and Widespread Slow Waves in Stable NREM Sleep: Evidence for Distinct Regulation Mechanisms
Bernardi, G., Siclari, F., Handjaras, G., Riedner, B. A., & Tononi, G. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00248 · Cited by 167 · see citing works
Parallel detection of theta and respiration-coupled oscillations throughout the mouse brain
Tort, A. B. L., Ponsel, S., Jessberger, J., Yanovsky, Y., Brankačk, J., & Draguhn, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-24629-z · Cited by 166 · see citing works
The thalamocortical network as a single slow wave-generating unit
Crunelli, V., David, F., Lörincz, M. L., & Hughes, S. W. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.09.001 · Cited by 162 · see citing works
Self-citation
UP-DOWN cortical dynamics reflect state transitions in a bistable network
Jercog, D., Roxin, A., Barthó, P., Luczak, A., Compte, A., & de la Rocha, J. (2017) · eLife · doi:10.7554/elife.22425 · Cited by 159 · see citing works
Memory improvement via slow-oscillatory stimulation during sleep in older adults
Westerberg, C. E., Florczak, S. M., Weıntraub, S., Mesulam, M. M., Marshall, L., Zee, P. C., & Paller, K. A. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.05.014 · Cited by 159 · see citing works
Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations
Fogerson, P. M., & Huguenard, J. R. (2016) · Neuron · doi:10.1016/j.neuron.2016.10.024 · Cited by 155 · see citing works
An inhibitory gate for state transition in cortex
Zucca, S., D’Urso, G., Pasquale, V., Vecchia, D., Pica, G., Bovetti, S., Moretti, C., Varani, S., Molano‐Mazón, M., Chiappalone, M., et al. (2017) · eLife · doi:10.7554/elife.26177 · Cited by 157 · see citing works
Pupil Size Coupling to Cortical States Protects the Stability of Deep Sleep via Parasympathetic Modulation
Yüzgeç, Ö., Prsa, M., Zimmermann, R. A., & Huber, D. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.049 · Cited by 153 · see citing works
Spinal Cord Injury Immediately Changes the State of the Brain
Aguilar, J., Humanes-Valera, D., Alonso‐Calviño, E., Yagüe, J. G., Moxon, K. A., Oliviero, A., & Foffani, G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0379-10.2010 · Cited by 151 · see citing works
Sparsity enables estimation of both subcortical and cortical activity from MEG and EEG
Krishnaswamy, P., Obregon-Henao, G., Ahveninen, J., Khan, S., Babadi, B., Iglesias, J. E., Hämäläinen, M., & Purdon, P. L. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705414114 · Cited by 149 · see citing works
A role for cortical nNOS/NK1 neurons in coupling homeostatic sleep drive to EEG slow wave activity
Morairty, S. R., Dittrich, L., Pasumarthi, R. K., Valladao, D., Heiss, J. E., Gerashchenko, D., & Kilduff, T. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314762110 · Cited by 146 · see citing works
Molecular Mechanisms of Cancer-Induced Sleep Disruption
Walker, W. H., II, & Borniger, J. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112780 · Cited by 146 · see citing works
Global Intracellular Slow-Wave Dynamics of the Thalamocortical System
Sheroziya, M., & Timofeev, I. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4460-13.2014 · Cited by 142 · see citing works
T-Type Ca2+Channels in Normal and Abnormal Brain Functions
Cheong, E., & Shin, H. (2013) · Physiological Reviews · doi:10.1152/physrev.00010.2012 · Cited by 136 · see citing works
Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial Cells
Griemsmann, S., Höft, S. P., Bedner, P., Zhang, J., von Staden, E., Beinhauer, A., Degen, J., Dublin, P., Cope, D. W., Richter, N., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu157 · Cited by 132 · see citing works
Self-citation
Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity
Crunelli, V., Lörincz, M. L., Connelly, W. M., David, F., Hughes, S. W., Lambert, R. C., Leresche, N., & Errington, A. C. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.151 · Cited by 131 · see citing works
Self-citation
Temporal dynamics of cortical sources underlying spontaneous and peripherally evoked slow waves
Riedner, B. A., Hulse, B. K., Murphy, M. J., Ferrarelli, F., & Tononi, G. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00013-2 · Cited by 130 · see citing works
Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures
McCafferty, C. P., David, F., Venzi, M., Lörincz, M. L., Delicata, F., Atherton, Z., Recchia, G. E., Orbán, G., Lambert, R. C., Giovanni, G. D., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0130-4 · Cited by 127 · see citing works
Self-citation
Decoupling of Sleep-Dependent Cortical and Hippocampal Interactions in a Neurodevelopmental Model of Schizophrenia
Phillips, K. G., Bartsch, U., McCarthy, A. P., Edgar, D. M., Tricklebank, M. D., Wafford, K. A., & Jones, M. W. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.016 · Cited by 124 · see citing works
The Roles of GABAB Receptors in Cortical Network Activity
Kohl, M. M., & Paulsen, O. (2010) · Advances in pharmacology · doi:10.1016/s1054-3589(10)58009-8 · Cited by 122 · see citing works
Hippocampal memory consolidation during sleep: a comparison of mammals and birds
Rattenborg, N. C., Martı́nez-González, D., Roth, T. C., & Витальевич, П. В. (2010) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2010.00165.x · Cited by 121 · see citing works
Perturbation of Brain Oscillations after Ischemic Stroke: A Potential Biomarker for Post-Stroke Function and Therapy
Rabiller, G., He, J.-W., Nishijima, Y., Wong, A. S. W., & Liu, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025605 · Cited by 117 · see citing works
Electrophysiological correlates of sleep homeostasis in freely behaving rats
Vyazovskiy, V. V., Cirelli, C., & Tononi, G. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53839-0.00002-8 · Cited by 111 · see citing works
A Neocortical Delta Rhythm Facilitates Reciprocal Interlaminar Interactions via Nested Theta Rhythms
Carracedo, L. M., Kjeldsen, H., Cunnington, L. G., Jenkins, A., Schofield, I. S., Cunningham, M. O., Davies, C. H., Traub, R. D., & Whittington, M. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0735-13.2013 · Cited by 113 · see citing works
Sleep, oscillations, interictal discharges, and seizures in human focal epilepsy
Frauscher, B., & Gotman, J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.04.007 · Cited by 108 · see citing works
Brain Structural and Functional Connectivity: A Review of Combined Works of Diffusion Magnetic Resonance Imaging and Electro-Encephalography
Babaeeghazvini, P., Rueda‐Delgado, L. M., Gooijers, J., Swinnen, S. P., & Daffertshofer, A. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.721206 · Cited by 106 · see citing works
Longitudinal sleep EEG trajectories indicate complex patterns of adolescent brain maturation
Feinberg, I., & Campbell, I. G. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00422.2012 · Cited by 105 · see citing works
Infraslow (<0.1Hz) oscillations in thalamic relay nuclei
Hughes, S. W., Lőrincz, M. L., Parri, H. R., & Crunelli, V. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00010-7 · Cited by 104 · see citing works
Self-citation
Low-frequency hippocampal–cortical activity drives brain-wide resting-state functional MRI connectivity
Chan, R. W., Leong, A. T. L., Ho, L. C., Gao, P. P., Wong, E. C., Dong, C. M., Wang, X., He, J., Chan, Y., Lim, L. W., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703309114 · Cited by 101 · see citing works
Local aspects of sleep
Nobili, L., De Gennaro, L., Proserpio, P., Moroni, F., Sarasso, S., Pigorini, A., De Carli, F., & Ferrara, M. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59427-3.00013-7 · Cited by 100 · see citing works
Dynamic Processes in Regulation and Some Implications for Biofeedback and Biobehavioral Interventions
Lehrer, P. M., & Eddie, D. (2013) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-013-9217-6 · Cited by 101 · see citing works
Interneuron‐mediated inhibition synchronizes neuronal activity during slow oscillation
Chen, J., Chauvette, S., Skorheim, S. W., Timofeev, I., & Bazhenov, M. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.227462 · Cited by 96 · see citing works
Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism
D’Antoni, S., Spatuzza, M., Bonaccorso, C. M., Musumeci, S. A., Ciranna, L., Nicoletti, F., Huber, K. M., & Catania, M. V. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.003 · Cited by 94 · see citing works
Differential effects on fast and slow spindle activity, and the sleep slow oscillation in humans with carbamazepine and flunarizine to antagonize voltage-dependent Na+ and Ca2+ channel activity
Ayoub, A., Aumann, D., Hörschelmann, A., Kouchekmanesch, A., Paul, P., Born, J., & Marshall, L. (2013) · Sleep · doi:10.5665/sleep.2722 · Cited by 91 · see citing works
High-frequency oscillations in human and monkey neocortex during the wake–sleep cycle
Quyen, M. L. V., Muller, L., Teleńczuk, B., Halgren, E., Cash, S. S., Hatsopoulos, N. G., Dehghani, N., & Alain Destexhe, A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1523583113 · Cited by 89 · see citing works
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Steriade, M., Contreras, D., & Nuiiez, A. (1993) · Cited by 584 · see citing works

Authors: Crunelli, V., & Hughes, S. W.
Affiliations: Cardiff University (GB)
Eli Lilly (United Kingdom) (GB)
Corresponding author: Crunelli, Vincenzo
ORCID: Crunelli, Vincenzo
Hughes, Stuart W
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2009-12-06
Volume: 13
Issue: 1
Pages: 9-17
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.2445
PMC: PMC2980822
OpenAlex: W2078049175
Semantic Scholar: 3ab0af75d4a753ac35afe4eed6a3db4f6dfe8853
Cited by: 435
References: 98
Citations by year: 2026: 7 · 2025: 12 · 2024: 14 · 2023: 15 · 2022: 24 · 2021: 22 · 2020: 23 · 2019: 27 · 2018: 30 · 2017: 28 · 2016: 26 · 2015: 40 · 2014: 39 · 2013: 44 · 2012: 32
FWCI: 2.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust (078403, 078311, 78403, 78311, 071436, 71436)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: slow-wave sleep, NREM sleep, EEG oscillations, cell assemblies, network plasticity
MeSH terms: Action Potentials, Anesthetics, Animals, Biological Clocks, Brain Mapping, Cats, Cerebral Cortex, Delta Rhythm, Humans, Models, Biological, Nerve Net, Neurons, Sleep Stages, Thalamus, In Vitro Techniques

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The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators

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