Cited by 129RNA Research and SplicingProtein Kinase Regulation and GTPase SignalingNeuroscience and Neuropharmacology Research

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Neuronal ELAV proteins enhance mRNA stability by a PKCα-dependent pathway

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Pascale, Alessia, Amadio, Marialaura, Scapagnini, Giovanni, Lanni, Cristina, Racchi, Marco, Provenzani, Alessandro, Govoni, Stefano, Alkon, Daniel L., Quattrone, Alessandro·2005·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0504702102PMC PMC1189326

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Abstract

More than 1 in 20 human genes bear in the mRNA 3′ UTR a specific motif called the adenine- and uridine-rich element (ARE), which posttranscriptionally determines its expression in response to cell environmental signals. ELAV (embryonic lethal abnormal vision) proteins are the only known ARE-binding factors that are able to stabilize the bound mRNAs, thereby positively controlling gene expression. Here, we show that in human neuroblastoma SH-SY5Y cells, neuron-specific ELAV (nELAV) proteins (HuB, HuC, and HuD) are up-regulated and redistributed by 15 min of treatment with the activators of PKC phorbol esters and bryostatin-1. PKC stimulation also induces nELAV proteins to colocalize with the translocated PKCα isozyme preferentially on the cytoskeleton, with a concomitant increase of nELAV threonine phosphorylation. The same treatment promotes stabilization of growth-associated protein 43 (GAP-43) mRNA, a well known nELAV target, and induces an early increase in GAP-43 protein concentration, again only in the cytoskeletal cell fraction. Genetic or pharmacological inactivation of PKCα abolishes nELAV protein cytoskeletal up-regulation, GAP-43 mRNA stabilization, and GAP-43 protein increase, demonstrating the primary role of this specific PKC isozyme in the cascade of nELAV recruitment. Finally, in vivo PKC activation is associated with an up-regulation of nELAV proteins in the hippocampal rat brain. These findings suggest a model for gene expression regulation by nELAV proteins through a PKCα-dependent pathway that is relevant for the cellular programs in which ARE-mediated control plays a pivotal role.

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10.1080/14734220310016150 · DOI
10.1172/JCI200112973 · DOI

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Increased Steady-State Levels of CUGBP1 in Myotonic Dystrophy 1 Are Due to PKC-Mediated Hyperphosphorylation
Kuyumcu-Martinez, N. M., Wang, G., & Cooper, T. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.027 · Cited by 445
PKC ε Activation Prevents Synaptic Loss, Aβ Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice
Hongpaisan, J., Sun, M., & Alkon, D. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5209-10.2011 · Cited by 231
Self-citation
The Survival of Motor Neuron (SMN) Protein Interacts with the mRNA-Binding Protein HuD and Regulates Localization of Poly(A) mRNA in Primary Motor Neuron Axons
Fallini, C., Zhang, H., Su, Y., Silani, V., Singer, R. H., Rossoll, W., & Bassell, G. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3631-10.2011 · Cited by 221
Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR
Doller, A., Pfeilschifter, J. M., & Eberhardt, W. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.05.007 · Cited by 218
RNA–protein interactions and control of mRNA stability in neurons
Bolognani, F., & Perrone‐Bizzozero, N. I. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21473 · Cited by 199

See all 129

Authors: Pascale, A., Amadio, M., Scapagnini, G., Lanni, C., Racchi, M., Provenzani, A., Govoni, S., Alkon, D. L., & Quattrone, A.
Affiliations: Johns Hopkins University (US)
ORCID: Pascale, Alessia
Amadio, Marialaura
Scapagnini, Giovanni
Lanni, Cristina
Racchi, Marco
Provenzani, Alessandro
Govoni, Stefano
Alkon, Daniel L.
Quattrone, Alessandro
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2005-08-11
Volume: 102
Issue: 34
Pages: 12065-12070
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0504702102
PMC: PMC1189326
OpenAlex: W2044429312
Cited by: 129
References: 85
Citations by year: 2026: 5 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 9 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 11 · 2012: 6
FWCI: 3.27
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Ente Cassa di Risparmio di Firenze
Università degli Studi di Firenze
Università degli Studi di Pavia
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: mRNA stability, protein kinase C alpha, post-transcriptional regulation, threonine phosphorylation, cytoskeleton, neuroblastoma cells, hippocampus, bryostatin 1, phorbol ester
MeSH terms: Animals, Cytoskeleton, Gene Expression Regulation, Hippocampus, Humans, Immunohistochemistry, Neurons, Phorbol Esters, RNA, Messenger, Blotting, Western, Signal Transduction, DNA Primers, Macrolides, GAP-43 Protein, Reverse Transcriptase Polymerase Chain Reaction, 3' Untranslated Regions, Amino Acid Motifs, RNA Stability, Cell Line, Tumor, Immunoprecipitation, Rats, Protein Kinase C-alpha, ELAV Proteins, Bryostatins

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Neuronal ELAV proteins enhance mRNA stability by a PKCα-dependent pathway

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