Sleep after spatial learning promotes covert reorganization of brain activity
Open accessAbstract
Sleep promotes the integration of recently acquired spatial memories into cerebral networks for the long term. In this study, we examined how sleep deprivation hinders this consolidation process. Using functional MRI, we mapped regional cerebral activity during place-finding navigation in a virtual town, immediately after learning and 3 days later, in subjects either allowed regular sleep (RS) or totally sleep-deprived (TSD) on the first posttraining night. At immediate and delayed retrieval, place-finding navigation elicited increased brain activity in an extended hippocampo-neocortical network in both RS and TSD subjects. Behavioral performance was equivalent between groups. However, striatal navigation-related activity increased more at delayed retrieval in RS than in TSD subjects. Furthermore, correlations between striatal response and behavioral performance, as well as functional connectivity between the striatum and the hippocampus, were modulated by posttraining sleep. These data suggest that brain activity is restructured during sleep in such a way that navigation in the virtual environment, initially related to a hippocampus-dependent spatial strategy, becomes progressively contingent in part on a response-based strategy mediated by the striatum. Both neural strategies eventually relate to equivalent performance levels, indicating that covert reorganization of brain patterns underlying navigation after sleep is not necessarily accompanied by overt changes in behavior.
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Activation in the right striatum positively predicts way finding in the virtual town only in the sleep group, and functional connectivity between striatum and hippocampus is modulated by sleep after learning.
“Activation in the right striatum positively predicted way finding in the virtual town only in the sleep group, and also functional connectivity between the striatum and hippocampus was modulated by sleep after learning.”
From About Sleep's Role in Memory (2013) · cites this paper as [873]
Sleep following learning spatial memories of a virtual town produces increased activation in the striatum at a recall test 3 days later compared with a group deprived of sleep after learning.
“Sleep following learning spatial memories of a virtual town produced increased activation in the striatum at a recall test 3 days later, when compared with a group deprived of sleep after learning (873).”
From About Sleep's Role in Memory (2013) · cites this paper as [873]
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- Authors
- Orban, P., Rauchs, G., Balteau, E., Degueldre, C., Luxen, A., Maquet, P., & Peigneux, P.
- Affiliations
- University of Liège (BE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-05-02
- Volume
- 103
- Issue
- 18
- Pages
- 7124-7129
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2035300025
- Cited by
- 167
- References
- 7
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 14 · 2013: 14 · 2012: 5
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- Fonds De La Recherche Scientifique - FNRS
- Fondation Fyssen
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- sleep, sleep deprivation, spatial memory consolidation, place navigation, hippocampus, striatum, functional connectivity, virtual worlds, memory retrieval
- MeSH terms
- Adult, Behavior, Brain, Female, Humans, Learning, Magnetic Resonance Imaging, Male, Nerve Net, Sleep, Sleep Deprivation
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