Sleep deprivation and hippocampal vulnerability: changes in neuronal plasticity, neurogenesis and cognitive function
Open accessAbstract
Despite the ongoing fundamental controversy about the physiological function of sleep, there is general consensus that sleep benefits neuronal plasticity, which ultimately supports brain function and cognition. In agreement with this are numerous studies showing that sleep deprivation (SD) results in learning and memory impairments. Interestingly, such impairments appear to occur particularly when these learning and memory processes require the hippocampus, suggesting that this brain region may be particularly sensitive to the consequences of sleep loss. Although the molecular mechanisms underlying sleep and memory formation remain to be investigated, available evidence suggests that SD may impair hippocampal neuronal plasticity and memory processes by attenuating intracellular cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling which may lead to alterations in cAMP response element binding protein (CREB)-mediated gene transcription, neurotrophic signaling, and glutamate receptor expression. When restricted sleep becomes a chronic condition, it causes a reduction of hippocampal cell proliferation and neurogenesis, which may eventually lead to a reduction in hippocampal volume. Ultimately, by impairing hippocampal plasticity and function, chronically restricted and disrupted sleep contributes to cognitive disorders and psychiatric diseases.
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Sleep dysfunction (including deprivation and fragmentation) is associated with changes in hippocampal morphology and neurogenesis in animal models.
“Experimental studies using animal models have shown that sleep dysfunction (including deprivation and fragmentation) is associated with changes in hippocampal morphology and neurogenesis.”
From Towards an Integrative Account of Potential Mechanisms Mediating the Path From Sleep Dysfunction to Hallucinations (2025) · cites this paper as [90]
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Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340 · see citing works
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394 · see citing works
Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760 · see citing works
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640 · see citing works
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292 · see citing works
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.2.274 · Cited by 3,262 · see citing works
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651 · see citing works
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151 · see citing works
Function and regulation of CREB family transcription factors in the nervous system
Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127 · see citing works
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120 · see citing works
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060 · see citing works
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,001 · see citing works
Learning induces long-term potentiation in the hippocampus
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913 · see citing works
Neurobiology of Pavlovian Fear Conditioning
Maren, S. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.897 · Cited by 1,805 · see citing works
Hippocampal volume and depression: a meta-analysis of MRI studies
Videbech, P., & Ravnkilde, B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1957 · Cited by 1,590 · see citing works
Human emotion and memory: Interactions of the amygdala and hippocampal complex
Phelps, E. A. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.015 · Cited by 1,577 · see citing works
Packard, M. G., & McGaugh, J. L. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0007 · Cited by 1,505 · see citing works
Regional dissociations within the hippocampus-memory and anxiety
Bannerman, D. M., Rawlins, J. N. P., McHugh, S. B., Deacon, R. M. J., Yee, B. K., Bast, T., Zhang, W.-N., Pothuizen, H. H. J., & Feldon, J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.004 · Cited by 1,462 · see citing works
Adenosine: A Mediator of the Sleep-Inducing Effects of Prolonged Wakefulness
Porkka-Heiskanen, T., Strecker, R. E., Thakkar, M., Bjørkum, A. A., Greene, R. W., & McCarley, R. W. (1997) · Science · doi:10.1126/science.276.5316.1265 · Cited by 1,252 · see citing works
Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis
Campbell, S., Marriott, M., Nahmias, C., & MacQueen, G. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.598 · Cited by 1,156 · see citing works
mTOR signaling: At the crossroads of plasticity, memory and disease
Hoeffer, C. A., & Klann, E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.003 · Cited by 1,128 · see citing works
Sleep-Dependent Learning and Memory Consolidation
Walker, M. P., & Stickgold, R. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.031 · Cited by 1,113 · cited 1× · see citing works
“…sleep loss or sleep disturbance have opposing effects, resulting in cognitive deficits, such as impaired attention, decision making, learning and various types of memory (for reviews, see Walker and Stickgold, 2004; Walker, 2008; Diekelmann and Born, 2010; Havekes et al., 2012; Abel et al., 2013).”
BackgroundClues to the functions of mammalian sleep
Siegel, J. M. (2005) · Nature · doi:10.1038/nature04285 · Cited by 1,040 · see citing works
Adult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971 · see citing works
Meerlo, P., Sgoifo, A., & Suchecki, D. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.007 · Cited by 948 · see citing works
Self-citationAstrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
Halassa, M. M., Florian, C., Fellin, T., Munoz, J. R., Lee, S.-Y., Abel, T. G., Haydon, P. G., & Frank, M. G. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.024 · Cited by 877 · see citing works
Self-citationVyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G. (2008) · Nature Neuroscience · doi:10.1038/nn2035 · Cited by 837 · cited 4× · see citing works
“For instance, whereas one study performed Western blot analysis specifically on synaptoneurosomal fractions (Vyazovskiy et al., 2008), others used membrane fractions or whole homogenates (e.”
BackgroundResultInfluentialLee, H.-K., Takamiya, K., Han, J.-S., Man, H., Kim, C.-H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R. S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00122-3 · Cited by 802 · see citing works
Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning
Zamanillo, D., Sprengel, R., Hvalby, Ø., Jensen, V., Burnashev, N., Rozov, A., Kaiser, K. M. M., Köster, H. J., Borchardt, T., Worley, P., et al. (1999) · Science · doi:10.1126/science.284.5421.1805 · Cited by 791 · see citing works
Are spatial memories strengthened in the human hippocampus during slow wave sleep?
Peigneux, P., Laureys, S., Fuchs, S., Collette, F., Perrin, F., Reggers, J., Phillips, C., Degueldre, C., Del Fiore, G., Aerts, J., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.007 · Cited by 766 · see citing works
Molecular mechanisms of memory acquisition, consolidation and retrieval
Abel, T. G., & Lattal, K. M. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00194-x · Cited by 689 · see citing works
Self-citationA deficit in the ability to form new human memories without sleep
Yoo, S.-S., Hu, P. T., Gujar, N., Jolesz, F. A., & Walker, M. P. (2007) · Nature Neuroscience · doi:10.1038/nn1851 · Cited by 597 · cited 4× · see citing works
“Several human and animal studies have shown that pre-training SD impairs acquisition and memory encoding in a variety of tasks, with empirical evidence pointing toward a particular sensitivity of hippocampus-dependent learning and memory (Dametto et al., 2002; McDermott et al., 2003; Ruskin et al., 2004; Guan et al.,…”
BackgroundMethodInfluentialAdenosine and sleep–wake regulation
Basheer, R., Strecker, R. E., Thakkar, M. M., & McCarley, R. W. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.004 · Cited by 589 · see citing works
Winters, B. D., Forwood, S., Cowell, R. A., Saksida, L. M., & Bussey, T. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1346-04.2004 · Cited by 588 · see citing works
Sleep, Plasticity and Memory from Molecules to Whole-Brain Networks
Abel, T. G., Havekes, R., Saletin, J., & Walker, M. P. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.025 · Cited by 551 · see citing works
Self-citationIs there a link between adult neurogenesis and learning?
Leuner, B., Gould, E., & Shors, T. J. (2006) · Hippocampus · doi:10.1002/hipo.20153 · Cited by 530 · see citing works
Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning
Graves, L. A., Heller, E. A., Pack, A. I., & Abel, T. (2003) · Learning & Memory · doi:10.1101/lm.48803 · Cited by 476 · see citing works
Self-citationSleep viewed as a state of adaptive inactivity
Siegel, J. M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2697 · Cited by 468 · cited 1× · see citing works
“Sleep is a condition of partial unconsciousness, characterized by reduced motor activity and responsiveness, from which an individual can be aroused by stimulation (Siegel, 2009).”
BackgroundSleep deprivation impairs cAMP signalling in the hippocampus
Vecsey, C. G., Baillie, G. S., Jaganath, D., Havekes, R., Daniels, A., Wimmer, M., Huang, T., Brown, K. M., Li, X.-Y., Descalzi, G., et al. (2009) · Nature · doi:10.1038/nature08488 · Cited by 454 · see citing works
Self-citationLucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Fuchs, E., Oomen, C. A., & Czéh, B. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.08.003 · Cited by 449 · see citing works
Self-citationCzéh, B., & Lucassen, P. J. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0728-0 · Cited by 419 · see citing works
McDermott, C. M., LaHoste, G. J., Chen, C., Musto, A., Bazan, N. G., & Magee, J. C. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-29-09687.2003 · Cited by 407 · see citing works
Macromolecule biosynthesis: a key function of sleep
Mackiewicz, M., Shockley, K. R., Romer, M. A., Galante, R. J., Zimmerman, J. E., Naidoo, N. N., Baldwin, D. A., Jensen, S. T., Churchill, G. A., & Pack, A. I. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00275.2006 · Cited by 378 · see citing works
Homer1a is a core brain molecular correlate of sleep loss
Maret, S., Dorsaz, S., Gurcel, L., Pradervand, S., Petit, B., Pfister, C., Hagenbüchle, O., O’Hara, B. F., Franken, P., & Tafti, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710131104 · Cited by 366 · see citing works
Li, F. R., & Tsien, J. Z. (2009) · New England Journal of Medicine · doi:10.1056/nejmcibr0902052 · Cited by 363 · see citing works
Long-term depression: multiple forms and implications for brain function
Massey, P. V., & Bashir, Z. I. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.02.005 · Cited by 325 · see citing works
New neurons in the adult brain: the role of sleep and consequences of sleep loss
Meerlo, P., Mistlberger, R. E., Jacobs, B. L., Craig Heller, H., & McGinty, D. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.07.004 · Cited by 318 · see citing works
Self-citationSleep benefits subsequent hippocampal functioning
Van Der Werf, Y. D., Altena, E., Schoonheim, M. M., Sanz-Arigita, E. J., Vis, J. C., De Rijke, W., & Van Someren, E. J. W. (2009) · Nature Neuroscience · doi:10.1038/nn.2253 · Cited by 313 · see citing works
Watkins, J. C., & Jane, D. E. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706444 · Cited by 312 · see citing works
Igaz, L. M., Vianna, M. R. M. R., Medina, J. H., & Izquierdo, I. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06781.2002 · Cited by 305 · see citing works
The Role of the Hippocampus in Solving the Morris Water Maze
Redish, A. D., & Touretzky, D. S. (1998) · Neural Computation · doi:10.1162/089976698300017908 · Cited by 304 · see citing works
Changes in brain morphology associated with obstructive sleep apnea
Morrell, M. J., McRobbie, D. W., Quest, R. A., Cummin, A. R. C., Ghiassi, R., & Corfield, D. R. (2003) · Sleep Medicine · doi:10.1016/s1389-9457(03)00159-x · Cited by 292 · see citing works
Circadian modulation of learning and memory in fear-conditioned mice.
Chaudhury, D., & Colwell, C. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00471-5 · Cited by 282 · see citing works
Dash, M. B., Douglas, C. L., Vyazovskiy, V. V., Cirelli, C., & Tononi, G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5486-08.2009 · Cited by 278 · see citing works
Backhaus, J., Junghanns, K., Born, J., Hohaus, K., Faasch, F., & Hohagen, F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.051 · Cited by 265 · see citing works
The role of protein synthesis in memory consolidation: Progress amid decades of debate
Hernandez, P. J., & Abel, T. G. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.09.010 · Cited by 264 · see citing works
Self-citationChronic Insomnia and MRI-Measured Hippocampal Volumes: A Pilot Study
Riemann, D. W., Voderholzer, U., Spiegelhalder, K., Hornyak, M., Buysse, D. J., Nissen, C., Hennig, J., Perlis, M. L., van Elst, L. T., & Feige, B. (2007) · SLEEP · doi:10.1093/sleep/30.8.955 · Cited by 256 · see citing works
Effects of Sleep and Wake on Oligodendrocytes and Their Precursors
Bellesi, M., Pfister‐Genskow, M., Maret, S., Keleş, S., Tononi, G., & Cirelli, C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5102-12.2013 · Cited by 254 · see citing works
Adenosine analogs and sleep in rats.
Radulovacki, M. G., Virus, R. M., Djuricic-Nedelson, M., & Green, R. D. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21636-6 · Cited by 251 · see citing works
Cellular and molecular connections between sleep and synaptic plasticity
Benington, J. H., & Frank, M. G. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00018-2 · Cited by 244 · see citing works
Paradoxical sleep and memory storage processes
Fishbein, W. I., & Gutwein, B. M. (1977) · Behavioral Biology · doi:10.1016/s0091-6773(77)91903-4 · Cited by 235 · see citing works
Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids
Mirescu, C., Peters, J. D., Noiman, L., & Gould, E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608644103 · Cited by 233 · see citing works
Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning
Hairston, I. S., Little, M. T. M., Scanlon, M. D., Barakat, M. T., Palmer, T. D., Sapolsky, R. M., & Heller, H. C. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00218.2005 · Cited by 223 · see citing works
Post-training reversible inactivation of the hippocampus enhances novel object recognition memory
Oliveira, A. M. M., Hawk, J. D., Abel, T., & Havekes, R. (2010) · Learning & Memory · doi:10.1101/lm.1625310 · Cited by 222 · see citing works
Self-citationBrain Gray Matter Deficits in Patients with Chronic Primary Insomnia
Joo, E. Y., Noh, H. J., Kim, J. S., Koo, D. L., Kim, D., Hwang, K. J., Kim, J. Y., Kim, S. T., Kim, M. R., & Hong, S. B. (2013) · SLEEP · doi:10.5665/sleep.2796 · Cited by 222 · see citing works
Slow and Fast Gamma Rhythms Coordinate Different Spatial Coding Modes in Hippocampal Place Cells
Bieri, K. W., Bobbitt, K. N., & Colgin, L. L. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.013 · Cited by 221 · see citing works
Evidence for a paradoxical sleep window for place learning in the Morris water maze
Smith, C., & Rose, G. M. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02054-3 · Cited by 211 · see citing works
Lesku, J. A., Roth, T. C., Amlaner, C. J., & Lima, S. L. (2006) · The American Naturalist · doi:10.1086/506973 · Cited by 211 · see citing works
Sleep deprivation suppresses neurogenesis in the adult hippocampus of rats
Guzmán-Marı́n, R., Suntsova, N., Methippara, M. M., Greiffenstein, R., Szymusiak, R. S., & McGinty, D. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04376.x · Cited by 210 · see citing works
Guan, Z., Peng, X., & Fang, J. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.032 · Cited by 208 · see citing works
Suppression of hippocampal plasticity‐related gene expression by sleep deprivation in rats
Guzman‐Marin, R., Ying, Z., Suntsova, N., Methippara, M., Bashir, T., Szymusiak, R., Gomez‐Pinilla, F., & McGinty, D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.115287 · Cited by 206 · see citing works
Tartar, J. L., Ward, C. P., McKenna, J. T., Thakkar, M., Arrigoni, E., McCarley, R. W., Brown, R. E., & Strecker, R. E. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04808.x · Cited by 206 · see citing works
Conti, B., Maier, R., Barr, A. M., Morale, M. C., Lu, X., Sanna, P. P., Bilbe, G., Hoyer, D., & Bartfai, T. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001897 · Cited by 205 · see citing works
Florian, C., Vecsey, C. G., Halassa, M. M., Haydon, P., & Abel, T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5761-10.2011 · Cited by 202 · see citing works
Self-citationJoo, E. Y., Kim, H., Suh, S. A., & Hong, S. B. (2014) · SLEEP · doi:10.5665/sleep.3836 · Cited by 199 · see citing works
Insomnia: Pathophysiology and implications for treatment
Roth, T. G., Roehrs, T., & Pies, R. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2006.06.002 · Cited by 197 · see citing works
Sleep deprivation reduces proliferation of cells in the dentate gyrus of the hippocampus in rats
Guzmán‐Marín, R., Suntsova, N., Stewart, D. R., Gong, H., Szymusiak, R., & McGinty, D. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.041665 · Cited by 197 · see citing works
Insufficient Sleep Reversibly Alters Bidirectional Synaptic Plasticity and NMDA Receptor Function
Kopp, C., Longordo, F., Nicholson, J. R., & Lüthi, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2702-06.2006 · Cited by 192 · see citing works
Sleep deprivation impairs object recognition in mice
Palchykova, S., Winsky‐Sommerer, R., Meerlo, P., Dürr, R., & Tobler, I. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.11.005 · Cited by 192 · see citing works
Self-citationElmenhorst, D., Meyer, P. T., Winz, O., Matusch, A., Ermert, J., Coenen, H. H., Basheer, R., Haas, H. L., Zilles, K., & Bauer, A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5066-06.2007 · Cited by 189 · see citing works
Havekes, R., Vecsey, C. G., & Abel, T. G. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.02.010 · Cited by 188 · see citing works
Self-citationHagewoud, R., Havekes, R., Novati, A., Keijser, J. N., van der Zee, E. A., & Meerlo, P. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2009.00799.x · Cited by 187 · see citing works
Self-citationHuston, J. P., Haas, H. L., Boix, F., Pfister, M., Decking, U. K. M., Schrader, J., & Schwarting, R. K. W. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00021-8 · Cited by 184 · see citing works
Role of adenosine in sleep and temperature regulation in the preoptic area of rats
Ticho, S. R., & Radulovacki, M. G. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90317-u · Cited by 182 · see citing works
Bjorness, T. E., & Greene, R. W. (2009) · Current Neuropharmacology · doi:10.2174/157015909789152182 · Cited by 178 · see citing works
McDermott, C. M., Hardy, M. N., Bazan, N. G., & Magee, J. C. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.093781 · Cited by 178 · see citing works
Ravassard, P., Pachoud, B., Comte, J.-C., Mejia-Perez, C., Scoté-Blachon, C., Gay, N., Claustrat, B., Touret, M., Luppi, P.-H., & Salin, P. A. (2009) · Sleep · doi:10.1093/sleep/32.2.227 · Cited by 177 · see citing works
Maintenance of superior learning and memory function in NR2B transgenic mice during ageing
Cao, X., Cui, Z., Feng, R., Tang, Y., Qin, Z., Mei, B., & Tsien, J. Z. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05431.x · Cited by 171 · see citing works
Sleep Deprivation Impairs Long-Term Potentiation in Rat Hippocampal Slices
Campbell, I. G., Guinan, M. J., & Horowitz, J. M. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.2.1073 · Cited by 169 · see citing works
Sleep after spatial learning promotes covert reorganization of brain activity
Orban, P., Rauchs, G., Balteau, E., Degueldre, C., Luxen, A., Maquet, P., & Peigneux, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510198103 · Cited by 167 · see citing works
Genomic analysis of sleep deprivation reveals translational regulation in the hippocampus
Vecsey, C. G., Peixoto, L., Choi, J. H. K., Wimmer, M. E., Jaganath, D., Hernandez, P. J., Blackwell, J. M., Meda, K., Park, A. J., Hannenhalli, S. S., et al. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00084.2012 · Cited by 164 · see citing works
Self-citationSchmitt, L. I., Sims, R. E., Dale, N., & Haydon, P. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5689-11.2012 · Cited by 162 · see citing works
Sleep: off-line memory reprocessing
Stickgold, R. (1998) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01258-3 · Cited by 161 · see citing works
Trifilieff, P., Herry, C., Vanhoutte, P., Caboche, J., Desmedt, A., Riedel, G., Mons, N. E., & Micheau, J. (2006) · Learning & Memory · doi:10.1101/lm.80206 · Cited by 161 · see citing works
Dash, P. K., Orsi, S. A., & Moore, A. N. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0671-06.2006 · Cited by 157 · see citing works
Alhaider, I. A., Aleisa, A. M., Tran, T. T., Alzoubi, K. H., & Alkadhi, K. A. (2010) · SLEEP · doi:10.1093/sleep/33.4.437 · Cited by 151 · see citing works
Melatonin Suppresses Nighttime Memory Formation in Zebrafish
Rawashdeh, O., de Borsetti, N. H., Roman, G., & Cahill, G. M. (2007) · Science · doi:10.1126/science.1148564 · Cited by 150 · see citing works
Disruptive effects of rapid eye movement sleep deprivation on long-term memory
Fishbein, W. (1971) · Physiology & Behavior · doi:10.1016/0031-9384(71)90155-7 · Cited by 147 · see citing works
Prince, T.-M., Wimmer, M., Choi, J., Havekes, R., Aton, S., & Abel, T. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.021 · Cited by 142 · see citing works
Neuronal Transgene Expression in Dominant-Negative SNARE Mice
Fujita, T., Chen, M. J., Li, B., Smith, N. A., Peng, W., Sun, W., Toner, M. J., Kress, B. T., Wang, L., Benraiss, A., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2585-14.2014 · Cited by 141 · see citing works
The impact of sleep loss on hippocampal functionPreprint
Prince, T.-M. N., & Abel, T. G. (2013) · Learning & Memory · doi:10.1101/lm.031674.113 · Cited by 141 · see citing works
Self-citationHippocampal neurogenesis is reduced by sleep fragmentation in the adult rat
Guzmán-Marı́n, R., Bashir, T., Suntsova, N., Szymusiak, R. S., & McGinty, D. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.030 · Cited by 139 · see citing works
The Relationship between Hippocampal Volume and Cognition in Patients with Chronic Primary Insomnia
Noh, H. J., Joo, E. Y., Kim, S. T., Yoon, S. M., Koo, D. L., Kim, D., Lee, G.-H., & Hong, S. B. (2012) · Journal of Clinical Neurology · doi:10.3988/jcn.2012.8.2.130 · Cited by 135 · see citing works
Restoration of spatial working memory by genetic rescue of GluR-A–deficient mice
Schmitt, W. B., Sprengel, R., Mack, V., Draft, R. W., SEEBURG, P. H., Deacon, R. M. J., Rawlins, J. N. P., & Bannerman, D. M. (2005) · Nature Neuroscience · doi:10.1038/nn1412 · Cited by 131 · see citing works
Neylan, T. C., Mueller, S. G., Wang, Z., Metzler, T. J., Lenoci, M., Truran, D., Marmar, C. R., Weiner, M. W., & Schuff, N. W. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.035 · Cited by 131 · see citing works
Alhaider, I. A., Aleisa, A. M., Tran, T. T., & Alkadhi, K. A. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.02.006 · Cited by 127 · see citing works
Effects of N6-cyclopentyladenosine and caffeine on sleep regulation in the rat
Schwierin, B., Borbély, A. A., & Tobler, I. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00021-0 · Cited by 125 · see citing works
Guzmán-Marı́n, R., Suntsova, N., Bashir, T., Nienhuis, R., Szymusiak, R. S., & McGinty, D. (2008) · SLEEP · doi:10.1093/sleep/31.2.167 · Cited by 125 · see citing works
Too Little Sleep Gradually Desensitizes the Serotonin 1A Receptor System
Román, V., Walstra, I., Luiten, P. G. M., & Meerlo, P. (2005) · SLEEP · doi:10.1093/sleep/28.12.1505 · Cited by 122 · see citing works
Self-citationSleep deprivation can inhibit adult hippocampal neurogenesis independent of adrenal stress hormones
Mueller, A. D., Pollock, M. S., Lieblich, S. E., Epp, J. R., Galea, L. A. M., & Mistlberger, R. E. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00858.2007 · Cited by 122 · see citing works
Sleep duration during weekdays affects hippocampal gray matter volume in healthy children
Taki, Y., Hashizume, H., Thyreau, B., Sassa, Y., Takeuchi, H., Wu, K., Kotozaki, Y., Nouchi, R., Asano, M., Asano, K., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.072 · Cited by 117 · see citing works
REM sleep deprivation inhibits LTP in vivo in area CA1 of rat hippocampus
Kim, E. Y., Mahmoud, G. S., & Grover, L. M. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.057 · Cited by 114 · see citing works
Impaired Sleep-Related Memory Consolidation in Primary Insomnia—A Pilot Study
Nissen, C., KLOEPFER, C., Nofzinger, E. A., Feige, B., Voderholzer, U., & Riemann, D. W. (2006) · SLEEP · doi:10.1093/sleep/29.8.1068 · Cited by 113 · see citing works
Brundege, J. M., & Dunwiddie, T. V. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-18-05603.1996 · Cited by 111 · see citing works
Chen, C., Hardy, M., Zhang, J., LaHoste, G. J., & Bazan, N. G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.021 · Cited by 107 · see citing works
Ruskin, D. N., Liu, C., Dunn, K. E., Bazan, N. G., & LaHoste, G. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03426.x · Cited by 107 · see citing works
Modulation of Hippocampal Glutamatergic Transmission by ATP Is Dependent on Adenosine A1 Receptors
Masino, S. A., Diao, L., Illés, P., et al. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.036731 · Cited by 106 · see citing works
Insomnia Does Not Appear to be Associated With Substantial Structural Brain Changes
Spiegelhalder, K., Regen, W., Baglioni, C., Klöppel, S., Abdulkadir, A., Hennig, J., Nissen, C., Riemann, D. W., & Feige, B. (2013) · SLEEP · doi:10.5665/sleep.2638 · Cited by 105 · see citing works
Zhao, Q., Peng, C. Y., Wu, X., Chen, Y., Wang, C., & You, Z. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.04.008 · Cited by 104 · see citing works
Why we sleep: a theoretical view of sleep function
Krueger, J. M., Obál, F., & Fang, J. (1999) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(99)90019-9 · Cited by 104 · see citing works
van der Borght, K., Ferrari, F., Klauke, K., Román, V., Havekes, R., Sgoifo, A., van der Zee, E. A., & Meerlo, P. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.08.012 · Cited by 101 · see citing works
Self-citationSleep-related memory consolidation in primary insomnia
Nissen, C., KLOEPFER, C., Feige, B., Piosczyk, H., Spiegelhalder, K., Voderholzer, U., & Riemann, D. W. (2010) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2010.00872.x · Cited by 100 · see citing works
Tobler, I., & Jaggi, K. (1987) · Journal of Comparative Physiology A · doi:10.1007/bf00603970 · Cited by 100 · see citing works
Foster, T. C., & Kumar, A. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.12.009 · Cited by 100 · see citing works
Ishikawa, A., Kanayama, Y., Matsumura, H., Tsuchimochi, H., Ishida, Y., & Nakamura, S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04874.x · Cited by 100 · see citing works
Hagewoud, R., Whitcomb, S. N., Heeringa, A. N., Havekes, R., Koolhaas, J. M., & Meerlo, P. (2010) · Sleep · doi:10.1093/sleep/33.10.1315 · Cited by 99 · see citing works
Self-citationPhylogenetics and the correlates of mammalian sleep: A reappraisal
Lesku, J. A., Roth, T. C., Rattenborg, N. C., Amlaner, C. J., & Lima, S. L. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.10.003 · Cited by 99 · see citing works
Radulovacki, M. G., Miletich, R. S., & Green, R. D. (1982) · Brain Research · doi:10.1016/0006-8993(82)90161-5 · Cited by 99 · see citing works
Cirelli, C. (2002) · Journal of Applied Physiology · doi:10.1152/jappl.2002.92.1.394 · Cited by 96 · see citing works
Romcy‐Pereira, R., & Pavlides, C. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03808.x · Cited by 95 · see citing works
Novati, A., Hulshof, H. J., Koolhaas, J. M., Lucassen, P. J., & Meerlo, P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.027 · Cited by 94 · see citing works
Self-citationSleep restriction by forced activity reduces hippocampal cell proliferation
Roman, V., Van der Borght, K., Leemburg, S. A., Van der Zee, E. A., & Meerlo, P. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.020 · Cited by 93 · see citing works
Self-citationCoping with Sleep Deprivation: Shifts in Regional Brain Activity and Learning Strategy
Hagewoud, R., Havekes, R., Tiba, P. A., Novati, A., Hogenelst, K., Weinreder, P., van der Zee, E. A., & Meerlo, P. (2010) · SLEEP · doi:10.1093/sleep/33.11.1465 · Cited by 92 · see citing works
Self-citationPostnatal Development of the Primate Hippocampal Formation
Lavenex, P., Lavenex, P. B., & Amaral, D. G. (2006) · Developmental Neuroscience · doi:10.1159/000096222 · Cited by 92 · see citing works
Effects of sleep deprivation and recovery sleep upon cell proliferation in adult rat dentate gyrus
Tung, A., Takase, L. F., Fornal, C. A., & Jacobs, B. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.008 · Cited by 89 · see citing works
Sleep deprivation upregulates A1 adenosine receptors in the rat basal forebrain
Basheer, R., Bauer, A., Elmenhorst, D., Ramesh, V., & McCarley, R. W. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3282f262f6 · Cited by 84 · see citing works
Alhaider, I. A., Aleisa, A. M., Tran, T. T., & Alkadhi, K. A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07175.x · Cited by 84 · see citing works
Yang, R., Hu, S.-J., Wang, Y., Zhang, W., Luo, W., & Chen, J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.033 · Cited by 80 · see citing works
Glucocorticoids Are Not Responsible for Paradoxical Sleep Deprivation-Induced Memory Impairments
Tiba, P. A., Oliveira, M. G. D. M., Rossi, V. C., Tufik, S., & Suchecki, D. (2008) · SLEEP · doi:10.1093/sleep/31.4.505 · Cited by 80 · see citing works
Sportiche, N., Suntsova, N., Methippara, M. M., Bashir, T., Mitrani, B., Szymusiak, R. S., & McGinty, D. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.038 · Cited by 76 · see citing works
Havekes, R., Bruinenberg, V. M., Tudor, J. C., Ferri, S. L., Baumann, A., Meerlo, P., & Abel, T. G. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2403-14.2014 · Cited by 73 · see citing works
Self-citationSleep-dependent memory processing
Walker, M. P. (2008) · Harvard Review of Psychiatry · doi:10.1080/10673220802432517 · Cited by 72 · see citing works
Lopez, J., Roffwarg, H. P., Dreher, A., Bissette, G., Karolewicz, B., & Shaffery, J. P. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.072 · Cited by 71 · see citing works
Computational analysis of gene regulation in animal sleep deprivation
Wang, H., Liu, Y., Briesemann, M., & Yan, J. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00205.2009 · Cited by 70 · see citing works
REM restriction persistently alters strategy used to solve a spatial taskPreprint
Bjorness, T. E., Riley, B. T., Tysor, M. K., & Poe, G. R. (2005) · Learning & Memory · doi:10.1101/lm.84805 · Cited by 69 · see citing works
Xia, Z., & Storm, D. R. (2012) · Learning & Memory · doi:10.1101/lm.027128.112 · Cited by 68 · see citing works
Watts, A., Gritton, H. J., Sweigart, J., & Poe, G. R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0170-12.2012 · Cited by 68 · see citing works
Hsieh, K., Robinson, E. L., & Fuller, C. A. (2008) · SLEEP · doi:10.5665/sleep/31.9.1239 · Cited by 67 · see citing works
Sahu, S., Kauser, H., Ray, K., Kishore, K., Kumar, S., & Panjwani, U. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.07.021 · Cited by 66 · see citing works
Circadian modulation of performance on an aversion-based place learning task in hamsters
Cain, S. W., Chou, T., & Ralph, M. R. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.07.001 · Cited by 65 · see citing works
Hagewoud, R., BULTSMA, L. J., Barf, R. P., Koolhaas, J. M., & Meerlo, P. (2010) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2010.00895.x · Cited by 65 · see citing works
Self-citationEffects of sleep disruption on rat dentate granule cell LTP in vivo
Marks, C. A., & Wayner, M. J. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.03.018 · Cited by 60 · see citing works
Mueller, A. D., Mear, R. J., & Mistlberger, R. E. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.019 · Cited by 54 · see citing works
Ruskin, D. N., Dunn, K. E., Billiot, I., Bazan, N. G., & LaHoste, G. J. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.11.003 · Cited by 53 · see citing works
Cheval, H., Chagneau, C., Levasseur, G., Veyrac, A., Biguet, N. F., Laroche, S., & Davis, S. (2011) · Hippocampus · doi:10.1002/hipo.20926 · Cited by 50 · see citing works
Region-specific alteration in brain glutamate: Possible relationship to risk-taking behavior
Cortese, B. M., Mitchell, T. R., Galloway, M. P., Prevost, K. E., Fang, J., Moore, G. J., & Uhde, T. W. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.12.005 · Cited by 50 · see citing works
Hippocampal volume and memory in narcoleptics with cataplexy
Joo, E. Y., Kim, S. H., Kim, S., et al. (2012) · Sleep Medicine · doi:10.1016/j.sleep.2011.09.017 · Cited by 47 · see citing works
Tadavarty, R., Rajput, P. S., Wong, J. M., Kumar, U., & Sastry, B. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024933 · Cited by 47 · see citing works
Social stress does not interact with paradoxical sleep deprivation-induced memory impairment
Dametto, M., Suchecki, D., Bueno, O. F. A., Moreira, K. D. M., Tufik, S., & Oliveira, M. G. M. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00345-x · Cited by 43 · see citing works
Li, S., Tian, Y., Ding, Y., Jin, X., Yan, C., & Shen, X. (2009) · Learning & Behavior · doi:10.3758/lb.37.3.246 · Cited by 42 · see citing works
NR2A at CA1 Synapses Is Obligatory for the Susceptibility of Hippocampal Plasticity to Sleep Loss
Longordo, F., Kopp, C., Mishina, M., Luján, R., & Lüthi, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1215-09.2009 · Cited by 42 · see citing works
García‐García, F., la Herrán-Arita, A. K. D., Juárez‐Aguilar, E., Regalado‐Santiago, C., Millán‐Aldaco, D., Blanco‐Centurion, C., & Drucker-Colı́n, R. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.01.003 · Cited by 41 · see citing works
Tadavarty, R., Kaan, T. K. Y., & Sastry, B. R. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.11.012 · Cited by 37 · see citing works
Duşak, A., Ursavaş, A., Hakyemez, B., Gökalp, G., Taşkapılıoğlu, Ö., & Parlak, M. (2013) · PubMed · Cited by 37 · see citing works
Ethosecretogram: relation of behavior to plasma corticosterone in freely moving rats
Shiraishi, I., Honma, K., Honma, S., et al. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.247.1.r40 · Cited by 36 · see citing works
A Molecular Basis for Interactions Between Sleep and Memory
Hernandez, P. J., & Abel, T. G. (2011) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2010.12.004 · Cited by 35 · see citing works
Self-citationChang, H., Liao, W., Sheu, J., Chang, C., Lan, C., & Mai, F.-D. (2012) · Microscopy and Microanalysis · doi:10.1017/s1431927612000086 · Cited by 29 · see citing works
Mueller, A. D., Parfyonov, M., Pavlovski, I., Marchant, E. G., & Mistlberger, R. E. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.001 · Cited by 22 · see citing works
Effects of daytime, night and sleep pressure on long-term depression in the hippocampus in vivo
Yang, Z., Zhang, W.-C., Wang, M., Ruan, D., & Chen, J. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.01.050 · Cited by 21 · see citing works
AMPA receptors mediate passive avoidance deficits induced by sleep deprivation
Dubiela, F. P., Queiroz, C. M., Moreira, K. D. M., Nóbrega, J. N., Sita, L. V., Tufik, S., & Hipólide, D. C. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.037 · Cited by 20 · see citing works
Aspects of learned fear related to the hippocampus are sleep-dependent
Ruskin, D. N., & LaHoste, G. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.011 · Cited by 20 · see citing works
Adenosine A1 receptors presynaptically modulate excitatory synaptic input onto subiculum neurons
Hargus, N. J., Bertram, E. H., & Patel, M. K. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.027 · Cited by 9 · see citing works
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Hablitz, L. M., Plá, V., Giannetto, M., Vinitsky, H. S., Stæger, F. F., Metcalfe, T., Nguyen, R., Benrais, A., & Nedergaard, M. (2020) · Nature Communications · doi:10.1038/s41467-020-18115-2 · Cited by 704 · see citing works
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Tempesta, D., Socci, V., De Gennaro, L., & Ferrara, M. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.12.005 · Cited by 443 · see citing works
Raven, F., Van der Zee, E. A., Meerlo, P., & Havekes, R. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.05.002 · Cited by 331 · see citing works
Self-citationWang, Z., Chen, W.-H., Li, S.-X., He, Z.-M., Zhu, W.-L., Ji, Y.-B., Wang, Z., Zhu, X.-M., Yuan, K., Bao, Y.-P., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01113-1 · Cited by 307 · see citing works
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Sindi, S., Kåreholt, I., Johansson, L., Skoog, J., Sjöberg, L., Wang, H., Johansson, B., Fratiglioni, L., Soininen, H., Solomon, A., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.05.012 · Cited by 144 · see citing works
Zhao, N., Chen, Q.-G., Chen, X., Liu, X.-T., Geng, F., Zhu, M.-M., Yan, F.-L., Zhang, Z.-J., & Ren, Q.-G. (2023) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.11.013 · Cited by 105 · see citing works
A brief period of sleep deprivation causes spine loss in the dentate gyrus of mice
Raven, F., Meerlo, P., Van der Zee, E. A., Abel, T., & Havekes, R. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.03.018 · Cited by 96 · see citing works
“The role of glucocorticoids in synaptic plasticity and memory deficits associated with SD has been extensively discussed previously (Havekes et al., 2015; Kreutzmann et al., 2015) and briefly in the discussion of the present paper.”
Elmenhorst, D., Elmenhorst, E.-M., Hennecke, E., Kroll, T., Matusch, A., Aeschbach, D., & Bauer, A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614677114 · Cited by 92 · see citing works
Desai, R. I., Limoli, C. L., Stark, C. E. L., & Stark, S. M. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104676 · Cited by 55 · see citing works
Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy
Nehls, M. (2016) · Journal of Molecular Psychiatry · doi:10.1186/s40303-016-0018-8 · Cited by 41 · see citing works
Wang, S., Zhang, Z., Yao, L., Ding, N., Jiang, L., & Wu, Y. (2020) · PLOS ONE · doi:10.1371/journal.pone.0232798 · Cited by 35 · see citing works
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Sheaves, B., Cropley, V. L., Moseley, P., Woodruff, P. W. R., Punton, G., Speth, C., Speth, J., Meerlo, P., & Brederoo, S. G. (2025) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaf107 · Cited by 6 · see citing works
Self-citation
- Authors
- Kreutzmann, J. C., Havekes, R., Abel, T., & Meerlo, P.
- Affiliations
- University of Groningen (NL)
- University of Pennsylvania (US)
- Corresponding author
- Meerlo, P.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 309
- Pages
- 173-190
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2086155425
- Cited by
- 309
- References
- 172
- Citations by year
- 2026: 18 · 2025: 30 · 2024: 29 · 2023: 26 · 2022: 20 · 2021: 36 · 2020: 29 · 2019: 42 · 2018: 24 · 2017: 31 · 2016: 20 · 2015: 3
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- sleep deprivation, hippocampus, neuroplasticity, neurogenesis, hippocampal cell proliferation, learning and memory impairment, cAMP signaling, protein kinase A, CREB, gene transcription, neurotrophic signaling, glutamate receptors, hippocampal volume, cognitive function, chronic sleep restriction, sleep disruption, cognitive disorders, mental illness
- MeSH terms
- Animals, Cognition Disorders, Hippocampus, Humans, Learning, Memory, Neuronal Plasticity, Sleep, Sleep Deprivation, Neurogenesis
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