Glutamate receptor dynamics in dendritic microdomains.
Open accessAbstract
Among diverse factors regulating excitatory synaptic transmission, the abundance of postsynaptic glutamate receptors figures prominently in molecular memory and learning-related synaptic plasticity. To allow for both long-term maintenance of synaptic transmission and acute changes in synaptic strength, the relative rates of glutamate receptor insertion and removal must be tightly regulated. Interactions with scaffolding proteins control the targeting and signaling properties of glutamate receptors within the postsynaptic membrane. In addition, extrasynaptic receptor populations control the equilibrium of receptor exchange at synapses and activate distinct signaling pathways involved in plasticity. Here, we review recent findings that have shaped our current understanding of receptor mobility between synaptic and extrasynaptic compartments at glutamatergic synapses, focusing on AMPA and NMDA receptors. We also examine the cooperative relationship between intracellular trafficking and surface diffusion of glutamate receptors that underlies the expression of learning-related synaptic plasticity.
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NMDAR-dependent LTD involves clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs).
“NMDA receptor (NMDAR)–dependent LTD, an extensively studied form of LTD, involves a rise in postsynaptic Ca2+ concentration, activation of a serine-threonine protein phosphatase cascade, and clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs) [1]–[10].”
From Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD (2009) · cites this paper as [5]
The passage labeled Abstract (page unavailable) says that NMDA receptor-induced LTD is associated with AMPAR loss and endocytosis, and that LTD induction forms AMPAR-containing endocytic vesicles. It describes those vesicles as only likely to arise from a clathrin-containing endocytic zone and says it remains unknown whether certain AMPARs are internalized through that zone. It does not establish that the endocytosis is clathrin-dependent or rapid. (LLM, conf=0.84)
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- Authors
- Newpher, T. M., & Ehlers, M. D.
- Affiliations
- Duke Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Ehlers, Michael D.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 58
- Issue
- 4
- Pages
- 472-497
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2572138
- OpenAlex
- W2162642602
- Cited by
- 356
- References
- 40
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 1 · 2023: 7 · 2022: 5 · 2021: 12 · 2020: 12 · 2019: 7 · 2018: 11 · 2017: 17 · 2016: 8 · 2015: 18 · 2014: 22 · 2013: 31 · 2012: 32
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1903 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Israel National Road Safety Authority
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- glutamate receptors, AMPA receptors, NMDA receptor, extrasynaptic receptors, synaptic plasticity, receptor trafficking, scaffold proteins, excitatory synaptic transmission, learning and memory
- MeSH terms
- Animals, Dendrites, Humans, Receptors, Glutamate, Nonlinear Dynamics, Membrane Microdomains
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