Cited by 192Neural dynamics and brain functionMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

On the formation of gamma-coherent cell assemblies by oriens lacunosum-moleculare interneurons in the hippocampus

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Tort, Adriano B. L., Rotstein, Horacio G., Dugladze, Tamar, Gloveli, Tengis, Kopell, Nancy J.·2007·Proceedings of the National Academy of Sciences

Abstract

Gamma frequency (30–80 Hz) network oscillations have been observed in the hippocampus during several behavioral paradigms in which they are often modulated by a theta frequency (4–12 Hz) oscillation. Interneurons of the hippocampus have been shown to be crucially involved in rhythms generation, and several subtypes with distinct anatomy and physiology have been described. In particular, the oriens lacunosum-moleculare (O-LM) interneurons were shown to synapse on distal apical dendrites of pyramidal cells and to spike preferentially at theta frequency, even in the presence of gamma-field oscillations. O-LM cells have also recently been shown to present higher axonal ramification in the longitudinal axis of the hippocampus. By using a hippocampal network model composed of pyramidal cells and two types of interneurons (O-LM and basket cells), we show here that the O-LM interneurons lead to gamma coherence between anatomically distinct cell modules. We thus propose that this could be a mechanism for coupling longitudinally distant cells excited by entorhinal cortex inputs into gamma-coherent assemblies.

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Crossref · 10.1073/pnas.0705708104

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  • Theta is a slow rhythm in which faster rhythms such as gamma can nest and aid long-range communication.

    “However, theta is well known to be a slow rhythm in which faster rhythms such as gamma, can nest (60–62) and aid long-range communication (63).”

    From Layer and rhythm specificity for predictive routing (2020) · cites this paper as [63]

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Authors
Tort, A. B. L., Rotstein, H. G., Dugladze, T., Gloveli, T., & Kopell, N. J.
Affiliations
  • Boston University (US)
  • New Jersey Institute of Technology (US)
  • Charité – Universitätsmedizin Berlin (DE)
Venue
Proceedings of the National Academy of Sciences
Published
2007-08-14
Volume
104
Issue
33
Pages
13490-13495
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1998240840
Cited by
192
References
40
Citations by year
2026: 2 · 2025: 7 · 2024: 10 · 2023: 10 · 2022: 12 · 2021: 7 · 2020: 15 · 2019: 9 · 2018: 11 · 2017: 14 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 12 · 2012: 13
FWCI
6.01
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01 NS46058, R01NS046058)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
gamma oscillations, oriens-lacunosum moleculare interneurons, hippocampus, theta oscillations, gamma coherence, basket cells, pyramidal neurons, neuronal network model
MeSH terms
Animals, Hippocampus, Interneurons, Mice, Inbred C57BL, Synapses, Mice

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