Cited by 205Fungal and yeast genetics researchBioinformatics and Genomic NetworksGene Regulatory Network Analysis

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Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes

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Dixon, Scott J., Fedyshyn, Yaroslav, Koh, Judice L. Y., Prasad, T. S. Keshava, Chahwan, Charly, Chua, Gordon, Toufighi, Kiana, Baryshnikova, Anastasija, Hayles, Jacqueline, Hoe, Kwang-Lae, Kim, Dong-Uk, Park, Han-Oh, Myers, Chad L., Pandey, Akhilesh, Durocher, Daniel, Andrews, Brenda J., Boone, Charles·2008·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0806261105PMC PMC2575475

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Abstract

Synthetic lethal genetic interaction networks define genes that work together to control essential functions and have been studied extensively in Saccharomyces cerevisiae using the synthetic genetic array (SGA) analysis technique ( Sc SGA). The extent to which synthetic lethal or other genetic interaction networks are conserved between species remains uncertain. To address this question, we compared literature-curated and experimentally derived genetic interaction networks for two distantly related yeasts, Schizosaccharomyces pombe and S. cerevisiae . We find that 23% of interactions in a novel, high-quality S. pombe literature-curated network are conserved in the existing S. cerevisiae network. Next, we developed a method, called S. pombe SGA analysis ( Sp SGA), enabling rapid, high-throughput isolation of genetic interactions in this species. Direct comparison by Sp SGA and Sc SGA of ∼220 genes involved in DNA replication, the DNA damage response, chromatin remodeling, intracellular transport, and other processes revealed that ∼29% of genetic interactions are common to both species, with the remainder exhibiting unique, species-specific patterns of genetic connectivity. We define a conserved yeast network (CYN) composed of 106 genes and 144 interactions and suggest that this network may help understand the shared biology of diverse eukaryotic species.

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Conservation of the genetic interaction network between two yeast speciesPreprint
Pons, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.21.677604
Additional file 1 of Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome
Horváth, A., Róna, G., Pagano, M., & Jordan, P. W. (2020) · Figshare · doi:10.6084/m9.figshare.12276824
Additional file 3 of Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome
Horváth, A., Róna, G., Pagano, M., & Jordan, P. W. (2020) · Figshare · doi:10.6084/m9.figshare.12276836
Additional file 2 of Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome
Horváth, A., Róna, G., Pagano, M., & Jordan, P. W. (2020) · Figshare · doi:10.6084/m9.figshare.12276827
Additional file 5 of Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome
Horváth, A., Róna, G., Pagano, M., & Jordan, P. W. (2020) · Figshare · doi:10.6084/m9.figshare.12276842
Additional file 4 of Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome
Horváth, A., Róna, G., Pagano, M., & Jordan, P. W. (2020) · Figshare · doi:10.6084/m9.figshare.12276839

Authors: Dixon, S. J., Fedyshyn, Y., Koh, J. L. Y., Prasad, T. S. K., Chahwan, C., Chua, G., Toufighi, K., Baryshnikova, A., Hayles, J., Hoe, K.-L., Kim, D.-U., Park, H.-O., Myers, C. L., Pandey, A., Durocher, D., Andrews, B. J., & Boone, C.
Affiliations: Mount Sinai Hospital (CA)
University of Toronto (CA)
Institute of Bioinformatics (IN)
University of Calgary (CA)
Cancer Research UK (GB)
Korea Research Institute of Bioscience and Biotechnology (KR)
Bioneer Corporation, 49-3, Munpyeong-dong, Daedeok-gu, Daejeon 306-220, Republic of Korea;
University of Minnesota (US)
Johns Hopkins University (US)
ORCID: Dixon, Scott J.
Fedyshyn, Yaroslav
Prasad, T. S. Keshava
Chahwan, Charly
Chua, Gordon
Hayles, Jacqueline
Hoe, Kwang-Lae
Kim, Dong-Uk
Park, Han-Oh
Myers, Chad L.
Pandey, Akhilesh
Durocher, Daniel
Andrews, Brenda J.
Boone, Charles
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2008-10-28
Volume: 105
Issue: 43
Pages: 16653-16658
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0806261105
PMC: PMC2575475
OpenAlex: W2083646206
Cited by: 205
References: 34
Citations by year: 2026: 2 · 2025: 9 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 11 · 2019: 7 · 2018: 9 · 2017: 21 · 2016: 6 · 2015: 17 · 2014: 16 · 2013: 17 · 2012: 25
FWCI: 6.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
KRIBB Repository (submittedVersion)
Funders: National Institutes of Health
Canadian Institutes of Health Research
National Cancer Institute
National Center for Research Resources (U54RR020839)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords: synthetic lethality, genetic interaction networks, Schizosaccharomyces pombe, Saccharomyces cerevisiae, synthetic genetic array, DNA replication, DNA damage response, chromatin remodeling, intracellular transport
MeSH terms: Genes, Fungal, Genes, Lethal, Phylogeny, Saccharomyces cerevisiae, Schizosaccharomyces, Gene Regulatory Networks

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Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes

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