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Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes
Open accessAbstract
Synthetic lethal genetic interaction networks define genes that work together to control essential functions and have been studied extensively in Saccharomyces cerevisiae using the synthetic genetic array (SGA) analysis technique ( Sc SGA). The extent to which synthetic lethal or other genetic interaction networks are conserved between species remains uncertain. To address this question, we compared literature-curated and experimentally derived genetic interaction networks for two distantly related yeasts, Schizosaccharomyces pombe and S. cerevisiae . We find that 23% of interactions in a novel, high-quality S. pombe literature-curated network are conserved in the existing S. cerevisiae network. Next, we developed a method, called S. pombe SGA analysis ( Sp SGA), enabling rapid, high-throughput isolation of genetic interactions in this species. Direct comparison by Sp SGA and Sc SGA of ∼220 genes involved in DNA replication, the DNA damage response, chromatin remodeling, intracellular transport, and other processes revealed that ∼29% of genetic interactions are common to both species, with the remainder exhibiting unique, species-specific patterns of genetic connectivity. We define a conserved yeast network (CYN) composed of 106 genes and 144 interactions and suggest that this network may help understand the shared biology of diverse eukaryotic species.
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“It is clear that the digenic interactions we have mapped in yeast can be conserved in different yeast species over hundreds of millions of years of evolution (49, 50).”
From A global genetic interaction network maps a wiring diagram of cellular function (2016) · cites this paper as [49]
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Functional profiling of the Saccharomyces cerevisiae genome
Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Véronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., André, B., et al. (2002) · Nature · doi:10.1038/nature00935 · Cited by 4,316
Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants
Tong, A. H. Y., Evangelista, M., Parsons, A. B., Xu, H., Bader, G. D., Pagé, N., Robinson, M., Raghibizadeh, S., Hogue, C. W. V., Bussey, H., et al. (2001) · Science · doi:10.1126/science.1065810 · Cited by 2,138
Self-citationGlobal Mapping of the Yeast Genetic Interaction Network
Tong, A. H. Y., Lesage, G., Bader, G. D., Ding, H., Xu, H., Xin, X., Young, J., Berriz, G. F., Brost, R. L., Chang, M., et al. (2004) · Science · doi:10.1126/science.1091317 · Cited by 2,089
Self-citationThe Concept of Synthetic Lethality in the Context of Anticancer Therapy
Kaelin, W. G. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1691 · Cited by 1,405
Principles for the buffering of genetic variation
Hartman, J. L., Garvik, B., & Hartwell, L. (2001) · Science · doi:10.1126/science.1056072 · Cited by 808
The origin and evolution of model organisms
Hedges, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg929 · Cited by 806
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W., & Friend, S. H. (1997) · Science · doi:10.1126/science.278.5340.1064 · Cited by 789
The BioGRID Interaction Database: 2008 update
Breitkreutz, B., Stark, C., Reguly, T., Boucher, L., Breitkreutz, A., Livstone, M. S., Oughtred, R., Lackner, D. H., Bähler, J., Wood, V., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1001 · Cited by 698
Exploring genetic interactions and networks with yeast
Boone, C., Bussey, H., & Andrews, B. J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2085 · Cited by 661
Self-citationGenome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions
Simmer, F., Moorman, C., van der Linden, A. M., Kuijk, E., van den Berghe, P. V. E., Kamath, R. S., Fraser, A. G., Ahringer, J., & Plasterk, R. H. A. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000012 · Cited by 655
Matsuyama, A., Arai, R., Yashiroda, Y., Shirai, A., Kamata, A., Sekido, S., Kobayashi, Y., Hashimoto, A., Hamamoto, M., Hiraoka, Y., et al. (2006) · Nature Biotechnology · doi:10.1038/nbt1222 · Cited by 560
Lehner, B., Crombie, C., Tischler, J., Fortunato, A., & Fraser, A. G. (2006) · Nature Genetics · doi:10.1038/ng1844 · Cited by 502
Periodic gene expression program of the fission yeast cell cycle
Rustici, G., Mata, J., Kivinen, K., Lió, P., Penkett, C. J., Burns, G., Hayles, J., Brāzma, A., Nurse, P., & Bähler, J. (2004) · Nature Genetics · doi:10.1038/ng1377 · Cited by 490
Self-citationMani, R., St.Onge, R. P., Hartman, J. L., Giaever, G. N., & Roth, F. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712255105 · Cited by 482
Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis
Boyartchuk, V., Ashby, M. N., & Rine, J. (1997) · Science · doi:10.1126/science.275.5307.1796 · Cited by 361
Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae
Reguly, T., Breitkreutz, A., Boucher, L., Breitkreutz, B.-J., Hon, G. C., Myers, C. L., Parsons, A., Friesen, H., Oughtred, R., Tong, A., et al. (2006) · Journal of Biology · doi:10.1186/jbiol36 · Cited by 326
Self-citationA Robust Toolkit for Functional Profiling of the Yeast Genome
Pan, X., Yuan, D., Xiang, D., Wang, X., Sookhai-Mahadeo, S., Bader, J. S., Hieter, P., Spencer, F. A., & Boeke, J. D. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.09.035 · Cited by 314
Lineage-specific loss and divergence of functionally linked genes in eukaryotes
Aravind, L., Watanabe, H., Lipman, D. J., & Koonin, E. V. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200346997 · Cited by 295
Fen1 mutations result in autoimmunity, chronic inflammation and cancers
Zheng, L., Dai, H., Zhou, M., Li, M., Singh, P., Qiu, J., Tsark, W. M. K., Huang, Q. M., Kernstine, K. H., Zhang, X., et al. (2007) · Nature Medicine · doi:10.1038/nm1599 · Cited by 255
Centromeres of budding and fission yeasts
Clarke, L. (1990) · Trends in Genetics · doi:10.1016/0168-9525(90)90149-z · Cited by 180
A global analysis of genetic interactions in Caenorhabditis elegans
Byrne, A. B., Weirauch, M. T., Wong, V., Koeva, M., Dixon, S. J., Stuart, J. M., & Roy, P. J. (2007) · Journal of Biology · doi:10.1186/jbiol58 · Cited by 174
Self-citationReview: Postchaperonin Tubulin Folding Cofactors and Their Role in Microtubule Dynamics
Fanárraga, M. L., Ávila, J., Guasch, A., Coll, M., & Zabala, J. C. (2001) · Journal of Structural Biology · doi:10.1006/jsbi.2001.4386 · Cited by 154
High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe
Roguev, A., Wirén, M., Weissman, J. S., & Krogan, N. J. (2007) · Nature Methods · doi:10.1038/nmeth1098 · Cited by 144
Evolutionary plasticity of genetic interaction networks
Tischler, J., Lehner, B., & Fraser, A. G. (2008) · Nature Genetics · doi:10.1038/ng.114 · Cited by 129
Comparative proteomic and transcriptomic profiling of the fission yeast Schizosaccharomyces pombe
Schmidt, M. W., Houseman, A., Ivanov, A. R., & Wolf, D. A. (2007) · Molecular Systems Biology · doi:10.1038/msb4100117 · Cited by 114
NatC Nα-terminal Acetyltransferase of Yeast Contains Three Subunits, Mak3p, Mak10p, and Mak31p
Polevoda, B. V., & Sherman, F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011440200 · Cited by 98
Tam, A., Schmidt, W. K., & Michaelis, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106150200 · Cited by 77
Schizosaccharomyces pombe Essential Genes: A Pilot StudyPreprint
Decottignies, A., Sánchez‐Pérez, I., & Nurse, P. (2003) · Genome Research · doi:10.1101/gr.636103 · Cited by 73
Tarailo‐Graovac, M., Tarailo, S., & Rose, A. M. (2007) · Genetics · doi:10.1534/genetics.107.080408 · Cited by 45
Zolezzi, F., Fuss, J. O., Uzawa, S., & Linn, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207890200 · Cited by 39
Prospects for functional genomics in Schizosaccharomyces pombe
Sunnerhagen, P. (2002) · Current Genetics · doi:10.1007/s00294-002-0335-6 · Cited by 21
Essential and distinct roles of the F-box and helicase domains of Fbh1 in DNA damage repair
Sakaguchi, C., Morishita, T., Shinagawa, H., & Hishida, T. (2008) · BMC Molecular Biology · doi:10.1186/1471-2199-9-27 · Cited by 19
Maxwell, C. A., Moreno, V. R., Solé, X., Gómez, L., Hernández, P., Urruticoechea, A., & Pujana, M. Á. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-4 · Cited by 14
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A global genetic interaction network maps a wiring diagram of cellular function
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Csermely, P., Korcsmáros, T., Kiss, H., London, G., & Nussinov, R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.016 · Cited by 911
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Ideker, T., & Krogan, N. J. (2012) · Molecular Systems Biology · doi:10.1038/msb.2011.99 · Cited by 795
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Kim, D.-U., Hayles, J., Kim, D., Wood, V., Park, H.-O., Won, M., Yoo, H.-S., Duhig, T., Nam, M., Palmer, G., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1628 · Cited by 742
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Metadata
- Authors
- Dixon, S. J., Fedyshyn, Y., Koh, J. L. Y., Prasad, T. S. K., Chahwan, C., Chua, G., Toufighi, K., Baryshnikova, A., Hayles, J., Hoe, K.-L., Kim, D.-U., Park, H.-O., Myers, C. L., Pandey, A., Durocher, D., Andrews, B. J., & Boone, C.
- Affiliations
- Mount Sinai Hospital (CA)
- University of Toronto (CA)
- Institute of Bioinformatics (IN)
- University of Calgary (CA)
- Cancer Research UK (GB)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Bioneer Corporation, 49-3, Munpyeong-dong, Daedeok-gu, Daejeon 306-220, Republic of Korea;
- University of Minnesota (US)
- Johns Hopkins University (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-10-28
- Volume
- 105
- Issue
- 43
- Pages
- 16653-16658
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2575475
- OpenAlex
- W2083646206
- Cited by
- 205
- References
- 34
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 11 · 2019: 7 · 2018: 9 · 2017: 21 · 2016: 6 · 2015: 17 · 2014: 16 · 2013: 17 · 2012: 25
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- KRIBB Repository (submittedVersion)
- Funders
- National Institutes of Health
- Canadian Institutes of Health Research
- National Cancer Institute
- National Center for Research Resources (U54RR020839)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- synthetic lethality, genetic interaction networks, Schizosaccharomyces pombe, Saccharomyces cerevisiae, synthetic genetic array, DNA replication, DNA damage response, chromatin remodeling, intracellular transport
- MeSH terms
- Genes, Fungal, Genes, Lethal, Phylogeny, Saccharomyces cerevisiae, Schizosaccharomyces, Gene Regulatory Networks
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