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Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes
Open accessAbstract
Synthetic lethal genetic interaction networks define genes that work together to control essential functions and have been studied extensively in Saccharomyces cerevisiae using the synthetic genetic array (SGA) analysis technique ( Sc SGA). The extent to which synthetic lethal or other genetic interaction networks are conserved between species remains uncertain. To address this question, we compared literature-curated and experimentally derived genetic interaction networks for two distantly related yeasts, Schizosaccharomyces pombe and S. cerevisiae . We find that 23% of interactions in a novel, high-quality S. pombe literature-curated network are conserved in the existing S. cerevisiae network. Next, we developed a method, called S. pombe SGA analysis ( Sp SGA), enabling rapid, high-throughput isolation of genetic interactions in this species. Direct comparison by Sp SGA and Sc SGA of ∼220 genes involved in DNA replication, the DNA damage response, chromatin remodeling, intracellular transport, and other processes revealed that ∼29% of genetic interactions are common to both species, with the remainder exhibiting unique, species-specific patterns of genetic connectivity. We define a conserved yeast network (CYN) composed of 106 genes and 144 interactions and suggest that this network may help understand the shared biology of diverse eukaryotic species.
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“It is clear that the digenic interactions we have mapped in yeast can be conserved in different yeast species over hundreds of millions of years of evolution (49, 50).”
From A global genetic interaction network maps a wiring diagram of cellular function (2016) · cites this paper as [49]
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Metadata
- Authors
- Dixon, S. J., Fedyshyn, Y., Koh, J. L. Y., Prasad, T. S. K., Chahwan, C., Chua, G., Toufighi, K., Baryshnikova, A., Hayles, J., Hoe, K.-L., Kim, D.-U., Park, H.-O., Myers, C. L., Pandey, A., Durocher, D., Andrews, B. J., & Boone, C.
- Affiliations
- Mount Sinai Hospital (CA)
- University of Toronto (CA)
- Institute of Bioinformatics (IN)
- University of Calgary (CA)
- Cancer Research UK (GB)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Bioneer Corporation, 49-3, Munpyeong-dong, Daedeok-gu, Daejeon 306-220, Republic of Korea;
- University of Minnesota (US)
- Johns Hopkins University (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-10-28
- Volume
- 105
- Issue
- 43
- Pages
- 16653-16658
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2575475
- OpenAlex
- W2083646206
- Cited by
- 205
- References
- 34
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 11 · 2019: 7 · 2018: 9 · 2017: 21 · 2016: 6 · 2015: 17 · 2014: 16 · 2013: 17 · 2012: 25
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- KRIBB Repository (submittedVersion)
- Funders
- National Institutes of Health
- Canadian Institutes of Health Research
- National Cancer Institute
- National Center for Research Resources (U54RR020839)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- synthetic lethality, genetic interaction networks, Schizosaccharomyces pombe, Saccharomyces cerevisiae, synthetic genetic array, DNA replication, DNA damage response, chromatin remodeling, intracellular transport
- MeSH terms
- Genes, Fungal, Genes, Lethal, Phylogeny, Saccharomyces cerevisiae, Schizosaccharomyces, Gene Regulatory Networks
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