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Brain mast cells link the immune system to anxiety-like behavior

Nautiyal, Katherine M., Ribeiro, Ana C., Pfaff, Donald W., Silver, Rae·2008·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0809479105
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Abstract

Mast cells are resident in the brain and contain numerous mediators, including neurotransmitters, cytokines, and chemokines, that are released in response to a variety of natural and pharmacological triggers. The number of mast cells in the brain fluctuates with stress and various behavioral and endocrine states. These properties suggest that mast cells are poised to influence neural systems underlying behavior. Using genetic and pharmacological loss-of-function models we performed a behavioral screen for arousal responses including emotionality, locomotor, and sensory components. We found that mast cell deficient Kit W−sh/W−sh (sash −/− ) mice had a greater anxiety-like phenotype than WT and heterozygote littermate control animals in the open field arena and elevated plus maze. Second, we show that blockade of brain, but not peripheral, mast cell activation increased anxiety-like behavior. Taken together, the data implicate brain mast cells in the modulation of anxiety-like behavior and provide evidence for the behavioral importance of neuroimmune links.

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Research works printed but not linked: 62

  1. 10.1073/pnas.1534743100 · DOI
  2. 10.1038/nature05713 · DOI
  3. 10.1016/0301-0082(88)90032-9 · DOI
  4. 10.1016/0166-2236(96)81863-7 · DOI
  5. 10.1159/000144540 · DOI
  6. 10.1038/nri1460 · DOI
  7. 10.1002/1096-9861(20000904)424:4<651::AID-CNE7>3.0.CO;2-G · DOI
  8. 10.1159/000236338 · DOI
  9. 10.1016/j.it.2005.10.002 · DOI
  10. 10.1007/BF00993271 · DOI
  11. 10.1016/0166-2236(89)90059-3 · DOI · Paper page
  12. 10.1523/JNEUROSCI.20-01-00401.2000 · DOI · Paper page
  13. 10.1016/j.jneuroim.2005.07.026 · DOI
  14. 10.1111/j.1600-065X.2007.00512.x · DOI
  15. 10.1111/j.1460-9568.2005.04429.x · DOI
  16. 10.1016/j.brainres.2007.07.034 · DOI
  17. 10.1016/j.neulet.2005.09.029 · DOI
  18. 10.1016/j.brainres.2005.07.022 · DOI
  19. 10.1006/hbeh.2002.1799 · DOI
  20. 10.1016/j.brainres.2006.07.100 · DOI
  21. 10.1016/S0163-1047(80)91283-2 · DOI
  22. 10.1006/brbi.1998.0505 · DOI
  23. 10.1016/S0163-1047(79)90448-5 · DOI
  24. D Pfaff Brain Arousal and Information Theory: Neural and Genetic Mechanisms (Harvard Univ Press, Cambridge, MA, 2005).
  25. 10.1016/j.expneurol.2007.03.005 · DOI
  26. 10.1242/dev.118.3.705 · DOI
  27. 10.1016/S0002-9440(10)62055-X · DOI · Paper page
  28. AJ Bugajski, Z Chlap, J Bugajski, J Borycz, Effect of compound 48/80 on mast cells and biogenic amine levels in brain structures and on corticosterone secretion. J Physiol Pharmacol 46, 513–522 (1995).
  29. 10.1007/BF01244623 · DOI
  30. 10.1016/0024-3205(82)90434-9 · DOI
  31. 10.1126/science.6153130 · DOI
  32. 10.1111/j.1365-2222.1996.tb00661.x · DOI
  33. 10.3109/02770909309066375 · DOI
  34. G Addolorato, et al., Anxiety and depression: A common feature of health care seeking patients with irritable bowel syndrome and food allergy. Hepatogastroenterology 45, 1559–1564 (1998).
  35. 10.1016/j.bbi.2007.01.002 · DOI
  36. 10.1196/annals.1366.028 · DOI
  37. 10.1182/blood-2007-11-078097 · DOI · Paper page
  38. 10.2169/internalmedicine.33.23 · DOI
  39. 10.1212/01.wnl.0000168897.35545.61 · DOI
  40. 10.1016/j.tips.2008.06.002 · DOI
  41. 10.1016/S0301-0082(00)00039-3 · DOI
  42. 10.1007/BF00428315 · DOI
  43. 10.1016/S0091-3057(02)00708-6 · DOI
  44. 10.1016/j.ejphar.2008.01.003 · DOI
  45. 10.1111/j.1460-9568.2004.03546.x · DOI
  46. 10.1016/S0091-3057(00)00320-8 · DOI
  47. 10.1016/S0006-3223(98)00139-5 · DOI
  48. 10.1016/S0893-133X(99)00045-7 · DOI
  49. 10.1038/nrn1256 · DOI · Paper page
  50. 10.1016/0163-7258(95)00004-Z · DOI
  51. 10.2741/1341 · DOI
  52. 10.1111/j.1749-6632.2001.tb05826.x · DOI
  53. 10.1073/pnas.80.6.1735 · DOI
  54. 10.1073/pnas.79.19.6093 · DOI
  55. 10.1073/pnas.262663799 · DOI
  56. 10.1210/endo.141.3.7352 · DOI
  57. 10.1007/BF02007774 · DOI
  58. 10.1016/S0006-8993(99)01935-6 · DOI
  59. 10.1016/j.bbi.2007.01.010 · DOI · Paper page
  60. 10.1016/j.tips.2008.06.005 · DOI
  61. 10.1073/pnas.0408154101 · DOI
  62. 10.1002/bies.950100604 · DOI

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Metadata

Authors
Nautiyal, K. M., Ribeiro, A. C., Pfaff, D. W., & Silver, R.
Affiliations
  • Department of Psychology, Columbia University, 1190 Amsterdam Avenue, New York, NY 10027;
  • Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021;
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2008-11-18
Volume
105
Issue
46
Pages
18053-18057
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.0809479105
Cited by
167
References
10
Language
en
Licence
www.pnas.org/site/misc/userlicense.xhtml (vor, 174 d)

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CoChat. (2026). Citation check: Brain mast cells link the immune system to anxiety-like behavior. https://app.cochat.ai/papers/10.1073/pnas.0809479105
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Nautiyal, K. M., Ribeiro, A. C., Pfaff, D. W., & Silver, R. (2008). Brain mast cells link the immune system to anxiety-like behavior. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0809479105